PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

A quantum leap in carotenoid analysis: Speed and precision unlocked

A novel computational technique offers a faster, more accurate approach for measuring bioactive carotenoids, reducing error rates and analysis time

A quantum leap in carotenoid analysis: Speed and precision unlocked
2024-12-06
(Press-News.org)

Carotenoids, the pigments responsible for the vibrant hues of tomatoes, carrots, and some seafood, are well-regarded for their antioxidant effects and health benefits. A few examples of commercially significant carotenoids are lycopene, β-carotene, and astaxanthin. These compounds are frequently used in functional foods, skincare products, and dietary supplements. However, the bioactivity of these carotenoids depends heavily on their isomeric form, with Z-isomers typically showing higher biological activity but being more challenging to quantify. Traditional methods often require months of analysis and can produce error rates reaching up to 100 %.

 

In this view, a team of researchers with Dr. Yasushi Honda from HPC Systems Inc. and Dr. Masaki Honda from Meijo University have now introduced an innovative solution. “Our new technique leverages quantum chemical calculations, enabling us to analyze carotenoid isomers quickly and accurately, reducing the margin of error to just 2%,” explains Dr. Yasushi Honda. This study was published in the journal Biochemical and Biophysical Research Communications on 19th October 2024.

 

Using density functional theory (DFT), the team successfully simulated the UV-visible spectra such as peak shifts and intensity changes of both all-E- (trans) and Z- (cis) isomers. The computational data closely matched experimental measurements, accurately reproducing key spectral features. Crucially, this approach enabled precise calculation of response factors for the Z-isomers, which are difficult to determine through conventional lab methods. This method, believed to be a world-first application of quantum chemistry for quantitative purposes, significantly boosts both the precision and speed of analysis. Traditional methods for analyzing (Z)-carotenoids could take months (because it is necessary to prepare a large amount of high-purity (Z)-carotenoids), but this new approach reduces the time to just a few ten minutes.

 

The findings highlighted the utility of quantum chemical calculations in obtaining precise Q-ratios, which describe the relative intensity of Z-peaks to main absorption peaks. These ratios are crucial for identifying isomers in complex mixtures. The study also identified that the sum of intensities of main peaks and Z-peaks almost remained consistent across isomers, providing a novel analytical marker for carotenoid characterization.

 

Also, parameters such as response factors essential for correcting HPLC detection sensitivity differences were predicted with exceptional precision. The average deviation between theoretical and experimental response factors was less than 2.5%. This breakthrough eliminates the reliance on experimentally derived response factors, which are often limited in scope and accuracy. At present, many product labels only include the content of the more stable all-E-isomers, potentially underestimating the accurate amount of bioactive compounds. The new method offers a path to more detailed and truthful labelling, benefiting both manufacturers and end-users.

 

While the results of the study are promising, the researchers acknowledge that their simulations were conducted in a vacuum environment, which might not entirely reflect conditions in real-world applications involving solvents. Future research will focus on refining the method to account for these environmental factors and expanding its use to a wider variety of compounds.

 

“This approach goes beyond carotenoids. We’re optimistic that it can be adapted to analyze other rare or unstable molecules, which could have significant implications on the industrial world in various fields, including food, cosmetics, and pharmaceuticals,” says Dr. Masaki Honda while highlighting the impact of the study.

 

The research team plans to explore further the use of quantum chemical calculations for various functional compounds, potentially opening new avenues for innovation, quality control, and research across multiple industries.

END


[Attachments] See images for this press release:
A quantum leap in carotenoid analysis: Speed and precision unlocked

ELSE PRESS RELEASES FROM THIS DATE:

Kumamoto University researchers discover groundbreaking antidiabetic compound

Kumamoto University researchers discover groundbreaking antidiabetic compound
2024-12-06
Kumamoto University scientists have unveiled a novel compound, HPH-15, with dual effects of reducing blood glucose levels and combating fat accumulation, marking a significant leap in diabetes treatment innovation. Type 2 diabetes, a condition affecting millions worldwide, is often accompanied by complications like fatty liver and insulin resistance, which challenge current treatment methods. The research team, led by Visiting Associate Professor Hiroshi Tateishi and Professor Eiichi Araki, has identified HPH-15 as a promising alternative to existing medications like metformin. The study, published in Diabetologia, a top journal in the field of diabetes, demonstrates ...

