Successful navigation requires the ability to separate memories in a context-dependent manner. For example, to find lost keys, one must first remember whether the keys were left in the kitchen or the office. How does the human brain retrieve the contextual memories that drive behavior? J.B. Julian of the Princeton Neuroscience Institute at Princeton University, USA, and Christian F. Doeller of the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, Germany, found in a recent study that modulation of map-like representations in our brain's hippocampal formation can predict contextual memory retrieval in an ambiguous environment. The researchers developed a novel virtual reality navigation task in which human participants learned object positions in two different ...

The future of particle acceleration has begun. Awake is a promising concept for a completely new method with which particles can be accelerated even over short distances. The basis for this is a plasma wave that accelerates electrons and thus brings them to high energies. A team led by the Max Planck Institute for Physics now reports a breakthrough in this context. For the first time, they were able to precisely time the production of the proton microbunches that drive the wave in the plasma. This fulfills an important prerequisite for using the Awake technology for collision experiments. How do you create a wave for electrons? The carrier substance for this is a plasma (i.e., an ionized gas in which positive and negative charges are separated). Directing a proton beam through ...

The human immune system comprises functionally specialised cellular defence mechanisms that protect the body against disease. These include the dendritic cells. Their main function is to present antigens to other immune cells, especially T cells, thereby activating a primary immune response. Dendritic cells are divided into Type 1 (DC1) and Type 2 (DC2) dendritic cells. Each type fulfils different functions: DC1 provide an immune response to bacteria and viruses, DC2 protect against fungal or parasitic infections. In a recent study conducted at MedUni Vienna's Institute of Cancer Research, researchers found that a particular group of proteins plays a major role in the development of Type 1 dendritic ...

WHAT: In a mouse study, National Institutes of Health researchers have identified and mapped a diverse spectrum of motor neurons along the spinal cord. These neurons, which send and receive messages throughout the body, include a subset that is susceptible to neurodegenerative diseases. Created with a genetic sequencing technique, the atlas reveals 21 subtypes of neurons in discrete areas throughout the spinal cord and offers insight into how these neurons control movement, how they contribute to the functioning of organ systems and why some are disproportionately affected in neurodegenerative diseases. The study ...

Researchers have developed a brain-like computing device that is capable of learning by association. Similar to how famed physiologist Ivan Pavlov conditioned dogs to associate a bell with food, researchers at Northwestern University and the University of Hong Kong successfully conditioned their circuit to associate light with pressure. The research will be published April 30 in the journal Nature Communications. The device's secret lies within its novel organic, electrochemical "synaptic transistors," which simultaneously process and store information just like the human brain. The researchers demonstrated ...

The provenance of oxygen on Earth and other solar planetary bodies is a fundamental issue. It is widely accepted that the prebiotic pathway of oxygen production in the Earth primitive atmosphere was via vacuum ultraviolet (VUV) photodissociation of CO2 and subsequent recombination of two O atoms. In contrast, the photodissociation of H2O, one of the dominant oxygen carriers, has long been assumed to proceed mainly to produce hydroxyl (OH)- and hydrogen (H)-atom primary products, and its contribution to oxygen production is limited. Recently, a research group ...

The Worldwide Innovative Network in personalized cancer medicine consortium - WIN Consortium announces the publication of the Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival for cancer patients in NPJ Precision Oncology (10.1038/s41698-021-00171-6) Precision oncology has led to approved, molecularly specific, biomarker-defined indications for targeted therapies. With the number of validated drug targets increasing, testing each patient's tumor for all markers related to all possible targeted therapies becomes infeasible due to limited amount of tissue usually obtained by biopsies. In addition, the current companion diagnostic approach ...

Targeting a pathway that is essential for the survival of certain types of acute myeloid leukaemia could provide a new therapy avenue for patients, the latest research has found. Researchers from the Wellcome Sanger Institute found that a specific genetic mutation, which is linked with poor prognosis in blood cancer, is involved in the development of the disease when combined with other mutations in mice and human cell lines. The study, published today (30th April) in Nature Communications, provides a greater understanding of how the loss-of-function mutation in the CUX1 gene leads to the development and survival of acute myeloid leukaemia. ...

