Oncotarget published "Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity" which reported that these authors recently documented that gain-of-function mutant p53 R273H in triple negative breast cancer cells interacts with replicating DNA and PARP1. The missense R273H GOF mtp53 has a mutated central DNA binding domain that renders it unable to bind specifically to DNA, but maintains the capacity to interact tightly with chromatin. Both the C-terminal domain ...

Oncotarget published "TERT and its binding protein: overexpression of GABPA/B in high grade gliomas" which reported that all GA-binding proteins progress through the glioma grades and have the highest expression levels in secondary glioblastomas. In secondary glioblastomas after chemotherapy, GABPB1 and GABPB1-L are expressed on a lower level than without treatment. Between primary and secondary glioblastomas with and without chemotherapy, TERT is elevated in the former while GABPB1 is increased in the secondary glioblastomas. GABPA and GABPB1, GABPB1-L and GABPB1-S positively correlate in primary glioblastomas. This ...

Thermal-imaging sensors that detect and capture images of the heat signatures of human bodies and other objects have recently sprung into use in thermostats to check facial temperatures in a contactless attempt to screen for COVID-19 at several building entrances. Under these circumstances, the smartphone industry is actively considering the incorporation of such sensors as portable features to create the add-on function of measuring temperature in real time. Additionally, the application of such technology to autonomous vehicles may facilitate safer autonomous driving. A research team lead by Dr. ...

The feeling of a needle piercing skin is familiar to most people, especially recently as COVID-19 vaccinations gain momentum. But what exactly happens when a needle punctures skin? The answer is revealed in a new paper published recently in the Journal of the Mechanics and Physics of Solids. ...

Even in the absence of bark beetle outbreaks and wildfire, trees in Colorado subalpine forests are dying at increasing rates from warmer and drier summer conditions, found recent University of Colorado Boulder research. The study, published in the May print issue of the Journal of Ecology, also found that this trend is increasing. In fact, tree mortality in subalpine Colorado forests not affected by fire or bark beetle outbreaks in the last decade has more than tripled since the 1980s. "We have bark beetle outbreaks and wildfires that cause very obvious mortality of trees in Colorado. But we're showing that even in the areas that people go hiking in and where the forest looks healthy, mortality is increasing ...

AMES, Iowa - A new study led by an Iowa State University scientist sheds light on how organisms have evolved to address imbalances in sex chromosomes. The study looks at a species of softshell turtle, but the results could help to illuminate an important evolutionary process in many species, said Nicole Valenzuela, professor of ecology, evolution and organismal biology and lead author of the study. Many organisms determine their sex by a pair of specialized chromosomes that appear in virtually every cell of an organism's body. A matched pair of chromosomes results in one sex, while a mismatched pair results in another sex. For instance, in humans and many other species, sex chromosomes are referred to as X and Y. Typically, two X chromosomes ...

Tokyo, Japan - Researchers from Tokyo Metropolitan University have developed a new technology which allows non-contact manipulation of small objects using sound waves. They used a hemispherical array of ultrasound transducers to generate a 3D acoustic fields which stably trapped and lifted a small polystyrene ball from a reflective surface. Although their technique employs a method similar to laser trapping in biology, adaptable to a wider range of particle sizes and materials. The ability to move objects without touching them might sound like magic, but in the world of ...

At a glance: Researchers studied cells collected by nasal swabs at the moment of diagnosis for both mild and severe COVID-19 patients Cells taken from patients who went on to develop severe disease had a muted antiviral response compared to those who went on to develop mild disease This suggests that it may be possible to develop early interventions that prevent severe COVID-19 from developing The team also identified infected host cells and pathways associated with protection against infection that may enable new therapeutic strategies for COVID-19 and other respiratory viral infections CAMBRIDGE, MA (July 23, 2021) -- Over the past 18 ...

St. Jude Children's Research Hospital investigators have demonstrated that comprehensive genomic sequencing of all pediatric cancer patients is feasible and essential to capitalize on the lifesaving potential of precision medicine. Results from the St. Jude Genomes for Kids study appear online today in the journal Cancer Discovery. Whole genome and whole exome sequencing of germline DNA was offered to all 309 patients who enrolled in the study. Whole genome, whole exome and RNA sequencing of tumor DNA was carried out for the 253 patients for whom adequate tumor samples were available. Overall, 86% of patients had at least one ...

