Artificial intelligence tools and deep learning models are a powerful tool in cancer treatment. They can be used to analyze digital images of tumor biopsy samples, helping physicians quickly classify the type of cancer, predict prognosis and guide a course of treatment for the patient. However, unless these algorithms are properly calibrated, they can sometimes make inaccurate or biased predictions. A new study led by researchers from the University of Chicago shows that deep learning models trained on large sets of cancer genetic and tissue histology data can easily identify the institution that submitted the images. The models, which use machine learning methods to "teach" themselves how to recognize certain cancer signatures, ...

Replication of SARS-CoV-2, the virus responsible for COVID-19, depends on a series of interactions between viral proteins and different cellular partners such as nucleic acids (DNA or RNA). Characterizing these interactions is crucial to elucidate the process of viral replication and identify new drugs for treating COVID-19. An interdisciplinary consortium of scientists from the Institut Pasteur, the Ecole Polytechnique, the Institut Curie, Inserm, the CNRS and the universities of Paris, Paris-Saclay, Bordeaux and Toulouse have demonstrated a specific interaction between a domain of a SARS-CoV-2 protein (Nsp3) and ...

When Alexander Flemming discovered a mould on a culture plate overgrown with bacteria in 1928, he did not expect to find one of the most widely used active substances: penicillin. Accidental discoveries and the identification of active ingredients from traditional remedies, such as the morphine of the opium poppy, have shaped the discovery of new medicines for a long time. Modern drug discovery - from chance to system Meanwhile, major developments in chemistry and molecular biology have been made that enable a systematic and targeted search for potential active substances in modern drug discovery. First, advances in the field of organic and ...

TROY, N.Y. -- An innovative testing platform that more closely mimics what cancer encounters in the body may allow for more precise, personalized therapies by enabling the rapid study of multiple therapeutic combinations against tumor cells. The platform, which uses a three-dimensional environment to more closely mirror a tumor microenvironment, is demonstrated in research published in Communications Biology. "This whole platform really gives us a way to optimize personalized immunotherapy on a rapid, high throughput scale," said Jonathan Dordick, Institute Professor of chemical and biological engineering and member of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute, ...

It's a favourite first-order for the day, but while a quick coffee may perk us up, new research from the University of South Australia shows that too much could be dragging us down, especially when it comes to brain health. In the largest study of its kind, researchers have found that high coffee consumption is associated with smaller total brain volumes and an increased risk of dementia. Conducted at UniSA's Australian Centre for Precision Health at SAHMRI and a team of international researchers*, the study assessed the effects of coffee on the brain among 17,702 UK Biobank participants (aged 37-73), finding that those who drank more than six cups of coffee a day had a 53 per cent increased risk of dementia. Lead researcher and UniSA PhD candidate, ...

Silicon, a semi-metal, bonds in its natural form with four other elements and its three-dimensional structure takes the form of a tetrahedron. For a long time, it seemed impossible to achieve the synthesis and characterisation of a two-dimensional equivalent - geometrically speaking, a square. Now scientists from the field of Inorganic Chemistry at Heidelberg University have succeeded in producing a crystalline complex with such a configuration. PD Dr Lutz Greb from the Institute of Inorganic Chemistry underlines that it has surprising physical and chemical properties and, in the field of molecular chemistry, will open up new approaches to using the second most abundant element in the Earth's crust for catalysis and materials research. As a classical ...

The touchscreen technology used in billions of smartphones and tablets could also be used as a powerful sensor, without the need for any modifications. Researchers from the University of Cambridge have demonstrated how a typical touchscreen could be used to identify common ionic contaminants in soil or drinking water by dropping liquid samples on the screen, the first time this has been achieved. The sensitivity of the touchscreen sensor is comparable to typical lab-based equipment, which would make it useful in low-resource settings. The researchers say their proof of concept could one day be expanded for a wide range of sensing applications, including for biosensing or medical diagnostics, right from the phone in your pocket. The results are reported ...

