BETHESDA, MD – Breaking down complex conditions such as Type 2 Diabetes and obesity into the specific metabolic proteins and processes that underlie them offers a new approach to studying the genetics of these diseases and how they are interrelated, according to research presented today at the American Society of Human Genetics (ASHG) 2014 Annual Meeting in San Diego. By studying specific proteins that contribute to such conditions – and the genes that encode them – scientists can develop new drugs that directly target the metabolic processes that do ...

Improving household electricity access in India over the last 30 years contributed only marginally to the nation's total carbon emissions growth during that time, according to a new study published in the journal Nature Climate Change. "Energy access is fundamental to development: it brings improvements to all aspects of life, including education, communication, and health," says IIASA researcher Shonali Pachauri, who conducted the study. While increased energy access is widely agreed to be an important goal for development efforts, such as the UN Sustainable Energy ...

VIDEO: Michael Helmrath, M.D., M.S., surgical director of the Intestinal Rehabilitation Program at Cincinnati Children's Hospital Medical Center, talks about researchers successfully growing human intestinal tissue in mice. The study describes... Click here for more information. CINCINNATI --Researchers have successfully transplanted "organoids" of functioning human intestinal tissue grown from pluripotent stem cells in a lab dish into mice – creating an unprecedented ...

DNA has garnered attention for its potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, biology, and more. Researchers have been working to master the ability to coax DNA molecules to self assemble into the precise shapes and sizes needed in order to fully realize these nanotechnology dreams. For the last 20 years, scientists have tried to design large DNA crystals with precisely prescribed depth and complex features – a design quest just fulfilled by a team at Harvard's Wyss Institute ...

AMHERST, Mass. ¬– The claim by microbiologist Derek Lovley and colleagues at the University of Massachusetts Amherst that the microbe Geobacter produces tiny electrical wires, called microbial nanowires, has been mired in controversy for a decade, but the researchers say a new collaborative study provides stronger evidence than ever to support their claims. UMass Amherst physicists working with Lovley and colleagues report in the current issue of Nature Nanotechnology that they've used a new imaging technique, electrostatic force microscopy (EFM), to resolve ...

Berlin, 19th October 2014 What's in a name? Doctors have found that the name of the drug you are prescribed significantly influences how the patient sees the treatment. Now in a significant shift, the world's major psychiatry organisations are proposing to completely change the terminology of the drugs used in mental disorders shifting it from symptom based (e.g. antidepressant, antipsychotic etc.) to pharmacologically based (e.g. focusing on pharmacological target (serotonin, dopamine etc.) and the relevant mode of action). This will mean that patient will no longer have ...

Scientists at The University of Manchester hope a major breakthrough could lead to more effective methods for detoxifying dangerous pollutants like PCBs and dioxins. The result is a culmination of 15 years of research and has been published in Nature. It details how certain organisms manage to lower the toxicity of pollutants. The team at the Manchester Institute of Biotechnology were investigating how some natural organisms manage to lower the level of toxicity and shorten the life span of several notorious pollutants. Professor David Leys explains the research: ...

Kansas City, MO - While megakaryocytes are best known for producing platelets that heal wounds, these "mega" cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. In fact, hematopoietic stem cells differentiate to generate megakaryocytes in bone marrow. The Stowers study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes). The findings from the lab Stowers Investigator Linheng Li, Ph.D., described ...

At least 2 percent of people over age 40 and 5 percent of people over 70 have mutations linked to leukemia and lymphoma in their blood cells, according to new research at Washington University School of Medicine in St. Louis. Mutations in the body's cells randomly accumulate as part of the aging process, and most are harmless. For some people, genetic changes in blood cells can develop in genes that play roles in initiating leukemia and lymphoma even though such people don't have the blood cancers, the scientists report Oct. 19 in Nature Medicine. The findings, based ...

CHICAGO – Oct. 19, 2014 – The first tear duct implant developed to treat inflammation and pain following cataract surgery has been shown to be a reliable alternative to medicated eye drops, which are the current standard of care, according to a study presented today at AAO 2014, the 118th annual meeting of the American Academy of Ophthalmology. The device, known as a punctum plug, automatically delivers the correct amount of postoperative medication in patients, potentially solving the issue of poor compliance with self-administering eye drops. After cataract ...

BETHESDA, MD – A child's genetic makeup may contribute to his or her mother's risk of rheumatoid arthritis, possibly explaining why women are at higher risk of developing the disease than men. This research will be presented Tuesday, October 21, at the American Society of Human Genetics (ASHG) 2014 Annual Meeting in San Diego. Rheumatoid arthritis, a painful inflammatory condition that primarily affects the joints, has been tied to a variety of genetic and environmental factors, including lifestyle factors and previous infections. Women are three times more likely ...

BETHESDA, MD – Scientists studying birth defects in humans and purebred dogs have identified an association between cleft lip and cleft palate – conditions that occur when the lip and mouth fail to form properly during pregnancy – and a mutation in the ADAMTS20 gene. Their findings were presented today at the American Society of Human Genetics (ASHG) 2014 Annual Meeting in San Diego. "These results have potential implications for both human and animal health, by improving our understanding of what causes these birth defects in both species," said Zena ...

Geneva, Switzerland – 19 October 2014: Women are more likely to develop anxiety and depression after a heart attack (myocardial infarction; MI) than men, according to research presented at Acute Cardiovascular Care 2014 by Professor Pranas Serpytis from Lithuania. Acute Cardiovascular Care is the annual meeting of the Acute Cardiovascular Care Association (ACCA) of the European Society of Cardiology (ESC) and takes place 18-20 October in Geneva, Switzerland. Professor Serpytis said: "The World Health Organization predicts that by 2020 depression will be the second ...