MEADVILLE, PA - July 22, 2021 - Shark Week is many things. First and foremost, it's a week of shark-themed documentary programming on the Discovery Channel. Now in its 33rd year, it's the longest-running cable event in history. It's the biggest audience that marine biologists and ocean conservationists get, attracting millions of viewers who might otherwise not ever think about sharks at all. It's a stage that has launched careers of shark scientists and inspired many others to pursue jobs as ocean scientists. However, a new analysis shows that Shark Week is also deeply flawed in ways that undermine its goals, potentially harming both sharks and shark scientists. To document just how pervasive ...

Toronto -- People post 500 million tweets and 4 billion pieces of content on Facebook a day. What makes them do it? An urge to share and connect with others seems obvious. But, despite how toxic the social media sandbox can get, people more often share attitudes that are framed in terms of support instead of opposition, according to new research. That happens regardless of whether the opinion itself is positive or negative. Take gun control. The research found that people were likelier to express themselves on that issue in terms of, "I support allowing guns," or, "I support banning guns," versus, "I oppose banning guns," or, "I oppose allowing guns." "There are a lot of controversial issues where both sides talk about what they support - pro-life and pro-choice on abortion, for example," ...

Recently, a research group led by Prof. YUAN Kaijun and Prof. YANG Xueming from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences revealed strong isotope effects in photodissociation of the water isotopologue (HOD) using the Dalian Coherent Light Source. Their findings were published in Science Advances on July 23. "Our experimental results illustrate dramatically different quantum state population distributions of OH and OD fragments from HOD photodissociation. The branching ratios of the H+OD and D+OH channels display large wavelength-dependent isotopic fractionation," said Prof. YUAN. Because ...

Research in mice, published today in Science Immunology by researchers at the Babraham Institute, UK and VIB-KU Leuven, Belgium, provides two solutions with potential to overcome a key clinical limitation of immune cell therapies. Regulatory T cells have potential in treating autoimmunity and inflammatory diseases yet they can switch from a protective to damaging function. By identifying the unstable regulatory T cells, and understanding how they can be purged from a cell population, the authors highlight a path forward for regulatory T cell transfer therapy. Cell therapy is based on purifying cells from a patient, growing them up in cell culture to improve their properties, and then reinfusing them into the patient. Professor Adrian ...

In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body. These organs-on-chips serve as a model of the state an actual cancer patient is in, thus allowing an opportunity to finding the correct treatment before administering it to the patient. At Texas A&M University, researchers are pushing these devices to new levels that could change the way clinicians approach cancer treatment, particularly ovarian cancer. The team has recently submitted a patent disclosure with the Texas A&M Engineering Experiment Station. "We claim several novelties in technological ...

A study by researchers at the Texas A&M University School of Public Health shows that inexpensive and convenient devices such as silicone wristbands can be used to yield quantitative air quality data, which is particularly appealing for periods of susceptibility such as pregnancy. The research team found that the wristbands, when used as passive samplers, have the ability to bind smaller molecular weight semi-volatile polycyclic aromatic hydrocarbons (PAHs) -- a class of chemicals that occur naturally in coal, crude oil and gasoline and are produced when coal, oil, gas, wood, garbage and tobacco are burned -- in a similar pattern as active sampling. Published recently in Nature's ...

Small and seemingly specialized, the brain's locus coeruleus (LC) region has been stereotyped for its outsized export of the arousal-stimulating neuromodulator norepinephrine. In a new paper and with a new grant from the National Institutes of Health, an MIT neuroscience lab is making the case that the LC is not just an alarm button but has a more nuanced and multifaceted impact on learning, behavior and mental health than it has been given credit for. With inputs from more than 100 other brain regions and sophisticated control of where and when it sends out norepinephrine (NE), the LC's tiny population of surprisingly diverse cells may represent an important regulator of learning from ...

Alexandria, Va., USA - Hiba Nasir, Wayzata High School, Plymouth, Minn., presented the poster "Oral-Health Impact Profile 5: Analyzing A Private Practice Adult Population's Distribution" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. Nasir, a high school student, along with Sheila Riggs, University of Minnesota, Minneapolis, USA, performed an observational study to understand the ...

