Although lockdowns are undoubtedly associated with health harms, their impact on health is unlikely to be worse than the impact of the COVID-19 pandemic itself, concludes a review published in the online journal BMJ Global Health. During the COVID-19 pandemic, there has been an ongoing debate around whether the benefits of government "lockdowns"- either stay-at-home orders or interventions restricting movement - in reducing infections are outweighed by the negative impacts on the economy, social structure, education, and mental and physical health. In a nutshell, whether "the cure is worse than the disease." In this narrative review, an international team of doctors examine the ...

One in eight children have mental disorders that cause symptoms and impairment and therefore require treatment, but even in high-income countries most of these children will not gain access to services to treat them, reports a study published in the journal Evidence-Based Mental Health. Mental disorders that start in childhood and adolescence can significantly interfere with wellbeing and development. Despite the social and economic implications of not addressing these disorders, including long-term healthcare costs, justice system costs and the loss of human potential, mental health service provision for children continues to lag behind provision of services for physical ...

Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. 1. Rapid screening, face masks may prevent SARS-CoV-2 transmission at indoor mass-gathering events Abstract: https://www.acpjournals.org/doi/10.7326/M21-2278 URL goes live when the embargo lifts An observational study in Barcelona, Spain found that implementation of same-day rapid screening, use of face masks, and improved ventilation was ...

Although people in early 2020 hoarded toilet paper, washed their hands incessantly, and wouldn't leave home, 11 months later the public pushed the envelope on COVID-19 safety precautions and ignored warnings as time went on, a new University of California, Davis, study suggests. Researchers in the Department of Communication examined people's reactions and expressions of anxiety about news articles on Twitter. Additionally, they investigated reactions to fear-inducing health news over time, despite the steadily rising COVID-19 death toll, said Hannah Stevens, a doctoral student in communication and lead author of the paper. The paper, "Desensitization to Fear-Inducting COVID-19 Health News on Twitter: Observational Study," ...

Two common practices in the U.S. restaurant industry -- service with a smile and tipping -- contribute to a culture of sexual harassment, according to new research from the University of Notre Dame. "A perfect storm: Customer sexual harassment as a joint function of financial dependence and emotional labor" was recently published in the Journal of Applied Psychology from Timothy Kundro, assistant professor of management and organization at Notre Dame's Mendoza College of Business. In the study, co-authored by Alicia Grandey and Vanessa Burke from Penn State University and Gordon Sayre from Emlyon Business School in France, more than 66 percent of restaurant employees reported facing some form of sexual harassment in the past six months. Previous ...

By uprooting carbon trapped in soil, wild pigs are releasing around 4.9 million metric tonnes of carbon dioxide annually across the globe, the equivalent of 1.1 million cars. An international team led by researchers from The University of Queensland and The University of Canterbury have used predictive population models, coupled with advanced mapping techniques to pinpoint the climate damage wild pigs are causing across five continents. UQ's Dr Christopher O'Bryan said the globe's ever-expanding population of feral pigs could be a significant threat to the climate. "Wild pigs are just like tractors ploughing through fields, turning over soil to find food," Dr O'Bryan said. "When soils are ...

Research conducted at the Sharon Eccles Steele Center for Translational Medicine (SCTM) at the University of Utah's John A. Moran Eye Center explains why people carrying a block of genetic variants strongly associated with the development of age-related macular degeneration (AMD) may develop the disease and identifies a potential therapeutic pathway for slowing or even reversing disease progression. AMD is a major cause of irreversible blindness worldwide and the leading cause of blindness for Americans aged 55 and over. Following more than 15 years of research that has employed an extensive repository of donated human ocular ...

A new approach to analyse satellite measurements of Earth's cloud cover reveals that clouds are very likely to enhance global heating. The research, by scientists at Imperial College London and the University of East Anglia, is the strongest evidence yet that clouds will amplify global heating over the long term, further exacerbating climate change. The results, published today in Proceedings of the National Academy of Sciences, also suggest that at double atmospheric carbon dioxide (CO2) concentrations above pre-industrial levels, the climate is unlikely to warm below 2°C, and is more likely on average to warm more than 3°C. Pre-industrial CO2 levels were around 280 ppm (parts per million), ...

