Gene variant linked to benign prostate hyperplasia risk in Lebanese men
"Our results indicate a strong association between certain genotypes of the SNP -765 G>C of the PTGS2 gene and BPH."
2025-04-15
(Press-News.org)
“Our results indicate a strong association between certain genotypes of the SNP -765 G>C of the PTGS2 gene and BPH.”
BUFFALO, NY – April 15, 2025 – A new research paper was published in Oncotarget, Volume 16, on April 4, 2025, titled “Association between two single nucleotide polymorphisms of the Prostaglandin-Endoperoxide Synthase 1 and 2 genes and cell proliferative prostatic diseases in Lebanon.”
The team of researchers led by first author Brock J. Sheehan and corresponding author Ruhul H. Kuddus, from Utah Valley University, discovered that a specific genetic variation in the PTGS2 gene is associated with a higher risk of benign prostate hyperplasia (BPH), a common condition in aging men. The study, which focused on Lebanese men, suggests that the C allele of the -765 G>C polymorphism in the PTGS2 gene may increase risk to this non-cancerous but problematic prostate condition. This finding could help identify men at greater risk earlier and lead to better treatment choices.
Benign prostate hyperplasia and prostate cancer are two common conditions that involve abnormal cell growth in the prostate gland. While prostate cancer is malignant and potentially life-threatening, BPH is a non-cancerous enlargement that can still significantly affect quality of life. Both conditions are widespread in older men, with BPH affecting over 70% of men above 60. Researchers have long suspected that inflammation-related genes may play a role in their development. In this study, the focus was to study PTGS1 and PTGS2, genes that help produce enzymes involved in inflammation.
Using DNA samples from 168 Lebanese men, including 61 with prostate cancer, 51 with BPH, and 56 healthy controls, the researchers analyzed two common gene variants. They found no link between the PTGS1 variant and either condition. However, the PTGS2 variant showed a strong association with BPH. Men carrying the C version of this gene were more than twice as likely to have BPH compared to those without it. While a similar trend was observed in men with prostate cancer, the results were less conclusive.
“The C allele of SNP-765G>C of the PTGS2 gene was significantly associated with an increased risk of BPH (OR = 2.30, p-value = 0.01).”
This is the first study to report a genetic link between the C allele of the -765 G>C polymorphism in the PTGS2 gene and BPH in Lebanese men. It builds on earlier findings that associated this gene variant with various cancers, including prostate, colon, and stomach cancers. Although based on a relatively small and specific population, the study offers new insight that could help improve genetic screening and guide prevention strategies.
The research also points to the potential benefits of COX-2 inhibitors—drugs already used to treat prostate conditions—which may be more effective for men with certain PTGS2 gene types. Further studies in larger and more diverse groups are needed to confirm these results and explore how this gene variant influences prostate disease. In the future, simple genetic tests could help identify men at higher risk before symptoms appear, allowing for earlier and more personalized care.
Continue reading: DOI: https://doi.org/10.18632/oncotarget.28710
Correspondence to: Ruhul H. Kuddus — ruhul.kuddus@uvu.edu
Keywords: cancer, PTGS1 and PTGS2 genes, COX-1 and COX-2 isozymes, single nucleotide polymorphism association study, prostate cancer, benign prostate hyperplasia (BPH)
Click here to sign up for free Altmetric alerts about this article.
About Oncotarget:
Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:
X
Facebook
YouTube
Instagram
LinkedIn
Pinterest
Spotify, and available wherever you listen to podcasts
Click here to subscribe to Oncotarget publication updates.
For media inquiries, please contact media@impactjournals.com.
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2025-04-15
Teoxane reinforces its commitment to scientific innovation with the publication of a new study in Plastic and Reconstructive Surgery – Global Open, providing robust preclinical and clinical evidence on the safety, biocompatibility, and performance of RHA®4* in midface augmentation.
The study confirms that RHA®4[1], a resilient hyaluronic acid filler designed for dynamic facial areas[2],[3], integrates harmoniously within subcutaneous adipose tissue, preserving its natural biomechanics while delivering effective volume restoration. ...
2025-04-15
Herndon, VA, March 25, 2025 -- About two million people in the United States lack access to running water or indoor plumbing in their homes. Another 30 million people live where drinking water systems violate safety rules. Water privatization -- the transfer of public water systems ownership and/or management to private companies -- has been proposed as a potential solution to provide more Americans with safe, clean drinking water. But opponents argue that private companies may prioritize profits over public needs.
