For much of human history, animals and plants were perceived to follow a different set of rules than the rest of the universe. In the 18th and 19th centuries, this culminated in a belief that living organisms were infused by a non-physical energy or "life force" that allowed them to perform remarkable transformations that couldn't be explained by conventional chemistry or physics alone. Scientists now understand that these transformations are powered by enzymes - protein molecules comprised of chains of amino acids that act to speed up, or catalyze, ...

The rapid spread of the Alpha variant of COVID-19 resulted from biological changes in the virus and was enhanced by large numbers of infected people 'exporting' the variant to multiple parts of the UK, in what the researchers call a 'super-seeding' event. Results of the largest phylogeographic analysis ever conducted, published today in the journal Science, maps the spread of the variant (also known as lineage B.1.1.7) from its origins in Kent and Greater London in November 2020 to all but five counties in Wales, Scotland, Northern Ireland and England by 19 January. Dr ...

Engineers at the University of California San Diego developed a soft and stretchy ultrasound patch that can be worn on the skin to monitor blood flow through major arteries and veins deep inside a person's body. Knowing how fast and how much blood flows through a patient's blood vessels is important because it can help clinicians diagnose various cardiovascular conditions, including blood clots; heart valve problems; poor circulation in the limbs; or blockages in the arteries that could lead to strokes or heart attacks. The new ultrasound patch developed at UC San Diego can continuously monitor ...

Irvine, Calif., July 22, 2021 - To meet an ambitious goal of carbon neutrality by 2045, California's policymakers are relying in part on forests and shrublands to remove CO2 from the atmosphere, but researchers at the University of California, Irvine warn that future climate change may limit the ecosystem's ability to perform this service. In a paper published today in the American Geophysical Union journal AGU Advances, the UCI Earth system scientists stressed that rising temperatures and uncertain precipitation will cause a decrease in California's natural carbon storage capacity of as much as 16 percent under an extreme climate projection and of nearly 9 percent under a more moderate scenario. "This work highlights the conundrum ...

ITHACA, N.Y. - A new method that analyzes how individual immune cells react to the bacteria that cause tuberculosis could pave the way for new vaccine strategies against this deadly disease, and provide insights into fighting other infectious diseases around the world. The cutting-edge technologies were developed in the lab of Dr. David Russell, the William Kaplan Professor of Infection Biology in the Department of Microbiology and Immunology in the College of Veterinary Medicine, and detailed in new research published in the Journal of Experimental Medicine on July 22. For years, Russell's lab has sought to unravel how Mycobacterium tuberculosis (Mtb), the bacteria that cause tuberculosis, infect and persist in their host cells, which are typically ...

A new study, led by University of Minnesota Twin Cities engineering researchers, shows that the stiffness of protein fibers in tissues, like collagen, are a key component in controlling the movement of cells. The groundbreaking discovery provides the first proof of a theory from the early 1980s and could have a major impact on fields that study cell movement from regenerative medicine to cancer research. The research is published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS), a peer-reviewed, multidisciplinary, high-impact scientific journal. Directed cell movement, or what scientists call "cell contact guidance," refers to a phenomenon when the orientation of cells ...

Researchers at the University of São Paulo (USP) in Brazil investigated the effects of regular exercise on the physical and mental health of 344 volunteers during the pandemic. The study compared the effectiveness of three techniques: sessions led in person by a fitness instructor, sessions featuring an online instructor but no supervision, and sessions supervised remotely by an instructor via video call. The two kinds of session with professional supervision had the strongest effects on physical and mental health. According to the researchers, this was due to the possibility of increasing ...

New Brunswick, NJ--Even at term, gestational age may have an impact on children's academic performance, findings of a new study suggest. The research showed an association between gestational age at term and above-average rankings in a number of academic subjects. The study, published in Pediatrics, compared teacher-reported outcomes for 1,405 9-year-old children in the United States, analyzing performance in mathematics, science and social studies, and language and literacy, for those born at 37 through 41 weeks gestation. It found that longer gestational age was significantly associated with average or above-average rankings in all areas. It also suggested a general pattern of worse outcomes for children born at early term (37-38 weeks) and better outcomes for those born at late ...

Plastics offer many benefits to society and are widely used in our daily life: they are lightweight, cheap and adaptable. However, the production, processing and disposal of plastics are simply not sustainable, and pose a major global threat to the environment and human health. Eco-friendly processing of reusable and recyclable plastics derived from plant-based raw materials would be an ideal solution. So far, the technological challenges have proved too great. However, researchers at the University of Göttingen have now found a sustainable method - "hydrosetting", which uses water at normal conditions - to process and reshape a new type of hydroplastic polymer called cellulose cinnamate (CCi). The research was published ...

HOUSTON -- (July 22, 2021) -- Researchers who want bacteria to feel right at home in the laboratory have put out a new welcome mat. Rice University bioengineers and Baylor College of Medicine scientists looking for a better way to mimic intestinal infections that cause diarrhea and other diseases have built and tested a set of hydrogel-based platforms to see if they could make both transplanted cells and bacteria comfy. As a mechanical model of intestinal environments, the lab's soft, medium and hard polyethylene glycol (PEG) hydrogels were far more welcoming to the cells that normally line the gut than the glass and plastic usually used by laboratories. These cells can then host bacteria like Escherichia coli that are sometimes pathogenic. The ability to study their ...

Many people find it morally impermissible to put kidneys, children, or doctorates on the free market. But what makes a market transaction morally repugnant in the eyes of the public? And which transactions trigger the strongest collective disapproval? Researchers from the Max Planck Institute for Human Development and the Robert Koch Institute have addressed these questions. Their findings, published in Cognition, offer new entry points for policy interventions. Would you be willing to sell a kidney or be paid to spend time on a date? If not, then ...

Nuclear fusion offers the potential for a safe, clean and abundant energy source. This process, which also occurs in the sun, involves plasmas, fluids composed of charged particles, being heated to extremely high temperatures so that the atoms fuse together, releasing abundant energy. One challenge to performing this reaction on Earth is the dynamic nature of plasmas, which must be controlled to reach the required temperatures that allow fusion to happen. Now researchers at the University of Washington have developed a method that harnesses advances in the computer gaming industry: It uses a gaming graphics card, or GPU, to run the control system for their prototype fusion reactor. The team published ...

As any juror will tell you, piecing together a crime from a series of documents tendered in a courtroom is no easy feat, especially when a person's future hangs in the balance. Delivering the correct verdict on car accident and murder cases is contingent on good spatial awareness, but short of being at the scene of the crime, the room for error is large. However, thanks to the advent of virtual reality (VR), jurors now have a better chance of making the right decision. A new study published by the University of South Australia provides overwhelming evidence ...

The discovery of a Roman road submerged in the Venice Lagoon is reported in Scientific Reports this week. The findings suggest that extensive settlements may have been present in the Venice Lagoon centuries before the founding of Venice began in the fifth century. During the Roman era, large areas of the Venice Lagoon which are now submerged were accessible by land. Roman artefacts have been found in lagoon islands and waterways, but the extent of human occupation of the lagoon during Roman times has been unclear. Mapping the lagoon floor using sonar, Fantina Madricardo and colleagues discovered 12 archaeological structures aligned in a northeasterly direction for 1,140 metres, in an area of the lagoon ...

Newly-hatched pterosaurs may have been able to fly but their flying abilities may have been different from adult pterosaurs, according to a study published in Scientific Reports. Pterosaurs were a group of flying reptiles that lived during the Triassic, Jurassic and Cretaceous Periods (228 to 66 million years ago). Due to the rarity of fossilised pterosaur eggs and embryos, and difficulties distinguishing between hatchlings and small adults, it has been unclear whether newly-hatched pterosaurs were able to fly. Darren Naish and colleagues modelled hatchling flying abilities using previously obtained wing measurements from four established hatchling and embryo fossils from two pterosaur species, ...

Gene therapy in mouse models showed promise in preventing vision loss or blindness from serious retinal injury including optic nerve damage, and from retinal disease including diabetic retinopathy and glaucoma, Mount Sinai researchers report. Their study, published in the July 22 online publication of Cell, could transform treatment for those at risk of major vision loss from retinal degenerative diseases, which currently have no cure. The researchers focused on retinal ganglion cells, which process visual information by sending images to the brain. These cells can degenerate as a result of retinal injury and retinal disease. ...

Geneticists from Trinity College Dublin have discovered how a specific genetic mutation called H3K27M causes a devastating, incurable childhood cancer, known as diffuse midline glioma (DMG), and - in lab studies working with model cell types - successfully reverse its effects to slow cancer cell growth with a targeted drug. Their landmark work - just published in leading international journal, Nature Genetics and supported by Worldwide Cancer Research and The Brain Tumour Charity - translates crucial new understanding of the genetics of DMG progression into ...

A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH's National Eye Institute. The findings suggest a way forward for developing neuroprotective therapies for glaucoma, a leading cause of visual impairment and blindness. The report was published in Cell. Glaucoma results from irreversible neurodegeneration of the optic nerve, the bundle of axons from retinal ganglion cells that transmits signals from the eye to the brain to produce vision. Available therapies slow vision loss by lowering elevated eye pressure, however some glaucoma progresses to blindness despite normal eye pressure. Neuroprotective therapies would be a leap forward, meeting ...

Advances in microscopy have enabled researchers to picture loops of DNA strands for the first time. The images reveal how the human genome organises itself in three-dimensional space at much higher resolution than previously possible. The findings, published in a new study in the journal Molecular Cell, also reveal that the process of DNA being copied into RNA - transcription - indirectly shapes the architecture of the genome. An international team led by Pia Cosma at the Centre for Genomic Regulation (CRG) in Barcelona and Melike Lakadamyali at the Perelman ...

Manipulating RNA can allow plants to yield dramatically more crops, as well as increasing drought tolerance, announced a group of scientists from the University of Chicago, Peking University and Guizhou University. In initial tests, adding a gene encoding for a protein called FTO to both rice and potato plants increased their yield by 50% in field tests. The plants grew significantly larger, produced longer root systems and were better able to tolerate drought stress. Analysis also showed that the plants had increased their rate of photosynthesis. "The change really is dramatic," said University of Chicago Prof. Chuan He, who together with Prof. Guifang Jia at Peking University, led ...

A new study showed that a wearable computer vision device can reduce collisions for both people who are blind or those who are visually impaired and using a long cane and/or guide dog by 37 percent, compared to using other mobility aids alone. People who have visual impairments are at a significantly higher risk for collisions and falls. Commonly used mobility aids like long canes and guide dogs can offer benefits, but come with limitations in effectiveness and costs, respectively. While some electronic devices are marketed direct-to-consumer claiming to warn wearers of surrounding objects, there has been little evidence of their effectiveness in actual daily mobility settings. This is one of the first randomized-controlled trials to look at the potential benefit of the ...

What The Study Did: This study included 647 patients with untreated nonmetastatic prostate cancer (269 patients during the pandemic and 378 from before the pandemic). During the initial COVID-19 lockdown, only 1% of Black men underwent prostatectomy, while 26% of white patients did. Prior to the pandemic, there was no difference in the rate of prostatectomy between the two races (18% of Black men and 19% of white men). The lessons from this study suggest systemic inequities within health care and are likely applicable across medical specialties. Public health efforts are needed to fully recognize the unintended consequence of diversion of cancer resources to the COVID-19 pandemic to develop balanced mitigation strategies as viral rates continue to fluctuate. Authors: ...

Drought can have a lasting impact on the community of microbes that live in and around roots of rice plants, a team led by UC Davis researchers has found. Root-associated microbes help plants take up nutrients from the soil, so the finding could help in understanding how rice responds to dry spells and how it can be made more resilient to drought. The work is published July 22 in Nature Plants. The root microbiome of irrigated rice plants goes through a sequence of changes as the plants grow and stabilizes when they flower. The sequence of changes in the root ...

Restoration of degraded drylands is urgently needed to mitigate climate change, reverse desertification and secure livelihoods for the two billion people who live there, experts warn in a major new paper in Nature Ecology & Evolution. Scientists leading the Global Arid Zone Project examined restoration seeding outcomes at 174 sites on six continents, encompassing 594,065 observations of 671 plant species - with the lessons learned important to meeting ambitious future restoration targets. Flinders University Dr Martin Breed, one of three Australian researchers who helped coordinate ...

LONDON, 22 July 2021 - DeepMind today announced its partnership with the European Molecular Biology Laboratory (EMBL), Europe's flagship laboratory for the life sciences, to make the most complete and accurate database yet of predicted protein structure models for the human proteome. This will cover all ~20,000 proteins expressed by the human genome, and the data will be freely and openly available to the scientific community. The database and artificial intelligence system provide structural biologists with powerful new tools for examining a protein's three-dimensional structure, and offer a treasure trove of data that could unlock future advances and herald a new era for AI-enabled biology. AlphaFold's recognition in December 2020 by the ...