PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Popular diabetes and obesity drugs also protect kidneys, study shows

GLP-1 agonists significantly reduced kidney deterioration and failure, regardless of diabetes status

2024-11-26
(Press-News.org) The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular outcomes shows they have significant benefits in people with and without diabetes.1 Findings were published today in The Lancet Diabetes & Endocrinology.

Originally developed to treat diabetes, GLP-1 receptor agonists mimic the action of a hormone called glucagon-like peptide 1, which stimulates insulin production and lowers blood sugar levels. More recently, they have emerged as effective treatments for obesity - slowing digestion, increasing feelings of fullness, and reducing hunger.

But while the benefits of GLP-1 receptor agonists for the treatment of type 2 diabetes, obesity and cardiovascular disease are well known, their impact on chronic kidney disease (CKD) has been less certain.

Researchers conducted a meta-analysis of 11 large-scale clinical trials of GLP-1 receptor agonists involving a total of 85,373 people (67,769 people with type 2 diabetes and 17,604 people with overweight or obesity and cardiovascular disease but without diabetes). Seven different GLP-1 receptor agonists were investigated among the trials, including semaglutide (also known as Ozempic or Wegovy), dulaglutide (Trulicity) and liraglutide (Victoza).

The results showed that compared to placebo, GLP-1 receptor agonists reduced the risk of kidney failure by 16% and the worsening of kidney function by 22% (defined by a drop in estimated glomerular filtration rate - a measure of how much blood the kidneys filter clean every minute - of at least 50%). The combined reduction in the risk of kidney failure, worsening kidney function, and death due to kidney disease was 19%.

The analysis also confirmed previous findings that GLP-1 receptor agonists protect cardiovascular health, with a 14% reduction in the risk of cardiovascular death, non-fatal heart attack, and non-fatal stroke, compared to placebo. Death by any cause was 13% lower among patients treated with GLP-1 receptor agonists.

Lead author Professor Sunil Badve, Professorial Fellow at The George Institute for Global Health and UNSW Sydney said the study expanded current knowledge about this class of drugs in key areas, including benefits in people with CKD, and in people with and without diabetes.

“This is the first study to show a clear benefit of GLP-1 receptor agonists on kidney failure or end-stage kidney disease, suggesting they have a key role in kidney-protective and heart-protective treatment for patients with common medical conditions like type 2 diabetes, overweight or obesity with cardiovascular disease, or CKD,” he said.

“These results are particularly important for patients with chronic kidney disease. It is a progressive condition eventually leading to kidney failure requiring dialysis or kidney transplantation and is associated with premature death, mostly from heart disease. It has a significant impact on patients’ quality of life and incurs substantial healthcare costs.”

CKD is estimated to affect one in ten people worldwide, equivalent to around 850 million people.2 It is the tenth leading cause of death and is projected to become the fifth most common cause of death by 2050.3 Diabetes, cardiovascular disease and obesity are independent risk factors for CKD and represent a major global health burden.4

Professor Vlado Perkovic, Professorial Fellow at The George Institute, Provost at UNSW Sydney and senior author on the study said, “This research shows that GLP-1 receptor agonists could play an important role in addressing the global burden of non-communicable diseases. Our study will have a major impact on clinical guidelines for the management of chronic kidney disease and cardiovascular disease in people with and without diabetes.”

“More work is now needed to implement the results of this study into clinical practice and improve access to GLP-1 receptor agonists to people who will benefit from them,” he added.

