Nine potentially modifiable risk factors may contribute to up to two thirds of Alzheimer's disease cases worldwide, suggests an analysis of the available evidence, published online in the Journal of Neurology Neurosurgery & Psychiatry. The analysis indicates the complexity of Alzheimer's disease development and just how varied the risk factors for it are. But the researchers suggest that preventive strategies, targeting diet, drugs, body chemistry, mental health, pre-existing disease, and lifestyle may help to stave off dementia. This could be particularly important, ...

In a Policy View published in The Lancet Neurology journal, a group of leading experts on the epidemiology of dementia state that the number of people with dementia - both new cases and total numbers with the disease - in some Western European countries is stabilising despite population ageing, in direct contrast to the "dementia epidemic" reported in some recent studies. The Policy View discusses data from five large epidemiological studies done in Sweden, the Netherlands, the UK, and Spain that compare dementia occurrence in old people across two periods of time using ...

Highlights Among kidney transplant recipients, patients with mostly IgG3 donor-specific HLA antibodies had a higher likelihood of organ rejection soon after transplantation. If rejection occurred in those with mostly IgG4 antibodies, it was usually much later after transplantation. Washington, DC (August 20, 2015) -- The dominant antibody type present in the blood of transplant recipients may indicate their likelihood of experiencing organ rejection, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). ...

DALLAS, Aug. 20, 2015 -- Caregiver spouses of stroke survivors are at an increased risk of mental and physical health issues that may continue for years, according to research in the American Heart Association journal Stroke. Swedish researchers evaluated 248 stroke survivors, below age 70 (average mid-sixties), and their spouses at stroke onset and compared the results with 245 non-stroke controls for seven years after the stroke event. At the seven-year follow-up, 16.5 percent of survivors had suffered a recurrent stroke. Spouses of survivors reported lower scores ...

Boston, MA -- A widely used class of industrial chemicals linked with cancer and interference with immune function--perfluorinated alkylate substances, or PFASs--appears to build up in infants by 20%-30% for each month they're breastfed, according to a new study co-authored by experts from Harvard T.H. Chan School of Public Health. It is the first study to show the extent to which PFASs are transferred to babies through breast milk, and to quantify their levels over time. "We knew that small amounts of PFAS can occur in breast milk, but our serial blood analyses now show ...

In-depth interviews conducted by researchers at the Johns Hopkins University School of Medicine of 20 young women attending an urban sexually transmitted disease clinic have documented a variety of unexpected, unintended sexual encounters linked to their alcohol use before sex occurs. Links between alcohol use and risky or deleterious sexual encounters are not necessarily new, say investigators, but this small study identifies very specifically the disconnect between what young women have in mind when they drink and have sex and what really happens. "The idea behind ...

According to a survey conducted by Rhode Island Hospital researchers, there is significant variability regarding how clinicians manage catheters placed in the arteries of patients in intensive care units. Some practices may increase risk of infection associated with these catheters. Fewer than half of those surveyed complied with current Centers for Disease Control and Prevention (CDC) infection prevention guidelines for arterial catheter insertions. The study was published today in Critical Care Medicine. "Barrier precautions are employed inconsistently by critical care ...

Washington, DC - August 20, 2015 - Swedish exchange students who studied in India and in central Africa returned from their sojourns with an increased diversity of antibiotic resistance genes in their gut microbiomes. The research is published 10 August in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology. In the study, the investigators found a 2.6-fold increase in genes encoding resistance to sulfonamide, a 7.7-fold increase in trimethoprim resistance genes, and a 2.6-fold increase in resistance to beta-lactams, all of this without ...

PHOENIX, Ariz. -- Aug. 20, 2015 -- A study by the Translational Genomics Research Institute (TGen) and other major research institutes, found a new set of genes that can indicate improved survival after surgery for patients with pancreatic cancer. The study also showed that detection of circulating tumor DNA in the blood could provide an early indication of tumor recurrence. In conjunction with the Stand Up To Cancer (SU2C) Pancreatic Cancer Dream Team, the study was published in the prestigious scientific journal Nature Communications. Using whole-exome sequencing ...

If dark energy is hiding in our midst in the form of hypothetical particles called "chameleons," Holger Müller and his team at the University of California, Berkeley, plan to flush them out. The results of an experiment reported in this week's issue of Science narrows the search for chameleons a thousand times compared to previous tests, and Müller, an assistant professor of physics, hopes that his next experiment will either expose chameleons or similar ultralight particles as the real dark energy, or prove they were a will-o'-the-wisp after all. Dark energy ...

Management of boreal forests needs greater attention from international policy, argued forestry experts from the International Institute for Applied Systems Analysis (IIASA), Natural Resources Canada, and the University of Helsinki in Finland in a new article published this week in the journal Science. The article, which reviews recent research in the field, is part of a special issue on forests released in advance of the World Forestry Congress in September. "Boreal forests have the potential to hit a tipping point this century," says IIASA Ecosystems Services and Management ...

This news release is available in Japanese. Humans are just one of many predators in this world, but a new study highlights how their intense tendency to target and kill adult prey, as well as other carnivores, sets them distinctly apart from other predators. As humans kill other species in their reproductive prime, there can be profound implications -- including widespread extinction and restructuring of food webs and ecosystems--in both terrestrial and marine systems. To evaluate the nature of human predation compared to nonhuman predation, Chris Darimont et al. conducted ...

