Null causal relationship between inflammatory bowel disease and lipid profile
2024-06-27
(Press-News.org)
A new study has illuminated the connection between inflammatory bowel disease (IBD) and lipid profile. IBD is a chronic condition that causes inflammation in the intestines. Abnormal lipid factor levels such as cholesterol in IBD patients have been observed in previous studies, but whether this association is causal remained unclear.
This study employed Mendelian randomization (MR) to investigate the potential causal link between lipid profile and IBD. The results revealed no significant causal relationship between seven lipid factors and the risk of developing IBD. Consistent results were obtained for two subtypes of IBD, Crohn's disease and ulcerative colitis.
The authors acknowledge that prior studies have shown discrepancies in lipid levels among IBD patients. For example, some reports indicate lower cholesterol levels in individuals with IBD compared to healthy controls, while others find no substantial differences. These inconsistencies underscore the limitations of conventional observational studies, which are prone to confounding factors and reverse causation. In contrast, MR can overcome these limitations.
This study provides valuable insights into the complex interplay between IBD and lipid profile. The findings suggest that regulating lipid levels may not directly influence the risk of IBD. However, further research is necessary to fully understand the relationship between lipids and IBD.
See the article:
Pang X, Yang H, Li M, et al. To explore the causal association between the serum lipid profile and inflammatory bowel disease using bidirectional Mendelian randomisation analysis. eGastroenterology 2024;2:e100034. doi:10.1136/egastro-2023-100034
About eGastroenterology
eGastroenterology is a new, open-access, and open peer-reviewed BMJ Journal, which focuses on basic, clinical, translational, and evidence-based medicine research in all areas of gastroenterology (including hepatology, pancreatology, esophagology, and gastrointestinal surgery).
For more information, please visit: egastroenterology.bmj.com and follow us on Twitter (@eGastro_BMJ).
Sign-up to Email Alerts for eGastroenterology: https://emails.bmj.com/k/Bmj/jausu/egastroenterology
END
ELSE PRESS RELEASES FROM THIS DATE:
2024-06-27
In recent years, rehabilitation robots have become increasingly popular in the field of healthcare, able to mimic the movements of a therapist and enhance patients' mobility through carefully designed control methods. A team from the Automation College of Beijing Institute of Technology, led by Kexin Hu, Zhongjing Ma, Suli Zou, Jian Li, and Haoran Ding, in collaboration with collaborators from the University College London, has recently proposed a novel impedance sliding mode control method that combines stiffness scheduling technology, which has brought significant advancements to rehabilitation robot systems.
This research has broken through the ...
2024-06-27
Around the time of the untimely death of Freddie Gray, a 25-year-old Black man in police custody, researchers from Johns Hopkins University were collecting data for Communities CARING, a study that examined the relationship of health behaviors among public housing residents in East and West Baltimore communities in Maryland. Led by Kristal Lyn Brown, PhD, an assistant professor in Drexel University’s College of Nursing and Health Professions, a secondary analysis of the data collected for Communities CARING examined the relationship between a high-profile event (Gray’s death) and disordered eating ...
2024-06-27
Korean researchers are strengthening South Korea’s leadership in the global market through the development of 6G, the next-generation mobile communication technology.
Electronics and Telecommunications Research Institute (ETRI) announced that they showcased their latest research results at the “6G Symposium Spring 2024” held in Oulu, Finland, from April 9 to 11, drawing the attention of attendees.
At this symposium, ETRI particularly showcased its “service mesh” technology. This technology is a key 6G technology that addresses complex communication issues among numerous cloud-nativemobile network functions that ...
2024-06-27
Researchers have identified a protein called PFDN6 that may play a role in the development and spread of colorectal cancer (CRC). The study, published in [journal name], found that PFDN6 levels are increased in CRC patients and contribute to tumor growth. By reducing PFDN6 in lab studies, scientists were able to slow cancer cell spread and increase cell death. These findings suggest that PFDN6 could be a target for future CRC treatments.
CRC is the third most common cancer worldwide and has a poor prognosis, especially ...
2024-06-27
When operating on the heart, surgeons may find another issue in the patient. Depending on what they see, the surgical team may address on the secondary condition during the same operation.
These are sometimes called concomitant procedures.
However, two studies led by Michigan Medicine find that female patients who undergo heart surgery are less likely to have secondary ailments corrected during a procedure — despite guidelines that indicate they should.
“Across the spectrum of cardiovascular care, from medical management to transcatheter and surgical procedures, there is growing evidence that women ...
2024-06-27
LONDON, ON – A team at Lawson Health Research Institute is the first in Canada to perform a transplant using a technique called abdominal normothermic regional perfusion (A-NRP), which could lead to more organs being available for transplant. The technique was used to optimize organs from two donors in April 2024 at London Health Sciences Centre (LHSC), resulting in the successful transplantation of two kidneys and two livers to four patients.
“Organ donation after circulatory death (when the heart stops beating) has historically been less reliable than organ donation after brain death,” explained Dr. Anton Skaro, Associate Scientist ...
2024-06-27
Researchers have discovered that zinc plays a crucial role in the nitrogen fixation process of legumes. This finding, along with the transcriptional regulator Fixation Under Nitrate (FUN), could revolutionize legume-based agriculture by optimizing crop efficiency and reducing reliance on synthetic fertilizers. By understanding how zinc and FUN regulate nitrogen fixation, researchers might be able to enhance nitrogen delivery, improve crop yields, and promote more sustainable agricultural practices.
The new knowledge about zinc can change the way we cultivate crops, as plants can ...
2024-06-27
Just four per cent of talented teen academy prospects make it to the top tier of professional football, a new study has shown.
A sample of nearly 200 players, aged between 13-18, also revealed only six per cent of the budding ballers even go on to play in lower leagues.
The University of Essex researchers discovered the players who succeeded excelled in self-confidence, ball reception skills, dribbling and coaches’ subjective technical assessments.
The study – published in the International Journal ...
2024-06-27
Experts have identified 240 Chinese cities whose emission reduction are mainly benefiting from the carbon mitigation actions of other cities, whilst putting in less effort themselves.
Researchers studied the phenomenon across 309 Chinese cities using data from 2012 to 2017 – a period when China underwent economic reform and industrial transformation.
Constructing a city-level input-output model to assess carbon footprints, the researchers identified 78% of the cities as ‘outsourced beneficiaries’, ...
2024-06-27
It is widely accepted that biological interactions are stronger or more important in generating and maintaining biodiversity in the tropics than in temperate regions. However, this hypothesis has not been fully tested in ecology and evolutionary biology.
In a study published in Nature Ecology and Evolution, researchers from the Xishuangbanna Tropical Botanical Garden (XTBG) of the Chinese Academy of Sciences have provided strong support for this central prediction by examining phytochemical diversity and herbivory in 60 tree communities ...
LAST 30 PRESS RELEASES:
[Press-News.org] Null causal relationship between inflammatory bowel disease and lipid profile