Alexandria, Va., USA - Ruth Lipman, American Dental Association (ADA) Science and Research Institute, Chicago, Ill., U.S., presented the poster "Strategies for Disseminating Guidance to Dentists during the COVID-19 Pandemic" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. Rapidly formulated, actionable infection risk mitigation strategies for dental care professionals were needed during the initial acceleration phase of the COVID-19 ...

Coffee shops and casual restaurants are an important part of American life. Even beyond the food and drinks they sell, they offer us a place to use the restroom or rest our feet while we're out and about, and they provide internet access to those on the go, those in need of a temporary office, or those who don't have an internet connection at home. Many of us take for granted that a nearby Starbucks or McDonald's can offer us a little respite, even if we don't always make a purchase. But access to these sorts of quasi-public spaces isn't always equal in America, particularly for Black people and other people of color. One such example of this is the infamous 2018 incident in Philadelphia when two Black men waiting at Starbucks for an acquaintance were ...

BIRMINGHAM, Ala. - There are many reasons that an intranasal vaccine against the SARS-CoV-2 virus would be helpful in the fight against COVID-19 infections, University of Alabama at Birmingham immunologists Fran Lund, Ph.D., and Troy Randall, Ph.D., write in a viewpoint article in the journal Science. That route of vaccination gives two additional layers of protection over intramuscular shots because it produces: 1) immunoglobulin A and resident memory B and T cells in the respiratory mucosa that are an effective barrier to infection at those sites, and 2) cross-reactive resident memory B and T cells that can respond earlier than other immune cells if a viral variant does start ...

July 23, 2021 - Last year, the American Cancer Society (ACS) issued an updated set of guidelines for cervical cancer screening - emphasizing the shift toward screening with primary human papillomavirus (HPV) testing. While the ACS recommendation accounts for a transition period to implement primary HPV screening, additional factors should be considered to operationalize these guidelines, according to a special white paper in the July issue of the Journal of Lower Genital Tract Disease (JLGTD), official journal of ASCCP. The journal is published in the Lippincott portfolio by Wolters Kluwer. In the article, the ASCCP Cervical ...

Rainforests are a powerful, natural solution to combat climate change -- providing water filtration, capturing carbon and regulating global temperatures. But major threats like large-scale land use changes, including agricultural expansion and clearcutting, have turned these biodiversity havens into one of the most endangered habitats on our planet. In 2019, select scientists, including the University of Delaware's Rodrigo Vargas, met at the National Geographic headquarters in Washington, D.C., to discuss the threats to rainforests. The researchers pinpointed a need to develop a worldwide tracking system, which would find trends to help fight land degradation ...

Attitudes toward diversity vary, and its meaning can often be difficult to find consensus about in an increasingly diverse but politically polarized nation such as the United States. In a report published by Personality and Social Psychology Bulletin, University of Illinois Chicago researchers detail findings from three studies that explore the connection between political ideology, attitudes, and beliefs toward diversity. "Our studies explored the possibility that atti­tudes toward 'diversity' are multidimensional rather than unidimensional and that ideological differences in diversity attitudes vary as a function of diversity subtype," said the report's ...

Researchers created a global dataset of job footprints in 50 countries and used a model to investigate how trying to meet the Paris Agreement global climate target of staying well below 2°C would affect energy sector jobs. They found that action to reach said target would increase net jobs by about 8 million by 2050, primarily due to gains in the solar and wind industries. The analysis appears July 23 in the journal One Earth. "Currently, an estimated 18 million people work in the energy industries--a number that is likely to increase, not decrease, to 26 million or by over 50% if we reach our global climate targets," says corresponding author Johannes Emmerling (@JohannesEmm), an environmental economist at the RFF-CMCC ...

Humid tropical forests, vital in global efforts to limit rising temperatures, are under threat as a result of changes in land use and climate. Now, researchers reporting in the journal One Earth on July 23 have developed a new way to keep tabs on the vulnerability of these forests on a global scale using satellite data. Called the tropical forest vulnerability index (TFVI), the hope is that this method will serve as an early warning for areas that are under the greatest threat to enable actions aimed at protecting these forests before it's too late. "Frequent droughts, higher temperature, and longer dry seasons, along with increasing pressures from deforestation and ...