References

Badve S et al. Effects of glucagon-like peptide-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials. Lancet Diabetes Endocrinol. 2024. https://doi.org/10.1016/S2213-8587(24)00271-7 Jager KJ, et al. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Kidney Int. 2019. https://doi.org/10.1016/j.kint.2019.07.012 GBD 2021 Forecasting Collaborators. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021. Lancet. 2024. https://doi.org/10.1016/S0140-6736(24)00685-8 The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardio-metabolic risk factors between 1980 and 2010: comparative risk assessment. Lancet Diabetes Endocrinol. 2015. https://doi.org/10.1016/S2213-8587(14)70102-0 END


ELSE PRESS RELEASES FROM THIS DATE:

Stevens INI receives funding to expand research on the neural underpinnings of bipolar disorder

2024-11-25
Leila Nabulsi, PhD, a postdoctoral researcher in computational neuroscience at the Keck School of Medicine of USC’s Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) has received funding to expand research on the neurocircuitry that underlies bipolar disorder. Nabulsi was awarded the prestigious 2025 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation, a highly competitive grant that provides early-career researchers with crucial pilot funding to pursue new avenues in ...

Protecting nature can safeguard cities from floods

Protecting nature can safeguard cities from floods
2024-11-25
A new UBC-led study shows that safeguarding key natural ecosystems across Canada can help reduce flood risks for more than half of the country’s urban areas at high risk for flooding. The research reveals that preserving the most important five per cent of watersheds—about 201,000 square kilometres or two per cent of Canada’s land—can significantly reduce rainwater runoff, protect homes and livelihoods, and safeguard croplands. “This is the first national study to assess the role of Canadian ecosystems in flood prevention and to identify where conservation could have the greatest impact,” said Dr. Matthew ...

NCSA receives honors in 2024 HPCwire Readers’ and Editors’ Choice Awards

NCSA receives honors in 2024 HPCwire Readers’ and Editors’ Choice Awards
2024-11-25
The National Center for Supercomputing Applications was recognized by the HPCwire Readers’ and Editors’ Choice Awards for its outstanding achievements in artificial intelligence and the use of high-performance computing in the physical sciences. Announced at Supercomputing Conference 2024 (SC24) in Atlanta on November 18, NCSA was awarded the Readers’ Choice Award: Best HPC Collaboration and Editors’ Choice: Best Use of HPC in Physical Sciences. It’s the 14th consecutive ...

Warning: Don’t miss Thanksgiving dinner, it’s more meaningful than you think

2024-11-25
Book the flight home for Thanksgiving, go to that party even though you’re tired, and write that thank you note. You may feel these experiences are not that significant in your busy life today, but according to Erin Westgate, assistant professor of psychology at the University of Florida, you are likely wrong. Westgate and her team of researchers at the Florida Social Cognition and Emotion Lab recently received a grant from the National Science Foundation to investigate the factors that lead people ...

Expanding HPV vaccination to all adults aged 27-45 years unlikely to be cost-effective or efficient for HPV-related cancer prevention

2024-11-25
Embargoed for release until 5:00 p.m. ET on Monday 25 November 2024     @Annalsofim          Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf ...

Trauma care and mental health interventions training help family physicians prepare for times of war

2024-11-25
Special Report Background and Goal: In wars and conflict, family physicians are frequently called on to serve in expanded roles and are witnesses to the enormous mental and physical suffering of individuals, families, communities, and populations. This special report examines the role of family physicians in the Israel–Hamas conflict and other current wars to inform future practices in family medicine. Key Insights: Family physicians must share timely, accurate information with colleagues on all sides of the conflict while acknowledging the narratives ...

Adapted nominal group technique effectively builds consensus on health care priorities for older adults

2024-11-25
Background and Goal: The participatory research approach is an important tool of family medicine and primary health care research. However, standard consensus methods like the Delphi and nominal group techniques can be time consuming and may not represent a broad range of opinions. To address these issues, researchers developed an adapted nominal group technique (aNGT) to efficiently build consensus among stakeholders with diverse perspectives. Approach: This study focused on shaping care trajectories for adults aged 65 and older, aiming to prioritize key domains and identify new care indicators. Researchers used ...