This news release is available in Japanese. In this special issue, the editors of Science invite experts to provide closer looks at how natural and human-induced environmental changes are affecting forests around the world, from the luscious, diverse forests of the tropics, to the pristine, resilient boreal forests of the north. The special issue is complemented by a package from Science's news department. Amid extreme environmental and climate changes, Susan Trumbore and colleagues highlight the urgency of monitoring forest health, especially ...

This news release is available in Japanese. Amid continued difficulties around assessing bioweapons threats, especially given limited empirical data, Crystal Boddie and colleagues took another route to gauge their danger: the collective judgment of multiple experts. The experts' opinions on bioweapons-related risks were quite diverse, the Policy Forum authors say, adding to the challenge around developing a regulatory system for legitimate dual use research. Boddie et al. explain how they employed a Delphi Method study to query the beliefs and opinions of 59 experts ...

An examination of the immune genes of the southern African Khoe-San people has revealed a completely new kind of mutation, according to researchers at the Stanford University School of Medicine. The gene variant likely contributes to healthier babies, although the variant can also lower resistance to disease. The findings grew out of a long-term effort by Peter Parham, PhD, professor of structural biology and of microbiology and immunology, to understand how immune system genes make us reject organ transplants. A paper detailing the findings will be published online ...

CORVALLIS, Ore. - Myriad regulations and certification requirements around the world are making it virtually impossible to use genetically engineered trees to combat catastrophic forest threats, according to a new policy analysis published this week in the journal Science. In the United States, the time is ripe to consider regulatory changes, the authors say, because the federal government recently initiated an update of the overarching Coordinated Framework for the Regulation of Biotechnology, which governs use of genetic engineering. North American forests are suffering ...

Are humans unsustainable 'super predators'? Want to see what science now calls the world's "super predator"? Look in the mirror. Research published today in the journal Science by a team led by Dr. Chris Darimont, the Hakai-Raincoast professor of geography at the University of Victoria, reveals new insight behind widespread wildlife extinctions, shrinking fish sizes and disruptions to global food chains. "These are extreme outcomes that non-human predators seldom impose," Darimont's team writes in the article titled "The Unique Ecology of Human Predators." "Our ...

Scientists have exposed a chink in the armour of disease-causing bugs, with a new discovery about a protein that controls bacterial defences. Bacteria react to stressful situations - such as running out of nutrients, coming under attack from antibiotics or encountering a host body's immune system - with a range of defence mechanisms. These include constructing a resistant outer coat, growing defensive structures on their surface or producing enzymes that break down the DNA of an attacker. The new research shows that a protein called sigma54 holds a bacterium's defences ...

WEST LAFAYETTE, Ind. -- Results of the XENON100 experiment are a bright spot in the search for dark matter. The team of international scientists involved in the project demonstrated the sensitivity of their detector and recorded results that challenge several dark matter models and a longstanding claim of dark matter detection. Papers detailing the results will be published in upcoming issues of the journals Science and Physical Review Letters. Dark matter is an abundant but unseen matter in the universe considered responsible for the gravitational force that keeps the ...

Scientists studying the 2009 A/H1N1 influenza pandemic have found that the inconsistent regional timing of pandemic waves in Mexico was the result of interactions between school breaks and regional variations in humidity. The research published in PLOS Computational Biology, led by Dr. James Tamerius at the University of Iowa and Dr. Gerardo Chowell at Georgia State University, applied mathematical models to understand the social and environmental processes that generated two distinct pandemic outbreaks ("waves") in Mexico during the summer and fall of 2009. The summer ...

Children who have been abused or exposed to other types of trauma typically experience more intense emotions than their peers, a byproduct of living in volatile, dangerous environments. But what if those kids could regulate their emotions? Could that better help them cope with difficult situations? Would it impact how effective therapy might be for them? A University of Washington-led team of researchers sought to address those questions by studying what happens in the brains of maltreated adolescents when they viewed emotional images, and then tried to control their ...

PRINCETON, N.J.--Tracking mobile phone data is often associated with privacy issues, but these vast datasets could be the key to understanding how infectious diseases are spread seasonally, according to a study published in the Proceedings of the National Academy of Sciences. Princeton University and Harvard University researchers used anonymous mobile phone records for more than 15 million people to track the spread of rubella in Kenya and were able to quantitatively show for the first time that mobile phone data can predict seasonal disease patterns. Harnessing ...

Glenview, Ill. (August 20, 2015)--The popularity of electronic cigarettes has steadily increased worldwide, but little is known about their effects on health. New research suggests that the single use of an electronic cigarette approximating the nicotine exposure of one tobacco cigarette reduces the sensitivity of the cough reflex. The study tested 30 adult lifetime nonsmokers with no history of asthma or respiratory diseases and used cough tests to determine how e-cigarettes affect the cough reflex. Capsaicin, the pungent extract of red peppers, was used to induce a ...

Medicaid is expected to save billions of dollars a year as patents for several blockbuster antipsychotic medications expire and use of generic versions of these drugs increases, according to a new study by researchers at the University of Maryland School of Medicine. These savings may provide relief from the high costs of these medications and allow policymakers to lift restrictions on patients' access, the researchers argue. The study forecast that annual Medicaid payments for antipsychotic medicines will decrease by nearly $1.8 billion (or nearly 50 percent) by 2016 ...

HOUSTON - (Aug. 20, 2015) - Rice University chemists who developed a unique form of graphene have found a way to embed metallic nanoparticles that turn the material into a useful catalyst for fuel cells and other applications. Laser-induced graphene, created by the Rice lab of chemist James Tour last year, is a flexible film with a surface of porous graphene made by exposing a common plastic known as polyimide to a commercial laser-scribing beam. The researchers have now found a way to enhance the product with reactive metals. The research appears this month in the ...