BETHESDA, MD – Human geneticists have discovered that a region of the genome associated with autism contains genetic variation that evolved in the last 250,000 years, after the divergence of humans from ancient hominids, and likely plays an important role in disease. Their findings were presented today at the American Society of Human Genetics (ASHG) 2014 Annual Meeting in San Diego. Researchers at the University of Washington analyzed the genomes of 2,551 humans, 86 apes, one Neanderthal, and one Denisovan. They closely examined a region of human chromosome 16 ...

Berlin, 19th October 2014 All humans have a natural opioid system in the brain. Now new research, presented at the ECNP Congress in Berlin, has found that the opioid system of pathological gamblers responds differently to those of normal healthy volunteers. The work was carried out by a group of UK researchers from London and Cambridge, and was funded by the Medical Research Council. This work is being presented at the European College of Neuropsychopharmacology congress in Berlin. Gambling is a widespread behaviour with about 70% of the British population gambling occasionally. ...

Berlin, 19th October 2014 Psychological stress and stress-related psychiatric disorders are associated with increased risk for aging-related diseases, but the molecular mechanisms underlying this relation are unknown. Understanding these mechanisms may contribute to the development of targeted preventive strategies and new or improved treatments for these devastating diseases. This work is presented at the European College of Neuropsychopharmacology congress in Berlin. Now an international group of researchers from Germany and the US has found that both ageing and depression ...

Berlin 19th October New research shows that the season you are born has a significant impact on your risk of developing mood disorders. People born at certain times of year may have a greater chance of developing certain types of affective temperaments, which in turn can lead to mood disorders (affective disorders). This work is being presented at the European College of CNP Congress in Berlin. Seasons of birth have traditionally been associated with certain personality traits, such as novelty seeking, and various folklore justifications, such as astrology, have sought ...

Audrey Lapidus adored her baby's sunny smile and irresistible dimples, but grew worried when Calvin did not roll over or crawl by 10 months and suffered chronic digestive problems. Four neurologists dismissed his symptoms and a battery of tests proved inconclusive. Desperate for answers, Audrey and her husband agreed to have their son become UCLA's first patient to undergo a powerful new test called exome sequencing. Using DNA collected from Calvin's and his parents' blood, a sophisticated sequencing machine rapidly scanned the boy's genome, compared it to his parents' ...

HOUSTON -- (Oct. 18, 2014) – Approximately one-fourth of the 3,386 patients whose DNA was submitted for clinical whole exome testing received a diagnosis related to a known genetic disease, often ending a long search for answers for them and their parents, said researchers from the Baylor College of Medicine departments of molecular and human genetics and pediatrics and the Baylor Human Genome Sequencing Center and the University of Texas Health Science Center at Houston. In an online report in the Journal of the American Medical Association, the scientists led ...

Among a group of 2,000 patients referred for evaluation of suspected genetic conditions, whole-exome sequencing provided a potential molecular diagnosis for 25 percent, including detection of a number of rare genetic events and new mutations contributing to disease, according to a study appearing in JAMA. The study is being released to coincide with the American Society of Human Genetics annual meeting. Whole-exome sequencing analyzes the exons or coding regions of thousands of genes simultaneously using next-generation sequencing techniques. By sequencing the exome of ...

In a sample of patients with undiagnosed, suspected genetic conditions, a certain type of exome sequencing method was associated with a higher molecular diagnostic yield than traditional molecular diagnostic methods, according to a study appearing in JAMA. The study is being released to coincide with the American Society of Human Genetics annual meeting. Exome sequencing, which sequences the protein­coding region of the genome (the complete set of genes or genetic material present in a cell or organism), has been rapidly applied in research settings and recent increases ...

CHICAGO – Oct. 18, 2014 – A thin ring inserted into the eye could soon offer a reading glasses-free remedy for presbyopia, the blurriness in near vision experienced by many people over the age of 40, according to a study released today at AAO 2014, the 118th annual meeting of the American Academy of Ophthalmology. A corneal inlay device currently undergoing clinical review in the United States improved near vision well enough for 80 percent of the participating patients to read a newspaper without disturbing far distance vision needed for daily activities like ...

CHICAGO – Oct. 18, 2014 – Smartphone technology is a widely available resource which may also be a portable and effective tool for imaging the inside of the eye, according to results of a study released today at AAO 2014, the 118th annual meeting of the American Academy of Ophthalmology. Researchers from the Ross Eye Institute at the University at Buffalo-SUNY are successfully using an iPhone® application as an inexpensive, portable and effective tool for imaging the inside of the eye, including in patients who are challenging to photograph by traditional ...

Geneva, Switzerland – 18 October 2014: Vitamin D deficiency increases the risk of poor brain function after sudden cardiac arrest by seven-fold, according to research presented at Acute Cardiovascular Care 2014 by Dr Jin Wi from Korea. Vitamin D deficiency also led to a higher chance of dying after sudden cardiac arrest. Acute Cardiovascular Care is the annual meeting of the Acute Cardiovascular Care Association (ACCA) of the European Society of Cardiology (ESC) and takes place 18-20 October in Geneva, Switzerland. Dr Wi said: "In patients resuscitated after sudden ...

A new study published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that children who have been infected with enterovirus are 48% more likely to have developed type 1 diabetes. The study is by Dr Tsai Chung-Li, China Medical University, Taiwan, and colleagues. "Type 1 diabetes is considered to be caused by complex interaction between genetic susceptibility, the immune system, and environmental factors," say the authors. "Though the cue for genetic predisposition has been elucidated, evidence also points to involvement of enterovirus ...