Kansas City, MO - While megakaryocytes are best known for producing platelets that heal wounds, these "mega" cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. In fact, hematopoietic stem cells differentiate to generate megakaryocytes in bone marrow. The Stowers study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes). The findings from the lab Stowers Investigator Linheng Li, Ph.D., described ...

At least 2 percent of people over age 40 and 5 percent of people over 70 have mutations linked to leukemia and lymphoma in their blood cells, according to new research at Washington University School of Medicine in St. Louis. Mutations in the body's cells randomly accumulate as part of the aging process, and most are harmless. For some people, genetic changes in blood cells can develop in genes that play roles in initiating leukemia and lymphoma even though such people don't have the blood cancers, the scientists report Oct. 19 in Nature Medicine. The findings, based ...

CHICAGO – Oct. 19, 2014 – The first tear duct implant developed to treat inflammation and pain following cataract surgery has been shown to be a reliable alternative to medicated eye drops, which are the current standard of care, according to a study presented today at AAO 2014, the 118th annual meeting of the American Academy of Ophthalmology. The device, known as a punctum plug, automatically delivers the correct amount of postoperative medication in patients, potentially solving the issue of poor compliance with self-administering eye drops. After cataract ...

BETHESDA, MD – A child's genetic makeup may contribute to his or her mother's risk of rheumatoid arthritis, possibly explaining why women are at higher risk of developing the disease than men. This research will be presented Tuesday, October 21, at the American Society of Human Genetics (ASHG) 2014 Annual Meeting in San Diego. Rheumatoid arthritis, a painful inflammatory condition that primarily affects the joints, has been tied to a variety of genetic and environmental factors, including lifestyle factors and previous infections. Women are three times more likely ...

BETHESDA, MD – Scientists studying birth defects in humans and purebred dogs have identified an association between cleft lip and cleft palate – conditions that occur when the lip and mouth fail to form properly during pregnancy – and a mutation in the ADAMTS20 gene. Their findings were presented today at the American Society of Human Genetics (ASHG) 2014 Annual Meeting in San Diego. "These results have potential implications for both human and animal health, by improving our understanding of what causes these birth defects in both species," said Zena ...

Geneva, Switzerland – 19 October 2014: Women are more likely to develop anxiety and depression after a heart attack (myocardial infarction; MI) than men, according to research presented at Acute Cardiovascular Care 2014 by Professor Pranas Serpytis from Lithuania. Acute Cardiovascular Care is the annual meeting of the Acute Cardiovascular Care Association (ACCA) of the European Society of Cardiology (ESC) and takes place 18-20 October in Geneva, Switzerland. Professor Serpytis said: "The World Health Organization predicts that by 2020 depression will be the second ...

BETHESDA, MD – Human geneticists have discovered that a region of the genome associated with autism contains genetic variation that evolved in the last 250,000 years, after the divergence of humans from ancient hominids, and likely plays an important role in disease. Their findings were presented today at the American Society of Human Genetics (ASHG) 2014 Annual Meeting in San Diego. Researchers at the University of Washington analyzed the genomes of 2,551 humans, 86 apes, one Neanderthal, and one Denisovan. They closely examined a region of human chromosome 16 ...

Berlin, 19th October 2014 All humans have a natural opioid system in the brain. Now new research, presented at the ECNP Congress in Berlin, has found that the opioid system of pathological gamblers responds differently to those of normal healthy volunteers. The work was carried out by a group of UK researchers from London and Cambridge, and was funded by the Medical Research Council. This work is being presented at the European College of Neuropsychopharmacology congress in Berlin. Gambling is a widespread behaviour with about 70% of the British population gambling occasionally. ...

Berlin, 19th October 2014 Psychological stress and stress-related psychiatric disorders are associated with increased risk for aging-related diseases, but the molecular mechanisms underlying this relation are unknown. Understanding these mechanisms may contribute to the development of targeted preventive strategies and new or improved treatments for these devastating diseases. This work is presented at the European College of Neuropsychopharmacology congress in Berlin. Now an international group of researchers from Germany and the US has found that both ageing and depression ...

