ANN ARBOR, Mich. - What happens in the moments just before death is widely believed to be a slowdown of the body's systems as the heart stops beating and blood flow ends. But a new laboratory study by the University of Michigan Medical School reveals a storm of brain activity that erupts as the heart deteriorates and plays a surprising destabilizing role in heart function. This near-death brain signaling may be targeted to help cardiac arrest patients survive. Most of the more than 400,000 Americans who experience cardiac arrest at home, at work or in public die without ...

Researchers sketching out a wiring diagram for rat brains -- a field known as "connectomics" -- have discovered that its structure is organized like the Internet. For years, scientists looking for clues to brain function through its structure focused on what could be seen -- the brain's lobes, grooves and folds. Now, with a more comprehensive picture of how neurons connect to one another, they've discovered local networks of neurons nested into one another like shells. "The cerebral cortex is like a mini-Internet," said Larry Swanson, professor at the USC Dornsife College ...

Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have identified a cellular receptor for rhinovirus C, a cold-causing virus that is strongly associated with severe asthma attacks. A variant in the gene for this receptor previously had been linked to asthma in genetic studies, but the potential role of the receptor, called CDHR3, in asthma was unknown. The new findings help clarify the function of CDHR3 and point to a novel target for the development of prevention and treatment strategies against ...

Researchers are always searching for improved technologies, but the most efficient computer possible already exists. It can learn and adapt without needing to be programmed or updated. It has nearly limitless memory, is difficult to crash, and works at extremely fast speeds. It's not a Mac or a PC; it's the human brain. And scientists around the world want to mimic its abilities. Both academic and industrial laboratories are working to develop computers that operate more like the human brain. Instead of operating like a conventional, digital system, these new devices ...

New mothers in the Philippines spend more time in the bedroom with their partner in the first few weeks after giving birth than they did before they became pregnant. This might be a type of survival strategy to keep the relationships with the fathers of their new babies alive and well, to ensure continued support for their offspring. So says Michelle Escasa-Dorne of the University of Colorado in the US, after studying how women from a society with a low divorce rate such as the Philippines adapt to being both mothers and lovers. The study appears in Springer's journal Human ...

WINSTON-SALEM, N.C. - April 6, 2015 - A commonly prescribed antidepressant caused up to a six-fold increase in atherosclerosis plaque in the coronary arteries of non-human primates, according to a study by researchers at Wake Forest Baptist Medical Center. Coronary artery atherosclerosis is the primary cause of heart attacks. The study is published in the current online issue of the journal Psychosomatic Medicine. "The medical community has known for years that depression is closely associated with heart disease, but we didn't know if treating it would reduce the heart ...

A new UCLA study takes another step toward the early understanding of a degenerative brain condition called chronic traumatic encephalopathy, or CTE, which affects athletes in contact sports who are exposed to repetitive brain injuries. Using a new imaging tool, researchers found a strikingly similar pattern of abnormal protein deposits in the brains of retired NFL players who suffered from concussions. The innovative imaging technique uses a chemical marker combined with positron emission tomography, or PET scan, and was initially tested in five retired NFL players ...

SAN FRANCISCO--The Pacific and North America plate boundary off the coast of British Columbia and southeastern Alaska is a complex system of faults capable of producing very large earthquakes. The recent 2012 Mw 7.8 Haida Gwaii and 2013 Mw 7.5 Craig earthquakes released strain built up over years, but did not release strain along the Queen Charlotte Fault, which remains the likely source of a future large earthquake, according to reports published in a special issue of the Bulletin of the Seismological Society of America (BSSA). "The study of these two quakes revealed ...

Massachusetts General Hospital (MGH) investigators have identified an inflammatory molecule that appears to play an essential role in the autoimmune disorder systemic lupus erythematosus, commonly known as lupus. In their report being published online in Nature Immunology, the researchers describe finding that a protein that regulates certain cells in the innate immune system - the body's first line of defense against infection - activates a molecular pathway known to be associated with lupus and that the protein's activity is required for the development of lupus symptoms ...

MIT researchers have developed a new, ultrasensitive magnetic-field detector that is 1,000 times more energy-efficient than its predecessors. It could lead to miniaturized, battery-powered devices for medical and materials imaging, contraband detection, and even geological exploration. Magnetic-field detectors, or magnetometers, are already used for all those applications. But existing technologies have drawbacks: Some rely on gas-filled chambers; others work only in narrow frequency bands, limiting their utility. Synthetic diamonds with nitrogen vacancies (NVs) -- ...

Dividing cells--whether they're in an embryo or an adult--rely on the right processes happening at the right time to turn out healthy. Now, researchers at the University of Iowa have identified a mechanism that dividing cells in worms use to ensure their proper development, and they believe the same process could be going on in humans. The mechanism, unknown until now, describes one part of the cell, called the centrosome, as an "internal timekeeper"--like a train conductor. A crucial protein in charge of gene expression, beta-catenin, is described as a "hitchhiker"--it ...

Physical activity that makes you puff and sweat is key to avoiding an early death, a large Australian study of middle-aged and older adults has found. The researchers followed 204,542 people for more than six years, and compared those who engaged in only moderate activity (such as gentle swimming, social tennis, or household chores) with those who included at least some vigorous activity (such as jogging, aerobics or competitive tennis). They found that the risk of mortality for those who included some vigorous activity was 9 to 13 per cent lower, compared with those ...

Leading coral reef scientists say Australia could restore the Great Barrier Reef to its former glory through better policies that focus on science, protection and conservation. In a paper published in the journal Nature Climate Change, the authors argue that all the stressors on the Reef need to be reduced for it to recover. An Australian Government report into the state of the Great Barrier Reef found that its condition in 2014 was "poor and expected to further deteriorate in the future". In the past 40 years, the Reef has lost more than half of its coral cover and ...

