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Age, race impact AI performance on digital mammograms

Age, race impact AI performance on digital mammograms
( OAK BROOK, Ill. – In a study of nearly 5,000 screening mammograms interpreted by an FDA-approved AI algorithm, patient characteristics such as race and age influenced false positive results. The study’s results were published today in Radiology, a journal of the Radiological Society of North America (RSNA).

“AI has become a resource for radiologists to improve their efficiency and accuracy in reading screening mammograms while mitigating reader burnout,” said Derek L. Nguyen, M.D., assistant professor at Duke University in Durham, North Carolina. “However, the impact of patient characteristics on AI performance has not been well studied.”

Dr. Nguyen said while preliminary data suggests that AI algorithms applied to screening mammography exams may improve radiologists’ diagnostic performance for breast cancer detection and reduce interpretation time, there are some aspects of AI to be aware of.

“There are few demographically diverse databases for AI algorithm training, and the FDA does not require diverse datasets for validation,” he said. “Because of the differences among patient populations, it’s important to investigate whether AI software can accommodate and perform at the same level for different patient ages, races and ethnicities.”

In the retrospective study, researchers identified patients with negative (no evidence of cancer) digital breast tomosynthesis screening examinations performed at Duke University Medical Center between 2016 and 2019. All patients were followed for a two-year period after the screening mammograms, and no patients were diagnosed with a breast malignancy.

The researchers randomly selected a subset of this group consisting of 4,855 patients (median age 54 years) broadly distributed across four ethnic/racial groups. The subset included 1,316 (27%) white, 1,261 (26%) Black, 1,351 (28%) Asian, and 927 (19%) Hispanic patients.

A commercially available AI algorithm interpreted each exam in the subset of mammograms, generating both a case score (or certainty of malignancy) and a risk score (or one-year subsequent malignancy risk).

“Our goal was to evaluate whether an AI algorithm’s performance was uniform across age, breast density types and different patient race/ethnicities,” Dr. Nguyen said.

Given all mammograms in the study were negative for the presence of cancer, anything flagged as suspicious by the algorithm was considered a false positive result. False positive case scores were significantly more likely in Black and older patients (71-80 years) and less likely in Asian patients and younger patients (41-50 years) compared to white patients and women between the ages of 51 and 60.

“This study is important because it highlights that any AI software purchased by a healthcare institution may not perform equally across all patient ages, races/ethnicities and breast densities,” Dr. Nguyen said. “Moving forward, I think AI software upgrades should focus on ensuring demographic diversity.”

Dr. Nguyen said healthcare institutions should understand the patient population they serve before purchasing an AI algorithm for screening mammogram interpretation and ask vendors about their algorithm training.

“Having a baseline knowledge of your institution’s demographics and asking the vendor about the ethnic and age diversity of their training data will help you understand the limitations you’ll face in clinical practice,” he said. 


“Patient Characteristics Impact Performance of AI Algorithm in Interpreting Negative Screening Digital Breast Tomosynthesis Studies.” Collaborating with Dr. Nguyen were Yinhao Ren, Ph.D., Tyler M. Jones, B.S., Samantha M. Thomas, M.S., Joseph Y. Lo, Ph.D., and Lars J. Grimm, M.D., M.S.

Radiology is edited by Linda Moy, M.D., New York University, New York, N.Y., and owned and published by the Radiological Society of North America, Inc. (

RSNA is an association of radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Illinois. (

For patient-friendly information on breast cancer screening, visit


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[] Age, race impact AI performance on digital mammograms