A new study finds Black patients are more likely to die after their heart bypass surgery if they're at a hospital where some care teams see mostly white patients and others see mostly Black patients. On the other hand, mortality rates are comparable between Black and white patients after heart bypass surgery when the teams of health care providers at their hospitals all care for patients of all races. Some level of care team segregation within hospitals was very common, and the findings bring up another angle to better understand racial inequities in surgical outcomes, says co-first author John Hollingsworth, M.D., M.Sc., a professor of urology at Michigan Medicine and of health management and policy at the University of Michigan School of Public Health. Previous studies ...

Most detailed study to date including 345,000 people from 48 randomised clinical trials finds that blood pressure-lowering medication is effective in adults regardless of starting blood pressure level. Each 5mmHg reduction in systolic blood pressure lowered the relative risk of cardiovascular events by around 10%, even in people with normal blood pressure and those who had never had a heart attack or stroke. Authors call for global guidelines to be changed so that anyone with increased risk of cardiovascular disease is considered for blood-pressure lowering ...

BOSTON - After patients with cancer undergo surgery to remove a tumor and sometimes additional chemotherapy, tools are used to identify patients at highest risk of recurrence. Non-invasive tools to detect microscopic disease are of especially high value. In a new study published in END ...

Researchers from the HSE International Laboratory for Supercomputer Atomistic Modelling and Multi-scale Analysis, JIHT RAS and MIPT have compared the performance of popular molecular modelling programs on GPU accelerators produced by AMD and Nvidia. In a paper published by the International Journal of High Performance Computing Applications, the scholars ported LAMMPS on the new open-source GPU technology, AMD HIP, for the first time. The scholars thoroughly analysed the performance of three molecular modelling programs - LAMMPS, Gromacs and OpenMM - on GPU ...

A new study led by University of Minnesota astrophysicists shows that high-energy light from small galaxies may have played a key role in the early evolution of the Universe. The research gives insight into how the Universe became reionized, a problem that astronomers have been trying to solve for years. The research is published in The Astrophysical Journal, a peer-reviewed scientific journal of astrophysics and astronomy. After the Big Bang, when the Universe was formed billions of years ago, it was in an ionized state. This means that the electrons and protons floated freely throughout space. As the Universe ...

In August 2016 a massive storm on par with a Category 2 hurricane churned in the Arctic Ocean. The cyclone led to the third-lowest sea ice extent ever recorded. But what made the Great Arctic Cyclone of 2016 particularly appealing to scientists was the proximity of the Korean icebreaker Araon. For the first time ever, scientists were able to see exactly what happens to the ocean and sea ice when a cyclone hits. University of Alaska Fairbanks researchers and their international colleagues recently published a new study showing that sea ice declined ...

Older adults were significantly affected by isolation and stress during Oregon's initial COVID-19 lockdown last spring, but they were also able to find connection and meaning in community, new hobbies and time for themselves, a recent Oregon State University study found. If resilience is understood as the ability to see positives in the midst of a negative situation, then many of the study's participants demonstrated resilience during that time, the researchers said. "A lot of times we think about resilience as a personality trait, and it's true that there are some qualities that may help people experience that. But in the end, resilience is something that is shared," said Heidi Igarashi, ...

DALLAS, April 29, 2021 – Last Friday, the Centers for Disease Control and Prevention (CDC) and the U.S. Food & Drug Administration (FDA) lifted the pause in administration of the Johnson & Johnson (Janssen) COVID-19 vaccine in the U.S. The temporary pause was due to reports of a serious condition called cerebral venous sinus thrombosis (CVST), which refers to blood clots in the brain’s veins - not in the arteries, as is the case for most strokes - in combination with thrombocytopenia (low blood platelet count). CVST and thrombocytopenia together is called thrombosis-thrombocytopenia syndrome (TTS). When TTS is linked to receiving a COVID-19 vaccine, it is called vaccine-induced immune thrombotic thrombocytopenia ...

