PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Textbooks need to be rewritten: RNA, not DNA, is the main cause of acute sunburn

2025-01-17
(Press-News.org) We have all been told to avoid direct sunlight between 12 noon and 3 p.m., seek out shade and put on sunscreen and a hat. Nevertheless, most of us have been experienced sunburn at least once. The skin turns bright red, feels irritated and needs cooling.

You may also have been told that sunburn damages the DNA. But that is not the full truth, the researchers responsible for a new study conducted at the University of Copenhagen and Nanyang Technological University, Singapore (NTU Singapore) explain.

“Sunburn damages the DNA, leading to cell death and inflammation. So the textbooks say. But in this study we were surprised to learn that this is a result of damage to the RNA, not the DNA that causes the acute effects of sunburn,” says Assistant Professor Anna Constance Vind from the Department of Cellular and Molecular Medicine, who is one of the researchers responsible for the new study.

The study, ’The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo’, has been published in Molecular Cell.

RNA is similar to DNA, but whereas DNA is long lived, RNA is a more transient molecule. A type of RNA, known as messenger RNA (mRNA), functions as the intermediate ‘messenger’ that carries information from DNA to make proteins - the basic building blocks of cellular components.

“DNA damage is serious as the mutations will get passed down to progenies of the cells, RNA damage happens all the time and does not cause permanent mutations. Therefore, we used to believe that the RNA is less important, as long as the DNA is intact. But in fact, damages to the RNA are the first to trigger a response to UV radiation,” Anna Constance Vind explains.

The new study was conducted on mice as well as human skin cells, and the objective was to describe the impact of UV radiation on the skin and what causes these damages. The researchers found the same skin response to UV radiation exists in both mice and human cells.

A built-in surveillance system for RNA damage mRNA damage triggers a response in ribosomes (protein complexes that “read” the mRNA to synthesise protein), orchestrated by a protein known as ZAK-alpha – the so-called ribotoxic stress response – the new study shows. The response can be described as a surveillance system within the cells, which registers the RNA damage, leading to inflammatory signalling and recruitment of immune cells, which then leads to inflammation of the skin.

“We found that the first thing the cells respond to after being exposed to UV radiation is damage to the RNA, and that this is what triggers cell death and inflammation of the skin. In mice exposed to UV radiation we found responses such as inflammation and cell death, but when we removed the ZAK gene, these responses disappeared, which means that ZAK plays a key role in the skin’s response to UV-induced damage,” says Professor Simon Bekker-Jensen from the Department of Cellular and Molecular Medicine, who is one of the other researchers responsible for the study. He adds:

“So you could say that everything depends on this one response, which monitors all protein translations occurring. The cells respond to the RNA damage, realising that something is wrong, and this is what leads to cell death.”

Faster and more effective response The result of the study changes our understanding of sunburn and the skin’s defence mechanisms: that RNA damage triggers a faster and more effective response, protecting the skin from further damage.

“The fact that the DNA does not control the skin’s initial response to UV radiation, but that something else does and that it does so more effectively and more quickly, is quite the paradigm shift,” says Anna Constance Vind.

We need to understand the function of RNA damage, as it may in the long term change our entire approach to prevention and treatment of sunburn.

“Many inflammatory skin diseases are worsened by sun exposure. Thus, understanding how our skin responds at the cellular level to UV damage opens the door to innovative treatments for certain chronic skin conditions,” says co-author Dr Franklin Zhong, Nanyang Assistant Professor at NTU's Lee Kong Chian School of Medicine.

“This new knowledge turns things upside down. I think most people associate sunburn with DNA damage; it is established knowledge. But now we need to rewrite the textbooks, and it will affect future research on the effects of UV radiation on the skin,” Simon Bekker-Jensen concludes.

