(Press-News.org) Highlights
In the largest study of its kind, a variant within the multidrug resistance 1 (MDR-1) gene in kidney transplant donors was linked to a 69% increased risk for long-term failure of transplanted organs.
This variant affects the expression of the protein that the MDR-1 gene encodes, which pumps drugs out of cells. (Immunosuppressant drugs are critical for preventing organ rejection but are also toxic to the kidneys.)
Washington, DC (October 11, 2012) — A single genetic variant in kidney donors' cells may help determine whether their transplanted organs will survive long term, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings provide new information that might be used to improve transplant longevity by revealing that the genetic make-up of kidney transplant donors affects the survival of transplanted organs.
A transplant recipient must take lifelong immunosuppressive drugs to prevent rejection of the new organ, but these drugs can have serious side effects, including kidney damage. So, ironically, the very drugs needed to prevent kidney rejection can also be toxic to the kidneys. Research suggests that how well certain proteins pump these drugs out of kidney cells may influence the drugs' kidney toxicity.
Richard Borrows, MB (Queen Elizabeth Hospital Birmingham, in the UK) and his colleagues looked to see if variants in the genes that encode such pumps might influence the health of transplanted kidneys. They investigated the links between donor and recipient gene variants with kidney outcome among 811 immunosuppressant-treated kidney transplant recipients.
Among the major findings:
One particular variant within the multidrug resistance 1 (MDR-1) gene in donors was linked to a 69% increased risk for long-term failure of transplanted organs.
The researchers validated the link in another 3,660 donors, making this the largest study of its kind.
This variant affects the expression of the protein that the MDR-1 gene encodes, the drug transporter P-glycoprotein.
No other genetic variants in donors or recipients were linked with organ survival or failure.
"The study of donor, as opposed to recipient, gene variation is relatively uncommon in the field of transplantation, and it certainly warrants more attention," said Dr. Borrows. He added that a single genetic variant probably has limited effect on its own, but when combined, multiple genetic variants may play an important role in transplant longevity.
###
Study co-authors include Jason Moore, MBBS, Amy Jayne McKnight, PhD, Bernd Döhler, PhD, Matthew Simmonds, PhD, Aisling Courtney, PhD, Oliver Brand, PhD, David Briggs, PhD, Simon Ball, PhD, Paul Cockwell, PhD, Christopher Patterson, PhD, Alexander Maxwell, PhD, Stephen Gough, PhD, and Gerhard Opelz, PhD.
Disclosures: The authors reported no financial disclosures.
The article, entitled "Donor ABCB1 Variant Associates with Increased Risk for Kidney Allograft Failure," will appear online at http://jasn.asnjournals.org/ on October 11, 2012, doi: 10.1681/ASN.2012030260.
The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.
Founded in 1966, and with more than 13,500 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.
END
Boston, MA -- New research that combines cell phone data from 15 million people in Kenya with detailed information on the regional incidence of malaria has revealed, on the largest scale so far, how human travel patterns contribute to the disease's spread. The findings from researchers at Harvard School of Public Health (HSPH) and seven other institutions indicate that malaria, in large part, emanates from Kenya's Lake Victoria region and spreads east, chiefly toward the capital, Nairobi.
The study appears in the October 12, 2012 issue of the journal Science.
"This ...
COLUMBUS, Ohio – A group of researchers have proposed creating a new web-based data network to help researchers and policymakers worldwide turn existing knowledge into real-world applications and technologies and improve science and innovation policy.
Researchers around the world have created datasets that, if interlinked with other datasets and made more broadly available could provide the needed foundation for policy and decision makers. But these datasets are spread across countries, scientific disciplines and data providers, and appear in a variety of inconsistent ...
MADISON — Scientists have identified three neighboring genes that make soybeans resistant to the most damaging disease of soybean. The genes exist side-by-side on a stretch of chromosome, but only give resistance when that stretch is duplicated several times in the plant.
"Soybean cyst nematode is the most important disease of soybean, according to yield loss, worldwide, year after year," says senior author Andrew Bent, professor of plant pathology at University of Wisconsin-Madison. "As we try to feed a world that is going from 6 billion toward 9 billion people, soybean ...
Sophia Antipolis, 12 October 2012: Urgent actions including smoking bans in public places, salt restrictions and improved blood pressure control are needed to fight rising cardiovascular disease in China. Half of male physicians in China smoke and they can lead the way to healthy lifestyles by kicking the habit.
Cardiovascular disease is the top cause of death in China and causes more than 40% of all deaths.
"Every year three million Chinese people die from cardiovascular disease and every 10 seconds there is one death from CVD in China," said Professor Dayi Hu, chief ...
The relatively new field in microbiology that focuses on quorum sensing has been making strides in understanding how bacteria communicate and cooperate. Quorum sensing describes the bacterial communication between cells that allows them to recognize and react to the size of their surrounding cell population. While a cell's output of extracellular products, or "public goods," is dependent on the size of its surrounding population, scientists have discovered that quorum sensing, a type of bacterial communication, controls when cells release these public goods into their environments. ...
Scientists at Scripps Institution of Oceanography at UC San Diego have used 20 years of satellite data to reveal a geological oddity unlike any seen on Earth.
At the border of Argentina, Bolivia and Chile sits the Altiplano-Puna plateau in the central Andes region, home to the largest active magma body in Earth's continental crust and known for a long history of massive volcanic eruptions. A study led by Yuri Fialko of Scripps and Jill Pearse of the Alberta Geological Survey has revealed that magma is forming a big blob in the middle of the crust, pushing up the earth's ...
October 12, 2012 – The human mouth is home to a teeming community of microbes, yet still relatively little is known about what determines the specific types of microorganisms that live there. Is it your genes that decide who lives in the microbial village, or is it your environment? In a study published online in Genome Research (www.genome.org), researchers have shown that environment plays a much larger role in determining oral microbiota than expected, a finding that sheds new light on a major factor in oral health.
Our oral microbiome begins to take shape as soon ...
(Edmonton) A meteorite that landed in the Moroccan desert 14 months ago is providing more information about Mars, the planet where it originated.
University of Alberta researcher Chris Herd helped in the study of the Tissint meteorite, in which traces of Mars' unique atmosphere are trapped.
"Our team matched traces of gases found inside the Tissint meteorite with samples of Mars' atmosphere collected in 1976 by Viking, NASA's Mars lander mission," said Herd.
Herd explained that 600 million years ago the meteorite started out as a fairly typical volcanic rock on the surface ...
Fly eyes have the fastest visual responses in the animal kingdom, but how they achieve this has long been an enigma. A new study shows that their rapid vision may be a result of their photoreceptors - specialised cells found in the retina - physically contracting in response to light. The mechanical force then generates electrical responses that are sent to the brain much faster than, for example, in our own eyes, where responses are generated using traditional chemical messengers. The study was published today, 12 October, in the journal Science.
It had been thought ...
At very low temperatures, close to absolute zero, chemical reactions may proceed at a much higher rate than classical chemistry says they should – because in this extreme chill, quantum effects enter the picture. A Weizmann Institute team has now confirmed this experimentally; their results would not only provide insight into processes in the intriguing quantum world in which particles act as waves, it might explain how chemical reactions occur in the vast frigid regions of interstellar space.
Long-standing predictions are that quantum effects should allow the formation ...
