CAMBRIDGE, MA -- A new study from MIT neuroscientists reveals how rare variants of a gene called ABCA7 may contribute to the development of Alzheimer’s in some of the people who carry it. Dysfunctional versions of the ABCA7 gene, which are found in a very small proportion of the population, contribute strongly to Alzheimer’s risk. In the new study, the researchers discovered that these mutations can disrupt the metabolism of lipids that play an important role in cell membranes.  This disruption makes neurons hyperexcitable and ...

About The Study: In this retrospective cohort study of pediatric in-hospital cardiac arrest in a large, national, administrative dataset, children of racial and ethnic minority groups receiving cardiopulmonary resuscitation (CPR) had higher odds of in-hospital mortality. In addition, the odds of in-hospital mortality among children receiving CPR were higher at hospitals with the highest proportion of Black patients. Corresponding Author: To contact the corresponding author, Amanda J. O’Halloran, MD, MSHP, email ohallorana@chop.edu. To access the embargoed study: Visit our For The Media website at this ...

About The Study: This trial found that a 12-week high-intensity interval training intervention did not improve hippocampal integrity or associated cognitive or mental health impairments while people continued to consume cannabis. However, results indicated that people with cannabis use disorder can engage in regular physical exercise programs and highlighted exercise as a potential strategy to reduce cannabis craving.  Corresponding Author: To contact the corresponding author, Murat Yücel, PhD, email murat.yucel@qimrb.edu.au. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2025.2319) Editor’s ...

NEW YORK — It’s natural to crave sugar when you feel tired and want a boost of energy. Now scientists at Columbia University’s Zuckerman Institute have linked a brain area in mice to the drive to consume not just sweets, but fats, salt and food. The findings show this area serves as a kind of dial that can amplify or repress consumption.  This discovery, detailed today in Cell, may inform novel treatments for both overeating and undereating. For instance, the results suggest that finding ways to modulate this brain circuit may help treat people suffering from the severe loss of appetite and muscle wasting often seen in large numbers of chemotherapy patients. “The ...

New York, NY [September 10, 2025]—Lung tumors don’t just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature [10.1038/s41586-025-09493-y] that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy. Immunotherapies, which rally the body’s defenses against cancer, have transformed care for many ...

Most of the Earth’s fresh water is locked in the ice that covers Antarctica. As the ocean and atmosphere grow warmer, that ice is melting at a startling pace with sea levels and global currents changing in response. To understand the potential implications, researchers need to know just how fast the ice is disappearing, and what is driving it back. The West Antarctic ice sheet, an unstable expanse bordering the Amundsen Sea, is one of the greatest sources of uncertainty in climate projections. Records indicate that it has been steadily shrinking since the 1940s, but key details are missing. Using environmental data gathered from ice samples, tree rings and corals, ...

EMBARGOED UNTIL 8AM PACIFIC TIME/11AM EASTERN TIME, SEPTEMBER 10   On September 14, 2015, a signal arrived on Earth, carrying information about a pair of remote black holes that had spiraled together and merged. The signal had traveled about 1.3 billion years to reach us at the speed of light—but it was not made of light. It was a different kind of signal: a quivering of space-time called gravitational waves, first predicted by Albert Einstein 100 years prior. On that day 10 years ago, the twin detectors of the Laser Interferometer Gravitational-Wave Observatory ...

A new study co-authored by Texas A&M University geologist Dr. Michael Tice has revealed potential chemical signatures of ancient Martian microbial life in rocks examined by NASA’s Perseverance rover. The findings, published by a large international team of scientists, focus on a region of Jezero Crater known as the Bright Angel formation — a name chosen from locations in Grand Canyon National Park because of the light-colored Martian rocks. This area in Mars’ Neretva Vallis channel contains fine-grained mudstones rich in oxidized iron (rust), phosphorus, sulfur and ...