Tomorrow's cutting-edge technology will need electronics that can tolerate extreme conditions. That's why a group of researchers led by Michigan State University's Jason Nicholas is building stronger circuits today. Nicholas and his team have developed more heat resilient silver circuitry with an assist from nickel. The team described the work, which was funded by the U.S. Department of Energy Solid Oxide Fuel Cell Program, on April 15 in the journal Scripta Materialia. The types of devices that the MSU team is working to benefit -- next-generation fuel cells, high-temperature semiconductors and solid oxide electrolysis cells -- could have ...

New research indicates that the computer-based models currently used to simulate how Earth's climate will change in the future underestimate the impact that forest fires and drying climate are having on the world's northernmost forests, which make up the largest forest biome on the planet. It's an important understanding because these northern forests absorb a significant amount of Earth's carbon dioxide. The finding, reached by studying 30 years of the world's forests using NASA satellite imaging data, suggests that forests won't be able to sequester as much carbon ...

In a novel effort to combat COVID-19 misinformation, a group of women researchers, including nurse scientists from the University of Pennsylvania School of Nursing (Penn Nursing), launched the Dear Pandemic social media campaign in March 2020. It delivers curated, comprehensive, and timely information about the COVID-19 pandemic in a question-and-answer format. Complex topics such as COVID-19 aerosol transmission, risk reduction strategies to avoid infection, and excess mortality are explained in common language and shared widely. Now with more than 100,000 followers and accounts on Facebook, ...

FINDINGS A UCLA-led study shows that physicians frequently order preventive medical services for adult Medicare beneficiaries that are considered unnecessary and of "low value" by the U.S. Preventive Services Task Force -- at a cost of $478 million per year. The researchers analyzed national survey data over a 10-year period, looking specifically at seven preventive services given a "D" rating by the task force, and discovered that these services were ordered more than 31 million times annually. BACKGROUND The U.S. Preventive Services Task Force, an independent panel appointed by the Department of Health and Human Services, makes recommendations on the value of clinical preventive ...

The field of soft robotics has exploded in the past decade, as ever more researchers seek to make real the potential of these pliant, flexible automata in a variety of realms, including search and rescue, exploration and medicine. For all the excitement surrounding these new machines, however, UC Santa Barbara mechanical engineering professor Elliot Hawkes wants to ensure that soft robotics research is more than just a flash in the pan. "Some new, rapidly growing fields never take root, while others become thriving disciplines," Hawkes said. To help guarantee the longevity of soft robotics ...

New York, NY--Research-practice partnerships (RPPs), long-term collaborations between researchers, policy makers and practitioners, represent an especially promising strategy for making sure that all children benefit from early childhood education, according to END ...

People living with a child who attends school in-person have an increased risk of reporting evidence of COVID-19, but teacher masking, symptom screening, and other mitigation measures in schools may be able to minimize that excess risk, suggests a study led by researchers at the Johns Hopkins Bloomberg School of Public Health. For their study, the researchers analyzed nearly 600,000 responses from an ongoing Facebook-based COVID-19 symptom survey in the United States over two periods between November 2020 and February 2021 before vaccines were widely available in the U.S. The researchers found that those living with a child engaged in full-time, ...

April 29, 2021 -An increasing number of digital mental health interventions are designed for adolescents and young people with a range of mental health issues, but the evidence on their effectiveness is mixed, according to research by Columbia University Mailman School of Public Health and Spark Street Advisors. Computerized cognitive behavioral therapy was found effective for anxiety and depression in adolescents and young people holding promise for increasing access to mental health treatment for these conditions. However, the effectiveness of other digital interventions, including therapeutic video games, mobile apps, or social networking sites, and addressing a range of other mental health outcomes remain ...

Archeologists have learned a lot about our ancestors by rummaging through their garbage piles, which contain evidence of their diet and population levels as the local flora and fauna changed over time. One common kitchen scrap in Africa -- shells of ostrich eggs -- is now helping unscramble the mystery of when these changes took place, providing a timeline for some of the earliest Homo sapiens who settled down to utilize marine food resources along the South African coast more than 100,000 years ago. Geochronologists at the University of California, Berkeley, and the Berkeley ...