Many applications, from fiber-optic telecommunications to biomedical imaging processes require substances that emit light in the near-infrared range (NIR). A research team in Switzerland has now developed the first chromium complex that emits light in the coveted, longer wavelength NIR-II range. In the journal Angewandte Chemie, the team has introduced the underlying concept: a drastic change in the electronic structure of the chromium caused by the specially tailored ligands that envelop it. Many materials that emit NIR light are based on expensive or rare metal complexes. Cheaper alternatives that emit in the NIR-I range between 700 and 950 nm have been developed but NIR-II-emitting complexes of non-precious metals remain extremely rare. Luminescence in the NIR-II range (1000 to 1700 ...

A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, two dimeric subcomplexes are formed, which independently exit the ER and only afterwards assemble into a four-subunit complex. This 'buckle up' mechanism is thought to prevent premature assembly and activity. The new insights are very relevant, as gamma-secretase is an important potential therapeutic target for Alzheimer's and other ...

A research team led by Dr Aixin YAN, Associate Professor from the Research Division for Molecular & Cell Biology, Faculty of Science, in collaboration with Honorary Clinical Professor Patrick CY WOO from the Department of Microbiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong (HKU), reported the development of a transferrable and integrative type I CRISPR-based platform that can efficiently edit the diverse clinical isolates of Pseudomonas aeruginosa, a superbug capable of infecting various tissues and organs and a major source of nosocomial infections. The ...

As cities worldwide expand their networks of cycling paths and more cyclists take to the streets, the chances of cycling accidents and potential collisions increase as well, underscoring the need for proper cycling safety in dense urban areas. According to a World Health Organisation report in 2020, more than 60 per cent of the reported bicycle-related deaths and long-term disabilities are a result of accidents with head injuries. Researchers from Nanyang Technological University, Singapore (NTU Singapore), in collaboration with French specialty materials leader Arkema, have developed a tougher, safer bicycle helmet using a combination of materials. The new helmet prototype has higher energy absorption, reducing the amount of energy ...

With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is conducted in mice and human liver tissue, shows that the degeneration of nerves is correlated with the severity of liver pathology. The results are being published in the journal Science Advances. Non-alcoholic fatty liver disease is the most common hepatic disorder, with prevalence around 25 percent globally. Approximately ...

The building sector in the U.S. accounts for 39 percent of energy use, with commercial buildings responsible for about half of that. As cities grapple with climate change, making commercial buildings more efficient is a key part of the solution. Researchers at the University of Pittsburgh Swanson School of Engineering and the Mascaro Center for Sustainable Innovation used the City of Pittsburgh to create a model built upon the design, materials and purpose of commercial buildings to estimate their energy usage and emissions. While other models may ...

FRANKFURT/HANNOVER. The international team of geoscientists led by Prof. Silke Voigt from the Goethe University Frankfurt, Prof. Ireneusz Walaszczyk from the University of Warsaw and Dr André Bornemann from LBEG have thoroughly investigated 40 metres of the geological strata sequence in the former limestone quarry at Hasselberg. The researchers determined that this is only sequence in the transition between Turonian and Coniacian without gaps and it therefore represents a perfect rock sequence to serve geoscientists from all over the world as a reference for their research - a "Global Stratotype Section and Point (GSSP)" or, in the jargon of geosciences, a "golden nail". Certain group of bivalve mollusks of the family Inoceramidae, first appeared in the Coniacian, and ...

ORLANDO, July 22, 2021 - Disagreement seems to spread online posts faster and further than agreement, according to a new study from the University of Central Florida. The finding comes from an examination of posts labeled controversial on social news aggregation site Reddit. To perform the study, the researchers analyzed more than 47,000 posts about cybersecurity in a Reddit dataset that was collected by the Computational Simulation of Online Social Behavior (SocialSim) program of the U.S. Defense Advanced Research Projects Agency. Researchers found that these posts were seen by nearly twice the number of people and traveled nearly twice as fast when compared ...

In a new study, published recently in the journal Circulation Research, scientists discover how the production of protective molecules known as specialised pro-resolving mediators (SPM) is altered in patients with COVID-19. The results suggest that treatments which increase SPM production, such as dexamethasone or SPM based drugs, could play a key role in limiting inflammation in these patients. Currently there is little understanding around the mechanisms that lead to uncontrolled inflammation in patients with COVID-19. The study found a link between decreased SPM blood levels and disrupted white blood cell responses in patients with a higher disease burden. The findings also revealed that dexamethasone, the first drug ...

More than 820 million people in the world don't have enough to eat, while climate change and increasing competition for land and water are further raising concerns about the future balance between food demand and supply. The results of a new IIASA-led study can be used to benchmark global food security projections and inform policy analysis and public debate on the future of food. Despite the fact that food supply has increased dramatically since the 1960s, the question of how to eradicate global hunger - one of the Sustainable Development Goals - and feed the growing world population in years to come, remains a major challenge. Climate change and increasing competition ...

Alexandria, Va., USA - Xingying Qi, West China Hospital of Stomatology, Sichuan University, Chengdu, China, presented the oral session "Cannabidiol Promotes Oral Ulcer Healing by Inactivating CMPK2-Mediated NLRP3 Inflammasome" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. The oral ulcer is a common oral inflammatory lesion with severe pain but little ...

Alexandria, Va., USA - Iain Chapple, University of Birmingham, England, presented the oral session "Longitudinal Serological and Vaccination Responses to SARS-COV-2 in Dental Professionals" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. The COVID-19 pandemic significantly impacted ...

An international team of scientists has reported strong indications of freshened groundwater offshore the coastline between Valletta and Marsascala, in the south-east of Malta. This discovery is based on an oceanographic expedition carried out in 2018. Seismic reflection profiles acquired during this expedition were used to generate a geological model of the seafloor offshore the Maltese Islands, whereas electromagnetic surveying was carried out to identify resistivity anomalies, or high values of electromagnetic resistivity beneath the seafloor. These observations indicate that freshened groundwater occurs as an isolated body hosted in Globigerina Limestone located 3 ...

Alexandria, Va., USA - Jiachen Lin, Harvard School of Dental Medicine, Boston, Mass., USA., presented the poster "Burden of Oral Diseases in Emerging Countries: A Prediction Model" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. The goal of this study was to investigate the burden of oral diseases and predict trends by 2025 in the U.S. and emerging countries. Global Burden of Disease data from 1990-2017 was used to analyze the prevalence and disability-adjusted life years of oral diseases ...

In a new publication from Opto-Electronic Advances; DOI 10.29026/oea.2021.200030 , Researchers led by Professor Liu Yan from Xidian University, China and Professor Gan Xuetao from Northwestern Polytechnical University, China consider generation and application of the high-Q resonance in all-dielectric metasurfaces. Metamaterials are artificial composite electromagnetic structures consisting of subwavelength units, which can realize efficient and flexible control of the electromagnetic waves. Metamaterials are an emerging research area for optoelectronics, physics, chemistry and materials, due to their novel ...

Hematopoietic cell transplantation (HCT) is a recognized treatment option for certain blood and bone marrow cancers as well as some autoimmune and hereditary disorders. Performed to replace or modulate the body's malfunctioning hematopoietic system (which produces blood cells) or a compromised immune system following a medical condition or treatment, HCT can be autologous or allogenic. In autologous HCT, a patient's own stem cells are injected into the bloodstream, while in allogenic HCT donor stem cells are used. Although a difficult procedure, over the years, the safety of HCT has been improved ...

Irvine, Calif., July 21, 2021 -- It's not exactly X-ray vision, but it's close. In research published in the journal Optica, University of California, Irvine researchers describe a new type of camera technology that, when aimed at an object, can rapidly retrieve 3D images, displaying its chemical content down to the micrometer scale. The new tech promises to help companies inspect things like the insides of computer chips without having to pry them open -- an advancement the researchers say could accelerate the production time of such goods by more than a hundred times. "This is a paper about a way to visualize things in 3D very fast, even at video rate," said Dmitry Fishman - director of laser spectroscopy labs in the UCI Department of ...

New University of Otago research has been examining how alpine-based hedgehogs hibernate from a different perspective - their backs. Dr Nick Foster from the Department of Zoology has been involved with the Te Manahuna Aoraki project and has been attaching small transmitting 'backpacks' onto hedgehogs in the Mackenzie Basin's alpine zones. The mammals are considered pests in New Zealand for the damage they cause to native insects and wildlife throughout the country. The goal of this study, which has just been published in the New Zealand Journal of Ecology, was to find out whether hedgehogs, which can be found up to 2000 metres in summer, travel ...