Cardiometabolic parameter change by weight regain on tirzepatide withdrawal in adults with obesity

JAMA Internal Medicine

2025-11-24

(Press-News.org) About The Study: In this post hoc analysis of the SURMOUNT-4 trial, among participants with obesity who achieved weight reduction with 36-week tirzepatide (a glucagon-like peptide-1 receptor agonist) treatment, withdrawing tirzepatide led to 25% or greater weight regain in most participants within 1 year and was associated with a greater reversal of their initial cardiometabolic parameter improvements compared with those who maintained weight reduction. These findings underscore the importance of continued obesity treatment.

Corresponding Author: To contact the corresponding author, Clare J. Lee, MD, MHS, email clare.lee@lilly.com.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamainternmed.2025.6112)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Cardiometabolic parameter change by weight regain on tirzepatide withdrawal in adults with obesity

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