Imaging technique allows rapid assessment of ovarian cancer subtypes and their response to treatment

Imaging technique allows rapid assessment of ovarian cancer subtypes and their response to treatment
2024-12-06
An MRI-based imaging technique developed at the University of Cambridge predicts the response of ovarian cancer tumours to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models. The technique, called hyperpolarised carbon-13 imaging, can increase the detected signal in an MRI scanner by more than 10,000 times. Scientists have found that the technique can distinguish between two different subtypes of ovarian cancer, to reveal their sensitivities to treatment. They used it to look at patient-derived cell models that closely mimic the behaviour of human high grade serous ovarian cancer, ...

Genetic study of native hazelnut challenges misconceptions about how ancient Indigenous peoples used the land

2024-12-06
By decoding the DNA of the beaked hazelnut (Corylus cornuta), a native plant that thrives in British Columbia, a team of multidisciplinary scientists is providing new insight into how ancestral Indigenous peoples stewarded plants across the province.  Led by Chelsey Geralda Armstrong, an assistant professor in Simon Fraser University’s (SFU) Department of Indigenous Studies, the innovative study was recently published in the Proceedings of the National Academy of Science (PNAS), a major scientific journal.  “The misconception that Indigenous ...

Greater patient education needed around antidepressants which may reduce genital sensitivity, SFU study finds

2024-12-06
The use of antidepressants is associated with sexual side effects including reduced genital sensitivity that persists after stopping the medication, a new Simon Fraser University study finds. The study, published in Social Psychiatry and Psychiatric Epidemiology, indicates that 13 per cent of people who used antidepressants reported a reduction in genital sensitivity, compared to one per cent of users of other psychiatric medications.  “It’s gone under the radar for so long, largely due to stigma, shame and embarrassment,” says Yassie Pirani, an SFU alumnus and lead author on the study. ...

Increases in US life expectancy forecasted to stall by 2050, poorer health expected to cause nation’s global ranking to drop

2024-12-06
SEATTLE, Wash., Dec. 5, 2024 – The U.S. is failing to keep pace with dozens of countries around the world due to the steady decline of the nation’s health progress, according to a detailed analysis of all 50 states and Washington, D.C., published in The Lancet. Researchers at the Institute for Health Metrics and Evaluation (IHME) produced health estimates and forecasts (the most likely future) of life expectancy, mortality, and morbidity due to more than 350 diseases and injuries and 68 risks in the U.S. from 1990 to 2050. U.S. life expectancy improvements slow, global ranking drops  Life expectancy (LE) in the U.S. is forecasted to increase from ...

Gut microbiota: A consensus paper to regulate the "wild west" of diagnostic tests

2024-12-06
The gut microbiota might perhaps one day become a routine tool for the early diagnosis of many diseases and to guide treatment, but at present there is a lack of solid scientific evidence to support these claims. Yet, day by day, there are more and more offers of commercial kits for do-it-yourself testing, at the moment totally lacking in meaning and scientific solidity. To put a stop to this drift, an international panel of experts, coordinated by Dr Gianluca Ianiro, has drawn up ‘instructions for use’ for best practice in microbiota testing and recommendations for its indications, methods of analysis, presentation of results and potential clinical ...

Pacific curators restore Indigenous voices to colonial-era collections

Pacific curators restore Indigenous voices to colonial-era collections
2024-12-06
Fault Lines: Imagining Indigenous futures for colonial collections, at the University of Cambridge’s Museum of Archaeology and Anthropology (MAA) from 6th December 2024 to 21st December 2025, examines interactions between Indigenous communities and colonial institutions in this vast and culturally diverse region. From the 18th century, Indigenous peoples across the Pacific have navigated a changing roster of imperial powers including Great Britain, France, Germany, the United States, Australia and New Zealand. The exhibition combines historic artefacts with newly commissioned artistic responses to examine the enduring legacies of cultural extraction and destruction during ...