Berlin 19th October New research shows that the season you are born has a significant impact on your risk of developing mood disorders. People born at certain times of year may have a greater chance of developing certain types of affective temperaments, which in turn can lead to mood disorders (affective disorders). This work is being presented at the European College of CNP Congress in Berlin. Seasons of birth have traditionally been associated with certain personality traits, such as novelty seeking, and various folklore justifications, such as astrology, have sought ...

Audrey Lapidus adored her baby's sunny smile and irresistible dimples, but grew worried when Calvin did not roll over or crawl by 10 months and suffered chronic digestive problems. Four neurologists dismissed his symptoms and a battery of tests proved inconclusive. Desperate for answers, Audrey and her husband agreed to have their son become UCLA's first patient to undergo a powerful new test called exome sequencing. Using DNA collected from Calvin's and his parents' blood, a sophisticated sequencing machine rapidly scanned the boy's genome, compared it to his parents' ...

HOUSTON -- (Oct. 18, 2014) – Approximately one-fourth of the 3,386 patients whose DNA was submitted for clinical whole exome testing received a diagnosis related to a known genetic disease, often ending a long search for answers for them and their parents, said researchers from the Baylor College of Medicine departments of molecular and human genetics and pediatrics and the Baylor Human Genome Sequencing Center and the University of Texas Health Science Center at Houston. In an online report in the Journal of the American Medical Association, the scientists led ...

Among a group of 2,000 patients referred for evaluation of suspected genetic conditions, whole-exome sequencing provided a potential molecular diagnosis for 25 percent, including detection of a number of rare genetic events and new mutations contributing to disease, according to a study appearing in JAMA. The study is being released to coincide with the American Society of Human Genetics annual meeting. Whole-exome sequencing analyzes the exons or coding regions of thousands of genes simultaneously using next-generation sequencing techniques. By sequencing the exome of ...

In a sample of patients with undiagnosed, suspected genetic conditions, a certain type of exome sequencing method was associated with a higher molecular diagnostic yield than traditional molecular diagnostic methods, according to a study appearing in JAMA. The study is being released to coincide with the American Society of Human Genetics annual meeting. Exome sequencing, which sequences the protein­coding region of the genome (the complete set of genes or genetic material present in a cell or organism), has been rapidly applied in research settings and recent increases ...

CHICAGO – Oct. 18, 2014 – A thin ring inserted into the eye could soon offer a reading glasses-free remedy for presbyopia, the blurriness in near vision experienced by many people over the age of 40, according to a study released today at AAO 2014, the 118th annual meeting of the American Academy of Ophthalmology. A corneal inlay device currently undergoing clinical review in the United States improved near vision well enough for 80 percent of the participating patients to read a newspaper without disturbing far distance vision needed for daily activities like ...

CHICAGO – Oct. 18, 2014 – Smartphone technology is a widely available resource which may also be a portable and effective tool for imaging the inside of the eye, according to results of a study released today at AAO 2014, the 118th annual meeting of the American Academy of Ophthalmology. Researchers from the Ross Eye Institute at the University at Buffalo-SUNY are successfully using an iPhone® application as an inexpensive, portable and effective tool for imaging the inside of the eye, including in patients who are challenging to photograph by traditional ...

Geneva, Switzerland – 18 October 2014: Vitamin D deficiency increases the risk of poor brain function after sudden cardiac arrest by seven-fold, according to research presented at Acute Cardiovascular Care 2014 by Dr Jin Wi from Korea. Vitamin D deficiency also led to a higher chance of dying after sudden cardiac arrest. Acute Cardiovascular Care is the annual meeting of the Acute Cardiovascular Care Association (ACCA) of the European Society of Cardiology (ESC) and takes place 18-20 October in Geneva, Switzerland. Dr Wi said: "In patients resuscitated after sudden ...