Vision happens when patterns of light entering the eye are converted into reliable patterns of brain activity. This reliability allows the brain to recognize the same object each time it is seen. Our brains, however, are not born with this ability; instead, we develop it through visual experience. Collaborating scientists at MPFI and the Frankfurt Institute for Advanced Studies have recently discovered key circuit changes that lead to the maturation of reliable brain activity patterns. Their findings, published in Neuron this week, are likely generalizable beyond vision, providing a ...

Researchers have uncovered a surprising role for electricity in keeping our body’s protective cell layers healthy. Cells bumping against one another use electricity to identify which of their neighbours has the least energy to kill them. The King’s College London study in partnership with the Francis Crick Institute provides insight into diseases including cancer and stroke, where cellular energy levels can be disrupted, preventing the maintenance of healthy cell numbers. Epithelial cells, which line all organs in the body, turnover rapidly to maintain a tightly packed protective layer. They undergo a process called ‘extrusion’ ...

WASHINGTON — Researchers have developed a motion-compensation method that allows single-pixel imaging to capture sharp images of complex dynamic scenes. The new approach could expand the practical utility of this computational imaging method by enabling clearer images of moving targets and improving the quality of surveillance images. Single-pixel imaging uses a single detector, rather than the traditional array of pixels, to acquire images. Although it offers several advantages, such as high sensitivity ...

Canadian Science Publishing (CSP) is pleased to announce that the Journal of Psychiatry and Neuroscience (JPN) is now officially part of our journal portfolio, following the completed acquisition from CMA Impact Inc. on September 2, 2025.  This marks a significant milestone for CSP, as JPN becomes the 23rd journal in our portfolio and our first in the fields of psychiatry and neuroscience. As the official journal of the Canadian College of Neuropsychopharmacology, JPN holds a leading position in its ...

As attention turns to this year’s New York City Marathon, observers will again ask a long-standing question: What do athletes draw upon when trying to complete this 26.2-mile run, especially at those stretches when finishing seems impossible?  Many might think that when fatigue sets in, the key to perseverance is reminding oneself why the effort is worth it or focusing on reasons why they set the goal—intuition that lines up with motivational posters, sports psychology clichés, and coaching advice. ...

URBANA, Ill. — Scientists from the University of Illinois Urbana-Champaign have developed a method to isolate genes from amounts of microbial DNA so tiny that it would take 20,000 samples to weigh as much as a single grain of sugar. In a new paper, the researchers discovered previously unknown antibiotic resistance genes in bacterial DNA isolated from human stool and from fish tanks at Chicago’s Shedd Aquarium. “With antibiotic resistance on the rise, it’s more important than ever to understand the full diversity of mechanisms bacteria may ...

PLYMOUTH MEETING, PA [September 10, 2025] — New research published in the September 2025 issue of JNCCN—Journal of the National Comprehensive Cancer Network validates the use of a specifically-curated tool for determining which medications may be causing harm for older patients with cancer. Researchers affiliated with the Veterans Affairs (VA) Healthcare System in Boston evaluated a tool based on information from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Older Adult Oncology, called the “Geriatric ...

Washington, September 10, 2025—State school finance reforms designed to close funding gaps between high- and low-income districts did not reduce racial and ethnic funding inequities and in some cases increased them, according to new research. As school desegregation efforts slowed in the decades following the 1980s, these findings highlight the limitations of income-based approaches in addressing racial funding disparities in education. The study, by Emily Rauscher of Brown University and Jeremy E. Fiel of Rice ...

WASHINGTON—The Endocrine Society today announced it has chosen 12 leading endocrinologists as winners of its prestigious 2026 Laureate Awards, the top honors in the field.    Endocrinologists are scientists and medical doctors who specialize in unraveling the mysteries of hormone disorders to care for patients and treat diseases. These professionals have achieved breakthroughs in scientific discoveries and clinical care benefiting people with hundreds of conditions, including diabetes, thyroid disorders, obesity, hormone-related cancers, growth problems, osteoporosis and infertility.    Established in 1944, the Society’s ...

