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New study explains why promising dementia drugs failed in clinical trials

2013-12-05
New study explains why promising dementia drugs failed in clinical trials Alzheimer's disease is the most common cause of dementia among older people, yet there currently are no effective drugs to stop, slow or prevent disease progression. A study online December 5th in the ...

Membrane enzymes 'stop and frisk' proteins indiscriminately

2013-12-05
Membrane enzymes 'stop and frisk' proteins indiscriminately New insights may explain difficulty of finding drugs for infectious disease For what is believed to be the first time, researchers at The Johns Hopkins University have illuminated the inner workings of ...

Sanford-Burnham researchers identify new target to treat psoriasis

2013-12-05
Sanford-Burnham researchers identify new target to treat psoriasis Scientists identify a molecular pathway that rebalances the immune system by turning down inflammatory T-cell responses providing a new target to treat inflammatory ailments ...

Protein clumps as memory

2013-12-05
Protein clumps as memory Yeast cells are able to form a memory through an aggregate Yeast has a somewhat complicated love life: on the one hand, a mother cell can produce genetically identical daughter cells through mitosis (cell division); on the other hand, yeast cells, ...

Geoengineering approaches to reduce climate change unlikely to succeed

2013-12-05
Geoengineering approaches to reduce climate change unlikely to succeed Reducing the amount of sunlight reaching the planet's surface by geoengineering may not undo climate change after all. Two German researchers used a simple energy balance analysis to explain ...

Probiotic therapy alleviates autism-like behaviors in mice

2013-12-05
Probiotic therapy alleviates autism-like behaviors in mice Autism spectrum disorder (ASD) is diagnosed when individuals exhibit characteristic behaviors that include repetitive actions, decreased social interactions, and impaired communication. Curiously, ...

NIH-funded scientists describe how mosquitoes are attracted to humans

2013-12-05
NIH-funded scientists describe how mosquitoes are attracted to humans Researchers identify compounds that reduce attraction, lure mosquitoes to traps WHAT: Scientists at the University of California, Riverside have ...

Large-scale erythrocyte production method established using erythrocyte progenitor cells

2013-12-05
Large-scale erythrocyte production method established using erythrocyte progenitor cells By transducing two genes (c-MYC and BCL-XL) into iPS cells and ES cells, a Kyoto University research team led by Prof. Koji ...

What is the central analgesic mechanism of acupuncture for migraine?

2013-12-05
What is the central analgesic mechanism of acupuncture for migraine? The central analgesic mechanism of acupuncture for migraine remains poorly understood. Acupuncture has been shown to become a recommended treatment for migraine sufferers. However, a single acupuncture ...

Who is the culprit to cause memory impairment during brain aging?

2013-12-05
Who is the culprit to cause memory impairment during brain aging? The N-methyl-D-aspartic acid (NMDA) receptor dysfunction in the brain of aged animals has been shown. In older rodents, N-methyl-D-aspartate receptor 2B subunit gene expression declines significantly ...

Pre-moxibustion and moxibustion prevent Alzheimer's disease

2013-12-05
Pre-moxibustion and moxibustion prevent Alzheimer's disease An increasing number of clinical and animal studies have confirmed that acupuncture is effective for the treatment of Alzheimer's disease. Moxibustion is reported to be more effective than electro-acupuncture ...

Better water purification with seeds from Moringa trees

2013-12-05
Better water purification with seeds from Moringa trees Seeds from Moringa oleifera trees can be used to purify water. Uppsala University leads a research group which has discovered that seed material can give a more efficient purification process than conventional ...

Crop-infecting virus forces aphids to spread disease

2013-12-05
Crop-infecting virus forces aphids to spread disease Viruses alter plant biochemistry in order to manipulate visiting aphids into spreading infection. University of Cambridge researchers have shown that viruses use aphids as pawns, discouraging the insects ...

Pulsatile blood flow unmasks new migraine features

2013-12-05
Pulsatile blood flow unmasks new migraine features With every heartbeat, the blood is sent to all our peripheral tissues, generating changes in pulsatile perfusion. Using these pulsatile changes as a source of information, researchers at the ...

Database tracks toxic side effects of pharmaceuticals

2013-12-05
Database tracks toxic side effects of pharmaceuticals Sometimes the cure can be worse than the disease. Pharmaceutical drugs are known for their potential side effects, and an important aspect of personalized medicine is to tailor therapies to individuals ...

'Soft' (and miniaturized) robots

2013-12-05
'Soft' (and miniaturized) robots Micro-robots will become soft and move like biological organisms Forget cogwheels, pistons and levers: miniaturized robots of the future will be "soft". "If I think of the robots of tomorrow, what ...

Added benefit of saxagliptin as monotherapy is not proven

2013-12-05
Added benefit of saxagliptin as monotherapy is not proven No data on patients with metformin intolerance or contraindication The drug saxagliptin (trade name: Onglyza) has been approved also as monotherapy in Germany since July ...

Home-based exercise as rehabiltation

2013-12-05
Home-based exercise as rehabiltation Cardiac patients benefit from home-based high intensity training Rapid rehabilitation is a must after a heart attack or other cardiovascular event. Different forms of exercise as a part of rehabilitation ...

Gentler heart surgery remains without signs of dementia

2013-12-05
Gentler heart surgery remains without signs of dementia Mental performance preserved throughout two years after catheter-based implantation of an aortic valve prosthesis Aortic valve stenosis is the most frequent heart valve defect of older people in Europe ...

A sudden interest in math -- how teachers can motivate their pupils

2013-12-05
A sudden interest in math -- how teachers can motivate their pupils Researchers create professional development program to promote open dialog in the classroom The lack of interest in math or natural sciences is one of the most frequently voiced causes for ...

Study points to differences in high-school crack, powder cocaine use

2013-12-05
Study points to differences in high-school crack, powder cocaine use The use of crack and powder cocaine both varies and overlaps among high school seniors, researchers at New York University and NYU Langone Medical Center have found. Their findings, which appear in ...

Studies assess impact of IOM report on nursing reforms

2013-12-05
Studies assess impact of IOM report on nursing reforms Researchers find progress and barriers to recommendations on residency programs and academic progression WASHINGTON, DC (December 5, 2013)--Two new studies ...

Liver transplant survival rates lower in black than white pediatric patients

2013-12-05
Liver transplant survival rates lower in black than white pediatric patients Novel research reveals racial and socioeconomic disparities among pediatric liver transplant patients. Findings published in Liver Transplantation, a journal of the American Association for the Study ...

Priming 'cocktail' shows promise as cardiac stem cell grafting tool

2013-12-05
Priming 'cocktail' shows promise as cardiac stem cell grafting tool New research by University of Vermont Associate Professor of Medicine Jeffrey Spees, Ph.D., and colleagues has identified a new tool that could help facilitate future stem cell therapy for ...

DNA helicity and elasticity explained on the nanoscale

2013-12-05
DNA helicity and elasticity explained on the nanoscale Korean researchers propose simple model to explain DNA helicity and elasticity on a nanometer scale A simple mechanical model to effectively implement the well-known double-stranded structure and the elasticity of ...
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