(Press-News.org)
“[...] this study is an initial examination of the associations between epigenetic and transcriptomic aging biomarkers and novel NMR lipoprotein biomarkers.”
BUFFALO, NY- May 7, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, “Associations among NMR-measured inflammatory and metabolic biomarkers and accelerated aging in cardiac catheterization patients.”
Research into aging has grown substantially with the creation of molecular biomarkers of biological age that can be used to determine age acceleration. Concurrently, nuclear magnetic resonance (NMR) assessment of biomarkers of inflammation and metabolism provides researchers with new ways to examine intermediate risk factors for chronic disease.
In this new study, researchers Henry Raab, Elizabeth R. Hauser, Lydia Coulter Kwee, Svati H. Shah, William E. Kraus, and Cavin K. Ward-Caviness from the U.S. Environmental Protection Agency and Duke University used data from a cardiac catheterization cohort to examine associations between biomarkers of cardiometabolic health and accelerated aging assessed using both gene expression (Transcriptomic Age) and DNA methylation (Hannum Age, GrimAge, Horvath Age, and Phenotypic Age).
“This study utilizes the CATHGEN cohort from the Jiang et al. study to investigate associations between multiple epigenetic and transcriptomic aging biomarkers and a broad array of NMR-based measures of inflammation, lipid homeostasis, and diabetes risk.”
Linear regression models were used to associate accelerated aging with each outcome (cardiometabolic health biomarkers) while adjusting for chronological age, sex, race, and neighborhood socioeconomic status. Their study shows a robust association between GlycA and GrimAge (5.71, 95% CI = 4.36, 7.05, P = 7.94 × 10−16), Hannum Age (1.81, 95% CI = 0.65, 2.98, P = 2.30 × 10−3), and Phenotypic Age (2.88, 95% CI = 1.91, 3.87, P = 1.21 × 10−8). The researchers also saw inverse associations between apolipoprotein A-1 and aging biomarkers.
“These associations provide insight into the relationship between aging and cardiometabolic health that may be informative for vulnerable populations.”
Read the full paper: DOI: https://doi.org/10.18632/aging.205758
Corresponding Author: Cavin K. Ward-Caviness
Corresponding Email: ward-caviness.cavin@epa.gov
Keywords: biological aging, NMR, biomarkers, cardiac catheterization
Click here to sign up for free Altmetric alerts about this article.
About Aging:
Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.
Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
Please visit our website at www.Aging-US.com and connect with us:
Facebook
X, formerly Twitter
Instagram
YouTube
LinkedIn
Reddit
Pinterest
Spotify, and available wherever you listen to podcasts
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker Str., Suite 1B
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
###
END
We are living in a very noisy world. From the hum of traffic outside your window to the next-door neighbor’s blaring TV to sounds from a co-worker’s cubicle, unwanted noise remains a resounding problem.
To cut through the din, an interdisciplinary collaboration of researchers from MIT and elsewhere developed a sound-suppressing silk fabric that could be used to create quiet spaces.
The fabric, which is barely thicker than a human hair, contains a special fiber that vibrates when a voltage is applied to it. The researchers leveraged those vibrations to suppress ...
NEW YORK, May 7, 2024 — A team of researchers from the CUNY Graduate Center, the CUNY Advanced Science Research Center (CUNY ASRC), Brooklyn College, and Lehman College has been selected to receive a highly competitive cooperative agreement award aimed at expanding and innovating NASA’s Global Learning and Observations to Benefit the Environment (GLOBE) program. The five-year, $11.1-million project awarded to the CUNY Graduate Center will help advance GLOBE’s mission to create a worldwide community of students, educators, scientists, and members of the public who work together to better understand, ...
Reston, VA—A novel investigational PET imaging agent can rapidly and accurately visualize lesions in clear cell renal cell cancer (ccRCC) patients according to new research published in the May issue of The Journal of Nuclear Medicine. The results of the study suggest that the agent 68Ga-DPI-4452 (Debio 0328) is superior to standard CT imaging in the context of ccRCC. It also allows for significantly faster imaging and, in the future, could be utilized as part of a theranostic pair.
ccRCC accounts for 70-80 percent of renal cell carcinoma ...
UCLA Health is set to host a unique symposium this week to explore the evolving research in psychedelic therapies and how combining it with reconnection to natural world could help to amplify their mental health benefits.
The all-day symposium on May 10 at the UCLA campus will bring together the expertise and insights of researchers from UCLA Health’s Psychedelic Studies Initiative and the Jane and Terry Semel Institute for Neuroscience and Human Behaviors as well as filmmakers, psychiatrists, urban planners, indigenous health experts, writers and environmental leaders from throughout the world.
“Promising ...
In a fast-paced digital age where patients can open their test results as soon as they are available, what happens when a patient reads through complicated results without a physician there to help them understand what it all means? And what happens when a patient misinterprets bad news as good news, or vice versa?
It’s a scenario Benjamin Vipler, MD, confronted after his mom received her colonoscopy results on her health system’s patient portal. Like many patients, she opened up her results before meeting with her clinician and tried to decipher the medical jargon. Thinking the results showed she ...
As people have more difficulty distinguishing fact from fiction in the United States, they are more likely to feel news fatigue and avoid news altogether, according to a University of Michigan study.
More than an unintentional avoidance because of lack of media exposure, the researchers say people actively avoid news.
The researchers also find that people who identify as strong Democrats begin relying more on nonpartisan news media when feeling misinformed, while people who identify as strong Republicans report using less news media overall, including less conservative news media. Their results are published in Journalism Studies.
"The more confusing ...
NEW ORLEANS, La. – Ochsner Health, a leader in patient care, research and education, has been named one of America’s Greatest Workplaces for Mental Wellbeing 2024 by Newsweek and Plant-A Insights Group. The ranking survey conducted included responses from more than 250,000 young professionals and more than 1.5 million company reviews.
Ochsner Health is committed to fostering an environment that prioritizes the mental well-being of each employee through innovative health initiatives, comprehensive support services and a culture ...
LA JOLLA, CA—Scripps Research professor emeritus John Johnson, PhD, has been elected to the National Academy of Sciences—one of the highest honors given to scientists. According to the Academy, members are selected “in recognition of their distinguished and continuing achievements in original research.”
“Becoming a member of the Academy is a great honor for me and the 70 graduate students and post docs that have worked in my lab since 1978, as well as numerous collaborators at Scripps and around the world,” says Johnson, who is also the Eldon R. Strahm Professor of Structural Virology in the Department of Integrative Structural ...
Construction of the National Center for Resilient and Regenerative Precision Agriculture at Nebraska Innovation Campus launched with a ceremonial turning of dirt on May 6.
The state-of-the-art research center is a partnership between the U.S. Department of Agriculture’s Agricultural Research Service, University of Nebraska–Lincoln and Nebraska Innovation Campus. The center will focus on the challenges and opportunities in agricultural innovation for the 21st century.
“There is a long history of scientific innovation and collaboration between ARS and UNL, typical of the USDA-land-grant ...
UPTON, N.Y. — The American Association for the Advancement of Science (AAAS) has recognized two staff scientists from the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory with the distinction of Fellow: Deputy Associate Laboratory Director for High Energy Physics Dmitri Denisov and Senior Chemist Anatoly Frenkel. Each year, AAAS bestows this honor on select members whose “efforts on behalf of the advancement of science, or its applications, are scientifically or socially distinguished.” Marking the 150th anniversary of the program, new fellows ...
