Using nanodot technology, Berkeley Lab researchers have demonstrated the first size-based form of chromatography that can be used to study the membranes of living cells. This unique physical approach to probing cellular membrane structures can reveal information critical to whether a cell lives or dies, remains normal or turns cancerous, that can't be obtained through conventional microscopy. "We've developed membrane-embedded nanodot array platforms that provide a physical means to both probe and manipulate membrane assemblies, including signaling clusters, while they ...

VIDEO: This shows regenerated auditory nerves, after gene therapy. Click here for more information. Researchers at UNSW Australia have for the first time used electrical pulses delivered from a cochlear implant to deliver gene therapy, thereby successfully regrowing auditory nerves. The research also heralds a possible new way of treating a range of neurological disorders, including Parkinson's disease, and psychiatric conditions such as depression through this novel way of delivering ...

The humble aspirin may have just added another beneficial effect beyond its ability to ameliorate headaches and reduce the risk of heart attacks: lowering colon cancer risk among people with high levels of a specific type of gene. The extraordinary finding comes from a multi-institutional team that analyzed data and other material from two long-term studies involving nearly 128,000 participants. The researchers found that individuals whose colons have high levels of a specific gene product — 15-hydroxyprostaglandin dehydrogenase (15-PGDH) RNA — dramatically reduce their ...

OAK RIDGE, Tenn., April 23, 2014 — Treating cadmium-telluride (CdTe) solar cell materials with cadmium-chloride improves their efficiency, but researchers have not fully understood why. Now, an atomic-scale examination of the thin-film solar cells led by the Department of Energy's Oak Ridge National Laboratory has answered this decades-long debate about the materials' photovoltaic efficiency increase after treatment. A research team from ORNL, the University of Toledo and DOE's National Renewable Energy Laboratory used electron microscopy and computational simulations ...

WASHINGTON D.C., April 23, 2014 -- For much of the 20th century, many of the technological innovations that drove U.S. economic growth emerged from "idea factories" housed within large companies -- research units like Bell Labs or Xerox PARC that developed everything from the transistor to the computer mouse. In recent decades, however, many large high-tech companies have eliminated in-house research programs, turning instead to startup companies as their primary source of breakthrough innovations. "Small startups have replaced corporate research centers as the drivers ...

Burning coal for domestic heating may contribute to early fetal death according to a new study by experts from The Saban Research Institute of Children's Hospital Los Angeles and Ulaanbaatar, Mongolia – the coldest capital city in the world. In a paper published today in the journal BMC Pregnancy and Childbirth, researchers report "alarmingly strong statistical correlations" between seasonal ambient air pollutants and pregnancy loss in Ulaanbaatar (UB), Mongolia. UB has one of the highest levels of air pollution of all world capitals, with sulfide dioxide and particulate ...

A fully functional quantum computer is one of the holy grails of physics. Unlike conventional computers, the quantum version uses qubits (quantum bits), which make direct use of the multiple states of quantum phenomena. When realized, a quantum computer will be millions of times more powerful at certain computations than today's supercomputers. A group of UC Santa Barbara physicists has moved one step closer to making a quantum computer a reality by demonstrating a new level of reliability in a five-qubit array. Their findings appear Thursday in the journal Nature. Quantum ...

A Michigan State University researcher is looking to give exercise enthusiasts the extra nudge they need during a workout, and her latest research shows that a cyber buddy can help. The study, which appears in the Games for Health Journal, is the first to indicate that although a human partner is still a better motivator during exercise, a software-generated partner also can be effective. "We wanted to demonstrate that something that isn't real can still motivate people to give greater effort while exercising than if they had to do it by themselves," said Deborah Feltz, ...

This news release is available in French and German. Man or woman? Male or female? In humans and other mammals, the difference between sexes depends on one single element of the genome: the Y chromosome. It is present only in males, where the two sexual chromosomes are X and Y, whereas women have two X chromosomes. Thus, the Y is ultimately responsible for all the morphological and physiological differences between males and females. But this has not always been the case. A very long time ago, the X and Y were identical, until the Y started to differentiate from the ...

April 23, 2014 – Genetic mutations are commonly studied because of links to diseases such as cancer; however, little is known about mutations occurring in healthy individuals. In a study published online in Genome Research, researchers detected over 400 mutations in healthy blood cells of a 115-year-old woman, suggesting that lesions at these sites are largely harmless over the course of a lifetime. Our blood is continually replenished by hematopoietic stem cells that reside in the bone marrow and divide to generate different types of blood cells, including white blood ...

CAMBRIDGE, Mass. (April 23, 2014) – Despite a well-documented history of dramatic genetic decay, the human Y chromosome has over the course of millions of years of evolution managed to preserve a small set of genes that has ensured not only its own survival but also the survival of men. Moreover, the vast majority of these tenacious genes appear to have little if any role in sex determination or sperm production. Taken together, these remarkable findings—published this week in the journal Nature—suggest that because these Y-linked genes are active across the body, they ...

ANN ARBOR, Mich. — Prostate cancer becomes deadly when anti-hormone treatments stop working. Now a new study suggests a way to block the hormones at their entrance. Researchers from the University of Michigan Comprehensive Cancer Center have found that a protein called BET bromodomain protein 4 binds to the hormone androgen receptor downstream of where current therapies work – targeting androgen receptor signaling. This could mean that when prostate cancer becomes resistant to current treatments, it might remain sensitive to a drug that targets BET bromodomain proteins. ...

Sequencing an entire human genome is faster and cheaper than ever before, leading to an explosion of studies comparing the genomes of people with and without a given disease. Often clinicians and researchers studying genetic contributions to a certain disease encounter variations that appear to be responsible, only to find other people with the same mutation who don't have the disease or who are affected to a lesser degree. How do doctors pinpoint the genetic changes that really cause disease? An open-access policy paper to be published Wednesday in Nature proposes guidelines ...

New University of Toronto Scarborough research shows that male black widow spiders prefer their female mates to be well-fed virgins – a rare example of mate preference by male spiders. The study, authored by UTSC post-doc Emily MacLeod and Maydianne Andrade, a professor in UTSC's Department of Biological Sciences, found in both controlled field studies and the wild that males overwhelmingly chose to mate with well-fed, unmated females. They also found male black widows can tell whether a potential mate is well-fed and unmated by pheromones released by females. "This ...

RICHLAND, Wash. -- Like a hungry diner ripping open a dinner roll, a fuel cell catalyst that converts hydrogen into electricity must tear open a hydrogen molecule. Now researchers have captured a view of such a catalyst holding onto the two halves of its hydrogen feast. The view confirms previous hypotheses and provides insight into how to make the catalyst work better for alternative energy uses. This study is the first time scientists have shown precisely where the hydrogen halves end up in the structure of a molecular catalyst that breaks down hydrogen, the team reported ...

WASHINGTON – A changing climate is increasing the accessibility of U.S. Arctic waters to commercial activities such as shipping, oil and gas development, and tourism, raising concern about the risk of oil spills. A new report from the National Research Council says that a full suite of proven oil response tools is needed to address potential oil spills in U.S. Arctic waters, but not all of them are readily available. While much is known about both oil behavior and response technologies in ice-covered environments, there are areas where additional research would enable ...

People diagnosed with Huntington's disease, most in their mid-thirties and forties, face a devastating prognosis: complete mental, physical, and behavioral decline within two decades. "Mutant" protein clusters, long blamed for the progression of the genetic disease, have been the primary focus of therapies in development by pharmaceutical companies. But according to new research from Prof. Gerardo Lederkremer and Dr. Julia Leitman of Tel Aviv University's Department of Cell Research and Immunology, in collaboration with Prof. Ulrich Hartl of the Max Planck Institute for ...

Fairfax, Va., April 23, 2014— The American Society for Radiation Oncology (ASTRO) has issued a new guideline, "The Role of Postoperative Radiation Therapy for Endometrial Cancer: An ASTRO Evidence-Based Guideline," that details the use of adjuvant radiation therapy in the treatment of endometrial cancer. The guideline's executive summary is published in the May-June 2014 issue of Practical Radiation Oncology (PRO), the official clinical practice journal of ASTRO. The full-length guideline is available as an open-access article online at http://www.practicalradonc.org. ASTRO's ...

This news release is available in French and Spanish. Montreal, 23 April 2014—Today, the CEC released its Conservation Assessment for the Big Bend-Río Bravo Region: A Binational Collaborative Approach to Conservation, which identifies 29 priority conservation areas in a region straddling the United States-Mexico border that includes 11 different protected areas in the states of Texas, Coahuila, and Chihuahua. This region features unique, highly diverse arid and semi-arid habitats inhabited by rare and endangered plants and animals, and provides a vital migratory ...

BUFFALO, N.Y. – A novel compound that targets an important brain receptor has a dramatic effect against a host of cocaine addiction behaviors, including relapse behavior, a University at Buffalo animal study has found. The research provides strong evidence that this may be a novel lead compound for treating cocaine addiction, for which no effective medications exist. The UB research was published as an online preview article in Neuropsychopharmacology last week. In the study, the compound, RO5263397, severely blunted a broad range of cocaine addiction behaviors. "This ...

Tropical Cyclone Jack had weakened to a tropical depression when NASA and JAXA's Tropical Rainfall Measuring Mission (TRMM) satellite passed above on April 22, 2014 at 1120 UTC/7:20 a.m. EDT. At that time, TRMM found that Jack was devoid of almost all rainfall near the tropical cyclone's center. Outside the center was a different story, however. That's where TRMM's precipitation radar instrument found rain falling at a rate of over 130mm/hr (about 5.1 inches) in a band of thunderstorms that stretched from east of Jack's center to the south. Some of the thunderstorms even ...

Alexandria, Va. – On a muggy day in mid-July 2009, a lone seven-story condominium complex northwest of Kobe, Japan, was violently shaken by an earthquake. Onlookers watched the 23-unit, wood-frame tower sway and bounce while, inside the building, furniture toppled and plates clattered to the floor. No one was hurt during the highly localized event and there was only minimal damage, in part because the building's wooden skeleton had been augmented to better resist earthquake shaking, but also because the whole event — from the seismicity to the partially furnished building ...

Johns Hopkins scientists report that rats exposed to high-energy particles, simulating conditions astronauts would face on a long-term deep space mission, show lapses in attention and slower reaction times, even when the radiation exposure is in extremely low dose ranges. The cognitive impairments — which affected a large subset, but far from all, of the animals — appear to be linked to protein changes in the brain, the scientists say. The findings, if found to hold true in humans, suggest it may be possible to develop a biological marker to predict sensitivity to radiation's ...

WEST LAFAYETTE, Ind. - Purdue University researchers have developed a way to detect and measure cancer levels in a living cell by using tiny gold particles with tails of synthetic DNA. A team led by Joseph Irudayaraj, professor of agricultural and biological engineering, used gold nanoparticles to target and bind to fragments of genetic material known as BRCA1 messenger RNA splice variants, which can indicate the presence and stage of breast cancer. The number of these mRNA splice variants in a cell can be determined by examining the specific signal that light produces ...

Purdue University researchers have identified an important enzyme pathway that helps prevent new cells from receiving too many or too few chromosomes, a condition that has been directly linked to cancer and other diseases. Mark Hall, associate professor of biochemistry, found that near the end of cell division, the enzyme Cdc14 activates Yen1, an enzyme that ensures any breaks in DNA are fully repaired before the parent cell distributes copies of the genome to daughter cells. This process helps safeguard against some of the most devastating genome errors, including the ...