Single-visit first-trimester care with point-of-care ultrasound cuts emergency visits by 81% for non-miscarrying patients

2024-11-25
The Bethesda Family Medicine Clinic in St. Paul, Minnesota, established a bi-monthly Early Pregnancy Dating & Risk Assessment Clinic in September 2022. The clinic introduced an integrated approach, combining point-of-care ultrasound with immediate, multidisciplinary first-trimester care. This integration allowed the clinic to quickly identify high-risk cases and offer timely intervention for issues such as miscarriage or abnormal pregnancies, reducing emergency visits, urgent clinic appointments, and first-trimester phone inquiries by 81% for non-miscarrying patients. Clinic implementation ...

Study reveals impact of trauma on health care professionals in Israel following 2023 terror attack

2024-11-25
Research Brief Background and Goal: The October 7, 2023, terrorist attack in southern Israel forced the evacuation of countless individuals, placing intense demands on health care personnel. Primary care clinicians, who are at the forefront of treating severely traumatized evacuees, are often exposed to secondary trauma, which can affect their mental health and job performance. This study investigated the levels of burnout, well-being, and resilience among health care staff working in primary care clinics in Israel during the aftermath of the attack. Study Approach: This cross-sectional ...

Primary care settings face barriers to screening for early detection of cognitive impairment

2024-11-25
Background and Goal: Early detection of cognitive impairment is essential for improving patient outcomes, but primary care settings face significant challenges in screening. This special report summarizes key points and gaps in knowledge about methods for detecting cognitive impairment in primary care clinics. Key Insights: The report highlights the importance of addressing the rising incidence of cognitive impairment as the population ages, particularly with new treatments for early Alzheimer’s disease now available. It advocates for creative solutions to manage the increased workload, such as partnering with community health workers and leveraging telehealth. ...

LAST 30 PRESS RELEASES:

Empowering older adults with home-care robots

New concept for sustainable fuel cell polymer electrolytes overcomes barriers in high-temperature, low-humidity use, advancing net-zero carbon goals

Sculpting the brain (without chisel or scalpel)

Wrong trees in the wrong place can make cities hotter at night, study reveals

New gene therapy reverses heart failure in large animal model

Young children less likely than adults to see discrimination as harmful

Tiny poops in the ocean may help solve the carbon problem

Study offers insight into chloroplast evolution

Advancing the synthesis of two-dimensional gold monolayers

Human disruption is driving ‘winner’ and ‘loser’ tree species shifts across Brazilian forests

A novel heme-model compound that treats lethal gas poisoning

Shape-changing device helps visually impaired people perform location task as well as sighted people - EMBARGO: Tuesday 10 December (10:00 UK time)

AI predicts that most of the world will see temperatures rise to 3°C much faster than previously expected

Second round of FRONTIERS Science Journalism Residency Program awards grants to ten journalists

The inequity of wildfire rescue resources in California

Aerosol pollutants from cooking may last longer in the atmosphere – new study

Breakthrough in the precision engineering of four-stranded β-sheets

Family income predicts adult problems more than neighborhood poverty

Leading stress expert Ron de Kloet on hormone's dual nature: From protection to harm

Almost half of young vapers are able to stop with quitline help

After a divisive election, most U.S. adults ready to avoid politics this holiday

Food insecurity in LA County remains well above national average, despite slight decline

People with a positive attitude are built differently

AML, sickle cell disease research among highlights of UC ASH abstracts

Dozens of presentations advance multiple myeloma research at the 2024 American Society for Hematology (ASH) meeting

ASH 2024: Study shows that genetic mutations accumulate in smokers with myelodysplastic syndromes and worsen outcomes

Nature inspires self-assembling helical polymer

Could US-style summer holiday programs boost Aussie kids’ health?

Towards safer, higher performance batteries through network topology optimization

ASH: Triplet combination regimens demonstrate high response rates in multiple leukemias

[Press-News.org] Popular diabetes and obesity drugs also protect kidneys, study shows
GLP-1 agonists significantly reduced kidney deterioration and failure, regardless of diabetes status