(Press-News.org) About The Study: In a cohort composed primarily of women with obesity, glucagon-like peptide-1 receptor agonist (GLP-1RA) use with subsequent pre-pregnancy or early pregnancy discontinuation was associated with more gestational weight gain and a higher risk of preterm delivery, gestational diabetes, and hypertensive disorders of pregnancy.
Corresponding Authors: To contact the corresponding authors, email Jacqueline Maya, MD, (jmaya@mgh.harvard.edu) and Camille E. Powe, MD, (camille.powe@mgh.harvard.edu).
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2025.20951)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.20951?guestAccessKey=585472d4-fd5f-4365-9e38-a1599ead515e&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112425
END
Gestational weight gain and pregnancy outcomes after GLP-1 receptor agonist discontinuation
JAMA
2025-11-24
ELSE PRESS RELEASES FROM THIS DATE:
Increasing postpartum use of GLP-1 receptor agonists
2025-11-24
About The Study: Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are increasingly used for postpartum weight loss since the introduction of semaglutide for weight loss in late 2022. Most users were overweight prior to pregnancy and only 23% had a documented diabetes diagnosis, suggesting that the primary indication for use was weight reduction.
Corresponding Author: To contact the corresponding author, Mette Bliddal, PhD, email mbliddal@health.sdu.dk.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2025.20947)
Editor’s Note: Please see the article for additional information, including ...
Patients who discontinued GLP-1s had more weight gain, complications during pregnancy
2025-11-24
In a study led by researchers at Mass General Brigham, pregnant individuals who stopped taking popular weight loss GLP-1 medications before or early in their pregnancy tended to gain more weight and have higher risks of diabetes and hypertensive disorders during pregnancy, and experienced preterm delivery more so than people who had never taken GLP-1 drugs. The findings are published in JAMA.
“The use of glucagon-like peptide-1 receptor agonists—or GLP-1RAs—has increased dramatically, but recommendations suggest their discontinuation before pregnancy ...
Untreated sleep apnea raises risk of Parkinson’s, study finds
2025-11-24
New research reveals that people with untreated obstructive sleep apnea have a higher risk of developing Parkinson’s disease. However, they can significantly reduce the risk by improving the quality of their sleep by using continuous positive airway pressure, or CPAP.
The study, which published today in the journal JAMA Neurology, examined electronic health records covering more than 11 million U.S. military veterans who received care through the Department of Veterans Affairs between 1999 and 2022.
The research was led by Oregon Health & Science University ...
Prevalence, characteristics, and genetic architecture of avoidant/restrictive food intake phenotypes
2025-11-24
About The Study: This cohort study found that the prevalence of avoidant/restrictive food intake in the general pediatric population was substantial, and affected children had an associated elevated risk of developmental difficulties across multiple domains. The findings suggest a need for broad support interventions and advance understanding of the genetic underpinnings of avoidant/restrictive food intake.
Corresponding Author: To contact the corresponding author, Ludvig Daae Bjorndal, PhD, email l.d.bjorndal@psykologi.uio.no.
To ...
Cardiometabolic parameter change by weight regain on tirzepatide withdrawal in adults with obesity
2025-11-24
About The Study: In this post hoc analysis of the SURMOUNT-4 trial, among participants with obesity who achieved weight reduction with 36-week tirzepatide (a glucagon-like peptide-1 receptor agonist) treatment, withdrawing tirzepatide led to 25% or greater weight regain in most participants within 1 year and was associated with a greater reversal of their initial cardiometabolic parameter improvements compared with those who maintained weight reduction. These findings underscore the importance of continued obesity treatment.
Corresponding Author: To contact the corresponding author, Clare J. Lee, MD, MHS, ...
US burden of disorders affecting the nervous system
2025-11-24
About The Study: This cross-sectional study of the Global Burden of Disease 2021 study data found that, among the U.S. population of 332.7 million, disorders affecting nervous system health impacted 180.3 million U.S. individuals and were the top cause of disability. Conditions with the greatest collective disability were stroke, Alzheimer disease and
other dementias, diabetic neuropathy, and migraine. The U.S. should prioritize efforts to combat these conditions with development and implementation of new and effective prevention strategies, therapeutics, and focused rehabilitation.
Corresponding ...
Social media detox and youth mental health
2025-11-24
About The Study: In this cohort of young adults, reducing social media use for 1 week was associated with reductions in symptoms of depression, anxiety, and insomnia; however, the durability of these therapeutic outcomes and their associations with behavior warrant further study, particularly in more diverse populations.
