Metabolic bariatric surgery in the era of GLP-1 receptor agonists for obesity management

JAMA Network Open

2024-10-25

(Press-News.org) About The Study: This cross-sectional study of privately insured patients found a more than 2-fold increase in use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) as anti-obesity medications from 2022 to 2023, with a 25.6% decrease in the rate of metabolic bariatric surgery during the same period. Our results provide a national contemporaneous estimate of the decline in metabolic bariatric surgery associated with the era of GLP-1 RAs.

Corresponding Author: To contact the corresponding author, Thomas C. Tsai, MD, MPH, email ttsai@bwh.harvard.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.41380)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.41380?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=102524

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

‘The way to a man’s heart disease’: Can social expectations of masculinity be bad for cardiovascular health?

2024-10-25

Cardiovascular disease remains a top cause of sickness and death in the U.S. and worldwide. Doctors and researchers have it especially high on their radar because it’s more modifiable and preventable than many other diseases and causes of death. Importantly, though, modification and prevention rely on early detection and mitigation of risk factors like hypertension and high cholesterol. Unfortunately, detection and mitigation are suboptimal throughout the U.S. population: Experts estimate that up to 75% of young adults who have risk factors such as hypertension and high cholesterol are unaware ...

New machine learning model quickly and accurately predicts dielectric function

2024-10-25

Researchers Tomohito Amano and Shinji Tsuneyuki of the University of Tokyo with Tamio Yamazaki of CURIE (JSR-UTokyo Collaboration Hub) have developed a new machine learning model to predict the dielectric function of materials, rather than calculating from first-principles. The dielectric function measures the polarization of negative and positive charges within materials, the phenomenon underlying dielectric materials. Thus, the fast and accurate prediction of dielectric function facilitates the development of novel dielectric materials, an ingredient of many cutting-edge technologies such as 6G ...

Malicious social media bots increased significantly during the COVID-19 pandemic and continue to influence public health communication

2024-10-25

The information environment in Finland during the coronavirus pandemic was exceptional and intense in many ways. The spread of disinformation and the number of actors involved reached unprecedented levels. The demand for accurate information was enormous, and the situation was constantly evolving. Information was disseminated through various channels. Official information played a crucial role, but at the same time, social media posed challenges in the fight against false and misleading information. Malicious bots increased significantly during the pandemic. The operation of bots – i.e. ...

Sociodemographic factors associated with depression among people living with human immunodeficiency virus on antiretroviral therapy at a university teaching hospital in a Nigerian cosmopolitan city

2024-10-25

Background and objectives Depression can lead to poor outcomes during antiretroviral therapy, and current evidence suggests high rates of depression among people living with human immunodeficiency virus (PLHIV), especially in low-and middle-income countries. This study was designed to investigate the sociodemographic factors associated with depression among PLHIV on antiretroviral therapy in a Nigerian cosmopolitan city. Methods A hospital-based, cross-sectional study was conducted among 592 consenting, ...

Surveillance imaging and GAAD/GALAD scores for detection of hepatocellular carcinoma in patients with chronic hepatitis

2024-10-25

Background and Aims Early detection of hepatocellular carcinoma (HCC) is crucial for improving survival in patients with chronic hepatitis. The GALAD algorithm combines gender (biological sex), age, α-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and protein induced by vitamin K absence or antagonist-II (PIVKA-II) for HCC detection. Similarly, the GAAD algorithm incorporates gender (biological sex), age, AFP, and PIVKA-II. This study aimed to assess the clinical utility of AFP-L3 in the GALAD algorithm and its potential synergies with ultrasound. We compared the clinical performance of GALAD with GAAD; AFP; AFP-L3; and PIVKA-II, with ...

Advanced liver fibrosis predicts liver outcomes in biopsy-proven metabolic dysfunction-associated steatotic liver disease

2024-10-25

Background and Aims Data regarding risk factors and long-term outcomes of U.S. patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease (MASLD) are limited. This study aimed to investigate the role of clinical and histologic risk factors on long-term outcomes in patients with MASLD. Methods A retrospective cohort study of 451 adults with biopsy-proven MASLD was conducted at a U.S. academic hospital from 2012 to 2020. An experienced pathologist evaluated the index liver biopsy. Patients with a prior liver transplant or alternative etiologies of chronic liver disease were excluded. The duration ...

A new spectroscopy reveals water’s quantum secrets

2024-10-25

Water is synonymous with life, but the dynamic, multifaceted interaction that brings H2O molecules together – the hydrogen bond – remains mysterious. Hydrogen bonds result when hydrogen and oxygen atoms between water molecules interact, sharing electronic charge in the process. This charge-sharing is a key feature of the three-dimensional ‘H-bond’ network that gives liquid water its unique properties, but quantum phenomena at the heart of such networks have thus far been understood only through theoretical simulations. Now, researchers led by Sylvie Roke, head of the Laboratory for Fundamental BioPhotonics in EPFL’s School of Engineering, ...

Sliver of cool surface water helps the ocean absorb more carbon

2024-10-25

Subtle temperature differences at the ocean surface allow more carbon dioxide (CO₂) to be absorbed, new research shows. Scientists studied the “ocean skin” – a sliver less than 2 mm deep at the ocean surface that is fractionally cooler than the rest. Theoretical and lab work have suggested this temperature difference should increase the amount of CO₂ absorbed by the ocean – but this had never been successfully observed at sea before. The new study – led by researchers from the University of Exeter’s Penryn Campus in Cornwall – used precision measurements to confirm that the ...

Study: Invasive silver carp reduce movement in Chicago-area water

2024-10-25

URBANA, Ill. — Invasive silver carp have been spreading throughout the Mississippi River Basin since their introduction a half-century ago. Yet, try as they might, the fish have not advanced beyond a particular stretch of the Illinois River north of Kankakee. Research from the University of Illinois Urbana-Champaign shows the fish are likely avoiding contaminants from the Chicago Area Waterway, which flows south before petering out around Kankakee. A new study, published today in Scientific Reports, shows silver carp change their behavior and metabolism when introduced to water from the Illinois River north of Kankakee, representing Chicago-area water. “When animals ...

A lung pathogen’s dilemma: infect or resist antibiotics?

2024-10-25

Imagine trying to settle into a new home while constantly being attacked. That’s what the bacterium Pseudomonas aeruginosa faces when it infects the lungs, and it can’t both spread and protect itself from antibiotics at the same time. Nonetheless, it’s one of the top culprits in hospital-acquired infections and it’s notorious for causing long-lasting, antibiotic-resistant infections, causing damage especially in people with lung diseases like cystic fibrosis, COPD, or bronchiectasis. To survive tough conditions, P. aeruginosa forms colonies ...

The Lancet: Deeply entrenched racial and geographic health disparities in the USA have increased over the last two decades—as life expectancy gap widens to 20 years

Mass General Brigham and BIDMC researchers unveil an AI protein engineer capable of making proteins ‘better, faster, stronger’

Metabolic and bariatric surgery safe and effective for patients with severe obesity

Smarter city planning: MSU researchers use brain activity to predict visits to urban areas

Using the world’s fastest exascale computer, ACM Gordon Bell Prize-winning team presents record-breaking algorithm to advance understanding of chemistry and biology

Metabolic bariatric surgery in the era of GLP-1 receptor agonists for obesity management

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: