A diverse team of scientists from UCLA's Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread. The study, led by Dr. Caius Radu, an associate professor of molecular and medical pharmacology at UCLA, and Dr. David Nathanson, an assistant professor of molecular and medical pharmacology, was published in the Journal of Experimental Medicine. Elements ...

Researchers at the Buck Institute have identified and categorized thousands of protein interactions involving huntingtin, the protein responsible for Huntington's disease (HD). To use an analogy of a human social network, the identified proteins are like "friends" and "friends of friends" of the HD protein. The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility. HD is an incurable, fatal, inherited neurological disorder that causes severe degeneration ...

Everyone knows a basketball player is more likely to miss a three-point shot if a defender is in his face, but a new automated method for analyzing team formations, created by Disney Research Pittsburgh, shows how players get open for a shot: via defensive role swaps. "To an expert, this makes obvious sense – if a defensive player has to move, the space where they moved from is suddenly open and, if their teammate doesn't cover that space quickly, it creates a potential open shot for the offense," said Patrick Lucey, a Disney researcher who specializes in measuring the ...

An automated analysis by Disney Research Pittsburgh of team formations used during an entire season of professional soccer provides further evidence that visiting teams are less successful than home teams because they play conservatively, not because of a mythical home advantage. The researchers, employing the first automated method for detecting formations, analyzed a whole season of player and ball tracking data compiled by Prozone for a top-tier professional soccer league. They found that teams usually played the same formations for both home and away games, but that ...

The question of why an individual would actively kill itself has been an evolutionary mystery. Death could hardly provide a fitness advantage to the dying individual. However, a new study has found that in single-celled algae, suicide benefits the organism's relatives. "Death can be altruistic – we showed that before – but now we know that programmed cell death benefits the organism's relatives and not just anybody," says Dr Pierre Durand from the Department of Molecular Medicine and Haematology and the Sydney Brenner Institute for Molecular Bioscience (SBIMB) at Wits ...

Despite widespread use of a single term, Alzheimer's disease is actually a diverse collection of diseases, symptoms and pathological changes. What's happening in the brain often varies widely from patient to patient, and a trigger for one person may be harmless is another. In a unique study, an international team of researchers led by USC psychologist Margaret Gatz compared the brains of twins where one or both died of Alzheimer's disease. They found that many of the twin pairs not only had similar progressions of Alzheimer's disease and dementia prior to death, but they ...

A bright supernova discovered only six weeks ago in a nearby galaxy is provoking new questions about the exploding stars that scientists use as their main yardstick for measuring the universe. Called SN 2014J, the glowing supernova was discovered by a professor and his students in the United Kingdom on Jan. 21, about a week after the stellar explosion first became visible as a pinprick of light in its galaxy, M82, 11.4 million light years away. Still visible today through small telescopes in the Big Dipper, it is the brightest supernova seen from Earth since SN1987A, ...

An international team of researchers led by an endocrinologist at Ludwig-Maximilians-Universitaet (LMU) in Munich has identified genetic mutations that result in uncontrolled synthesis and secretion of the stress hormone cortisol. Cortisol is a hormone that is produced by the adrenal gland in response to stressful events, and modulates a whole spectrum of physiological processes. An international research collaboration has now identified genetic mutations that lead to the production and secretion of cortisol in the absence of an underlying stressor. The discovery emerged ...

It might seem too good to be true, but dark chocolate is good for you and scientists now know why. Dark chocolate helps restore flexibility to arteries while also preventing white blood cells from sticking to the walls of blood vessels. Both arterial stiffness and white blood cell adhesion are known factors that play a significant role in atherosclerosis. What's more, the scientists also found that increasing the flavanol content of dark chocolate did not change this effect. This discovery was published in the March 2014 issue of The FASEB Journal. "We provide a more ...

Over the last ten years, a number of studies have suggested that, in animal cells, translation and protein turnover play a larger role in determining the different levels at which proteins are expressed than transcription. The major evidence supporting these claims is a weak correlation between system-wide protein and mRNA abundance measurements. A highly cited Nature article by Schwanhausser et al. in 2011 provides the most comprehensive example of such analyses. A new study just published in PeerJ by Li et al., however, questions the conclusions of these papers. This ...

CINCINNATI—Cincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body's immune system, could initiate the immune response to fight cancer. These findings, published in the Feb. 27 online edition of the journal Gene Therapy, build on previously reported research and could lead to new treatments for cancer. Principal Investigator John Morris, MD, clinical co-leader of the Molecular Therapeutics and Diagnosis Program for ...

The Dust Devils Microgravity Research Team of Arizona State University has been accepted to this year's Microgravity University run by the National Aeronautics and Space Administration (NASA). The proposal consisted of an astrophysics experiment testing the first seconds of galaxy formation. ASU's Microgravity Research Team will be heading to Texas's Ellington Field, part of Johnson Space Center, in April to test their experiment on the modified Boeing 727-200, a plane that creates near-weightlessness during the flight. The astrophysics experiment being tested tries ...

The past decade has been a time of great upheaval for the publishing industry, with the major publishers' stranglehold over the book world being wrested away by independent authors seeking more creative control over their work. But it is no easy thing for an author to challenge these corporate Goliaths; funding their projects alone can seem an insurmountable task. For one independent author, the $7,500.00 needed to bring his novel to life would be impossible alone. However, thanks to the relatively new phenomenon of crowdfunding, Paul Combs, author of the novel "The ...

Blair, Bohle & Whitsitt, PLLC (BBW) announces a major expansion of its current operations through an agreement to merge with Austin and Falls, CPAs effective January 1, 2014. The combined firm will offer an enhanced mix of tax compliance, assurance, and advisory services to individuals and the business community in Charlotte and the counties surrounding it. The merger will expand BBW's pre-merger annual revenue by approximately 25%, but will continue to focus on individuals and businesses seeking client-centered services from an experienced team of trusted advisors. ...

Today, Fit Armadillo, a fitness company specializing in online exercise options, announced the start of their newest group fitness program: Run Away from Winter, Get 5K Fit.  Since starting online group fitness programs last year, Fit Armadillo has run several 8 week programs to help busy individuals tone up without a gym membership. The Run Away from Winter, Get 5K Fit program will have the same goal, but with the added excitement that comes from training for a specific event.  With a March 31st start date, this group session allows beginning runners the ability to kick ...

Prudential, a leading UK pensions provider, has selected Anaplan's integrated sales, operations and finance business modeling and planning platform to underpin improvements to its bonus modeling process. Anaplan's real-time modeling and calculation capabilities will enable Prudential to significantly shorten the end-to-end process for bonus calculation and payment across its UK Intermediary Channel. Prudential is implementing an uncluttered, streamlined system that will be the backbone of the bonus process. "By switching to Anaplan's platform, which allows us to ...

IOMIC USA, manufacturer of innovative, revolutionary and dynamically designed grips, announced today that IOMIC grips were used by pro staff member and third place finisher, Catriona Matthew, the second place finisher, and one other top-5 finisher at the Honda LPGA Thailand. According to Katz Murai, General Manager, IOMIC USA, "Our great feeling, colorful grips have been extremely popular on the LPGA Tour and it is always exciting to watch so many professionals play well with our grips. The three top-5 finishers were all using IOMIC grips in a variety of bold colors. ...

According to the Trillium Gift of Life Network Website, Canada still faces a greater need for organs and tissue than the number of them available for transplantation. Why this might be will be open for discussion on March 16 in Classroom B of the Juravinski Innovation Tower at St. Joseph's Healthcare Hamilton, 50 Charlton Ave. East. Hosted by the Hamilton Chapter of the Polycystic Kidney Disease (PKD) Foundation of Canada, Ethics Researcher Michael Campbell will give a presentation starting at 2pm and he will answer questions about the ethical considerations involved ...

Canadian Web Hosting (http://www.canadianwebhosting.com), a leading provider of web hosting, cloud hosting and infrastructure as a service (IaaS) in Canada, announced today that they have begun testing several new technologies including Google Glass in two of their Canadian data centers. As a company, Canadian Web Hosting began an initiative more than 18-months ago to transform how they interact with their infrastructure, customers and internal systems. "Like everyone, we've seen so many great things happening in technology that are literally transforming our lives ...

Two raw food proponents will be among those delivering the raw truth (as they see it) at the 4th annual New York City Vegetarian Food Festival, throughout the first weekend of March in Manhattan. Steve Meyerowitz, who styles himself as the Sproutman, will speak on Saturday morning, March 1. His talk is entitled "Clean Out, Lighten Up, Feel Great." A sought-after speaker on health and raw diets, Meyerowitz is one of the world's leading proponents of juicing, fasting, wheatgrass, indoor gardening, and pure water. His books include Sprouts: the Miracle Food, ...

Tamlin Homes was presented a Georgie Award for "Best 2013 Custom Home valued between $750,000 - $1,500,000" in a Gala Event held at the Vancouver Convention Center on February 1, 2014. The nomination, finalist announcement and subsequent award was for the "Gambier". Co-owner, Chris Lynn designed the home and worked on site throughout the 8 month remote access project. The judging panel comprises of industry professionals from outside of B.C. who are selected based on their specific area of expertise. Potential judges are selected by their respective ...

GroundLevel Technologies (GLT), North America's leading curator of real-time promotional offers, now makes it possible for publishers of location-based services to deliver an enhanced tier of local merchant content to their users. Each day, millions of consumers search hundreds of publisher sites, mobile apps and navigational tools for local merchant information. These users are accustomed to finding the basics: venue name, address, phone, web link, map, customer reviews and static venue attributes. Now with GLT content, users can discover time-sensitive, verified promotional ...

NuLiv Science, a scientifically proven all natural ingredient supplier specializing in sports nutrition and health essentials, today announced that Brian Peotter will be joining NuLiv Science as the Vice President of Sales, reporting to President Michael Wang. Brian brings more than 15 years of sales experience in the ingredient industry. He will be taking over all national and worldwide sales efforts of NuLiv Science. Brian comes to NuLiv Science previously from ESM Technologies as the West Regional Sales Manager, where he managed branded ingredient sales in all ...

Vanessa Giacoman, Managing Member of Panorama Government Solutions, will share her international business expertise at The Women Inspiring Leadership Development (WILD) Summit on Friday, April 4 in Westminster, Colo. The WILD Summit is an annual event hosted by The Women's Council, in partnership with The Leeds School of Business at the University of Colorado Boulder. Giacoman will co-present in the panel session entitled, Breaking in to International Markets. Along with Marissa Perry Saints, Founder of Dsenyo and Linda Appel Lipsius, Co-founder and CEO of Teatulia Organic ...

Plan a fun night out, Ottawa - and bring your friends! Visit Dermaworks Medical Aesthetics Clinic and learn about the new Dermaworks Medical Grade Skincare products, and Dysport - a new wrinkle and line-smoothing product. On February 27th from 5-7 pm, Dr. Demetra Vassiliou is hosting an open house event to introduce her clients and the community to her new line of medical grade skin-care products. Dermaworks Medical Grade Skincare products are scent-free and refreshing to apply, with no heavy residue. Our Chief Physician, Dr. Demetra Vassiliou, has developed a highly ...