A new study published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that children who have been infected with enterovirus are 48% more likely to have developed type 1 diabetes. The study is by Dr Tsai Chung-Li, China Medical University, Taiwan, and colleagues. "Type 1 diabetes is considered to be caused by complex interaction between genetic susceptibility, the immune system, and environmental factors," say the authors. "Though the cue for genetic predisposition has been elucidated, evidence also points to involvement of enterovirus ...

MADISON — Over the past two decades, the resident communities of birds that attend eastern North America's backyard bird feeders in winter have quietly been remade, most likely as a result of a warming climate. Writing this week in the journal Global Change Biology, University of Wisconsin-Madison wildlife biologists Benjamin Zuckerberg and Karine Princé document that once rare wintering bird species are now commonplace in the American Northeast. Using more than two decades of data on 38 species of birds gathered by thousands of "citizen scientists" through ...

PROVIDENCE, R.I. – Researchers from The Miriam Hospital have studied the effects of smoking during pregnancy and its impact on the stress response in newborn babies. Their research indicates that newborns of mothers who smoke cigarettes during pregnancy show lower levels of stress hormones, lowered stress response, and alterations in DNA for a gene that regulates passage of stress hormones from mother to fetus. The study and its findings have been published in the journal Psychoneuroendocrinology. "Our results suggest that these newborns may not be mounting adequate ...

NOAA's GOES-West satellite captured an image of Tropical Storm Ana that showed the outer clouds were already reaching the big island by 11 a.m. EDT and the storm resembled a giant question mark. Tropical Storm Ana was nearing hurricane strength mid-day on Oct. 17 and the Central Pacific Hurricane Center (CPHC) expects the storm to become a hurricane before reaching the big island of Hawaii. NOAA's GOES-West satellite took an infrared picture of Tropical Storm Ana as it was approaching Hawaii on Oct. 17 at 11 a.m. EDT (5 a.m. HST). Ana looked like a giant question mark ...

LEBANON, NH (Oct. 17, 2014) – People with severe mental illness such as schizophrenia, schizoaffective disorder or bipolar disorder use a popular social media website like YouTube to provide and receive naturally occurring peer support, Dartmouth researchers report in the journal PLOS ONE. "What we found most surprising about our findings was that people with severe mental illness were so open about their illness experiences on a public social media website like YouTube," said lead author John Naslund, A PhD student in health policy at The Dartmouth Institute for ...

Scientists have solved a long-standing mystery surrounding Australia's only active volcanic area, in the country's southeast. The research explains a volcanic region that has seen more than 400 volcanic events in the last four million years. The 500 kilometre long region stretches from Melbourne to the South Australian town of Mount Gambier, which surrounds a dormant volcano that last erupted only 5,000 years ago. "Volcanoes in this region of Australia are generated by a very different process to most of Earth's volcanoes, which occur on the edges of tectonic plates, ...

A study comparing the care delivered to patients coming to hospital emergency departments (EDs) for acute asthma attacks in recent years with data gathered more than 15 years earlier finds inconsistencies in how well hospitals are meeting nationally established treatment guidelines. A team led by Massachusetts General Hospital (MGH) investigators found that, while the achievement of most guidelines defining appropriate pharmacologic treatments for particular patients improved over the study period, hospitals did less well in meeting several other guidelines. The study that ...

Fairfax, Va., October 17, 2014—Image guided radiation therapy (IGRT) is a commonly used modality to ensure treatment accuracy in the management of pediatric tumors; however, consensus recommendations are needed in order to guide clinical decisions on the use of IGRT in treating pediatric patients, according to a study published in the September-October 2014 issue of Practical Radiation Oncology (PRO), the official clinical practice journal of the American Society for Radiation Oncology (ASTRO). IGRT is the process of using frequent imaging, typically performed in ...