(Press-News.org) Teoxane reinforces its commitment to scientific innovation with the publication of a new study in Plastic and Reconstructive Surgery – Global Open, providing robust preclinical and clinical evidence on the safety, biocompatibility, and performance of RHA®4* in midface augmentation.
The study confirms that RHA®4[1], a resilient hyaluronic acid filler designed for dynamic facial areas[2],[3], integrates harmoniously within subcutaneous adipose tissue, preserving its natural biomechanics while delivering effective volume restoration. Findings highlight its ability to promote rapid collagen formation and to support extracellular matrix remodeling, contributing to long-term structural and functional benefits. Clinically, RHA®4 was shown to safely and effectively lift both deep and superficial fat compartments without compromising facial expressiveness.
Additionally, the study reinforces the efficacy of Teoxane’s Multilayering Technique (MLT) as an efficient treatment approach, optimizing aesthetic outcomes and natural looking midface rejuvenation.
Study Methodology
The collaborative work involved a comprehensive preclinical research and clinical real-world evidence, including two case studies, one of those followed up for 2 years, to demonstrate the long-term safety and effectiveness of RHA®4 for midface augmentation, using the Multilayering Technique (MLT).
Researchers assessed volume retention, longevity, safety, and the ability to sustain facial dynamics and expressions.
Preclinical Biocompatibility Assessment:
To assess the performance of RHA®4 in subcutaneous layer, implantation study was performed over a 52-week period, focusing on long-term tolerability and tissue integration.
Ex vivo studies further explored the biomechanical impact of RHA®4 on soft tissue dynamics. In this model, 1 mL of RHA®4 was injected into human adipose tissue obtained from abdominoplasty procedures to assess its ability to project, support, and stabilize subcutaneous fat pads while preserving their natural movement.
Clinical Performance:
A clinical data collection of 35 patients assessed the efficacy and safety of RHA®4 in midface augmentation.
Patients were treated at the Teoxane Academy by expert injectors, involving the Multilayering Technique, and guided by Teoxane’s ATP assessment protocol (Anatomy, Technique, and Product), to target both deep and superficial fat compartments.
The aesthetic outcomes are described in a selected case by means of Quantificare analysis, to show the anterior projection and lifting effect with minimal volume injection.
Two-Years Case Study:
To examine long-term performance, a 64-year-old patient with midface volume loss and sagging was treated by Dr. Fang-Wen Tseng using RHA®4 for deep volumization.
Key Findings
The study reinforced the safety, efficacy, and tissue integration properties of RHA®4, confirming its suitability for midface augmentation with long-term stability (up to 2 years) and natural aesthetic outcomes.
High Biocompatibility & Seamless Tissue Integration
RHA®4 showed minimal tissue reaction, progressive gel absorption, and no fibroplasia, ensuring rapid collagen formation with minimal inflammation. Results demonstrated that RHA®4 preserved Tissue Dynamics. It increases overall tissue height, without altering the natural biomechanics of adipose tissue, indicating a high degree of mechanical compatibility and seamless integration into the fat layers.
Validated Clinical Performance in Midface Augmentation: Findings validated RHA®4 suitability for midface augmentation, through its ability to lift both deep and superficial fat compartments, supporting the Multilayering Technique for patient-tailored stable volume restoration.
Evaluations further demonstrated effective integration into the surrounding tissues, ensuring a natural aesthetic outcome while preserving dynamic facial expressions.
Long-Lasting Natural Results with No Migration
Over two years of follow-up, the patient exhibited sustained volume restoration without touch-ups, with no signs of filler migration, underscoring RHA®4’s durability and optimal tissue integration.
Its unique balance of strength and stretch ensures resilience against muscle movement contributing to stable, long-lasting rejuvenation over time both in static and dynamic conditions, while maintaining facial expressiveness and naturalness.
Enhanced Skin Quality Through Collagen Production
Beyond its volumizing properties, the preclinical research highlighted RHA®4’s role in stimulating collagen production, contributing to improved extracellular matrix remodeling and long-term clinical outcomes.
Proven Safety & High Patient Tolerability
RHA®4 showed a good safety profile, with minimal adverse events and no reports of severe complications. The findings reinforce RHA®4 as a well-tolerated and effective option for midface augmentation, with low incidence of swelling or prolonged reactions.
“This study represents a significant contribution to the aesthetics industry, reinforcing Teoxane’s commitment to advancing hyaluronic acid innovation. The findings demonstrate RHA®4's ability to provide natural-looking volume restoration by preserving the biomechanics of subcutaneous tissue during motion, thereby supporting the MLT approach. Additionally, the collagen deposition and subsequent progressive tissue integration highlight its role in enhancing skin attributes.” Jimmy Faivre - Teoxane Head of Research.
*RHA® 4 = Teosyal RHA® 4
Medical devices for professional use only. Product indications and availability vary from country to country. Please consult product instructions locally approved for more information.
Medical devices are regulated health products bearing the CE mark, CE2797, under the Medical Device Regulation (EU) 2017/745.
Contact for materiovigilance notification: medical@teoxane.com.