Many nursing home residents who underwent lower extremity revascularization died, did not walk or had functional decline following the procedure, which is commonly used to treat leg pain caused by peripheral arterial disease, wounds that will not heal or worsening gangrene, according to an article published online by JAMA Internal Medicine. Lower extremity revascularization is often performed so patients with peripheral arterial disease can maintain the ability to walk, which is a key component of functional independence. But outcomes among patients with high levels of ...

Quality of life was good and cognitive function was similar in patients with cardiac arrest who received targeted body-temperature management as a neuroprotective measure in intensive care units in Europe and Australia, according to an article published online by JAMA Neurology. Brain injury is the primary cause of death for patients treated in intensive care units after suffering cardiac arrest (CA) outside of a hospital. Targeted temperature management (TTM) has been implemented as a neuroprotective treatment for comatose CA survivors because of reports of improved ...

Application of pediatric guidelines for lipid levels for persons 17 to 21 years of age who have elevated low-density lipoprotein cholesterol (LDL-C) levels would result in statin treatment for more than 400,000 additional young people than the adult guidelines, according to an article published online by JAMA Pediatrics. Adolescence is a common time for the emergence of risk factors for cardiovascular disease, including abnormal cholesterol levels. The 2011 National Heart, Lung, and Blood Institute Integrated Guidelines for Cardiovascular Health and Risk Reduction in ...

Only a few U.S. nursing home residents who undergo lower extremity revascularization procedures are alive and ambulatory a year after surgery, according to UCSF researchers, and most patients still alive gained little, if any, function. The study appears in the April 6 issue of JAMA Internal Medicine. "Our findings can inform conversations among physicians, patients and families about the risks and expected outcomes of surgery and whether the surgery is likely to allow patients to achieve their treatment goals," said senior author Emily Finlayson, MD, MS, associate ...

Seventy per cent of glacier ice in British Columbia and Alberta could disappear by the end of the 21st century, creating major problems for local ecosystems, power supplies, and water quality, according to a new study by University of British Columbia researchers. The study found that while warming temperatures are threatening glaciers in Western Canada, not all glaciers are retreating at the same rate. The Rocky Mountains, in the drier interior, could lose up to 90 per cent of its glaciers. The wetter coastal mountains in northwestern B.C. are only expected to lose about ...

DURHAM, N.C. -- Duke researchers have developed a new method to precisely control when genes are turned on and active. The new technology allows researchers to turn on specific gene promoters and enhancers -- pieces of the genome that control gene activity -- by chemically manipulating proteins that package DNA. This web of biomolecules that supports and controls gene activity is known as the epigenome. The researchers say having the ability to steer the epigenome will help them explore the roles that particular promoters and enhancers play in cell fate or the risk ...

Stanford University scientists have invented the first high-performance aluminum battery that's fast-charging, long-lasting and inexpensive. Researchers say the new technology offers a safe alternative to many commercial batteries in wide use today. "We have developed a rechargeable aluminum battery that may replace existing storage devices, such as alkaline batteries, which are bad for the environment, and lithium-ion batteries, which occasionally burst into flames," said Hongjie Dai, a professor of chemistry at Stanford. "Our new battery won't catch fire, even if you ...

Most of today's anticancer drugs target the DNA or proteins in tumor cells, but a new discovery by University of California, Berkeley, scientists unveils a whole new set of potential targets: the RNA intermediaries between DNA and proteins. This RNA, called messenger RNA, is a blueprint for making proteins. Messenger RNA is created in the nucleus and shuttled out into the cell cytoplasm to hook up with protein-making machinery, the ribosome. Most scientists have assumed that these mRNA molecules are, aside from their unique sequences, generic, with few distinguishing ...

PROVIDENCE, R.I. - After analyzing stroke treatment records, researchers at Rhode Island Hospital in collaboration with researchers from the University of Cincinnati learned that women and men have different reasons for being excluded from receiving the common clot-dissolving drug, recombinant tissue plasminogen activator (rtPA). Importantly, more women had very high blood pressures, which reduced their eligibility to be treated with the highly effective drug. The study was recently published in the American Heart Association's (AHA) journal, Stroke. "Although men and ...

Women who believe smoking helps them manage their weight are less likely to try quitting in response to anti-smoking policies than other female smokers in the U.S. The study, published online in the journal Tobacco Control, is the first to find that smokers who are concerned about their weight are less swayed by anti-smoking policies - such as bumps in cigarette prices, smoke-free laws or anti-tobacco messaging -- than other smokers are. "We found that concerns about weight are a significant barrier to quitting," says lead author Ce Shang of the University of Illinois ...

NEW YORK--A sad TV drama comes to conclusion, fading to black as music swells, and leaving the audience emotionally torn about the future of the main characters. Suddenly, the TV cuts to a peppy commercial and viewers are faced with the relentless cheer of an insurance spokesperson pitching their latest money saving product. This is a common occurrence in today's prime time-driven entertainment culture, but new research from Columbia Business School shows that this juxtaposition of emotions can leave TV viewers puzzled at the swing in content and emotion, so much so that ...

AURORA, Colo. (April 6, 2015) - Brain activity affects the way the developing brain connects neurons and a study by researchers at the School of Medicine on the University of Colorado Anschutz Medical Campus and Children's Hospital Colorado suggests a new model for understanding that process. In a study of zebrafish, scientists tested how brain activity affected the development of insulating sheaths on selected axons, which are slender nerve fibers that conduct electrical impulses between neurons. They found that, while the wrapping of axons was indiscriminate, the molecular ...