SCOTTSDALE, Ariz. — June 5, 2014 — A clinical trial conducted by researchers at the Virginia G. Piper Cancer Center Clinical Trials, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen), showed that a new drug called MM-398, given in combination with 5-flourouracil (5FU) and leucovorin, produced a significant overall survival rate in patients with advanced, previously-treated pancreatic cancer. The NAPOLI-1 (NAnoliPOsomaL Irinotecan) Phase 3 study — a final confirmation of a drug's safety and effectiveness — was conducted ...

SAN ANTONIO, Texas (June 5, 2014) — Scientists this week reported that a molecular pathway called mTORC1 controls the conversion of unhealthy white fat into beige fat, an appealing target for increasing energy expenditure and reducing obesity. The team, led by researchers from the School of Medicine at The University of Texas Health Science Center at San Antonio, also found that a protein, Grb10, serves as the on-off switch for mTORC1 signaling and the "beigeing" of fat. The finding could inform development of novel diabetes and obesity drugs, the scientists said. The ...

Phytoplankton—tiny, photosynthetic organisms—are essential to life on Earth, supplying us with roughly half the oxygen we breathe. Like all other life forms, phytoplankton require the element phosphorus to carry out critical cellular activity, but in some parts of the world's ocean, P is in limited supply. How do phytoplankton survive when phosphorus is difficult to find? Phytoplankton can alter their biochemical make-up according to the availability of nutrients in the water. When phosphorus (P) is particularly abundant in the water, phytoplankton produce and store ...

Psoriasis is a common, long-lasting disease that causes itchy or sore patches of thick, red skin with silvery scales. Environmental contaminants can trigger psoriasis and other autoimmune disorders, and it is thought that a protein called the aryl hydrocarbon receptor (AhR), which senses environmental toxins, could play a role. A study published by Cell Press on June 5 in the journal Immunity shows that the severity of inflammation associated with psoriasis is unexpectedly suppressed by AhR. The findings suggest that stimulation of AhR could improve symptoms and may represent ...

When transplanted into the midbrains of adult patients with Parkinson's disease, dopamine neurons derived from fetal tissue can remain healthy for many years. The findings reported in the Cell Press journal Cell Reports on June 5th suggest that transplanted neurons don't degenerate over time as some had suggested and feared they would, which provides further rationale for pursuing stem cells as a source for transplant-ready dopamine neurons, according to the researchers. "Our findings show a robust expression of dopamine transporters and a lack of abnormal mitochondrial ...

Obesity is a worldwide epidemic that is causing alarming rates of diabetes and cardiovascular disease, but currently there is a lack of effective drug treatments. Two unrelated studies published by Cell Press June 5th in the journal Cell reveal an important role for immune pathways in activating good types body fat, called brown and beige fat, which burn stored calories, reduce weight, and improve metabolic health. The findings could pave the way for much-needed treatments for obesity and related metabolic diseases. "The idea that metabolic health can be improved by activation ...

While chemotherapy can save lives, it can also cause many side effects, including the depletion of immune cells. Also, even in the absence of chemotherapy, normal aging takes a heavy toll on the immune system, leading to immune deficiencies and a higher risk of developing leukemia and a variety of malignancies with age. Now researchers reporting in the June 5th issue of the Cell Press journal Cell Stem Cell have found that a simple dietary intervention—periodic fasting—may combat both chemotherapy-induced and aging-related changes in immune cell function by replenishing ...

OTTAWA, ON – June 5, 2014 – As part of the Finding of Rare Disease Genes (FORGE) research project, Canadian researchers have developed an expertise in understanding the underlying biology of rare childhood disorders. The first public commentary of this nationwide study is available today in the American Journal of Human Genetics. "When we launched this project, we predicted we might explain, or solve, 50 disorders; we've almost tripled that goal," said Dr. Kym Boycott, lead investigator of FORGE and clinician scientist at the Children's Hospital of Eastern Ontario ...