END


ELSE PRESS RELEASES FROM THIS DATE:

Brits still associate working-class accents with criminal behavior – study warns of bias in the criminal justice system

2025-01-17
  UNDER STRICT EMBARGO UNTIL 5:00AM (UK TIME) ON FRIDAY 17TH JANUARY 2025   People who speak with accents perceived as ‘working-class’ including those from Liverpool, Newcastle, Bradford and London risk being stereotyped as more likely to have committed a crime, and becoming victims of injustice, a new study suggests.   Received pronunciation (RP) accent perceived as highest status and less likely to commit crimes with the exception of a sexual offence.  Liverpool’s accent most closely associated with criminal behaviour in general. Welsh, Northern Irish and Scottish accents perceived more positively ...

What do you think ‘guilty’ sounds like? Scientists find accent stereotypes influence beliefs about who commits crimes

2025-01-17
The way you talk says a lot about you — but what people think it says may not be true. While no accent is better than any other, people use accents as markers for identifying and stereotyping social groups. In the justice system, these accent stereotypes could influence perceptions of guilt, leading to discrimination. Scientists collaborating on the Improving Voice Identification Procedures project explored this by testing participants’ perceptions of ten different accents heard around the UK. They found that speakers with accents considered lower-status were considered more ...

University of Calgary nursing study envisions child trauma treatment through a Marvel and DC lens

2025-01-17
Perhaps you’ve heard the story of Peter Parker, raised by his aunt and uncle after the death of his parents only to see his uncle murdered by the same criminal the radioactive spider-bitten teen neglected to apprehend that very day. His guilt drives him to become Spider-Man.   But childhood trauma doesn’t always inspire super-heroics. Heath Ledger’s psychotic Joker, as seen in 2008 film The Dark Knight, recounts tales of horrific abuse by a father who disfigures him. It’s a stark contrast to his heroic nemesis Batman, who saw his parents gunned down in ...

Research on performance optimization of virtual data space across WAN

Research on performance optimization of virtual data space across WAN
2025-01-17
For the high-performance computing in a WAN environment, the geographical locations of national supercomputing centers are scattered and the network topology is complex, so it is difficult to form a unified view of resources. To aggregate the widely dispersed storage resources of national supercomputing centers in China, the team led by Zhisheng Huo have previously proposed a global virtual data space named GVDS. However, the GVDS suffers from performance bottlenecks in data migration and access across WANs. To solve the problems, ...

Researchers reveal novel mechanism for intrinsic regulation of sugar cravings

2025-01-17
Excessive sugar consumption is linked to several non-communicable diseases, including obesity, cardiovascular disease, metabolic syndrome, and type 2 diabetes. Animals naturally crave sugar, and uncontrolled sugar preferences can lead to high sugar intake, raising the risk of hyperglycemia and metabolic diseases. Previous research suggests that food cravings in humans are driven by signals from the gut to the brain, highlighting the gut's crucial role in shaping dietary preferences. However, the regulation of sugar preference is complex, and the specific influence of gut microbes remains unclear. In a study published in Nature Microbiology, ...

Immunological face of megakaryocytes

Immunological face of megakaryocytes
2025-01-17
Megakaryocytes (MKs), known for their role in platelet production, have emerged as critical players in immune responses, showcasing versatility in both physiological and pathological contexts. Recent advances in technology have unveiled the diverse immune functions of MKs, which express immune sensors and participate in immune activities, thus expanding their traditional role beyond hemostasis and coagulation. This comprehensive review delves into the multifaceted immune roles of MKs, highlighting their distinct immunological roles under ...

Calorie labelling leads to modest reductions in selection and consumption

2025-01-17
A new Cochrane review has found that calorie labelling of food on menus and products leads people to choose slightly fewer calories.  The research team, led by scientists from UCL, Bath Spa University, the University of Cambridge and the University of Oxford, examined evidence from 25 studies on the impact of calorie labelling on food selection and consumption. They found that calorie labels in supermarkets, restaurants and other food outlets led to a small reduction in the calories people selected and purchased. The average reduction was 1.8%, which would equate ...

