When patients with COVID-19 arrive in emergency rooms, there are relatively few ways for doctors to predict which ones are more likely to become critically ill and require intensive care and which ones are more likely to enjoy a quick recovery. New Yale research could help them identify important early clues. In a recent study, researchers report that a series of biomarkers, or biological signals, associated with white blood cell activation and obesity can predict severe outcomes in COVID-19 patients. The findings appear in the Feb. 26 edition of Blood Advances. "Patients with high levels of these markers were much more like to require care in the intensive care unit, require ventilation, or die due to their COVID-19," said Dr. Hyung Chun, ...

PHOENIX, Arizona, February 26, 2021- Promising new research shows aerobic exercise may help slow memory loss for older adults living with Alzheimer's dementia. ASU Edson College of Nursing and Health Innovation Professor Fang Yu led a pilot randomized control trial that included 96 older adults living with mild to moderate Alzheimer's dementia. Participants were randomized to either a cycling (stationary bike) or stretching intervention for six months. Using the Alzheimer's Disease Assessment Scale-Cognition (ADAS-Cog) to assess cognition, the results of the trial were substantial. The six-month change in ADAS-Cog was 1.0±4.6 (cycling) and 0.1±4.1 (stretching), which were both significantly ...

Neutron scattering is a technique commonly used in physics and biology to understand the composition of complex multicomponent mixtures and is increasingly being used to study applied materials such as food. A new paper published in EPJ E by Gregory N Smith, Niels Bohr Institute, University of Copenhagen, Denmark, shows an example of neutron scattering in the area of food science. Smith uses neutron scattering to better investigate casein micelles in milk, with the aim of developing an approach for future research. Smith, also a researcher at the ISIS Neutron and Muon Source in ...

The past century or so has seen unprecedented technological, scientific, and sociological evolution worldwide. These have accompanied global shifts in people's lifestyles and rapid changes in the environment, both natural and man-made. An unfavorable consequence of these alterations has been the increasing burden of cancer on human society. As the country with the largest population, China has borne this burden heavily. Despite the massive progress China has made in healthcare since the 1950s, cancer has become the leading killer in the country. ...

Transfer RNAs (tRNAs) deliver specific amino acids to ribosomes during translation of messenger RNA into proteins. The abundance of tRNAs can therefore have a profound impact on cell physiology, but measuring the amount of each tRNA in cells has been limited by technical challenges. Researchers at the Max Planck Institute of Biochemistry have now overcome these limitations with mim-tRNAseq, a method that can be used to quantify tRNAs in any organism and will help improve our understanding of tRNA regulation in health and disease. A cell contains several hundred thousand tRNA molecules, each of which consists of only 70 to 90 nucleotides folded into a cloverleaf-like pattern. At one end, tRNAs carry one of the twenty amino acids that serve as protein building blocks, while the ...

What The Study Did: Researchers investigated whether home addresses recorded in the electronic medical record could be used to accurately estimate transmission risk of SARS-CoV-2 and identify risk factors for transmission. Authors: Joshua P. Metlay, M.D., Ph.D., of Massachusetts General Hospital in Boston, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2021.0304) Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial ...

What The Study Did: Researchers in this observational study assess at what age young people ages 12 to 17 start using cigarettes. Authors: Adriana Pérez, Ph.D., of the University of Texas Health Science Center at Houston in Austin, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.0218) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study is linked to ...

PHILADELPHIA-- Even though the use of rhythm control strategies for treating Paroxysmal Atrial Fibrillation (AF), a common abnormal heart rhythm, have increased overall in the United States, patients from racial and ethnic minority groups and those with lower income were less likely to receive rhythm control treatment - often the preferred treatment - according to new research from the Perelman School of Medicine at the University of Pennsylvania. The study is published in the JAMA Network Open. "Research has demonstrated the pervasive impact of structural racism on health outcomes among minoritized patients. We know, for instance, that there is less use of novel cardiovascular therapies among Black, Latinx, and patients of lower socioeconomic ...

A Mason Engineering researcher has discovered that artificial microswimmers accumulate where their speed is minimized, an idea that could have implications for improving the efficacy of targeted cancer therapy. Jeff Moran, an assistant professor of mechanical engineering in the Volgenau School of Engineering, and colleagues from the University of Washington in Seattle studied self-propelled half-platinum/half-gold rods that "swim" in water using hydrogen peroxide as a fuel. The more peroxide there is, the faster the swimming; without peroxide in pure water, the rods don't swim. In this work, they set out to understand ...

