PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

ASCO: Combination therapy significantly improves outcomes for patients with metastatic colorectal cancer

Combining immune-targeted therapy with chemotherapy improves both progression-free survival and overall survival when compared to those who received regorafenib alone

2024-05-24
(Press-News.org) FINDINGS

A study led by UCLA Health Jonsson Comprehensive Cancer Center researchers found that using a combination of experimental immunotherapy drugs with chemotherapy significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer who have previously undergone standard chemotherapy treatment when compared to those who received the targeted therapy regorafenib alone.

The median progression-free survival, which is the amount of time during and after treatment when the cancer does not worsen or progress, with the combination treatment was 6.2 months compared to 2.1 months for those in the targeted therapy only group. 

The median overall survival with the combination treatment was 19.7 months as compared to 9.5 months for those in the targeted therapy only group.

The results of the study also showed treatment with the novel combination therapy either partially or completely shrank tumors in 17.3% of patients. For patients on regorafenib only, 2.7% had tumor shrinkage.

BACKGROUND

When colorectal cancer starts to spread to other parts of the body, it can be more challenging to treat and often requires a combination of therapies, including surgery, chemotherapy, targeted therapies and immunotherapy. While these advancements in treatment options have improved outcomes for many patients with metastatic colorectal cancer, it still remains a significant health issue. Conventional treatments often become ineffective as the disease progresses, requiring the development of innovative therapeutic approaches. 

METHOD

This group of investigators looked at evaluating the efficacy of a novel treatment combination, called EZFB, which consists of etrumadenant (E), a dual A2a/A2b adenosine receptor antagonist, zimberelimab (Z), an immune checkpoint inhibitor, and a chemotherapy regimen (FB: mFOLFOX-6 ± bevacizumab), to see if it could improve outcomes for people who were previously treated for this aggressive form of cancer.

The team enrolled 112 participants with metastatic colorectal cancer who had previously undergone treatment with oxaliplatin and irinotecan-containing regimens in the Phase Ib/II trial. The patients were randomized into two groups: 75 receiving the EZFB combination and 37 receiving regorafenib alone.

IMPACT

The study's findings underscore the potential of combining immune-targeted therapy  with traditional chemotherapy to better control the spread of the cancer and enhance the effectiveness of the treatment in metastatic colorectal cancer.

"The improvement in both progression-free survival and overall survival observed with the EZFB combination represents a significant advancement in the management of refractory metastatic colorectal cancer,” said first author of the abstract Dr. Zev Wainberg, co-director of the UCLA Health GI Oncology Program and researcher at the UCLA Health Jonsson Comprehensive Cancer Center. “These results pave the way for further exploration of this promising treatment approach."

AUTHORS

The abstract’s senior author is Michael Cecchini from Yale University School of Medicine. Other authors are Sae-Won Han, Soohyeon Lee, Keun-Wook Lee, Scott Kopetz, Jonathan Mizrahi, Yong Sang Hong, François Ghiringhelli, Antoine Italiano, David Tougeron, Brandon Beagle, Mathew Boakye, Tingting Zhao, Joon Rhee and Dimitry Nuyten. 

SESSION

Wainberg will present the findings (Abstract 3508) at the annual American Society of Clinical Oncology meeting on Sunday, June 2 during the Oral Abstract Session of the Gastrointestinal Cancer—Colorectal and Anal Track from 8 to 11am CT.

The study was sponsored by Arcus Biosciences.

END


ELSE PRESS RELEASES FROM THIS DATE:

Euclid space mission releases first scientific results and new images of the cosmos

Euclid space mission releases first scientific results and new images of the cosmos
2024-05-24
European space mission Euclid has released early scientific papers based on observations made by the space telescope, along with five new astronomical images of the Universe, as the project sets about unravelling the secrets of the cosmos. The new images are part of Euclid’s Early Release Observations (EROs) and accompany the mission’s first scientific data and 10 forthcoming science papers. Their publication comes less than a year after the space telescope’s launch and some six months after it returned its first full-colour ...

