PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Study highlights the importance of infection prevention after CAR-T cell therapy

2024-07-08
(Press-News.org)

RESEARCH SUMMARY

Study highlights the importance of infection prevention after CAR-T cell therapy

Study Title: A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy 

Publication: Nature Medicine

Dana-Farber Cancer Institute authors: David M. Cordas dos Santos, MD, Irene M. Ghobrial, MD, Jean-Baptiste Alberge, PhD

Summary: Researchers at Dana-Farber Cancer Institute, in collaboration with colleagues from Memorial Sloan Kettering Cancer Center in New York (Dr. Kai Rejeski) and the LMU Hospital in Munich, Germany (Dr. Tobias Tix), have found that infections were the main driver of non-relapse mortality in patients receiving chimeric antigen receptor (CAR) T cell therapy. The team analyzed reports from 7604 patients across 18 clinical trials and 28 real world studies. Infections accounted for half of all reported non-relapse related deaths. Other cancers were the second most common driver at 7.8%. Cardiovascular or respiratory events were third, at 7.3%. Side effects specific to CAR-T cell therapy, such as cytokine release syndrome and neurotoxicity, played a minor role. Importantly, the researchers found non-relapse mortality to be associated with the underlying disease entity and certain CAR T-cell products, even when accounting for key study features. 

Significance: Much attention has been paid to the risks associated with CAR-T cell therapy and managing CAR-T cell therapy specific side effects, such as cytokine release syndrome and neurotoxicity. This study reveals that infections play a critical role in non-relapse related death and suggests a pressing need for comprehensive, evidence-based guidelines that inform infection prevention and management after CAR-T cell therapy. 

Funding: The German Cancer Consortium, Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), the Munich Clinician Scientist Program, the Bruno and Helene Jöster Foundation, the Bavarian Cancer Research Center, the National Institutes of Health/National Cancer Institute, and Arnold Ventures.

 

Contact:  Nicole Oliverio, nicole_oliverio@dfci.harvard.edu

END



ELSE PRESS RELEASES FROM THIS DATE:

New gold standard survey shows alarmingly high rate of sexual exploitation across the United States

2024-07-08
A revised version of the Sexual Experiences Survey – Victimization (SES-V), the gold standard measurement of sexual exploitation designed for adults over age 18, has been released in a special issue of the Journal of Sex Research. As the first revision since 2007, the new SES-V is an interdisciplinary collaboration among experts across more than 10 U.S. universities and the Kinsey Institute, led and coordinated by Dr. Mary Koss from the University of Arizona. It adopts more inclusive language and ...

Stench of a gas giant? Nearby exoplanet reeks of rotten eggs. And that’s a good thing

Stench of a gas giant? Nearby exoplanet reeks of rotten eggs. And that’s a good thing
2024-07-08
An exoplanet infamous for its deadly weather has been hiding another bizarre feature—it reeks of rotten eggs, according to a new Johns Hopkins University study of data from the James Webb Space Telescope. The atmosphere of HD 189733 b,  a Jupiter-sized gas giant, has trace amounts of hydrogen sulfide, a molecule that not only gives off a stench but also offers scientists new clues about how sulfur, a building block of planets, might influence the insides and atmospheres of gas worlds beyond the solar system. The findings are published today ...

Study backs RSV vaccine safety during pregnancy

2024-07-08
Vaccinating mothers against respiratory syncytial virus (RSV) during late pregnancy to protect their newborns is not associated with an increased risk of preterm birth or other poor outcomes, according to a study by Weill Cornell Medicine and NewYork-Presbyterian investigators. Infants are particularly vulnerable to the virus which can cause a serious lower respiratory illness. The study published in JAMA Network Open on July 8 adds real-world evidence to the existing data from clinical trials about the safety of Pfizer’s Abrysvo vaccine. The researchers found that there ...

Brigham study finds new program streamlined hospice transitions from the emergency department

2024-07-08
KEY TAKEAWAYS After implementing a new hospice transition program, 210 out of 388 patients (54.1 percent) at Brigham and Women’s Hospital transitioned to hospice from the emergency department (ED) within 96 hours, compared to 61 of 270 patients (22.1 percent) in the control period. Across all groups, the presence of a Medical Order for Life-Sustaining Treatment plan (MOLST), was independently associated with hospice transition. These findings suggest that hospice transition programs can help improve use of hospice for patients presenting at the ED near the end ...

Diet quality among children

2024-07-08
About The Study: Although total dietary quality scores among U.S. children improved overall during 2005-2020, the increase remained suboptimal: lower than 5 points, a significant threshold for children in this analysis of changes in diet quality. Corresponding Author: To contact the corresponding author, Yongjun Zhang, Ph.D., M.D., email zhangyongjun@sjtu.edu.cn. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2024.1880) Editor’s Note: Please see the article for additional information, ...