Throughout history, people of different cultures and stages of evolution have found ways to adapt, with varying success, to the gradual warming of the environment they live in. But can the past inform the future, now that climate change is happening faster than ever before? Yes, say an international team of anthropologists, geographers and earth scientists in Canada, the U.S. and France led by Université de Montréal anthropologist Ariane Burke. In a paper published today in the Proceedings of the National Academy of Sciences, Professor Burke and her colleagues ...

A major drought and forest fires in the Amazon rainforest killed billions of trees and plants and turned one of the world's largest carbon sinks into one of its biggest polluters. Triggered by the 2015-16 El Niño, extreme drought and associated mega-wildfires caused the death of around 2.5 billion trees and plants and emitted 495 million tonnes of CO2 from an area that makes up just 1.2 per cent of the entire Brazilian Amazon rainforest, and 1 per cent of the whole biome. The stark findings, discovered by an international team of scientists working for more than eight years on a long-term study in the Amazon before, during and after the El Niño, have significant implications for global efforts to control the atmospheric ...

The oil industry, pharmaceutical companies and bioreactor manufacturers all face one common enemy: bubbles. Bubbles can form during the manufacturing or transport of various liquids, and their formation and rupture can cause significant issues in product quality. Inspired by these issues and the puzzling physics behind bubbles, an international scientific collaboration was born. Stanford University chemical engineer Gerald Fuller along with his PhD students Aadithya Kannan and Vinny Chandran Suja, as well as visiting PhD student Daniele Tammaro from the University of Naples, teamed up to study how different kinds of bubbles pop. The researchers were particularly interested in bubbles with proteins embedded on their surfaces, which is a common occurrence in the pharmaceutical industry ...

New research has found marine seismic surveys used in oil and gas exploration are not impacting the abundance or behaviour of commercially valuable fishes in the tropical shelf environment in north-western Australia. The research is the first of its kind to use dedicated seismic vessels to measure the impacts of the survey's noise in an ocean environment, with the eight-month experiment conducted within a 2500 square kilometre fishery management zone near the Pilbara coast. It involved using multiple acoustic sensors, tagging 387 red emperor fish and deploying more than ...

KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 per cent of human tumours. The development of KRAS inhibitors is, thus, an extremely active line of research. Effective results have been elusive so far, though - no KRAS inhibitor had been available until a month ago, when the FDA granted approval to Sotorasib. KRAS encodes two gene products, KRAS4A and KRAS4B, whose levels can vary across organs and embryonic stages. When KRAS mutates, both variants, or isoforms, are activated. Though, some studies have focussed on approaches to target only KRAS4B, since it usually found to be expressed at ...

Evidence shows that early detection and treatment of cancer can significantly improve health outcomes, however women in Mississippi, particularly in underserved populations, experience the worst health outcomes for cervical, breast, and oropharyngeal cancer. ...

From the onset of the COVID-19 pandemic there have been countless comparisons to the 1918 influenza pandemic in terms of overall medical impact. Many of the comparisons addressed overall cases which, given the lack of a confirmatory lab test in 1918 and no meaningful case definitions for both pandemics, make such comparisons patently invalid. Overall mortality comparisons, although methodologically flawed as well, do offer a reasonably comparative outcome measure and offers a greater degree of validity. This measure is further enhanced when adjusted for population and average life years lost (see accompanying table for mortality comparisons ...

Researchers at Michigan Medicine have discovered yet another functional autoantibody in COVID-19 patients that contributes to the disease's development and the "firestorm" of blood clots and inflammation it induces. A growing body of studies suggests COVID-19 emulates many aspects of systemic autoimmune disorders, including the release of a flurry of overactive immune cells that produce toxic webs of proteins and DNA called neutrophil extracellular traps, or NETs. For this study, the team analyzed serum from over 300 hospitalized COVID patients, searching for a novel autoantibody that shields the toxic NETs from being destroyed and produces a lasting ...

The link between on-road traffic and air pollution is well-known, as are the negative health impacts of pollution exposure. However, the many factors that may influence commuters' exposure to pollutants - such as frequency, time, and duration of commute - and the overall impact of commuting remains a matter of on-going scientific discovery. Dr. Jenna Krall, assistant professor at the George Mason University College of Health and Human Services, is using statistical methods to better understand exposure to air pollution. Krall studies how commuting patterns impact exposure to fine particulate matter ...

