Oncotarget published "Dynamic cellular biomechanics in responses to chemotherapeutic drug in hypoxia probed by atomic force spectroscopy" which reported that by exploiting single-cell, force spectroscopy methods, the authors probed biophysical and biomechanical kinetics of brain, breast, prostate, and pancreatic cancer cells with standard chemotherapeutic drugs in normoxia and hypoxia over 12-24 hours. After exposure to the drugs, they found that brain, breast, and pancreatic cancer cells became approximately 55-75% less stiff, while prostate cancer cells became more stiff, due to either drug-induced ...

Butterflies and moths (order Lepidoptera) are one of the most diverse animal groups. To date, scientists have found as many as 5,000 species from the Alps alone. Having been a place of intensive research interest for 250 years, it is considered quite a sensation if a previously unknown species is discovered from the mountain range these days. This was the case when a Swiss-Austrian team of researchers described a new species of alpine moth in the open-access, peer-reviewed journal Alpine Entomology, solving a 180-year-old mystery. Decades of research work Initially, the team - Jürg Schmid, a full-time dentist, author and passionate butterfly and moth researcher from Switzerland, and Peter Huemer, head of the natural science collections ...

Researchers are using computer models to simulate COVID-19 infections on a cellular level - the basic structural level of the human body. The models allow for virtual trials of drugs and vaccines, opening the possibility of pre-assessment for drug and vaccine efficacy against the virus. The research team at the University of Waterloo includes Anita Layton, professor of applied mathematics and Canada 150 Research Chair in mathematical biology and medicine, and Mehrshad Sadria, an applied mathematics PhD student. The team uses "in silico" experiments to replicate how the human immune system deals with the COVID-19 virus. In silico refers to trials situated in the silicon of computer chips, as opposed to "in ...

PULLMAN, Wash. --Students who identify as LGBTQ+ in Washington state school districts with conservative voting records reported experiencing more bullying than their peers in more politically liberal areas, according to a new study. For the study in the journal Analyses of Social Issues and Public Policy, researchers explored the relationships among school district voting records in the 2016 presidential election, bullying experiences in schools and mental health outcomes of LGBTQ+ youth in the state. The study shows LGBTQ+ students are at a higher risk for psychological distress and suicidality as a result of bullying, particularly in school districts that voted for former ...

WHAT: In a perspective published in Neuropsychopharmacology, leaders from the National Institutes of Health address how using appropriate language to describe mental illness and addiction can help to reduce stigma and improve how people with these conditions are treated in health care settings and throughout society. The authors define stigma as negative attitudes toward people that are based on certain distinguishing characteristics. More than a decade of research has shown that stigma contributes significantly to negative health outcomes and can pose a barrier to seeking treatment for mental ...

New models of neutron stars show that their tallest mountains may be only fractions of millimetres high, due to the huge gravity on the ultra-dense objects. The research is presented today at the National Astronomy Meeting 2021. Neutron stars are some of the densest objects in the Universe: they weigh about as much as the Sun, yet measure only around 10km across, similar in size to a large city. Because of their compactness, neutron stars have an enormous gravitational pull around a billion times stronger than the Earth. This squashes every feature on the ...

Tokyo, Japan - Researchers from Tokyo Metropolitan University have analyzed long-term precipitation radar data from satellites and found significantly enhanced rainfall over the most recent decade during the annual Meiyu-Baiu rainy season in East Asia. The data spans 23 years and gives unprecedented insight into how rainfall patterns have changed. They showed that the increased rainfall was driven by the decadal increased transport of moisture from the tropics and frequent occurrence of the upper tropospheric trough over the front. From the second ...

Highlights The results of a new study support the validity of a score that considers various patient-reported outcome measures and preferences for assessing health-related quality of life in individuals with kidney failure. The score is calculated from assessments of cognitive function, depression, fatigue, pain interference, physical functioning, sleep disturbance, and ability to participate in social roles. Washington, DC (July 16, 2021) -- Results from a new study support the validity of a score that considers various patient-reported measures and preferences for assessing health-related quality of life and promoting patient-centered care in individuals with kidney failure. The study appears in an upcoming issue of CJASN. The ...

Highlights The sodium-glucose co-transporter 2 inhibitor dapagliflozin reduced kidney, cardiovascular, and mortality risks in patients with advanced chronic kidney disease, similar to benefits seen in individuals with normal or moderately impaired kidney function. Rates of serious side effects were similar in patients with advanced chronic kidney disease who received dapagliflozin or placebo. Washington, DC (July 16, 2021) -- Studies have shown that diabetes drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors can provide kidney- and cardiovascular-related ...

Researchers at University of California San Diego School of Medicine and Rady Children's Institute for Genomic Medicine have produced a stem cell model that demonstrates a potential route of entry of SARS-CoV-2, the virus that causes COVID-19, into the human brain. The findings are published in the July 9, 2021 online issue of Nature Medicine. "Clinical and epidemiological observations suggest that the brain can become involved in SARS-CoV-2 infection," said senior author Joseph Gleeson, MD, Rady Professor of Neuroscience at UC San Diego School of Medicine and ...

PITTSBURGH, July 16, 2021 - For the first time ever, researchers from the University of Pittsburgh School of Medicine discovered that phages--tiny viruses that attack bacteria--are key to initiating rapid bacterial evolution leading to the emergence of treatment-resistant "superbugs." The findings were published today in Science Advances. The researchers showed that, contrary to a dominant theory in the field of evolutionary microbiology, the process of adaptation and diversification in bacterial colonies doesn't start from a homogenous clonal population. They were shocked to discover that the cause of much of the early adaptation wasn't random ...

Researchers at UC San Francisco are zeroing in on how the immune system may play a role in miscarriage, which affects about a quarter of pregnancies. Working in mice, the researchers have found that a recently discovered subset of cells in the immune system may prevent the mother's immune system from attacking the placenta and fetus. If the research is confirmed in further animal studies, and the cells play a similar role in people, they could point the way toward new therapies for pregnancies that are threatened by defects in immune tolerance. The researchers showed that pregnant mice who did not have this subset of cells, known as extrathymic Aire-expressing cells, were twice as likely to miscarry, and in many ...

UNIVERSITY PARK, Pa. -- From biochemical reactions that produce cancers, to the latest memes virally spreading across social media, simple actions can generate complex behaviors. For researchers trying to understand these emergent behaviors, however, the complexity can tax current computational methods. Now, a team of researchers has developed a new algorithm that can serve as a more effective way to analyze models of biological systems, which in turn allows a new path to understanding the decision-making circuits that make up these systems. The researchers add that the algorithm will help scientists study how relatively ...

For thousands of years, people looked into the night sky with their naked eyes -- and told stories about the few visible stars. Then we invented telescopes. In 1840, the philosopher Thomas Carlyle claimed that "the history of the world is but the biography of great men." Then we started posting on Twitter. Now scientists have invented an instrument to peer deeply into the billions and billions of posts made on Twitter since 2008 -- and have begun to uncover the vast galaxy of stories that they contain. "We call it the Storywrangler," says Thayer Alshaabi, a doctoral student at the University of Vermont who co-led the new research. "It's like a telescope to look -- in real time -- at all this data that people ...

A new method developed by Institute for Systems Biology (ISB) and University of California, Riverside provides new insights into cancer biology by allowing researchers to show how fatty acids are absorbed by single cells. Fatty acids, along with glucose and amino acids, are a major energy source for cellular growth and proliferation, and abnormal fatty acid metabolism is often seen in cancer. Dr. Wei Wei's lab at ISB and Dr. Min Xue's lab at UC Riverside have been collaborating for years to develop a series of chemical probes and analytical approaches for quantifying cellular glucose uptake, lactate production, amino acid ...

Climate change is driving a large increase in intense, slow-moving storms, a new study by Newcastle University and the Met Office has found. Investigating how climate affects intense rainstorms across Europe, climate experts have shown there will be a significant future increase in the occurrence of slow-moving intense rainstorms. The scientists estimate that these slow-moving storms may be 14 times more frequent across land by the end of the century. It is these slow-moving storms that have the potential for very high precipitation accumulations, ...

New research published in Nature Medicine reveals willingness to get a COVID-19 vaccine was considerably higher in developing countries (80% of respondents) than in the United States (65%) and Russia (30%). The study provides one of the first insights into vaccine acceptance and hesitancy in a broad selection of low- and-middle income countries (LMIC), covering over 20,000 survey respondents and bringing together researchers from over 30 institutions including the International Growth Centre (IGC), Innovations for Poverty Action (IPA), WZB Berlin Social Science Center, the Yale Institute for Global Health, the Yale Research Initiative on Innovation and Scale (Y-RISE), ...