Acceptability of hospital-at-home care and capacity for caregiver burden

2024-07-08
About The Study: Survey respondents reported substantial acceptability of hospital-at-home care, which did not vary across sociodemographics, health insurance coverage, health status, prior hospitalizations, or telehealth use. Approximately half of respondents agreed that hospital-at-home care was effective, safe, and convenient. Most indicated capacity to perform many caregiver tasks. Corresponding Author: To contact the corresponding author, Melissa A. Frasco, Ph.D., email mfrasco@usc.edu. To access the embargoed ...

Semaglutide vs tirzepatide for weight loss in adults with overweight or obesity

2024-07-08
About The Study: In this population of adults with overweight or obesity, use of tirzepatide was associated with significantly greater weight loss than semaglutide. Future study is needed to understand differences in other important outcomes.  Corresponding Author: To contact the corresponding author, Nicholas L. Stucky, M.D., email nicholass@truveta.com. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2024.2525) Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest ...

AJPH study shows that permit to purchase laws are a promising avenue to reduce suicides in young adults

AJPH study shows that permit to purchase laws are a promising avenue to reduce suicides in young adults
2024-07-08
In 2020, suicide ranked as the third leading cause of death for adults aged 18 to 20 years in the United States.  Firearms were implicated in approximately half of these cases, and by 2017, they had surpassed motor vehicles as the leading cause of death in this age group. While ongoing debates on gun violence and mental health have increased public support for restricted firearm access, not much is known about the impact of gun control policies on young adults.   To fill this knowledge gap, a recent study published in the August issue of the American Journal of Public Health on July 03, ...

Companies that mitigate climate change reduce their cost of capital

Companies that mitigate climate change reduce their cost of capital
2024-07-08
Fukuoka, Japan —The climate crisis is hitting home with more frequent extreme weather events. Companies, particularly those in high-emission industries, are major contributors to global carbon emissions, therefore making them key players in the fight against climate change. Recognizing this responsibility, many businesses are now taking proactive measures to reduce their carbon footprint, by reducing carbon emissions and transparently sharing their environmental strategies and data. The Task Force on Climate-Related Financial Disclosures ...

Case Western Reserve University receives $1.5M grant from Foundation Fighting Blindness to test possible new treatment for inherited retinal disease

Case Western Reserve University receives $1.5M grant from Foundation Fighting Blindness to test possible new treatment for inherited retinal disease
2024-07-08
CLEVELAND—There’s only one U.S. Food and Drug Administration-approved therapy for an inherited retinal disease, and dozens of retinitis pigmentosa (RP) genes for which no therapy is available. With a new three-year, $1.5 million grant from the Foundation Fighting Blindness, Shigemi Matsuyama, an associate professor of ophthalmology and visual sciences at the Case Western Reserve University School of Medicine, will test a possible breakthrough drug that can be taken by mouth—one that may address many RP disease manifestations, regardless of the underlying genetic mutation. “We believe it can serve as the basis of an oral medicine to prevent blindness in RP ...

LAST 30 PRESS RELEASES:

CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury

Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1

Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic ce

Acta Pharmaceutica Sinica B Volume 15, Issue 7 Publishes

New research expands laser technology

Targeted radiation offers promise in patients with metastasized small cell lung cancer to the brain

A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers

Mount Sinai researchers uncover differences in how males and females change their mind when reflecting on past mistakes

CTE and normal aging are difficult to distinguish, new study finds

Molecular arms race: How the genome defends itself against internal enemies

Tiny chip speeds up antibody mapping for faster vaccine design

KTU experts reveal why cultural heritage is important for community unity

More misfolded proteins than previously known may contribute to Alzheimer’s and dementia

“Too much going on”: Autistic adults overwhelmed by non-verbal social cues

What’s driving America’s deep freezes in a warming world?

A key role of brain protein in learning and memory is deciphered by scientists

Heart attacks don’t follow a Hollywood script

Erin M. Schuman wins 2026 Nakasone Award for discovery on neural synapse function and change during formation of memories

Global ocean analysis could replace costly in-situ sound speed profiles in seafloor positioning, study finds

Power in numbers: Small group professional coaching reduces rates of physician burnout by nearly 30%

Carbon capture, utilization, and storage: A comprehensive review of CCUS-EOR

New high-temperature stable dispersed particle gel for enhanced profile control in CCUS applications

State gun laws and firearm-related homicides and suicides

Use of tobacco and cannabis following state-level cannabis legalization

Long-term obesity and biological aging in young adults

Eindhoven University of Technology and JMIR Publications announce unlimited open access publishing agreement

Orphan nuclear receptors in metabolic dysfunction-associated steatotic liver disease development

A technological breakthrough for ultra-fast and greener AI

Pusan National University researchers identify key barriers hindering data-driven smart manufacturing adoption

Inking heterometallic nanosheets: A scalable breakthrough for coating, electronics, and electrocatalyst applications

[Press-News.org] Study highlights the importance of infection prevention after CAR-T cell therapy