Scientists from The University of Manchester have revealed new images which provide the clearest picture yet of how white blood immune cells attack viral infections and tumours. They show how the cells, which are responsible for fighting infections and cancer in the human body, change the organisation of their surface molecules, when activated by a type of protein found on viral-infected or tumour cells. Professor Daniel Davis, who has been leading the investigation into the immune cells, known as natural killers, said the work could provide important clues for tackling ...

OAK BROOK, Ill. – The rate at which women get called back for additional imaging after screening mammography may be higher at hospitals than at community office practices, mostly due to differences among the patients, according to a new study published online in the journal Radiology. The findings highlight the limitations of recall rates as a quality measure for breast cancer screening, the researchers said. Recall rates for mammography refer to the percentage of women who undergo screening and are called back for additional testing. Since recalls involve anxiety for ...

PROVIDENCE, R.I. – A new study at Rhode Island Hospital has found that academic medical centers have higher rates of recall following mammography than community radiology centers. The recall rate is the frequency at which a radiologist interprets an examination as positive and the patient is instructed to return for more testing. The study is published online in advance of print in the journal Radiology. "Recalling a patient for a mammogram has an impact on both the patient, and on the hospital," said lead researcher and author Ana Lourenco, M.D., a radiologist at Rhode ...

Chicago, US (July 22, 2013) --- Positive results from three new studies on human-animal interaction (HAI) are being presented today at the triennial conference of the International Association of Human-Animal Interaction Organizations (IAHAIO) in Chicago, IL. The studies, supported by funding from Mars and the WALTHAM® Centre for Pet Nutrition (WALTHAM®), examined how pets impact our physical and emotional well-being and our social relationships and community connectedness. WALTHAM® is the state-of-the-art petcare science centre for Mars Petcare and provides the science ...

Scientists from the Universities of Stirling, Oxford, Queensland and the Wildlife Conservation Society warn that current hunting trends in Central African forests could result in complete ecological collapse. The authors maintain that the current rate of unsustainable hunting of forest elephants, gorillas and other seed-dispersing species threatens the ability of forest ecosystems to regenerate, and that landscape-wide hunting management plans are needed to avoid an environmental catastrophe. The study appears in the latest version of Philosophical Transactions of ...

HONOLULU, HI – University of Hawaii Cancer Center Prevention and Control Program researchers Pallav Pokhrel, PhD and Thaddeus Herzog, PhD have found that smokers who use e-cigarettes as a tool to stop smoking tend to be younger and more motivated to quit smoking as compared to other smokers. Their study published online ahead of the print version in the American Journal of Public Health, found that approximately 13 percent of smokers had tried e-cigarettes as a means of quitting smoking. They also found that smokers who had tried e-cigarettes for smoking cessation help ...

A team led by a University of Arizona researcher has discovered a previously unknown mechanism that prevents the immune system from going into overdrive, shedding light not only on how our body controls its response to pathogens but on conditions such as autoimmune diseases, allergies and chronic inflammation as well. The group found a protein previously believed to only play a role in blood clotting acts as a negative feedback signal, telling defense cells to calm down, thereby preventing an immune reaction from spiraling out of control. The results, which could lead ...

Australian scientists have identified causes of a rapid warming in the upper subtropical oceans of the Southern Hemisphere. They partly attribute the observed warming, and preceding cooling trends to ocean circulation changes induced by global greenhouse gas emissions and aerosols predominantly generated in the Northern Hemisphere from human activity. The research, by scientists from CSIRO and the University of NSW, was published today in Scientific Reports. Mr Tim Cowan, lead author of the study, says his group was initially interested in the three decade long cooling ...

Rising temperatures, influenced by natural events such as El Niño, have a corresponding increase in the release of carbon dioxide from tropical forest ecosystems, according to a new study out today. The study, published in the journal Proceedings of the National Academy of Sciences, found that a temperature anomaly of just 1ºC (in near surface air temperatures in the tropics) leads to a 3.5-Petagram (billion tonnes of carbon) anomaly in the annual CO2 growth rate, on average. This is the equivalent of 1/3 of the annual global emissions from the combustion of fossil fuels ...