Sociodemographic heterogeneity in the associations of social isolation with mortality

2024-05-24
About The Study: Social isolation was associated with increased risks of all-cause, cardiovascular diseases, and malignant neoplasm mortality, with associations varying across populations. This study fills an important gap in research on social isolation, emphasizing its varied associations across demographic and socioeconomic groups.  Corresponding Author: To contact the corresponding author, Atsushi Nakagomi, M.D., Ph.D., email anakagomi0211@gmail.com. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.13132) Editor’s Note: Please ...

COVID-19 admission rates and changes in care quality in us hospitals

2024-05-24
About The Study: In this cross-sectional study, COVID-19 surges were associated with declines in hospital quality, highlighting the importance of identifying and implementing strategies to maintain care quality during periods of high hospital use.  Corresponding Author: To contact the corresponding author, Giacomo Meille, Ph.D., email giacomo.meille@ahrq.hhs.gov. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.13127) Editor’s Note: Please see the article for additional information, ...

Preterm and early-term delivery after heat waves in 50 US metropolitan areas

2024-05-24
About The Study: Preterm and early-term birth rates increased after heat waves, particularly among socioeconomically disadvantaged subgroups in this cohort study. Extreme heat events have implications for perinatal health.  Corresponding Author: To contact the corresponding author, Lyndsey A. Darrow, Ph.D., email ldarrow@unr.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.12055) Editor’s Note: Please see the article for additional information, including other authors, author contributions and ...

Research spotlight: Virtual scribes reduced physicians’ time spent on electronic health records

Research spotlight: Virtual scribes reduced physicians’ time spent on electronic health records
2024-05-24
Lisa Rotenstein, MD, of the Department of Medicine at Brigham and Women’s Hospital, is the lead author of a new study published in JAMA Network Open, “Virtual Scribes and Physician Time Spent on Electronic Health Records.” What question were you investigating? We sought to understand the impact of virtual scribes (human scribes who are not physically present in the exam room with the physician and patient) on how physicians spend their time and which characteristics are associated with physicians responding best to scribes. What methods or approach did you use? We studied the experiences of 144 physicians across specialties treating patients ...

Duke-NUS researchers develop new light-controlled ‘off switch’ for brain cells

Duke-NUS researchers develop new light-controlled ‘off switch’ for brain cells
2024-05-24
Researchers from Duke-NUS Medical School have found that a new class of light-sensitive proteins are capable of turning off brain cells with light, offering scientists an unprecedentedly effective tool to investigate brain function. The study, recently published in Nature Communications, opens exciting new opportunities to apply optogenetics to investigate the brain activity underlying neurodegenerative and psychiatric disorders such as Parkinson’s disease and depression. Optogenetics is a technique where specific cells are bioengineered to include light-sensitive proteins that act as switches, allowing ...

Liver lesions at risk of transformation into hepatocellular carcinoma in cirrhotic patients

Liver lesions at risk of transformation into hepatocellular carcinoma in cirrhotic patients
2024-05-24
Hepatocellular carcinoma (HCC) represents a significant global health burden as one of the most common malignancies in individuals with chronic liver disease or cirrhosis. This malignancy evolves through a multistep process, beginning with dysplastic nodules (DNs) and early HCC, progressing to overt HCC. Recent advancements in liver imaging, particularly the use of hepatocyte-specific contrast agents, have enhanced the detection of these precursor lesions, known as borderline hepatic nodules. These nodules, especially those hypointense in the hepatobiliary phase (HBP) without arterial phase hyperenhancement (APHE), present ...