[1] Flégeau, Killian PhD; Ballarini, Stefania PhD; Brusini, Romain PhD; Vantou, Camille MEng; Liao, Zhifeng MD; Hirt-Burri, Nathalie PhD; Bourdon, François MEng; Tseng, Fang-Wen MD; Faivre, Jimmy PhD. Safety and Performance of RHA4 in the Midface Using the Multilayering Technique: Preclinical and Clinical Evidence. Plastic & Reconstructive Surgery-Global Open 13(2):p e6560, February 2025
[2] Teosyal RHA® 4 – Instructions for Use
[3] Faivre J, Gallet M, Tremblais E, Trévidic P, Bourdon F. Advanced Concepts in Rheology for the Evaluation of Hyaluronic Acid-Based Soft Tissue Fillers. Dermatol Surg. 2021 May 1;47(5):e159-e167
END
Teoxane announces new study reinforcing the biocompatibility, safety and efficacy of RHA®4 in dynamic facial support
2025-04-15
ELSE PRESS RELEASES FROM THIS DATE:
Study identifies U.S. hotspots for drinking water quality violations and lack of access to safe, clean water
2025-04-15
Herndon, VA, March 25, 2025 -- About two million people in the United States lack access to running water or indoor plumbing in their homes. Another 30 million people live where drinking water systems violate safety rules. Water privatization -- the transfer of public water systems ownership and/or management to private companies -- has been proposed as a potential solution to provide more Americans with safe, clean drinking water. But opponents argue that private companies may prioritize profits over public needs.
To investigate how ...
Busted! Researchers revolutionize fraud detection with machine learning
2025-04-15
Fraud is widespread in the United States and increasingly driven by technology. For example, 93% of credit card fraud now involves remote account access, not physical theft. In 2023, fraud losses surpassed $10 billion for the first time. The financial toll is staggering: credit card fraud costs $5 billion annually, affecting 60% of U.S. cardholders, while identity theft resulted in $16.4 billion in losses in 2021. Medicare fraud costs $60 billion each year, and government losses range from $233 billion to $521 billion annually, with improper payments totaling $2.7 trillion since 2003.
Machine learning plays a critical ...
Earthworm-inspired multimodal pneumatic continuous soft robot enhanced by winding transmission
2025-04-15
A research paper by scientists at Tianjin University presented an earthworm-inspired multimodal pneumatic continuous soft robot enhanced by wire-winding transmission.
The research paper, published on Mar. 19, 2025 in the journal Cyborg and Bionic Systems, proposes an earthworm-inspired multimodal pneumatic continuous soft robot to simultaneously achieve multimodal motion and good motion performance. Using the derived overlapped continuous control law (DOCCL) and wire-winding transmission, the robot can achieve a maximum planar crawling speed that surpasses that of other robots of the same type by an order of magnitude.
With ...
Coastal heritage threatened by climate change
2025-04-15
Humans have always lived by coasts and waterways, and thus these locations are rich with archeological sites. Natural and cultural resource management are conducted separately, despite the fact that climate change, sea level rise, and extreme weather threaten them both. Jayur Mehta and colleagues argue a synergy of both approaches is required to protect coastal archaeological landscapes. The authors used LiDAR digital elevation models, site location data, and NOAA sea level rise models to define ...
A tale of two hummingbird bills
2025-04-15
There are two species of streamertail hummingbirds on the island of Jamaica, West Indies—one with red-billed males (Trochilus polytmus) and the other with black-billed males (T. scitulus). This is a puzzling situation, as many evolutionary biologists have argued that avian speciation is unlikely to occur on small oceanic islands. Caroline Duffie Judy and colleagues investigated the hybrid zone that separates the two species, which is as narrow as 3.2 km. The authors analyzed 186 Trochilus specimens from 12 ...
Corn leads to improved performance in lithium-sulfur batteries
2025-04-15
PULLMAN, Wash. -- Researchers at Washington State University have demonstrated a way to use corn protein to improve the performance of lithium-sulfur batteries, a finding that holds promise for expanding the use of the high-energy, lighter-weight batteries in electric vehicles, renewable energy storage and other applications.
Lithium-sulfur batteries are lighter for the same amount of energy and more environmentally friendly than commonly used lithium-ion batteries, but their commercial adoption has been limited by technological hurdles that shorten their lifespan.
The WSU team’s research, published in the Journal of Power Sources, ...
SynGAP Research Fund (SRF), dba Cure SYNGAP1, announces Board of Trustees Update 2025
2025-04-15
Mill Valley, CA – April 15, 2025 – SynGAP Research Fund (SRF), dba Cure SYNGAP1, the leading patient advocacy group dedicated to improving the lives of those affected by SYNGAP1-related disorders (SRD), today announced the appointment of Jaime Aranda, Steve Gore, Heather Mestemaker, and Brian Smith to its Board of Trustees, effective April 15, 2025. They will succeed outgoing Trustees Emily Barnes, Sydney Stelmaszek, and Stella Tavilla, whose terms conclude on April 14, 2025. Additionally, a seat previously held by Pavel Gerovich, who stepped ...
Machine learning unlocks superior performance in light-driven organic crystals
2025-04-15
Materials that convert external stimuli into mechanical motion, known as actuators, play a crucial role in robotics, medical devices, and other advanced applications. Among them, photomechanical crystals deform in response to light, making them promising for lightweight and remotely controllable actuation. Their performance depends on factors such as molecular structures, crystal properties, and experimental conditions.
A key performance indicator of these materials is the blocking force—the maximum force exerted when deformation is completely ...
Exploring the mutational landscape of colorectal cancer
2025-04-15
Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide. The mutational landscape of CRC is well characterized, revealing key pathogenic genetic abnormalities that drive carcinogenesis (cancer development) and disease progression. Moreover, a step-wise colorectal carcinogenesis model has been proposed wherein normal epithelial cells transition to adenoma (non-cancerous tumor) and then to carcinoma (cancerous tumor) as they sequentially acquire genetic mutations.
Mutations ...
Researchers have mapped the hidden control system of vision
2025-04-15
Vision is one of the most complex functions of our brain and requires a seamless interaction between many different brain structures to decode shapes, colours, depths, and movements and turn them into a meaningful whole. Just like other brain functions, vision also depends on a balanced and controlled interaction between the chemical signals that "activate" and "brake" activity in the eye's cells – much like the accelerator and brake of a car. In research, the "brake" is known as GABA, which stands for gamma-aminobutyric ...