Corresponding Author: To contact the corresponding author, John Torous, MD, MBI, email torous@bidmc.harvard.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2025.45245)
Editor’s Note: Please ...
One in two people in the US is affected by a neurological disease or disorder
2025-11-24
EMBARGOED FOR RELEASE AT 11 A.M. ET, MONDAY, NOVEMBER 24, 2025
Highlights:
A new systematic analysis shows more than half the people living in the U.S., 54%, are affected by a neurological disease or disorder.
Disorders of the nervous system impacted more than 180 million of the nearly 333 million Americans in 2021 and were the top cause of health loss in the U.S.
The nervous system includes the brain, spinal cord and nerves.
The most prevalent conditions were tension-type headache affecting 122 million Americans, migraine affecting 58 million and diabetic neuropathy affecting 17 million.
The leading causes of health loss were stroke, Alzheimer’s disease and ...
Colliding ribosomes signal cellular stress
2025-11-24
LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell.
Ribosomes, the protein factories of the cell, are essential for all living organisms. They bind to mRNA and move along the messenger molecule, reading the genetic code as they go. Using this information, they link amino acids to make proteins. But their function goes far beyond pure production: Ribosomes are also important sensors for cellular stress and initiate protective reactions when problems arise. An international team led by Professor Roland Beckmann from LMU’s Gene Center ...
New doctoral network aims to establish optical vortex beams as key technology for advanced light-matter interaction
2025-11-24
A new Doctoral Network coordinated by Tampere University has secured €4.4 million in funding from the European Union’s Marie Skłodowska-Curie Actions (MSCA) programme. The High-Power Optical Vortices (HiPOVor) project will train 15 doctoral researchers in the generation, amplification and application of high-power optical vortex beams. The consortium has set an ambitious goal: to establish optical vortex beams as a key enabling technology for advanced light-matter interaction.
Optical vortices – light beams carrying orbital angular momentum – open up unique possibilities for ultra-precise material processing, particle acceleration, high-capacity ...
LAST 30 PRESS RELEASES:
An integrated monolithic synaptic device for C-tactile afferent perception and robot emotional interaction
‘Zap-and-freeze’ technique successfully used to watch human brain cell communication
Prebiotic in diet linked to less impulsivity in gambling rats with TBI
Gestational weight gain and pregnancy outcomes after GLP-1 receptor agonist discontinuation
Increasing postpartum use of GLP-1 receptor agonists
Patients who discontinued GLP-1s had more weight gain, complications during pregnancy
Untreated sleep apnea raises risk of Parkinson’s, study finds
Prevalence, characteristics, and genetic architecture of avoidant/restrictive food intake phenotypes
Cardiometabolic parameter change by weight regain on tirzepatide withdrawal in adults with obesity
US burden of disorders affecting the nervous system
Social media detox and youth mental health
One in two people in the US is affected by a neurological disease or disorder
Colliding ribosomes signal cellular stress
New doctoral network aims to establish optical vortex beams as key technology for advanced light-matter interaction
Vegan diet—even with ‘unhealthy’ plant-based foods—is better for weight loss than Mediterranean diet, finds new study
JMIR Publications joins STM and integrates STM’s Integrity Hub
NCSA receives honors in 2025 HPCwire Readers’ and Editors’ Choice Awards
New study reveals that differences between parent and child views best assess quality of life after pediatric liver transplant
Shapeshifting cancers’ masters, unmasked
Pusan National University researchers develop model to accurately predict vessel turnaround time
Nanowire breakthrough reveals elusive astrocytes
Novel liver cancer vaccine achieves responses in rare disease affecting children and young adults
International study finds gene linked with risk of delirium
Evidence suggests early developing human brains are preconfigured with instructions for understanding the world
Absolutely metal: scientists capture footage of crystals growing in liquid metal
Orangutans can’t master their complex diets without cultural knowledge
Ancient rocks reveal themselves as ‘carbon sponges’
Antarctic mountains could boost ocean carbon absorption as ice sheets thin
Volcanic bubbles help foretell the fate of coral in more acidic seas
Inspired by a family’s struggle, a scientist helps uncover defense against Alzheimer’s disease
[Press-News.org] Gestational weight gain and pregnancy outcomes after GLP-1 receptor agonist discontinuationJAMA