To investigate how ...
2025-04-15
Fraud is widespread in the United States and increasingly driven by technology. For example, 93% of credit card fraud now involves remote account access, not physical theft. In 2023, fraud losses surpassed $10 billion for the first time. The financial toll is staggering: credit card fraud costs $5 billion annually, affecting 60% of U.S. cardholders, while identity theft resulted in $16.4 billion in losses in 2021. Medicare fraud costs $60 billion each year, and government losses range from $233 billion to $521 billion annually, with improper payments totaling $2.7 trillion since 2003.
Machine learning plays a critical ...
2025-04-15
A research paper by scientists at Tianjin University presented an earthworm-inspired multimodal pneumatic continuous soft robot enhanced by wire-winding transmission.
The research paper, published on Mar. 19, 2025 in the journal Cyborg and Bionic Systems, proposes an earthworm-inspired multimodal pneumatic continuous soft robot to simultaneously achieve multimodal motion and good motion performance. Using the derived overlapped continuous control law (DOCCL) and wire-winding transmission, the robot can achieve a maximum planar crawling speed that surpasses that of other robots of the same type by an order of magnitude.
With ...
2025-04-15
Humans have always lived by coasts and waterways, and thus these locations are rich with archeological sites. Natural and cultural resource management are conducted separately, despite the fact that climate change, sea level rise, and extreme weather threaten them both. Jayur Mehta and colleagues argue a synergy of both approaches is required to protect coastal archaeological landscapes. The authors used LiDAR digital elevation models, site location data, and NOAA sea level rise models to define ...
2025-04-15
There are two species of streamertail hummingbirds on the island of Jamaica, West Indies—one with red-billed males (Trochilus polytmus) and the other with black-billed males (T. scitulus). This is a puzzling situation, as many evolutionary biologists have argued that avian speciation is unlikely to occur on small oceanic islands. Caroline Duffie Judy and colleagues investigated the hybrid zone that separates the two species, which is as narrow as 3.2 km. The authors analyzed 186 Trochilus specimens from 12 ...
2025-04-15
PULLMAN, Wash. -- Researchers at Washington State University have demonstrated a way to use corn protein to improve the performance of lithium-sulfur batteries, a finding that holds promise for expanding the use of the high-energy, lighter-weight batteries in electric vehicles, renewable energy storage and other applications.
Lithium-sulfur batteries are lighter for the same amount of energy and more environmentally friendly than commonly used lithium-ion batteries, but their commercial adoption has been limited by technological hurdles that shorten their lifespan.
The WSU team’s research, published in the Journal of Power Sources, ...
2025-04-15
Mill Valley, CA – April 15, 2025 – SynGAP Research Fund (SRF), dba Cure SYNGAP1, the leading patient advocacy group dedicated to improving the lives of those affected by SYNGAP1-related disorders (SRD), today announced the appointment of Jaime Aranda, Steve Gore, Heather Mestemaker, and Brian Smith to its Board of Trustees, effective April 15, 2025. They will succeed outgoing Trustees Emily Barnes, Sydney Stelmaszek, and Stella Tavilla, whose terms conclude on April 14, 2025. Additionally, a seat previously held by Pavel Gerovich, who stepped ...
2025-04-15
Materials that convert external stimuli into mechanical motion, known as actuators, play a crucial role in robotics, medical devices, and other advanced applications. Among them, photomechanical crystals deform in response to light, making them promising for lightweight and remotely controllable actuation. Their performance depends on factors such as molecular structures, crystal properties, and experimental conditions.
A key performance indicator of these materials is the blocking force—the maximum force exerted when deformation is completely ...
2025-04-15
Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide. The mutational landscape of CRC is well characterized, revealing key pathogenic genetic abnormalities that drive carcinogenesis (cancer development) and disease progression. Moreover, a step-wise colorectal carcinogenesis model has been proposed wherein normal epithelial cells transition to adenoma (non-cancerous tumor) and then to carcinoma (cancerous tumor) as they sequentially acquire genetic mutations.
Mutations ...
LAST 30 PRESS RELEASES:
[Press-News.org] Gene variant linked to benign prostate hyperplasia risk in Lebanese men
"Our results indicate a strong association between certain genotypes of the SNP -765 G>C of the PTGS2 gene and BPH."