What’s next for science: NRL to showcase advanced technology and research at AGU 2024

What’s next for science: NRL to showcase advanced technology and research at AGU 2024
2024-12-05
WASHINGTON — The U.S. Naval Research Laboratory (NRL) will feature advanced technologies and research ranging from Earth to space sciences during the 24th Annual American Geophysical Union (AGU) Conference at the Walter E. Washington Convention Center in Washington, D.C., Dec. 9-13. In addition to more than 70 NRL oral presentations and poster displays and an exhibit hall booth, attendees will have the opportunity to view the premier of the 5-minute CCOR-1 (Compact Coronagraph) film which details ...

Research alert: Changes in blood cell production over the lifetime could impact leukemia outcomes

2024-12-05
Researchers at University of California San Diego School of Medicine and their colleagues have developed the first comprehensive map of the dramatic changes that take place in the blood system over the course of the human lifetime. The team quantified the gene expression of more than 58,000 individual hematopoietic (blood) stem cells at seven stages, from early fetal development to old age. They documented consistent changes in the types of blood cells that are produced in response to the functional demands of each life stage:  The ...

Controlling cancer cells’ gluttony for glutamine

Controlling cancer cells’ gluttony for glutamine
2024-12-05
Cancer cells are like booming cities without urban planners. They expand quickly, and in doing so, the resulting tumors consume more energy and other resources than they can acquire from nearby blood vessels. Rather than limiting their growth to more sustainable rates, cancer cells adapt by finding alternative ways to scavenge what they need. One scrounging strategy prevalent in pancreatic ductal adenocarcinoma (PDAC) involves cancer cells reshaping their cell surfaces to snatch extra nutrients from the jelly-like substance between cells or extracellular ...

LAST 30 PRESS RELEASES:

Freeze-framing the cellular world to capture a fleeting moment of cellular activity

Computer hardware advance solves complex optimization problems

SOX2: a key player in prostate cancer progression and treatment resistance

Unlocking the potential of the non-coding genome for precision medicine

Chitinase-3-like protein 1: a novel biomarker for liver disease diagnosis and management

The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: August 22, 2025

Charisma Virtual Social Coaching named a finalist for Global Innovation Award

From the atmosphere to the abyss: Iron's role in Earth's climate history

US oil and gas air pollution causes unequal health impacts

Scientists reveal how microbes collaborate to consume potent greenhouse gas

UMass Amherst kinesiologist receives $2 million ‘outstanding researcher’ award from NIH

Wildfire peer review report for land Brandenburg, Germany, is now online

Wired by nature: Precision molecules for tomorrow's electronics

New study finds hidden body fat is linked to faster heart ageing

How a gift card could help speed up Alzheimer’s clinical research

Depression and anxiety symptoms in adults displaced by natural disasters

Cardiovascular health at the intersection of race and gender in Medicare fee for service

World’s first observation of the transverse Thomson effect

Powerful nodes for quantum networks

Mapping fat: How microfluidics and mass spectrometry reveal lipid landscapes in tiny worms

ATOX1 promotes hepatocellular carcinoma carcinogenesis via activation of the c-Myb/PI3K/AKT signaling pathway

Colibactin-producing E. coli linked to higher colorectal cancer risk in FAP patients

Animal protein not linked to higher mortality risk, study finds

Satellite insights into eutrophication trends on the Qinghai–Tibet plateau

Researchers develop an innovative method for large-scale analysis of metabolites in biological samples

Asteroid Bennu is a time capsule of materials bearing witness to its origin and transformation over billions of years

New AI model can help extend life and increase safety of electric vehicle batteries

Wildfires can raise local death rate by 67%, shows study on 2023 Hawaiʻi fires

Yogurt and hot spring bathing show a promising combination for gut health

Study explains how lymphoma rewires human genome

[Press-News.org] A quantum leap in carotenoid analysis: Speed and precision unlocked
A novel computational technique offers a faster, more accurate approach for measuring bioactive carotenoids, reducing error rates and analysis time