Update on the STING signaling pathway in developing nonalcoholic fatty liver disease

Update on the STING signaling pathway in developing nonalcoholic fatty liver disease
2024-05-24
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver condition worldwide, affecting about 25% of the global population due to the increasing rates of obesity and metabolic syndrome. NAFLD encompasses a spectrum of liver conditions ranging from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which can progress to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Despite its prevalence, there are limited effective treatment options available. Inflammation driven by metabolic disturbances is a key factor in the development and progression of ...

Autonomous medical intervention extends ‘golden hour’ for traumatic injuries with emergency air transport

Autonomous medical intervention extends ‘golden hour’ for traumatic injuries with emergency air transport
2024-05-24
For the first time, a closed loop, autonomous intervention nearly quadrupled the “golden hour” during which surgeons could save the life of a large animal with internal traumatic bleeding while in emergency ground and air transport. This breakthrough in trauma care, announced today in Intensive Care Medicine Experimental by physician-scientists at the University of Pittsburgh School of Medicine and funded by the U.S. Department of Defense, has enormous potential for saving the lives of traumatically injured ...

More than spins: Exploring uncharted territory in quantum devices

More than spins: Exploring uncharted territory in quantum devices
2024-05-24
Many of today’s quantum devices rely on collections of qubits, also called spins. These quantum bits have only two energy levels, the ‘0’ and the ‘1’. However, spins in real devices also interact with light and vibrations known as bosons, greatly complicating calculations. In a new publication in Physical Review Letters, researchers in Amsterdam demonstrate a way to describe spin-boson systems and use this to efficiently configure quantum devices in a desired state. Quantum devices use the quirky behaviour of quantum ...

LAST 30 PRESS RELEASES:

Discovery of spontaneous inflow and outflow states of high-temperature plasma by energetic ions

Tax the rich, say a majority of adults across 17 G20 countries surveyed

Semaglutide leads to greater weight loss in women than men with HF, improves HF symptoms in both sexes

12.5, the 1st Impact Factor of COMMTR released!

Circadian clock impact on cluster headaches funded by $2.4M NIH grant for UTHealth Houston research

Study identifies first drug therapy for sleep apnea

How old is your bone marrow?

Boosting biodiversity without hurting local economies

ChatGPT is biased against resumes with credentials that imply a disability — but it can improve

Simple test for flu could improve diagnosis and surveillance

UT Health San Antonio researcher awarded five-year, $2.53 million NIH grant to study alcohol-assisted liver disease

Giving pre-med students hands-on clinical training

CAMH research suggests potential targets for prevention and early identification of psychotic disorders

Mapping the heart to prevent damage caused by a heart attack

Study challenges popular idea that Easter islanders committed ‘ecocide’

Chilling discovery: Study reveals evolution of human cold and menthol sensing protein, offering hope for future non-addictive pain therapies.

Elena Beccalli, new rector of Università Cattolica del Sacro Cuore, takes office on 1st July

Pacific Northwest Research Institute uncovers hidden DNA mechanisms of rare genetic diseases

Empowering older adults: Wearable tech made easier with personalized support

Pennington Biomedical researchers partner on award-winning Long Covid study

Cooling ‘blood oranges’ could make them even healthier – a bonus for consumers

Body image and overall health found important to the sexual health of older gay men, according to new studies

Lab-grown muscles reveal mysteries of rare muscle diseases

Primary hepatic angiosarcoma: Treatment options for a rare tumor

Research finds causal evidence tying cerebral small-vessel disease to Alzheimer’s, dementia

Navigating the Pyrocene: Recent Cell Press papers on managing fire risk

Restoring the Great Salt Lake would have environmental justice as well as ecological benefits

Cannabis, tobacco use, and COVID-19 outcomes

A 5:2 intermittent fasting meal replacement diet and glycemic control for adults with diabetes

Scientists document self-propelling oxygen decline in the oceans

[Press-News.org] ASCO: Combination therapy significantly improves outcomes for patients with metastatic colorectal cancer
Combining immune-targeted therapy with chemotherapy improves both progression-free survival and overall survival when compared to those who received regorafenib alone