April 8, 2021 - Women undergoing surgery to treat stress urinary incontinence (SUI) are not at increased risk of developing pelvic cancers, according to a large-scale, population-based study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer. "In a very large population with extended follow-up, we found no increase in the risk of any pelvic malignancy in women who underwent stress urinary incontinence surgery," comments lead author Humberto ...

Detecting and analyzing breast cancer goes beyond the initial discovery of the cancer itself. If a patient has a tumor removed and it needs to be analyzed to determine further treatment, it might be OK for the results to take 24 hours. But if the patient is still on the operating table and clinicians are waiting to make sure no cancer cells are present along the edges of the removed tumor, results need to be nearly immediate. A paper titled, "Breast cancer histopathology using infrared spectroscopic imaging: The impact of instrumental configurations," ...

Many Mario Kart enthusiasts are familiar with the rush of racing down Rainbow Road, barely squeaking around a corner, and catching a power-up from one of the floating square icons on the screen--or, less ideally, slipping on a banana peel laid by another racer and flying off the side of the road into oblivion. This heated competition between multiple players, who use a variety of game tokens and tools to speed ahead or thwart their competitors, is part of what makes the classic Nintendo racing game that has been around since the early 1990s so appealing. "It's been fun since I was a kid, it's fun ...

Whatever ultimately caused inhabitants to abandon Cahokia, it was not because they cut down too many trees, according to new research from Washington University in St. Louis. Archaeologists from Arts & Sciences excavated around earthen mounds and analyzed sediment cores to test a persistent theory about the collapse of Cahokia, the pre-Columbian Native American city in southwestern Illinois that was once home to more than 15,000 people. No one knows for sure why people left Cahokia, though many environmental and social explanations have been proposed. One oft-repeated theory is tied to resource exploitation: specifically, that Native Americans ...

Scientists could be a step closer to finding a way to reduce the impact of traumatic memories, according to a Texas A&M University study published recently in the journal END ...

New Haven, Conn. -- Alzheimer's disease is known for its slow attack on neurons crucial to memory and cognition. But why are these particular neurons in aging brains so susceptible to the disease's ravages, while others remain resilient? A new study led by researchers at the Yale School of Medicine has found that susceptible neurons in the prefrontal cortex develop a "leak" in calcium storage with advancing age, they report April 8 in the journal Alzheimer's & Dementia, The Journal of the Alzheimer's Association. This disruption of calcium storage in turns ...

WEST LAFAYETTE, Ind. - New insights into the immune response to SARS-CoV-2 infections could bring better treatments for COVID-19 cases. An international team of researchers unexpectedly found that a biochemical pathway, known as the immune complement system, is triggered in lung cells by the virus, which might explain why the disease is so difficult to treat. The research is published this week in the journal Science Immunology. The researchers propose that the pairing of antiviral drugs with drugs that inhibit this process may be more effective. Using an in vitro model using human lung ...

MADISON, WI, April 8, 2021 - USDA Forest Service scientists have delivered a new comprehensive assessment of the invasive species that confront America's forests and grasslands, from new arrivals to some that invaded so long ago that people are surprised to learn they are invasive. The assessment, titled "Invasive Species in Forests and Rangelands of the United States: A Comprehensive Science Synthesis for the United States Forest Sector," serves as a one-stop resource for land managers who are looking for information on the invasive species that are already affecting the landscape, the species that may threaten the landscape, and what is known about control ...

Nobel laureate in physics Richard Feynman once described turbulence as "the most important unsolved problem of classical physics." Understanding turbulence in classical fluids like water and air is difficult partly because of the challenge in identifying the vortices swirling within those fluids. Locating vortex tubes and tracking their motion could greatly simplify the modeling of turbulence. But that challenge is easier in quantum fluids, which exist at low enough temperatures that quantum mechanics -- which deals with physics on the scale of atoms or subatomic particles -- govern their behavior. In a new study published in Proceedings of the National Academy of Sciences, Florida State University researchers ...

