A multi-institutional team of researchers has pinpointed exactly what goes wrong when chronic lymphocytic leukemia (CLL) patients develop resistance to ibrutinib, a highly effective, precisely targeted anti-cancer drug. In a correspondence published online May 28 in the New England Journal of Medicine, they show how the mutation triggers resistance. Their finding could guide development of new agents to treat drug-resistant disease. Ibrutinib received accelerated approval from the Food and Drug Administration for use in chronic lymphocytic leukemia in February. It has ...

MINNEAPOLIS – People with high levels of cynical distrust may be more likely to develop dementia, according to a study published in the May 28, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology. Cynical distrust, which is defined as the belief that others are mainly motivated by selfish concerns, has been associated with other health problems, such as heart disease. This is the first study to look at the relationship between cynicism and dementia. "These results add to the evidence that people's view on life and personality ...

Screening for lung cancer leads to early detection and treatment, but can it also make people stop smoking before they get cancer? The answer is that it depends on the seriousness of the results, according to a study published May 28 in the JNCI: Journal of the National Cancer Institute. To determine if there is an association between type of screening result and smoking cessation, Martin C. Tammemagi of the Department of Health Sciences, Brock University in St. Catharines, Ontario, Canada, and colleagues used data from the Lung Screening Study component of the US ...

People sometimes use indoor tanning in the belief that this will prevent burns when they tan outdoors. However, indoor tanning raises the risk of developing melanoma even if a person has never had burns from either indoor or outdoor tanning, according to a study published May 29 in the JNCI: Journal of the National Cancer Institute. To test the hypothesis that indoor tanning without burns prevents sunburn and subsequent skin cancer, researchers at the Masonic Cancer Center, Department of Dermatology, and Division of Epidemiology and Community Health, University of ...

If you've just received a coronary artery stent to prop open a blood vessel, your life may depend on filling your prescription and taking an anti-clotting drug within days of leaving the hospital, according to a large study in the Journal of the American Heart Association. The risk of heart attack and death is highest within the first 30 days for those who delay taking their medication than during long-term follow-up out to two years. Taking the drug clopidogrel plus aspirin is advised for a month in people who have a bare metal stent implanted, and six to 12 months ...

In a finding that runs counter to most health disparities research, Johns Hopkins researchers say that while younger black trauma patients are significantly more likely than whites to die from their injuries, black trauma patients over the age of 65 are 20 percent less likely to do so. A report on the research appears online May 28 in JAMA Surgery. "We have long found it vexing that minority patients consistently do worse, even in treatment for trauma that seems to leave little room for bias," says study leader Adil Haider, M.D., M.P.H., an associate professor of surgery ...

Bottom Line: Heroin users nowadays are predominantly white men and women in their late 20s living outside large urban areas who were first introduced to opioids through prescription drugs compared to the 1960s when heroin users tended to be young urban men whose opioid abuse started with heroin. Authors: Theodore J. Cicero, Ph.D., of Washington University, St. Louis, and colleagues. Background: Few studies on the demographics of present day heroin users have compared them to heroin users 40 to 50 years ago who were primarily young men from minority groups living ...

Bottom Line: Other than aging, risk factors for sagging eyelids include being a man, having lighter skin color and having a higher body mass index (BMI). Author: Leonie C. Jacobs, M.D., Erasmus Medical Center, Rotterdam, the Netherlands, and colleagues. Background: Sagging eyelids because of excess skin (dermatochalasis) is typically seen in middle-age or older adults. Typically a cosmetic concern, sagging eyelids also can cause visual field loss, irritation and headaches because patients force themselves to elevate their brow in order to see better. How ...

Bottom Line: Race and age affect trauma outcomes in older and younger patients. Author: Caitlin W. Hicks, M.D., M.S., of the Johns Hopkins School of Medicine, Baltimore. Background: Disparities in survival after traumatic injury among minority and uninsured patients has been well described for younger patients. But information is lacking on the effect of race on trauma outcomes for older patients. How the Study Was Conducted: The authors examined in-hospital mortality after trauma for black and white patients between the ages of 16 and 64 years and 65 ...

A nationwide survey indicates that heroin users are attracted to the drug not only for the "high" but because it is less expensive and easier to get than prescription painkillers. Researchers at Washington University School of Medicine in St. Louis published the survey's results May 28 in the journal JAMA Psychiatry. "In the past, heroin was a drug that introduced people to narcotics," said principal investigator Theodore J. Cicero, PhD. "But what we're seeing now is that most people using heroin begin with prescription painkillers such as OxyContin, Percocet or Vicodin, ...

The brains of children with gender dysphoria react to androstadienone, a musky-smelling steroid produced by men, in a way typical of their biological sex, but after puberty according to their experienced gender, finds a study for the first time in the open-access journal Frontiers in Endocrinology. Around puberty, the testes of men start to produce androstadienone, a breakdown product of testosterone. Men release it in their sweat, especially from the armpits. Its only known function is to work like a pheromone: when women smell androstadienone, their mood tends to improve, ...

(NEW YORK – May 28) Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment for clinical trials, and treatment decision-making. Researchers at Icahn School of Medicine at Mount Sinai, part of the International Committee on Clinical Trials of MS, collaborated to re-examine the standardized MS clinical course descriptions originally published in 1996 and recommend refined phenotype descriptions that include improved clinical descriptive terminology, MRI and other imaging techniques, ...