Researchers have discovered the first three-dimensionally preserved pterosaur eggs in China. The eggs were found among dozens, if not hundreds, of pterosaur fossils, representing a new genus and species (Hamipterus tianshanensis). The discovery, described in the Cell Press journal Current Biology on June 5, reveals that the pterosaurs—flying reptiles with wingspans ranging from 25 cm to 12 m—lived together in gregarious colonies. Xiaolin Wang of the Chinese Academy of Sciences' Institute of Vertebrate Paleontology and Paleoanthropology says it was most exciting to find ...

BELMONT, MA -- Researchers at Harvard-affiliated McLean Hospital have found that fetal dopamine cells transplanted into the brains of patients with Parkinson's disease were able to remain healthy and functional for up to 14 years, a finding that could lead to new and better therapies for the illness. The discovery, reported in the June 5, 2014 issue of the journal Cell Reports, could pave the way for researchers to begin transplanting dopamine neurons taken from stem cells grown in laboratories, a way to get treatments to many more patients in an easier fashion. "We ...

In the first evidence of a natural intervention triggering stem cell-based regeneration of an organ or system, a study in the June 5 issue of the Cell Press journal Cell Stem Cell shows that cycles of prolonged fasting not only protect against immune system damage — a major side effect of chemotherapy — but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal. In both mice and a Phase 1 human clinical trial, long periods of not eating significantly lowered white blood cell counts. In mice, fasting cycles then "flipped ...

The calorie-burning triggered by cold temperatures can be achieved biochemically – without the chill – raising hopes for a weight-loss strategy focused on the immune system rather than the brain, according to a new study by UC San Francisco researchers. The team determined that two signaling molecules secreted by cells of the immune system trigger the conversion of fat-storing white fat cells to fat-burning beige fat cells. Ajay Chawla, MD, PhD, an associate professor of medicine at the UCSF Cardiovascular Research Institute, led the study, published online June 5, 2014 ...

LA JOLLA, CA—June 5, 2014—A team led by researchers at The Scripps Research Institute (TSRI) has used advanced electron microscopy techniques to determine the first accurate structural map of Mediator, one of the largest and most complex "molecular machines" in cells. Mediator is crucial for the regulation of most genes' activity and works in the cells of all plants and animals. The mapping of its structure—which includes more than two dozen unique protein subunits—represents a significant advance in basic cell biology and should shed light on medical conditions involving ...

TORONTO, June 5, 2014 – From 2006 to 2008, nearly 75 per cent of Ontarians with diabetes did not receive all of the tests recommended to properly monitor their disease. How their doctor was paid was one of the factors determining the care they received, according to a study by researchers at St. Michael's Hospital and the Institute for Clinical Evaluative Sciences (ICES). The study, published today in the Canadian Journal of Diabetes, found that patients who were not actively enrolled with a family doctor were least likely to receive optimum diabetes care. The researchers ...

Proteins are responsible for the vast majority of the cellular functions that shape life, but like guests at a crowded dinner party, they interact transiently and in complex networks, making it difficult to determine which specific interactions are most important. Now, researchers from the University of Chicago have pioneered a new technique to simplify the study of protein networks and identify the importance of individual protein interactions. By designing synthetic proteins that can only interact with a pre-determined partner, and introducing them into cells, the team ...

New findings about the biological links between obesity, insulin resistance and type 2 diabetes may also shed light on the connection between obesity and cancer, says a scientist at The University of Texas at Dallas. In a study published online June 5 in the journal Cell, UT Dallas' Dr. Jung-whan (Jay) Kim and colleagues at the University of California, San Diego found that a protein called HIF-1 alpha plays a key role in the development of insulin resistance and type 2 diabetes in obese mice. The researchers genetically engineered mice to lack the HIF-1 alpha protein ...