The network of nerves connecting our eyes to our brains is sophisticated and researchers have now shown that it evolved much earlier than previously thought, thanks to an unexpected source: the gar fish. Michigan State University's Ingo Braasch has helped an international research team show that this connection scheme was already present in ancient fish at least 450 million years ago. That makes it about 100 million years older than previously believed. "It's the first time for me that one of our publications literally changes the textbook that I am teaching with," said Braasch, as assistant professor in the Department of Integrative Biology in the College ...

URBANA, Ill. - When scientists need to understand the effects of new infant formula ingredients on brain development, it's rarely possible for them to carry out initial safety studies with human subjects. After all, few parents are willing to hand over their newborns to test unproven ingredients. Enter the domestic pig. Its brain and gut development are strikingly similar to human infants - much more so than traditional lab animals, rats and mice. And, like infants, young pigs can be scanned using clinically available equipment, including non-invasive magnetic resonance imaging, or MRI. That means researchers can test nutritional interventions in pigs, look at their effects on the developing brain via MRI, and make educated predictions about how those ...

Modern human-like brains evolved comparatively late in the genus Homo and long after the earliest humans first dispersed from Africa, according to a new study. By analyzing the impressions left behind by the ancient brains that once sat inside now fossilized skulls, the authors discovered that the brains of the earliest Homo retained a primitive, great ape-like organization of the frontal lobe. The findings challenge the long-standing assumption that human-like brain organization is a hallmark of early Homo and suggest that the evolutionary history of the human brain is more complex than previously thought. Our modern brains are larger and structurally different than those of our closest living relatives, ...

Researchers present a new, low-temperature method for injection-molding transparent fused silica glass, similar to how many plastic objects are manufactured. According to the authors, the process offers the possibility of producing complex and high-quality glass components using the same fabrication methods that allowed polymers to become one of the most important materials of the 21st century. The optical, thermal, mechanical and chemical properties of silicate glasses make them an ideal non-carbon based, high-performance material with applications ranging from packaging and architecture to high-throughput fiber optic ...

Using a novel genetic editing system termed intMEMOIR, researchers reveal the cell lineage histories of individual cells within their native tissue context, according to a new study. The new approach provides a powerful new tool for recording cell lineage in diverse cellular systems. During multicellular development, a cell's spatial position and lineage play important roles in cell fate determination. The ability to visualize lineage relationships directly within their native tissues can provide valuable insight into the factors that affect development and disease. This promise has spurred the development of several ...

X-ray emissions from the Crab Pulsar are more intense during giant radio pulses (GRPs), researchers report. The new findings provide constraints on the mechanisms underlying GRPs and may provide insights into other transient radio phenomena observed throughout the Universe. Pulsars, or rapidly spinning neutron stars, emit pulses of electromagnetic radiation from their magnetospheres and are observed from Earth as regular sequences of radio pulses. Most radio pulses from these distant objects are of a consistent intensity. Occasionally, however, sporadic and short-lived ...

The functioning of the enzyme FAP, useful for producing biofuels and for green chemistry, has been decrypted. This result mobilized an international team of scientists, including many French researchers from the CEA, CNRS, Inserm, École Polytechnique, the universities of Grenoble Alpes, Paris-Saclay and Aix Marseille, as well as the European Synchrotron (ESRF) and synchrotron SOLEIL. The study is published in Science on April 09, 2021. The researchers decrypted the operating mechanisms of FAP (Fatty Acid Photodecarboxylase), which is naturally present in microscopic algae such as Chlorella. The enzyme had been identified in 2017 as able to use light energy to form hydrocarbons from fatty acids ...

Two studies published in the open-access journal PLOS Pathogens provide new evidence supporting an important role for the immune system in shaping the evolution of SARS-CoV-2, the virus that causes COVID-19. These findings--and the novel technology behind them--improve understanding of how new SARS-CoV-2 strains arise, which could help guide treatment and vaccination efforts. For the first study, Rachel Eguia of Fred Hutchinson Cancer Research Center in Seattle, Washington, and colleagues sought to better understand SARS-CoV-2 by investigating a closely related virus that has circulated widely for a far longer period of time: the common-cold virus ...

A group led by scientists from the RIKEN Cluster for Pioneering Research, using coordinated observations of the Crab pulsar in a number of frequencies, have discovered that the "giant radio pulses" which it emits include an increase in x-ray emissions in addition to the radio and visible light emissions that had been previously observed. This finding, published in Science, implies that these pulses are hundreds of times more energetic than previously believed and could provide insights into the mysterious phenomenon of "fast radio bursts (FRBs)." Giant radio pulses--a phenomenon where extremely short, millisecond-duration pulses of radio waves are emitted--have ...

Researchers at the Francis Crick Institute have found that blocking a specific protein could increase tumour sensitivity to treatment with PARP inhibitors. Their work published in Science , suggests combining treatments could lead to improved therapy for patients with inheritable breast cancers. Some cancers, including certain breast, ovarian and prostate tumours, are caused by a fault in the BRCA1 or BRCA2 genes, which are important for DNA repair. Treatment for these cancers has greatly improved thanks to the discovery of PARP inhibitors, drugs which capitalise on this weakness in the cancer ...

Scientists at the Victor Chang Cardiac Research Institute in Sydney have discovered a critical new gene that it is hoped could help human hearts repair damaged heart muscle after a heart attack. Researchers have identified a genetic switch in zebrafish that turns on cells allowing them to divide and multiply after a heart attack, resulting in the complete regeneration and healing of damaged heart muscle in these fish. It's already known that zebrafish can heal their own hearts, but how they performed this incredible feat remained unknown, until now. In research recently published in the prestigious journal, Science, the team at the Institute drilled down into a critical ...

Modern humans are fundamentally different from our closest living relatives, the great apes: We live on the ground, walk on two legs and have much larger brains. The first populations of the genus Homo emerged in Africa about 2.5 million years ago. They already walked upright, but their brains were only about half the size of today's humans. These earliest Homo populations in Africa had primitive ape-like brains - just like their extinct ancestors, the australopithecines. So when and where did the typical human brain evolve? CT comparisons of skulls reveal modern brain structures An international ...

Researchers have developed a new algorithm capable of identifying features of male zebra finch songs that may underlie the distinction between a short phrase sung during courtship, and the same phrase sung in a non-courtship context. Sarah Woolley of McGill University in Montreal, Canada, and colleagues present these findings in the open-access journal PLOS Computational Biology. Like many animals, male zebra finches adjust their vocal signals for their audience. They may sing the same sequence of syllables during courtship interactions with females as ...

DALLAS - April 8, 2021 - New research has uncovered a surprising role for so-called "jumping" genes that are a source of genetic mutations responsible for a number of human diseases. In the new study from Children's Medical Center Research Institute at UT Southwestern (CRI), scientists made the unexpected discovery that these DNA sequences, also known as transposons, can protect against certain blood cancers. These findings, published in Nature Genetics, led scientists to identify a new biomarker that could help predict how patients will respond to cancer therapies and find new therapeutic targets for acute myeloid leukemia (AML), the deadliest type of blood cancer in adults and children. Transposons ...

Every third-grader knows that plants absorb nutrients from the soil through their roots. The fact that they also release substances into the soil is probably less well known. And this seems to make the lives of plants a lot easier. That is at least the conclusion of the current study. The participating researchers studied several maize varieties that differ significantly in their yield. In their search for the cause, they came across an enzyme, flavone synthase 2. "The high-yield inbred line 787 we studied contains large amounts of this enzyme in its roots", explains Dr. Peng Yu ...

A global science collaboration using data from NASA's Neutron star Interior Composition Explorer (NICER) telescope on the International Space Station has discovered X-ray surges accompanying radio bursts from the pulsar in the Crab Nebula. The finding shows that these bursts, called giant radio pulses, release far more energy than previously suspected. A pulsar is a type of rapidly spinning neutron star, the crushed, city-sized core of a star that exploded as a supernova. A young, isolated neutron star can spin dozens of times each second, and its whirling magnetic ...