Neighborhood deprivation and DNA methylation and expression of cancer genes in breast tumors

JAMA Network Open

2023-11-06

(Press-News.org) About The Study: In this study of 185 women with breast cancer, high neighborhood deprivation was associated with differences in tissue DNA methylation and gene expression among Black women. These findings suggest that continued investment in public health interventions and policy changes at the neighborhood level may help to remedy biological alterations that could make minoritized populations more susceptible to chronic diseases.

Authors: Stefan Ambs, Ph.D., of the National Cancer Institute in Bethesda, Maryland, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2023.41651)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.41651?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=110623

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

UC Irvine-led science team shows how to eat our way out of the climate crisis

2023-11-06

Irvine, Calif., Nov. 6, 2023 — Agriculture is one of the hardest human activities to decarbonize; people must eat, but the land-use practices associated with growing crops account for roughly a quarter of global greenhouse gas emissions. Researchers at the University of California, Irvine and other institutions evaluate a new solution to this problem, one that eliminates farms altogether. In a study published today in Nature Sustainability, the UCI-led team of scientists assess the potential for widescale synthetic production of dietary fats through chemical and biological processes. The raw materials for this method are the same as those used by ...

Keeping an eye on the regions when it comes to climate change

2023-11-06

Keeping an eye on the regions when it comes to climate change Up to now, the results of climate simulations have sometimes contradicted the analysis of climate traces from the past. A team led by the physicist Thomas Laepple from the Alfred Wegener Institute in Potsdam and the climatologist Kira Rehfeld from the University of Tübingen has therefore brought together experts in climate models and climate tracks to clarify how the discrepancies come about. The surprising result has now been published in the journal Nature Geoscience: in a way, both sides ...

Abortion bans linked to increase in children entering foster system, researchers find

2023-11-06

BOSTON – In June 2022, the U.S. Supreme Court overruled Roe v. Wade, effectively ending 50 years of federal protections to abortion care. As of October 2023, twenty-six states have since enacted laws to ban or restrict abortion access, with 14 states completely banning the procedure. Today, an estimated 25 million American women of childbearing age, or about one third of women ages 15 to 45, live in areas where abortion care is severely restricted. Historically, many states were able to restrict access to abortion even before 2022 through Targeted Regulation of Abortion Providers (TRAP) laws; these laws decrease ...

A blood test shows MS worsening 1 to 2 years before it happens

2023-11-06

Multiple sclerosis patients whose blood tests reveal elevated NfL, a biomarker of nerve damage, could see worsening disability one to two years later, according to a new study spearheaded by researchers at UC San Francisco. The study is the first to quantify the timeframe preceding disability worsening in which injury to the central nervous system takes place, said co-first author Ahmed Abdelhak, MD, of the UCSF Department of Neurology and the Weill Institute for Neurosciences. Almost 1 million Americans ...

Major study validates Owkin’s best in class AI diagnostic for colorectal cancer biomarker aimed at optimizing patient access to immunotherapy

2023-11-06

Article in Nature Communications demonstrates that with 96% sensitivity, AI diagnostic MSIntuit™ CRC can rule out almost half of the MSS population of colorectal cancer patients unlikely to respond to checkpoint inhibitor therapy from additional screening. Such AI-enabled solutions have the potential to improve lab efficiency, addressing global pathology shortages and reducing testing burden to match the right patients to the right therapies. Paris and New York., 6 Nov 2023 – In a peer-reviewed study published today in Nature Communications, a team of scientists ...

Food waste prevention in Europe can generate major footprint savings

2023-11-06

New research shows that European food consumption draws unnecessarily excessively on global resources, which is why researchers are calling for political action. Many of the foods that are consumed in Europe are produced in countries outside Europe. Food loss – and waste later in the chain, (read more on waste terms below) – occurs along the food supply chain, from the primary agricultural sector in Europe or rest of the world, until it feeds mouths in Europe. “Halving Europe’s food loss and waste, together with a redistribution of global food resources, could solve the challenges of food shortages in the ...

NIH grant expands UIC brain bank into citywide effort to study epilepsy, brain cancer

2023-11-06

A new virtual brain bank spanning five Chicago academic medical centers and led by University of Illinois Chicago will create a powerful new resource for clinical care and research on epilepsy, brain tumors and neurological disorders. A $5 million grant from the National Institutes of Health will create a network of brain tissue research at UIC, Northwestern University, Lurie Children’s Hospital, Rush University and University of Chicago. The institutions will utilize a data platform developed at UIC called INTUITION that combines tissue data with clinical, functional, genetic and 3D imaging information to assist clinicians treating patients and help researchers better understand ...

Carbon-based sensors are poised to facilitate a seamless human-machine interface

2023-11-06

Interaction between machines and humans is paramount to the development of the new technologies of the metaverse, which are designed to augment the human experience through cloud computing and extended reality (XR). Graphene, a two-dimensional carbon material, has emerged as an ideal candidate for wearable sensor technology, paving the way for a new era of seamless human-machine interaction (HMI). A team of material scientists led by Tian-Ling Ren from Tsinghua University in Beijing, China recently outlined the state of graphene-based HMI sensor technology ...

Chronic liver diseases: What new insights are there?

2023-11-06

Fatty liver diseases (FLD) have become a significant health concern worldwide, affecting millions. The two most common types of FLD are non-alcoholic fatty liver disease (NAFLD) and alcoholic-associated liver disease (ALD). NAFLD is associated with obesity, insulin resistance, and metabolic syndrome, while ALD is caused by excessive alcohol consumption. Both NAFLD and ALD can progress to liver fibrosis, cirrhosis, and, ultimately, hepatocellular carcinoma (HCC), a primary liver cancer with a poor prognosis. Significant ...

Future therapies for managing inflammatory bowel disease

2023-11-06

Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) that affect the gastrointestinal tract. In recent decades, there have been significant advances in the understanding of IBD pathophysiology and the development of new treatments. The International Organisation for the Study of Inflammatory Bowel Diseases (IOIBD) developed the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) programs, which recommend specific treatment goals for UC and CD in children ...

Neighborhood deprivation and DNA methylation and expression of cancer genes in breast tumors

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: