The European Society of Endocrinology (ESE) has published an open access Revised Clinical Practice Guideline for the Treatment of Chronic Hypoparathyroidism in Adults in the European Journal of Endocrinology, Volume 193, Issue 5, November 2025.   The Revised Guideline has been developed by an expert multidisciplinary panel chaired by Professor Jens Bollerslev, Faculty of Medicine, University of Oslo, Norway. It is intended as practical guidance for health care providers involved in the diagnosis, management and monitoring of chronic hypoparathyroidism in adults.  The Revised Guideline has been endorsed by the ...

Embargoed to: 11:30 Eastern Time (UTC-5), 13 November 2025 New research shows that it’s possible to end the practice of using people as ‘human bait’ to catch and test the blackflies that spread river blindness (onchocerciasis). The study by international non-profit Sightsavers in partnership with the Global Institute for Disease Elimination (GLIDE) and ministries of health in Ghana, Cote d’Ivoire, Malawi and Mozambique, will be presented at the American Society of Tropical Medicine and Hygiene (ASTMH) on 13 November 2025. Every year countries across Africa collect many thousands of blackflies to monitor for the presence of river blindness, a parasitic ...

An analysis of national climate plans released today at the COP30 climate summit in Brazil warns that countries are failing to carry out core work required to reduce emissions by halting and reversing deforestation and forest degradation, and are instead pushing unrealistic carbon removal schemes, such as large-scale tree planting. The Land Gap 2025 report, led by the University of Melbourne alongside a global consortium of experts, explains why countries are relying on impractical levels of land-based efforts to achieve net-zero emissions, rather than pursuing more realistic climate solutions ...

COLUMBUS, Ohio – Fish species living in the deep sea feature a surprisingly large range of body shapes that evolved in different ways and at different rates depending on where the fishes live in the ocean, new research shows. Overall, the analysis of nearly 3,000 species showed more diversity of body types among the pelagic fishes, those that swim in open water, than among the benthic species spending their life on the ocean floor. Pelagic fish body types span from the round anglerfish to skinny eels, while benthic fishes ...

Background and Aims Further decompensation in cirrhosis is associated with increased mortality. However, reliable tools to predict further decompensation after transjugular intrahepatic portosystemic shunt (TIPS) are currently limited. This study aimed to investigate the incidence and risk factors of further decompensation within one year post-TIPS in patients with cirrhosis and to develop a predictive model for identifying high-risk individuals. Methods This retrospective cohort study enrolled 152 patients with cirrhosis undergoing TIPS for variceal bleeding and/or refractory ascites (January 2018–January 2024). Patients were stratified according to one-year decompensation ...

There’s no scientific evidence that the gut microbiome causes autism, a group of scientists argue in an opinion paper publishing November 13 in the Cell Press journal Neuron. They point to the fact that conclusions from past research that supported this hypothesis—including observational studies, mouse models of autism, and human clinical trials—are undermined by flawed assumptions, small sample sizes, and inappropriate statistical methods.   “Despite ...

NEW YORK, NY (Nov. 13, 2025)--A study of a pig kidney that flourished for two months in a brain-dead recipient shows that a protocol developed by Columbia University immunologists can help prevent long-term rejection of a xenotransplant.  In the study, surgeons at New York University Langone Health transplanted a pig kidney and the same animal’s thymus gland into a 57-year-old man with glioblastoma who had been declared brain-dead at the hospital. The study ...

Researchers have uncovered and then overcome an obstacle that has led to the failure of pioneering efforts in xenotransplantation, in which an animal kidney is transplanted into a human.  More than 800,000 Americans have late-stage kidney disease yet only 3% receive a transplant each year, according to the U.S. Centers for Disease Control and Prevention. To boost the supply of available organs, experts are exploring the use of genetically modified pig kidneys. The genetic changes are meant to keep the human ...