The effectiveness of intradialytic parenteral nutrition with ENEFLUID???? infusion

The effectiveness of intradialytic parenteral nutrition with ENEFLUID???? infusion
2025-01-17
Niigata and Tokyo, Japan - In recent years, advancements in dialysis therapy and the growing number of elderly patients starting dialysis have contributed to the aging of the overall dialysis population. Consequently, malnutrition-related conditions such as sarcopenia, frailty, and protein energy wasting (PEW) have become significant issues for dialysis patients. Nutritional interventions, including nutritional counseling, oral supplements, and intradialytic parenteral nutrition (IDPN), are recommended to address these challenges. On dialysis days, patients tend to consume less ...

New study reveals AI’s transformative impact on ICU care with smarter predictions and transparent insights

2025-01-17
New INFORMS Information Systems Research Study Key Takeaways: The AI model achieves approximately 90% classification precision in predicting ICU length of stay, enabling hospitals to more effectively optimize resource management. Clear, evidence-based explanations provided by the model empower ICU doctors to make better-informed decisions regarding patient care. Real-world testing with ICU clinicians demonstrated the model’s potential to enhance care efficiency, reduce hospital costs and improve patient outcomes.   BALTIMORE, MD, January 16, 2025 – Intensive care units (ICUs) face mounting pressure to effectively manage resources while delivering ...

Snakes in potted olive trees ‘tip of the iceberg’ of ornamental plant trade hazards

Snakes in potted olive trees ‘tip of the iceberg’ of ornamental plant trade hazards
2025-01-17
Continental European snakes, geckos and Italian wall lizards are making their way to northern Europe undetected among imports of ornamental olive trees destined for gardens and green spaces.  These hitchhiking intruders can become invasive pests that cause extensive damage to the natural environment - as has happened in previously snake-free islands of the Mediterranean like Majorca. They’re also a red flag for a bigger problem: the range of potentially serious agricultural and environmental pests being unwittingly imported to Britain and ...

LAST 30 PRESS RELEASES:

New jab protects babies from serious lung infection, study shows

July Tip Sheet from Sylvester Comprehensive Cancer Center

Current application status and innovative development of surgical robot

Counterfeited in China: New book assesses state of industry and its future

Machine learning reveals historical seismic events in the Yellowstone caldera

First analyses of Myanmar earthquake conclude fault ruptured at supershear velocity

Curved fault slip captured on CCTV during Myanmar earthquake

Collaboration rewarded for work to further deployment of batteries in emerging economies

Heart-healthy habits also prevent cancer, Alzheimer’s, COPD, other diseases, Emory study finds

Scientists will use a $1M grant to build a support system addressing sea level rise and flooding in South Florida

New research examines how pH impacts the immune system

Inhaled agricultural dust disrupts gut health

New study reveals hidden regulatory roles of “junk” DNA

Taking the sting out of ulcerative colitis

Deep life’s survival secret: Crustal faulting generates key energy sources, study shows

Idaho National Laboratory to lead advancements in US semiconductor manufacturing

AI-assisted sorting, other new technologies could improve plastic recycling

More than just larks and owls!

Call for nominations: 2026 Dan David Prize

New tool gives anyone the ability to train a robot

Coexistence of APC and KRAS mutations in familial adenomatous polyposis and endometrial cancer: A mini-review with case-based perspective

First global-to-local study reveals stark health inequalities from COVID-19 in 2020–2021

rcssci: Simplifying complex data relationships with enhanced visual clarity

Why some ecosystems collapse suddenly—and others don’t

One-third of U.S. public schools screen students for mental health issues

GLP-1 RA use and survival among older adults with cancer and type 2 diabetes

Trends in physician exit from fee-for-service Medicare

Systematic investigation of tumor microenvironment and antitumor immunity with IOBR

Common feature between forest fires and neural networks reveals the universal framework underneath

New R package revolutionizes gene set enrichment analysis visualization for biomedical research

[Press-News.org] Textbooks need to be rewritten: RNA, not DNA, is the main cause of acute sunburn