Endometrial cancer is a major gynecologic malignancy, with HGEC comprising aggressive variants such as Grade 3 endometrioid, serous, clear cell, undifferentiated/dedifferentiated carcinomas, carcinosarcoma, and mesonephric-like adenocarcinoma. These tumors are characterized by poor prognosis and resistance to conventional therapies. The limitations of traditional histopathological diagnosis underscore the need for molecular refinement to guide clinical management. Histopathological Subtypes of HGEC FIGO Grade 3 Endometrioid Carcinoma (HG-EEC): Characterized ...

AMHERST, Mass. — Physicists have long believed that black holes explode at the end of their lives, and that such explosions happen—at most—only once every 100,000 years. But new research published in Physical Review Letters by physicists at the University of Massachusetts Amherst has found a more than 90% probability that one of these black-hole explosions might be seen within the decade, and that, if we are prepared, our current fleet of space and earthbound telescopes could witness the event. Such an explosion would be strong evidence of a theorized but never observed kind of black hole, called a “primordial black hole,” ...

The university stage, particularly its beginning, is a time of tension and emotional stress for young students—many of whom are under the age of 20. This is a group in which suicidal ideation has increased significantly in recent years, surpassing the general population. Now, a study led by the Hospital del Mar Research Institute has quantified the prevalence of suicidal thoughts among university students and identified the main associated risk factors. The study, part of the World Mental Health International College Student Initiative (WMH-ICS) led by Harvard University in the United States, ...

University of Virginia School of Medicine researchers have received a $2.3 million grant from the U.S. Department of Defense to test whether a cutting-edge magnetic resonance imaging (MRI) scanner can identify now-undetectable brain injuries in soldiers exposed to blasts. Previous research studies have shown blast exposures may create distinct brain scarring caused by nervous system cells called astrocytes, said James R. Stone, MD, PhD, the UVA Health radiologist leading the research team. However, this scarring can only be seen after a patient’s ...

For patients who have mobility impairments or other conditions that require inpatient rehabilitation, Mount Sinai Health System has opened a new, modern, high-tech facility at Mount Sinai Morningside on the West Side of Manhattan at 1111 Amsterdam Avenue (at 114th Street). All inpatient services formerly housed at The Mount Sinai Hospital on the East Side have relocated to this newly renovated space with enhanced equipment and technology, still called the Mount Sinai Rehabilitation Center. It aims to enhance care to patients with a wide range of rehabilitative needs, including brain and spinal cord injuries, stroke, ...

Washington, D.C.:  Today, Breakthrough Discoveries for thriving with Bipolar Disorder (BD²) announced the opening of a fourth round of funding opportunities for the Discovery Research program. BD² invites scientists across all disciplines to apply for up to $4.5 million per grant. Successful teams will undertake groundbreaking research into the genetic, molecular, cellular, circuit, and behavioral mechanisms of bipolar disorder, especially applications that address the following: Cellular and molecular mechanisms of mood-state switching; Biological ...

Household waste constitutes 30–40% of municipal solid waste globally. Separating waste at the household level into compostable, recyclable, and non-recyclable is a crucial first step for local governments to process solid waste effectively. However, large gaps between a person’s willingness to separate waste and actually separating waste have been seen across the world. Understanding the factors that affect people’s intention and behavior of separating household waste can help create more effective policies regarding household-level waste separation.   However, ...

Flexible pressure sensors can detect subtle mechanical stimuli, making them suitable for use in wearable sensors for human health monitoring and motion analysis. However, current sensors suffer from insufficient sensitivity, poor durability, and subpar stability. In a new study, taking inspiration from cat whiskers, researchers developed novel biomass fiber/sodium alginate aerogel (BFA)-based sensors that demonstrated excellent pressure sensitivity, durability, and rapid response, while being suitable for human physiological monitoring and motion analysis. The rapid development of wearable electronic sensors for use in health monitoring, ...