Platelets are small, disc-shaped cell fragments in the blood that are essential to stop bleeding and to initiate blood clotting after injury. Platelet transfusions in patients with severe trauma or medical conditions, including bone marrow disease, leukemia, or sepsis, can be lifesaving. Despite being a standard clinical practice, platelet transfusions face issues related to the availability of blood donations from which platelets are isolated, the relatively short shelf life of purified platelets, and the risk of an immune response in patients receiving platelets from unmatched donors. A potential solution to this has been proposed ...

About The Study: The current analysis illustrates that drug promotion content is frequently posted by individual creators, lacks essential risk information, and bears the hallmarks of undisclosed marketing. These findings suggest that posts circumvented established advertising principles and potentially eroded the fair balance crucial for informed patient decision-making, consistent with prior literature on traditional direct-to-consumer advertising’s impact on prescribing. Corresponding Author: To contact the corresponding author, Alex Kresovich, PhD, email kresovich-alex@norc.org. To access the embargoed ...

About The Study: In this study, higher ultraprocessed food intake was associated with increased risk of early-onset colorectal conventional adenomas. These data highlight the important role of ultraprocessed foods in early-onset colorectal tumorigenesis and support improving dietary quality as a strategy to mitigate the increasing burden of early-onset colorectal cancer.  Corresponding Author: To contact the corresponding author, Andrew T. Chan, MD, MPH, email achan@mgh.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaoncol.2025.4777) Editor’s Note: Please see the ...

Thoughtful electronic health record system design can nudge physicians toward evidence-based, less invasive treatments Doctors offered two or more treatment alternatives were significantly more likely to choose a better option (62%) than those offered only one (44%) ‘We’re trying to make it easier for physicians to do the right thing’ CHICAGO --- Having more options is always better — until it’s not.  Doctors face this paradox daily when choosing treatment plans for patients, especially under the pressure of packed clinical schedules. Too few choices can limit care, but too many can lead to decision ...

Colorectal cancer used to be associated with old age, but diagnoses have become increasingly common in adults aged 50 or younger particularly in high-income countries like the United States. The reason for this trend is unclear, but a new study led by Mass General Brigham researchers, as part of the Cancer Grand Challenges PROSPECT team, suggests an important link to ultra-processed foods that merits closer investigation. By analyzing the diets and endoscopy results from almost 30,000 women, the team ...

Pinned between the stomach and spine, the pancreas supervises both digestion and blood sugar in the body. It’s also the site of an aggressive cancer called pancreatic ductal adenocarcinoma, or PDAC.  PDAC is the most common type of pancreatic cancer, the third-leading cause of cancer deaths in the U.S. It’s difficult to detect and recurs about 70% of the time after treatment. Only 13% of those diagnosed survive more than five years.  A team of surgeons, anesthesiologists and engineers at the University of ...

Taking a page from market research tactics, UC San Francisco experts are studying whether artificial intelligence (AI) can improve diagnosis of a complex liver condition by using the clinical notes of multiple providers.    Their recent study, published in Gastro Hep Advances, focused on hepatorenal syndrome (HRS), a complex condition associated with liver disease that is often difficult to diagnose during hospitalization. The researchers sought to learn if large language models could analyze the clinical notes of multiple physicians and other providers to improve ...

University of Virginia School of Medicine researchers have identified the first death caused by what is commonly called the “meat allergy” being spread by ticks. A healthy 47-year-old man from New Jersey died abruptly four hours after consuming beef. The cause of his death had been a mystery until UVA Health’s Thomas Platts-Mills, MD, PhD, investigated. A world-renowned allergist, Platts-Mills discovered the allergy and remains the foremost expert on it. The allergy is caused by the bite of the Lone Star tick. Bites can sensitize people to alpha-gal, a sugar found in mammalian meat. People who become sensitized to the sugar can have allergic symptoms such as rash, nausea ...

Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disorder globally, with a rising incidence linked to metabolic syndrome. Its pathogenesis involves a complex interplay of lipid metabolic dysregulation, insulin resistance, oxidative stress, chronic inflammation, and gut-liver axis disruption. Despite recent advances such as Resmethron for advanced metabolic-associated steatohepatitis (MASH), early-stage interventions remain limited. This ...

“This review synthesizes current evidence to inform clinical decision-making and outlines future directions for durable, personalized lymphoma care.” BUFFALO, NY — November 13, 2025 — A new review was published in Volume 12 of Oncoscience on October 13, 2025, titled “Targeted therapies and resistance mechanisms in lymphoma: Current landscape and emerging solutions.” In this article by Bishal Tiwari, Roshan Afshan and Shruthi Sridhar, from Nassau University Medical Center and Detroit Medical Center Wayne State University, researchers reviewed the latest scientific ...

Stories describing what can happen when science is manipulated or misapplied are among the winners of the 2025 AAAS Kavli Science Journalism Awards. Winning journalists also did stories on science at its best, revealing new understanding about the natural world. Independent panels of science journalists select the winners of the awards, which are administered by the American Association for the Advancement of Science (AAAS) and endowed by The Kavli Foundation. There is a Gold Award ($5,000) and Silver Award ($3,500) for each of the eight categories. The global awards program drew entries from 67 countries this year, and 55 percent of the ...

Well-being and school results are inter-connected, but some children simply do not enjoy school. So what can we do to make school a happier experience for more children? Professor Hermundur Sigmundsson works at the Norwegian University of Science and Technology (NTNU’s) Department of Psychology and has spent many years conducting research on learning and schooling. He and his colleagues are currently carrying out a project in Vestmannaeyjar in Iceland. Among other things, they have investigated ...

A blocked coronary artery causing an acute heart attack must be opened immediately with a stent procedure. However, if other coronary arteries also appear to be narrowed, it is safe to wait and treat those later. This approach cuts the number of stent procedures in half, according to cardiologists from Radboud university medical center, writing in The New England Journal of Medicine. Each year, 33,600 people are admitted to the hospital with a heart attack. In those cases, doctors must quickly open the blocked artery with angioplasty to prevent part of the heart muscle from dying. Yet during the procedure, it often becomes ...

Peer-reviewed. Literature Review. Ecology.  University of Leeds news    Efforts to join up isolated plant and animal habitats across the world should also protect against unintentionally harming them, new research shows.   The paper, led by the Universities of Leeds and Oxford and published today in Nature Reviews Biodiversity journal, states that work to connect fragmented wildlife habitats is essential - but it may also pose ecological risks including the unintentional spread of wildlife diseases and invasive species.  Wildlife or ecological corridors ...

For decades, Lyme disease has frustrated both physicians and patients alike. Caused by the corkscrew-shaped bacterium Borrelia burgdorferi, the infection, if left untreated, can linger for months, leading to fever, fatigue and painful inflammation. In a new study, Northwestern University and Uniformed Services University (USU) scientists have uncovered a surprising — and ironic — vulnerability in the hardy bacterium. By exploiting this vulnerability, researchers could help disarm B. burgdorferi, potentially leading to new therapeutic strategies for Lyme disease. The Northwestern and USU team discovered ...

Florida’s beaches – particularly those in Palm Beach County – are among the world’s most vital nesting grounds for loggerhead sea turtles (Caretta caretta), accounting for 90% of all loggerhead nests in the Southeastern United States. Where a sea turtle chooses to nest is a delicate balance between the energy spent searching for the right spot and the benefits that location provides for successful egg incubation. Because nest placement directly influences hatchling survival, emergence success, and even sex ratios, ...

LOS ANGELES — City of Hope® Research Spotlight offers a glimpse into groundbreaking scientific and clinical discoveries advancing lifesaving cures for patients with cancer, diabetes and other chronic, life-threatening diseases. Each spotlight features research-related news, such as recognitions, collaborations and the latest research defining the future of medical treatment.  To learn more about research at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center ranked among the nation’s top cancer centers by U.S. News & World Report, visit our newsroom.    Long-Term ...