An update on the survival of the first 50 face transplants worldwide

JAMA Surgery

2024-09-18

(Press-News.org) About The Study: In this study, the overall survival of the face transplants is encouraging. These data suggest that the acceptable long-term survival of face transplants makes them a reconstructive option for extensive facial defects.

Quote from corresponding author Pauliina Homsy, MD, PhD:

“A total of 50 face transplants have been performed since 2005. Activity has been concentrated with only 18 centers in 11 countries giving this treatment. Our study demonstrates an overall 5- and 10-year survival of face transplants at 85% and 74%, respectively.

“The majority of patients with severe facial defects can be treated with conventional methods but there are those whose defect is too complex for it. The encouraging face transplant survival rate suggests that face transplantation can be a long-term reconstructive option for these patients.”

Contact information for Pauliina Homsy, MD, PhD: email pauliina.homsy@hus.fi.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamasurg.2024.3748)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2024.3748?guestAccessKey=6d63c824-4da2-4d41-8166-6a626581bc52&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091824

END

ELSE PRESS RELEASES FROM THIS DATE:

Social determinants of health and insurance claim denials for preventive care

2024-09-18

About The Study: In this cohort study of 1.5 million patients seeking preventive care, denials of insurance claims for preventive care were disproportionately more common among at-risk patient populations. This administrative burden potentially perpetuates inequitable access to high-value health care. Corresponding Author: To contact the corresponding author, Alex Hoagland, PhD, email alexander.hoagland@utoronto.ca. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.33316) Editor’s ...

Patient self-guided interventions to reduce sedative use and improve sleep

2024-09-18

About The Study: The results of this randomized clinical trial showed that transitioning insomnia care for older adults away from long-term sedative use and toward cognitive behavioral therapy for insomnia can be achieved using a mailed, direct-to-patient approach. Corresponding Author: To contact the corresponding author, David M. Gardner, PharmD, MSc CH&E, email david.gardner@dal.ca. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2024.2731) Editor’s ...

Brigham researchers use machine learning to improve cardiovascular risk assessment

2024-09-18

Risk calculators are used to evaluate disease risk for millions of patients, making their accuracy crucial. But when national models are adapted for local populations, they often deteriorate, losing accuracy and interpretability. Investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, used advanced machine learning to increase the accuracy of a national cardiovascular risk calculator while preserving its interpretability and original risk associations. Their results showed higher accuracy overall in an electronic health records cohort ...

How Ukraine can rebuild its energy system

2024-09-18

One of the main targets of Russia’s ongoing attacks on Ukraine is the energy infrastructure. The extent of the destruction is enormous. “One year after the start of the war in February 2022, 76 percent of thermal power plants had been destroyed; now the figure is 95 percent,” says Ukrainian scientist Iryna Doronina. “And all the large hydroelectric power plants have also failed.” The breaching of the Kakhovka dam proved to be particularly devastating. The huge outflow of water – the reservoir ...

Research points a way to modulate scarring in spinal cord injury

2024-09-18

Media Contact: laura.kurtzman@ucsf.edu, (415) 502-6397 Subscribe to UCSF News After a spinal cord injury, nearby cells quickly rush to action, forming protective scar tissue around the damaged area to stabilize and protect it. But over time, too much scarring can prevent nerves from regenerating, impeding the healing process and leading to permanent nerve damage, loss of sensation or paralysis. Now, UC San Francisco researchers have discovered how a rarely studied cell type controls the formation of scar tissue in spinal cord injuries. Activating ...

Breast and ovarian cancer newly linked to thousands of gene variants

2024-09-18

Scientists have pinpointed thousands of genetic changes in a gene that may increase a person’s risk of developing breast and ovarian cancer, paving the way for better risk assessment and more personalised care. Researchers from the Wellcome Sanger Institute and their collaborators focused on the ‘cancer protection’ gene RAD51C, finding over 3,000 harmful genetic changes that could potentially disrupt its function and increase ovarian cancer risk six-fold and risk of aggressive subtypes of breast ...

Metal exposure can increase cardiovascular disease risk

2024-09-18

Metal exposure from environmental pollution is associated with increased calcium buildup in the coronary arteries at a level comparable to traditional risk factors like smoking and diabetes, according to a study published today in JACC, the flagship journal of the American College of Cardiology. The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis. "Our findings highlight the importance ...

Penny for your thoughts? Master copper regulator discovery may offer Alzheimer’s clues

2024-09-18

New therapeutic opportunities often emerge from research on simple organisms. For instance, the 2020 Nobel Prize in Chemistry awarded to Emmanuelle Charpentier, Ph.D., and Jennifer Doudna, Ph.D., for their CRISPR-based DNA editing discovery began with studies using bacteria just a decade prior. Today, CRISPR therapies are approved for several disorders, and more such treatments are in the offing. Recognizing the translational potential of studies in simpler animal models, a team of scientists led by Randy D. Blakely, ...

Keck Hospital of USC named a 2024 top performer by Vizient, Inc.

2024-09-18

LOS ANGELES — Keck Hospital of USC has been named a top performer in the 2024 Bernard A. Birnbaum, MD, Quality Leadership award by Vizient, Inc., a leading health care performance improvement company. The top performer designation acknowledges the hospital’s excellence in delivering high-quality care as measured by the annual Vizient Quality and Accountability Study. Keck Hospital was among 14 top performers out of 115 comprehensive academic medical centers nationally and achieved a five-star ...

NSF and Simons Foundation launch 2 AI Institutes to help astronomers understand the cosmos

2024-09-18

Note: Embargoed until 8:00 a.m. ET on Sept. 18, 2024 From the early telescopes made hundreds of years ago by Galileo to the sophisticated astronomical observatories of today, people have built increasingly innovative tools to probe and measure the cosmos. Soon, researchers at two new institutes funded by the U.S. National Science Foundation and the Simons Foundation will build a new breed of astronomical tools by harnessing the uniquely powerful abilities of artificial intelligence to assist and accelerate humanity's understanding of the universe. The new National Artificial Intelligence ...

TF-rs1049296 C>T variant modifies the association between hepatic iron stores and liver fibrosis in metabolic dysfunction-associated steatotic liver disease

ASH publishes clinical practice guidelines on diagnosis of light chain amyloidosis

SLAS receives grant from Alfred P. Sloan Foundation to develop lab automation educational guidelines

Serum interleukin-8 for differentiating invasive pulmonary aspergillosis from bacterial pneumonia in patients with HBV-associated acute-on-chronic liver failure

An update on the survival of the first 50 face transplants worldwide

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: