Living organisms are often exposed to stress stimuli generated either by external or internal factors, and they need to respond accordingly. At a cellular level, stress usually triggers the activation of survival pathways that contribute to the recovery of cell homeostasis. However, when stress is too high, a process of cell death is initiated that eliminates the damaged cell. Scientists led by ICREA researcher Dr. Angel Nebreda, head of the Signalling and Cell Cycle laboratory at IRB Barcelona, have identified an important role of the p38-MK2 pathway in determining cell fate in response to stress. "Our ...

Computer vision technology is increasingly used in areas such as automatic surveillance systems, self-driving cars, facial recognition, healthcare and social distancing tools. Users require accurate and reliable visual information to fully harness the benefits of video analytics applications but the quality of the video data is often affected by environmental factors such as rain, night-time conditions or crowds (where there are multiple images of people overlapping with each other in a scene). Using computer vision and deep learning, a team of researchers led by Yale-NUS College Associate Professor of Science (Computer Science) Robby Tan, who is also from the National University of Singapore's (NUS) Faculty of Engineering, ...

Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have discovered that acetate, a major metabolite produced by some intestinal bacteria, is involved in regulating other intestinal bacteria. Specifically, experiments showed that acetate could trigger an immune response against potentially harmful bacteria. The findings, published in the scientific journal Nature, will lead to the development of new ways to regulate the balance of intestinal bacteria. You may be surprised to know that 40 trillion important bacteria live in our intestines. They help keep us healthy by producing essential nutrients and eliminating foreign pathogens. On the other ...

Some COVID-19 patients who experience acute respiratory failure respond by significantly increasing their respiratory effort - breathing faster and more deeply There is concern among some doctors that this level of respiratory effort can lead to further damage to these patients' lungs. Working with an international team of leading intensive care clinicians, engineering researchers at the University of Warwick have used computational modelling to provide new evidence that high respiratory efforts in COVID-19 patients can produce pressures and strains inside the lung that can result in injury. The impact of high breathing efforts on the lungs of patients suffering with acute respiratory failure due to COVID-19 ...

The carbon-hydrogen bonds in alkanes--particularly those at the ends of the molecules, where each carbon has three hydrogen atoms bound to it--are very hard to "crack" if you want to replace the hydrogen atoms with other atoms. Methane (CH(4)) and ethane (CH(3)CH(3)) are made up, exclusively, of such tightly bound hydrogen atoms. In the journal Angewandte Chemie, a team of researchers has now described how they break these bonds while forming new carbon-nitrogen bonds (amidation). If it were possible to easily break the C-H bonds in hydrocarbons, it would be possible to synthesize complex organic ...

The struggle to get your child to go to sleep and stay asleep is something most parents can relate to. Once the bedtime battle is over and the kids have finally nodded off, many parents tune out as well. But University of South Australia researcher Professor Kurt Lushington is calling for parents to check on their small snoozers before switching off. He says knowing the quality of a child's sleep is important, as it could be an indicator of sleep-disordered breathing - an under-reported medical condition that can affect a child's health and wellbeing. "During sleep, the muscles keeping the upper airway stiff relax, and as a consequence, the airway narrows, which ...

Computer vision has progressed much over the past decade and made its way into all sorts of relevant applications, both in academia and in our daily lives. There are, however, some tasks in this field that are still extremely difficult for computers to perform with acceptable accuracy and speed. One example is object tracking, which involves recognizing persistent objects in video footage and tracking their movements. While computers can simultaneously track more objects than humans, they usually fail to discriminate the appearance of different objects. This, in turn, can lead to the algorithm to mix up objects in a scene and ultimately produce incorrect tracking results. At the Gwangju Institute of Science ...

A new Tel Aviv University study found that, like humans, bats living in Tel Aviv enjoy the wide variety and abundance of food that the city has to offer, in contrast to rural bats living in Beit Guvrin, who are content eating only one type of food. The study was led by research student Katya Egert-Berg, under the guidance of Prof. Yossi Yovel, head of Tel Aviv University's Sagol School of Neuroscience and a faculty member of the School of Zoology in the George S. Wise Faculty of Life Sciences and the Steinhardt Museum of Natural History, as well as a recipient of the 2021 Kadar Family Award for Outstanding ...

The July issues of two of the American Psychiatric Association journals, The American Journal of Psychiatry and Psychiatric Services are available online. The American Journal of Psychiatry is the most widely read psychiatric journal in the world. Its July issue offers a collection of articles discussing the impacts of structural racism, socioeconomic deprivation and stigmatization on mental health. This includes the article From Womb to Neighborhood: A Racial Analysis of Social Determinants of Psychosis in the United States, which was featured at the APA Annual Meeting in May. Among other highlights: Dismantling Structural Racism in Psychiatry: A Path to Mental Health Equity Modification of Heritability for Educational Attainment and Fluid Intelligence by Socioeconomic ...

When it comes to making eggs, female flies and female humans are surprisingly similar. And that could be a boon for women seeking better birth control methods, a UConn researcher reports in the July 5 issue of PNAS. There are about 61 million women of reproductive age in the US, and about 43 million of them are sexually active but don't want a pregnancy right now, according to the Guttmacher Institute. And while there are a dozen or so different methods of birth control available, most have undesirable side effects for some of the women who try them. Despite the need, ...

Using advanced remote sensing techniques can help the early detection of oak tree decline and control many other forest diseases worldwide, says new research from Swansea University. The research published in Remote Sensing of Environment examined holm oak decline, which in its early stages causes changes to the tree's physiological condition that is not readily visible. It is only later, when the tree is more advanced in its decline, that outward changes to its leaf pigment and canopy structure become apparent. The researchers used an integrated approach of hyperspectral and thermal imaging, a 3-D radiative transfer ...

Philadelphia, July 19, 2021--Researchers at Children's Hospital of Philadelphia (CHOP) have developed a novel method for producing new antibiotics to combat resistant bacteria. Through an approach that would target bacteria with an antibiotic that is masked by a prodrug, which the bacteria would themselves remove, the researchers identified a method that would allow for development of new, effective antibiotics that could overcome issues of resistance. The findings were published today in eLife. "We've created a sort of 'Trojan Horse' that would allow antibiotics to reach desired tissues undisturbed, ...

(Edmonton, AB) Firefighters at the centre of the battle against the massive Fort McMurray wildfire in 2016 have persistent lung damage, according to new findings published by a University of Alberta occupational health research team. "Those who were dealing with burning organic matter were exposed to a barrage of small particles in the smoke, and the ones with the highest exposure have long-term consequences," said principal investigator Nicola Cherry, an occupational epidemiologist, professor of medicine and Tripartite Chair of Occupational Health in the Faculty of Medicine & Dentistry. The firefighters had more ...

BIRMINGHAM, Ala. - An experimental drug reported in Nature Communications suggests that a "path is clearly achievable" to treat currently untreatable cases of cystic fibrosis disease caused by nonsense mutations. This includes about 11 percent of cystic fibrosis patients, as well as patients with other genetic diseases, including Duchenne muscular dystrophy, β-thalassemia and numerous types of cancers, that are also caused by nonsense mutations. The drug is a small molecule with a novel mechanism of action, say David Bedwell, Ph.D., and Steven Rowe, M.D., MSPH, co-senior authors. Bedwell is professor and chair of the University of Alabama at Birmingham Department of Biochemistry and Molecular ...

Scientists from the University of Graz, Kanzelhöhe Observatory, Skoltech, and the World Data Center SILSO at the Royal Observatory of Belgium, have presented the Catalogue of Hemispheric Sunspot Numbers. It will enable more accurate predictions of the solar cycle and space weather, which can affect human-made infrastructure both on Earth and in orbit. The study came out in the Astronomy & Astrophysics journal, and the catalogue is available from SILSO -- the World Data Center for the production, preservation, and dissemination of the international sunspot number. Our Sun is a big boiling ball of gas, most of which is so hot that electrons are ripped off from atoms, creating a circulating mix of charged particles, called plasma. These moving charges ...

A potentially life-saving treatment for heart attack victims has been discovered from a very unlikely source - the venom of one of the world's deadliest spiders. A drug candidate developed from a molecule found in the venom of the Fraser Island (K'gari) funnel web spider can prevent damage caused by a heart attack and extend the life of donor hearts used for organ transplants. The discovery was made by a team led by END ...

The research team led by Prof. WEI Haiming and Prof. TIAN Zhigang from Division of Life Sciences and Medicine, University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS), collaborating with the research group led by Prof. SUN Zimin from the First Affiliated Hospital of USTC revealed the pathological mechanism of severe pre-engraftment syndrome (PES) after umbilical cord blood transplantation, not only providing a treatment strategy for patients with PES, but significantly guiding for further improvement in the curative effect of unrelated cord blood transplantation (UCBT). This study was published in Nature Communications. UCBT is an important means to cure hematological ...

In February 2020, a trio of bio-imaging experts were sitting amiably around a dinner table at a scientific conference in Washington, D.C., when the conversation shifted to what was then a worrying viral epidemic in China. Without foreseeing the global disaster to come, they wondered aloud how they might contribute. Nearly a year and a half later, those three scientists and their many collaborators across three national laboratories have published a comprehensive study in Biophysical Journal that - alongside other recent, complementary studies of coronavirus proteins ...

Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer's, Parkinson's, and other severe brain pathologies. These substances can provide a breakthrough in the treatment of neurodegenerative pathologies. New molecules of pyrrolyl- and indolylazine classes activate intracellular mechanisms to combat one of the main causes of "aged" brain diseases - an excess of so-called amyloid structures that accumulate in the human brain with age. The essence of the study was published in the European Journal of Medicinal Chemistry. Experts from the Institute of Cytology of the Russian Academy of Sciences, the Institute of Organic Synthesis of the Ural Branch of the Russian ...

A new mathematical model helps predict the tiny changes in carbon-based materials that could yield interesting properties. Scientists at Tohoku University and colleagues in Japan have developed a mathematical model that abstracts the key effects of changes to the geometries of carbon material and predicts its unique properties. The details were published in the journal Carbon. Scientists generally use mathematical models to predict the properties that might emerge when a material is changed in certain ways. Changing the geometry of three-dimensional (3D) graphene, which is made of networks of carbon atoms, by adding chemicals or introducing topological defects, can improve its catalytic properties, for example. But it has been difficult for scientists to understand why this happens exactly. The ...

Researchers from the Paul Scherrer Institute PSI and the Brookhaven National Laboratory (BNL), working in an international team, have developed a new method for complex X-ray studies that will aid in better understanding so-called correlated metals. These materials could prove useful for practical applications in areas such as superconductivity, data processing, and quantum computers. Today the researchers present their work in the journal Physical Review X. In substances such as silicon or aluminium, the mutual repulsion of electrons hardly affects the material properties. Not so with so-called correlated materials, in which the electrons interact strongly with one another. The movement of one electron in a correlated material leads ...

Prof. LI Chuanfeng, Prof. XU Jinshi and their colleagues from Prof. GUO Guangcan's group, University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS), realized the high-contrast readout and coherent manipulation of a single silicon carbide divacancy color center electron spin at room temperature for the first time in the world, in cooperation with Prof. Adam Gali, from the Wigner Research Centre for Physics in Hungary. This work was published in National Science Review on July 5, 2021. Solid-state spin color centers are of utmost importance in many applications of quantum technologies, the outstanding one among which is the nitrogen-vacancy (NV) center in diamond. Since the detection ...

African swine fever (ASF), first detected in Germany in domestic pigs on 15 July 2021, does not pose a health hazard to humans. "The ASF pathogen cannot be transferred to humans", explains Professor Dr. Dr. Andreas Hensel, President of the German Federal Institute for Risk Assessment (BfR). "No risk to health is posed by direct contact with diseased animals or from eating food made from infected domestic pigs or wild boar". The ASF pathogen is a virus which infects domestic pigs and wild boar and which leads to a severe, often lethal, disease in these animals. It is transferred via direct contact or with excretions from infected animals, or through ticks. The ASF virus is endemic to infected wild animals ...

Tokyo, Japan - Chronic obstructive pulmonary disease (COPD) causes illness and death worldwide. It is characterized by destruction of the walls of tiny air sacs in the lungs, known as emphysema, and a decline in lung function. Little has been known about the mechanisms by which it begins to develop. But now, researchers from Japan have found a protein that promotes the development of the early stages of emphysema, with the potential to be a therapeutic target. COPD can be triggered by environmental factors such as cigarette smoking that result in lung inflammation. The development of inflammation involves the movement ...

WINSTON-SALEM, NC, JULY 19, 2021 -- Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people. Immunotherapies, also known as biologic therapies, activate the body's own immune system to control, and eliminate cancer. Appendiceal cancer is historically resistant to systemic chemotherapy, and the effect of immunotherapy is essentially unknown because clinical trials are difficult to perform due to lack of ...