Researchers with NASA's Operation IceBridge have completed another successful Arctic field campaign. On May 23, NASA's P-3 research aircraft left Thule Air Base, Greenland, and returned to Wallops Flight Facility in Virginia marking the end of 11 weeks of polar research. During this campaign, researchers collected data on Arctic sea and land ice – both repeating measurements on rapidly changing areas and expanding coverage into new, unsurveyed regions. The mission also released two sea ice data products and provided a professional development opportunity for three science ...

DALLAS – May 28, 2014 – UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer. The protein, Aiolos, is produced by normal blood cells but commits a kind of "identity theft" of blood cells when expressed by cancer cells, allowing the latter to metastasize, or spread, to other parts of the body. Metastatic cancer cells have the ability to break free from ...

Clinical guidelines conflict on testing teens and adults whose symptoms point to a possible strep throat. A chief contention is whether negative tests results from a rapid analysis of a throat swab, done in a doctor's office, should be confirmed through a follow-up laboratory culture. The rapid test detects certain antigens, one of the body's efforts to fight off strep bacteria. Attempting to grow bacteria from a throat specimen double checks for the presence or absence of Group A Streptococcus bacteria, as well as a few other bacterial infections. A study published ...

PITTSBURGH—Keeping your friends close and your enemies closer may not be the best advice if you are 50 or older. New research from Carnegie Mellon University's Rodlescia Sneed and Sheldon Cohen shows that unpleasant or demanding interpersonal encounters increase hypertension risk among older adults. Published in the American Psychological Association's journal Health Psychology, the study provides some of the first concrete evidence that negative social interactions not only influence psychological well-being but also physical health – in this case, blood pressure ...

Sequenta, Inc. today announced publication of a study done in collaboration with researchers from UCSF and UCLA that used the company's proprietary LymphoSIGHT™ immune repertoire sequencing platform to investigate the effects of anti-CTLA-4 antibody on the number and types of T cells present in a patient's blood. The results, which appear in the May 28 issue of Science Translational Medicine, shed light on the mechanism of action of this type of cancer immunotherapy and suggest that immune repertoire sequencing could be used to predict which patients will have improved ...

Indiana University researchers put male rats to the test to determine the role amphetamines play when used in conjunction with exercise. When people or animals exercise in the heat, exhaustion is a safety gauge telling the body it is time to stop. Exhaustion occurs when the body's core temperature reaches a potentially dangerous point. The use of amphetamines is banned in many sports because they increase time to exhaustion. What they found: Amphetamines can delay exhaustion during exercise in the heat by increasing the temperature at which it occurs. This potentially ...

A Harvard-led team is the first to demonstrate the ability to use low-power light to trigger stem cells inside the body to regenerate tissue, an advance they reported in Science Translational Medicine. The research, led by Wyss Institute Core Faculty member David Mooney, Ph.D., lays the foundation for a host of clinical applications in restorative dentistry and regenerative medicine more broadly, such as wound healing, bone regeneration, and more. The team used a low-power laser to trigger human dental stem cells to form dentin, the hard tissue that is similar to bone ...

Alexandria, Va. — When author John-Manuel Andriote returned to his hometown in New England after years away, he noticed something that had been invisible to him while growing up there — the old stone walls tumbling off into the forests. The realization that the crumbling and overgrown walls meant those forests had once been cleared farm lands set Andriote on a years-long journey of discovery that highlights the intersections of geologic and human history. The story of New England's stone walls begins with the glaciers of the last ice age, meanders through the Colonial ...

SAN FRANCISCO – May 28, 2014 – There may be a connection between taking vasodilators and developing early-stage age-related macular degeneration (AMD), the leading cause of vision loss and blindness among Americans who are age 65 and older, according to a study published online in Ophthalmology, the journal of the American Academy of Ophthalmology. AMD – the deterioration of the eye's macula, which is responsible for the ability to see fine details clearly – affects an estimated 11 million people in the United States. In addition to increased age, the cause of AMD ...

Viewed as one of the most unfortunate outcomes of breast cancer treatment, lymphedema is characterized by an accumulation of lymph fluid in the interstitial spaces of the affected limb, leading to chronic ipsilateral limb swelling causing psychosocial distress and physical challenges for patients. Even conservative estimates suggest that 3% of women who have had sentinel lymph node biopsy and 20% of those who have had axillary lymph node dissection may develop lymphedema a year after breast cancer surgery. Two established risk factors for lymphedema are compromised ...

A treatment for dry eye—a burning, gritty condition that can impair vision and damage the cornea—could some day result from computer simulations that map the way tears move across the surface of the eye. Kara Maki, assistant professor in Rochester Institute of Technology's School of Mathematical Sciences, contributed to a recent National Science Foundation study seeking to understand the basic motion of tear film traversing the eye. "Tear Film Dynamic with Evaporation, Wetting and Time Dependent Flux boundary Condition on an Eye-shaped Domain," published in the journal ...

The first evidence for massive and abrupt iceberg calving in Antarctica, dating back 19,000 to 9,000 years ago, has now been documented by an international team of geologists and climate scientists. Their findings are based on analysis of new, long deep sea sediment cores extracted from the region between the Falkland Islands and the Antarctic Peninsula. The study in the May 28, 2014 issue of Nature bears witness to an unstable Antarctic ice sheet that can abruptly reorganize Southern Hemisphere climate and cause rapid global sea level rise. "One of the iceberg events ...

By cataloging over 18,000 proteins, researchers from TUM have produced an almost complete inventory of the human proteome. This information is now freely available in the ProteomicsDB database, which is a joint development of TUM and software company SAP. The database includes information for example on the types, distribution, and abundance of proteins in various cells and tissues as well as in body fluids. The investigations show that, on the one hand, around 10,000 proteins are concerned with housekeeping processes in many different places. On the other hand, it was ...