Engineers at UC Riverside have unveiled an air-powered computer memory that can be used to control soft robots. The innovation overcomes one of the biggest obstacles to advancing soft robotics: the fundamental mismatch between pneumatics and electronics. The work is published in the open-access journal, PLOS One. Pneumatic soft robots use pressurized air to move soft, rubbery limbs and grippers and are superior to traditional rigid robots for performing delicate tasks. They are also safer for humans to be around. Baymax, the healthcare companion robot in the 2014 animated Disney film, Big Hero 6, is a pneumatic robot for good reason. But existing systems for controlling pneumatic soft robots still use electronic valves ...

Imagine an orange cat. Now, imagine the same cat, but with coal-black fur. Now, imagine the cat strutting along the Great Wall of China. Doing this, a quick series of neuron activations in your brain will come up with variations of the picture presented, based on your previous knowledge of the world. In other words, as humans, it's easy to envision an object with different attributes. But, despite advances in deep neural networks that match or surpass human performance in certain tasks, computers still struggle with the very human skill of "imagination." Now, a USC ...

BUFFALO, N.Y. - Many legacy media outlets played an unwitting role in the growth of the four most successful fake Twitter accounts hosted by the Russian Internet Research Agency (IRA) that were created to spread disinformation during the 2016 U.S. presidential campaign, according to a study led by a University at Buffalo communication researcher. In roughly two years beginning in late 2015, these accounts went from obscurity to microcelebrity status, growing from about 100 to more than 100,000 followers. With its heavily populated follower base ready to spread the word -- like all heavily engaged Twitter audiences -- the IRA could strategically deploy messages and provide visible metrics, creating an illusion of authority and ...

As the Covid-19 pandemic raged, news reports show that sales of electronic air cleaners have surged due to concerns about airborne disease transmission. But a research team at the Georgia Institute of Technology has found that the benefits to indoor air quality of one type of purifying system can be offset by the generation of other pollutants that are harmful to health. Led by Associate Professor Nga Lee "Sally" Ng in Georgia Tech's School of Chemical and Biomolecular Engineering and the School of Earth and Atmospheric Sciences, the team evaluated the effect of a hydroxyl radical generator in an office setting. Hydroxyl radicals react with odors and pollutants, decomposing ...

A team of researchers from the University of Maryland has 3D printed a soft robotic hand that is agile enough to play Nintendo's Super Mario Bros. - and win! The feat, highlighted on the front cover of the latest issue of Science Advances, demonstrates a promising innovation in the field of soft robotics, which centers on creating new types of flexible, inflatable robots that are powered using water or air rather than electricity. The inherent safety and adaptability of soft robots has sparked interest in their use for applications like prosthetics and biomedical devices. Unfortunately, controlling the fluids that make these soft ...

Evolution is often portrayed as a tree, with new species branching off from existing lineages, never again to meet. The truth however is often much messier. In the case of adaptive radiation, in which species diversify rapidly to fill different ecological niches, it can be difficult to resolve relationships, and the phylogeny (i.e. evolutionary tree) may look more like a bush than a tree. This is because lineages may continue to interbreed as new species are established, and/or they may diverge and then re-hybridize, resulting in genetically mixed populations (known as admixture). Even after species diverge, the introduction of genes from one species to another (known as introgression) can occur. All of ...

A UC San Francisco study has found that the antibiotic azithromycin was no more effective than a placebo in preventing symptoms of COVID-19 among non-hospitalized patients, and may increase their chance of hospitalization, despite widespread prescription of the antibiotic for the disease. "These findings do not support the routine use of azithromycin for outpatient SARS-CoV-2 infection," said lead author Catherine E. Oldenburg, ScD, MPH, an assistant professor with the UCSF Proctor Foundation. SARS-CoV-2 is the virus that causes COVID-19. Azithromycin, a broad-spectrum antibiotic, is widely prescribed as a treatment for COVID-19 in the United States and the rest of the world. "The hypothesis is that it has anti-inflammatory properties that ...

ATLANTA--An oral prodrug developed by a team of scientists led by Binghe Wang, Regents' Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science. Although carbon monoxide (CO) gas is toxic in large doses, scientists have discovered it can have beneficial effects by reducing inflammation and protecting cells against injury. Previous studies have demonstrated the protective effects of CO against injury in the kidneys, lungs, gastrointestinal tract and liver, among other organs. For the past five years, Wang and his collaborators have worked to design a safe way to deliver CO to human patients via prodrugs -- inactive compounds that ...