People living with obesity tend to have unhealthy glucose and lipid levels in their blood, as well as high blood pressure. As a result, they are more at risk of cardiovascular and metabolic diseases. But scientists have observed that up to 45% of people living with obesity have healthy blood pressure and glucose and lipid levels, and therefore may not be at high risk of disease. The reason why this group of people with obesity remain healthy, has been poorly understood. But now a team of researchers - led by scientists at the University of Copenhagen and Icahn School of Medicine ...

Biologists from RUDN University confirmed that a well-known spasmolytic drug called hymecromone can suppress the inflammatory response in astrocytes, important glial cells of the central nervous system. Potentially, it could be used to develop medications against Alzheimer's disease and other neurodegenerative conditions. The results of the study were published in the International Journal of Molecular Sciences. All pathological processes in the nervous system, such as neurodegenerative diseases, injuries, or intoxications, are associated with inflammations. ...

An insecticide used to control pest infestations on squash and pumpkins significantly hinders the reproduction of ground-nesting bees -- valuable pollinators for many food crops, a new University of Guelph study has revealed. This first-ever study of pesticide impacts on a ground-nesting bee in a real-world context found female hoary squash bees exposed to imidacloprid dug 85 per cent fewer nests, collected less pollen from crop flowers and produced 89 per cent fewer offspring than unexposed bees. "Because they're not making nests and not collecting pollen, they cannot raise offspring," said Dr. Susan Willis Chan, a post-doc in the School of ...

Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise. Researchers at the German Center for Neurodegenerative Diseases (DZNE), the University Medical Center Göttingen (UMG) and the German Center for Cardiovascular Research (DZHK) come to this conclusion based on laboratory studies. They consider that they have found a possible cause for the increased risk of dementia in people with heart problems. In mice, a specific drug which is known to affect gene activity alleviated the mental deficits. The involved experts see these results as potential approaches for therapies. ...

HOUSTON - (Feb. 26, 2021) - Tracking the origin of synthetic genetic code has never been simple, but it can be done through bioinformatic or, increasingly, deep learning computational approaches. Though the latter gets the lion's share of attention, new research by computer scientist Todd Treangen of Rice University's Brown School of Engineering is focused on whether sequence alignment and pan-genome-based methods can outperform recent deep learning approaches in this area. "This is, in a sense, against the grain given that deep learning approaches have recently outperformed traditional approaches, such as BLAST," he said. "My goal with this study is to start a conversation about how to combine the expertise of both domains to achieve further improvements for this important computational ...

TORONTO, Feb. 26, 2021 - The maternal care of offspring is one of the behavioural drivers that has led some bee species to have an ever-expanding social life over the history of evolution, new research out of York University has found. By virtue of being in a social group, the genome itself may respond by selecting more social rather than non-social genes. The behaviour and social environment come first, setting the stage for future molecular evolution. In addition, the researchers have found that a similar genetic evolution happened independently in different species at different times, suggesting there is a unifying principle leading to the same social trait. "There seems to be something about sociality specifically that is driving the genome to evolve in this way. It's a very ...

COLUMBIA, Mo. -- Marilyn Rantz still remembers the day she got the call that her mother, whose health had been declining, had fallen and fractured her shoulder. After rushing to the hospital, her mother told her she didn't understand how she ended up on a helicopter pad after the traumatic incident. A nearby nurse told Rantz the noise from the MRI scanning tube had caused her frightened mother to mistakenly believe she had been airlifted to the hospital on a helicopter. Determined to prevent avoidable hospitalizations, as well as the stress and panic that often comes along with the ambulance ride, Rantz, ...

MEMPHIS, Tenn. - Extremely low birth weight (ELBW) infants with moderate to large patent ductus arteriosus (PDA) may benefit from transcatheter PDA closure (TCPC) in the first four weeks of life, according to research published by Le Bonheur Cardiologist Ranjit Philip, MD, and Medical Director of Interventional Cardiac Imaging and Interventional Catheterization Laboratory Shyam Sathanandam, MD. Early PDA closure may prevent early onset pulmonary vascular disease, promote growth and facilitate faster weaning off supplemental oxygen and ventilator support. "The primary objective of this study was to describe changes in hemodynamics, ...