The way we navigate from A to B is controlled by two brain regions which track the distance to our destination, according to new research funded by the Wellcome Trust and published in Current Biology. The study found that at the beginning of a journey, one region of the brain calculates the straight-line to the destination ('the distance as a crow flies'), but during travel a different area of the brain computes the precise distance along the path to get there. The findings pinpoint the precise brain regions used and in doing so change how scientists believed we use ...

HPV (human papillomavirus) infection is widely known to induce cancer. Many of the mutations that cause this virally-induced cancer are caused by a family of genes that normally combats viral infections, finds new UCL (University College London) research. This raises the possibility of developing drugs to regulate the activity of these genes to prevent HPV-associated cancers from developing and reduce the ability of existing cancers to evolve resistance to treatments. The research, published in Cell Reports, shows for the first time that genes from the 'APOBEC' family, ...

Cells must transport nutrients and messenger cargos through its membrane and transport them within the cell at the correct time and place. This procedure is complex and is regulated with the help of specific genes. If disturbances in the transport mechanism arise, severe diseases, such as diabetes, cancer and diverse neurological pathologies, are the consequence. The discovery of the molecular principles of cellular transport was honored with the Nobel Prize of physiology and medicine in 2013. While knowing the intracellular roads and the functioning of the cars that use ...

If you have it, you probably don't know it. Cytomegalovirus, or CMV, is perhaps one of the biggest pathogens you've never heard of—big, both proportionately and epidemiologically. It contains approximately 200 genes, compared to HIV's paltry 18, and it's everywhere. You can catch it as a preschooler salivating over blocks, or as a teenager experiencing your first kiss. Once you have it, you have it for life. Good news: If you're healthy, it's harmless. Your T cells keep it in check, and you'll be none the wiser. Bad news: If you have any medical condition that dampens ...

In laboratory tests, researchers have used electrical stimulation of retinal cells to produce the same patterns of activity that occur when the retina sees a moving object. Although more work remains, this is a step toward restoring natural, high-fidelity vision to blind people, the researchers say. The work was funded in part by the National Institutes of Health. Just 20 years ago, bionic vision was more a science fiction cliché than a realistic medical goal. But in the past few years, the first artificial vision technology has come on the market in the United States ...

When we talk about genetic material, we are usually referring to the DNA (deoxyribonucleic acid) that we inherit from our parents. This DNA is the factory where is built a similar molecule called RNA (ribonucleic acid) which produces our proteins, such as hemoglobin or insulin , allowing the lives of our cells. But there is a special group called non-coding RNA that has a more enigmatic function. The best known is microRNAs, tiny molecules that are responsible for turning on or off our genome like an electrical current switch. Today, an article published in the prestigious ...

Harvard Stem Cell Institute scientists at Boston Children's Hospital have new evidence in mice that it may be possible to repair a chronically diseased liver by forcing mature liver cells to revert back to a stem cell-like state. The researchers, led by Fernando Camargo, PhD, happened upon this discovery while investigating whether a biochemical cascade called Hippo, which controls how big the liver grows, also affects cell fate. The unexpected answer, published in the journal Cell, is that switching off the Hippo-signaling pathway in mature liver cells generates very ...

Twenty-seven chemical elements are considered to be essential for human life. Now there is a 28th – bromine. In a paper published Thursday by the journal Cell, Vanderbilt University researchers establish for the first time that bromine, among the 92 naturally-occurring chemical elements in the universe, is the 28th element essential for tissue development in all animals, from primitive sea creatures to humans. "Without bromine, there are no animals. That's the discovery," said Billy Hudson, Ph.D., the paper's senior author and Elliott V. Newman Professor of Medicine. The ...

Like many other insect pollinators, bees find their way around by using a polarization sensitive area in their eyes to 'see' skylight polarization patterns. However, while other insects are known to use such sensitivity to identify appropriate habitats, locate suitable sites to lay their eggs and find food, a non-navigation function for polarization vision has never been identified in bees – until now. Professor Julian Partridge, from Bristol's School of Biological Sciences and the School of Animal Biology at the University of Western Australia, with his Bristol-based ...