EAST LANSING, Mich. - Tens of millions of patients around the world suffer from persistent and potentially life-threatening wounds. These chronic wounds, which are also a leading cause of amputation, have treatments, but the cost of existing wound dressings can prevent them from reaching people in need. Now, a Michigan State University researcher is leading an international team of scientists to develop a low-cost, practical biopolymer dressing that helps heal these wounds. "The existing efficient technologies are far too expensive for most health care systems, ...

Researchers at the University of Maryland School of Medicine (UMSOM) launched a new online tool that could more quickly advance medical discoveries to reverse progressive hearing loss. The tool enables easy access to genetic and other molecular data from hundreds of technical research studies involving hearing function and the ear. The research portal called gene Expression Analysis Resource (gEAR) was unveiled in a study last month in Nature Methods. It is operated by a group of physician-scientists at the UMSOM Institute for Genome Sciences (IGS) in collaboration with their colleagues at other institutions. The portal allows researchers to rapidly access data and provides easily interpreted visualizations of datasets. Scientists can also input ...

New Curtin University-led research has called into question existing health advice that mothers wait a minimum of two years after giving birth to become pregnant again, in order to reduce the risk of adverse pregnancy outcomes, such as preterm and small-for-gestational age births. The research found that a World Health Organization (WHO) recommendation to wait at least 24 months to conceive after a previous birth may be unnecessarily long for mothers in high-income countries such as Australia, Finland, Norway and the United States. Lead researcher ...

Errors in the metabolic processes of mitochondria are responsible for a variety of diseases such as Parkinson's and Alzheimer's. Scientists needed to find out just how the necessary building blocks are imported into the complex biochemical apparatus of these cell areas. The TOM complex (translocase of the outer mitochondrial membrane) is considered the gateway to the mitochondrion, the proverbial powerhouse of the cell. The working group headed by Professor Chris Meisinger at the Institute of Biochemistry and Molecular Biology at the University of Freiburg has now demonstrated - in human cells - how signaling molecules control this gate. A signaling protein called DYRK1A modifies the molecular machinery of TOM and makes it more permeable ...

Three decades ago, child development researchers found that low-income children heard tens of millions fewer words in their homes than their more affluent peers by the time they reached kindergarten. This "word gap" was and continues to be linked to a socioeconomic disparity in academic achievement. While parenting deficiencies have long been blamed for the word gap, new research from the University of California, Berkeley, implicates the economic context in which parenting takes place -- in other words, the wealth gap. The findings, published this month in the journal Developmental Science, provide the first evidence that parents may talk less to their kids when experiencing financial scarcity. "We were interested in what happens when parents think about or experience financial scarcity ...

Electrical activity in the motor cortex of rats transforms from redundant to complex over the span of four days shortly after birth. Sleep twitches guide this metamorphosis, according to new research published in JNeurosci. Despite its name, the motor cortex doesn't control movement right off the bat. Early in development, this part of the brain is solely a sensory structure. Feedback from self-generated movements -- sleep twitches in particular -- may build representations of the body that will later orchestrate movement. To characterize this transition, Glanz et al. recorded electrical activity from the motor cortex of rat pups eight and 12 days after birth while monitoring their behavior. ...

Politicians may have good reason to turn to angry rhetoric, according to research led by political scientists from Colorado--the strategy seems to work, at least in the short term. In a new study, Carey Stapleton at the University of Colorado Boulder and Ryan Dawkins at the U.S. Air Force Academy discovered that political furor may spread easily: Ordinary citizens can start to mirror the angry emotions of the politicians they read about in the news. Such "emotional contagion" might even drive some voters who would otherwise tune out of politics to head to the polls. "Politicians want to get reelected, and anger is a powerful tool that they can use to make that happen," said Stapleton, who recently earned his PhD in political science at ...

ROCHESTER, Minn. -- Did you know multiple sclerosis (MS) means multiple scars? New research shows that the brain and spinal cord scars in people with MS may offer clues to why they developprogressive disability but those with related diseases where the immune system attacks the central nervous system do not. In a study published in Neurology, Mayo Clinic researchers and colleagues assessed if inflammation leads to permanent scarring in these three diseases: MS. Aquaporin-4 antibody positive neuromyelitis optica spectrum disorder (AQP4-NMOSD). Myelin oligodendrocyte glycoprotein antibody associated disorder (MOGAD). They also studied whether scarring may be a reason for ...