The National Cancer Institute's Genomic Data Commons (GDC), launched in 2016 by then-Vice President Joseph Biden and hosted at the University of Chicago, has become one of the largest and most widely used resources in cancer genomics, with more than 3.3 petabytes of data from more than 65 projects and over 84,000 anonymized patient cases, serving more than 50,000 unique users each month. In new papers published Feb. 22 in Nature Communications and Nature Genetics, the UChicago-based research team shares new details about the GDC, which is funded by the National Cancer Institute (NCI), via subcontract with the Frederick National Laboratory for Cancer Research, currently operated by ...

Climate alone is not a driver for human behavior. The choices that people make in the face of changing conditions take place in a larger human context. And studies that combine insights from archaeologists and environmental scientists can offer more nuanced lessons about how people have responded -- sometimes successfully -- to long-term environmental changes. One such study, from researchers at Washington University in St. Louis and the Chinese Academy of Sciences, shows that aridification in the central plains of China during the early Bronze Age did not cause population collapse, a result that highlights the importance of social ...

URBANA, Ill. - Economists and urban planners generally agree that local pollution sources disproportionally impact racial minorities in the U.S. The reasons for this are largely unclear, but a University of Illinois study provides new insights into the issue. "Our work finds experimental evidence that racial discrimination in the home-renting process actively sorts minority renters into neighborhoods with higher levels of pollution," says Peter Christensen, assistant professor in the Department of Agricultural and Consumer Economics (ACE) and an affiliate in Center for the Economics of Sustainability at University of Illinois. Christensen and co-authors Ignacio Sarmiento-Barbieri, U of I, and Christopher Timmins of Duke University conducted an empirical ...

Challenging the idea that older people with shorter life expectancies should rank lower in coronavirus immunization efforts, new UC Berkeley research shows that giving vaccine priority to those most at risk of dying from COVID-19 will save the maximum number of lives, and their potential or future years of life. The findings, published Feb. 25 in the journal Proceedings of the National Academy of Sciences, address the ethical dilemma of who should be first in line for a limited supply of vaccine shots amid a contagion that so far has killed 500,000 in the United States and 2.4 million globally. "Since older age is accompanied by falling life expectancy, it is widely assumed that means we're saving fewer years of life," said study lead author Joshua Goldstein, a UC Berkeley ...

Scientists at UCL and the IIT -Istituto Italiano di Tecnologia (Italian Institute of Technology) have created a temporary tattoo with light-emitting technology used in TV and smartphone screens, paving the way for a new type of "smart tattoo" with a range of potential uses. The technology, which uses organic light-emitting diodes (OLEDs), is applied in the same way as water transfer tattoos. That is, the OLEDs are fabricated on to temporary tattoo paper and transferred to a new surface by being pressed on to it and dabbed with water. The researchers, who ...

The investigation of Electron-Positron-Ion (EPI) plasma?--?a fully ionised gas of electrons and positrons that includes astrophysical plasmas like solar winds?--?has attracted a great deal of attention over the last twenty years. A new study published in EPJ D by Garston Tiofack, Faculty of Sciences, University of Marousa, Cameroon, and colleagues, assesses the dynamics of positron acoustic waves (PAWS) in EPI plasmas whilst under the influence of magnetic fields, or magnetoplasmas. The authors studied the changes in PAWs using a framework of Korteweg-de Vries (KdV) and modified Korteweg-de Vries (mKdV) equations finding a former led to compressive positron acoustic solitary waves (PASWs), whilst the latter resulted in the same and additional rarefactive ...

The total amount of data generated worldwide is expected to reach 175 ZB (Zettabytes; 1 ZB equals 1 billion Terabytes) by 2025. If 175 ZB were stored on Blu-ray disks, the disk stack would be 23 times the distance to the Moon. We face the urgent need to develop storage technologies that can accommodate this enormous amount of data. The demand to store ever-increasing volumes of information has resulted in the widespread implementation of data centers for Big Data. These centers consume massive amounts of energy (about 3% of global electricity supply) and rely on magnetization-based ...

IRS refers to the application of insecticide onto the interior walls of houses. The study, by the Wits Research Institute for Malaria (WRIM) and the London School of Hygiene and Tropical Medicine (LSHTM), was published in The Lancet on 25 February 2021. Targeted vs blanket Indoor Residual Spraying Malaria still represents one of the world's largest health crises, particularly on the African continent where 94% of cases and deaths occur (World Health Organization, 2020). Most countries in southern Africa have set the elimination of malaria within their borders as a policy target. In ...