STANFORD, Calif. — A gene long presumed dead comes to life under the full moon of inflammation, Stanford University School of Medicine scientists have found. The discovery, described in a study to be published July 23 in eLife, may help explain how anti-inflammatory steroid drugs work. It also could someday lead to entirely new classes of anti-inflammatory treatments without some of steroids' damaging side effects. Chronic inflammation plays a role in cancer and in autoimmune, cardiovascular and neurodegenerative diseases, among others. Anti-inflammatory steroid drugs ...

Massachusetts General Hospital (MGH) researchers and their colleagues have used digital versions of a standard molecular biology tool to detect a common tumor-associated mutation in the cerebrospinal fluid (CSF) of patients with brain tumors. In their report being published in the open-access journal Molecular Therapy – Nucleic Acids, the investigators describe using advanced forms of the gene-amplification technology polymerase chain reaction (PCR) to analyze bits of RNA carried in membrane-covered sacs called extracellular vesicles for the presence of a tumor-associated ...

A new method for producing electricity from carbon dioxide could be the start of a classic trash-to-treasure story for the troublesome greenhouse gas, scientists are reporting. Described in an article in ACS' newly launched journal Environmental Science & Technology Letters, the method uses CO2 from electric power plant and other smokestacks as the raw material for making electricity. Bert Hamelers, Ph.D., and colleagues explain that electric power-generating stations worldwide release about 12 billion tons of CO2 annually from combustion of coal, oil and natural gas. ...

Charlottesville, VA (July 23, 2013). Researchers from Durham University and Kings College London (United Kingdom) and the University of Erlangen-Nürnberg (Germany) found that patients who have suffered a subarachnoid hemorrhage (SAH) may not recover psychosocially as well as expected if their significant other is excessively fearful about the possibility of SAH recurrence. The researchers' findings are discussed in "Family and friends' fears of recurrence: impact on the patient's recovery after subarachnoid hemorrhage. Clinical article," by Judith Covey, Ph.D., Adam J. ...

CAMBRIDGE, Mass- Unlike barnacles, which cement themselves tightly to the surfaces of rocks, piers or ships, the clamlike bivalves called mussels dangle more loosely from these surfaces, attached by a collection of fine filaments known as byssus threads. This approach lets the creatures drift further out into the water, where they can absorb nutrients — although in the process, it exposes them to the risk of being torn away by the force of crashing waves. But that almost never happens. Despite the outwardly thin and fragile appearance of these threads, it turns out ...

(SACRAMENTO, Calif.) -- One of regenerative medicine's greatest goals is to develop new treatments for stroke. So far, stem cell research for the disease has focused on developing therapeutic neurons — the primary movers of electrical impulses in the brain — to repair tissue damaged when oxygen to the brain is limited by a blood clot or break in a vessel. New UC Davis research, however, shows that other cells may be better suited for the task. Published July 23 in the journal Nature Communications, the large, collaborative study found that astrocytes — neural cells that ...

Diffusion tensor imaging fiber tracking with reliable tracking orientation and flexible step size can show white matter fiber bundles in the healthy corpus callosum. Researchers used two sets of human data to assess the performance of this method; one was from a healthy volunteer and the other from a patient with low-grade glioma. Results verified that this method was superior to the single-tensor Fiber Assignment by Continuous Tracking and the two-tensor eXtended Streamline Tractography for showing detailed images of fiber bundles. A recent study published in the Neural ...

Recurrent laryngeal nerve injury is the most common serious complication of thyroid surgery. Therefore, preventing recurrent laryngeal nerve injury is an important goal in thyroid surgery. A retrospective clinical controlled study from Xinhua Hospital, Shanghai Jiao Tong University School of Medicine demonstrates that dissecting the recurrent laryngeal nerve during thyroid surgery is clinically significant for preventing nerve injury. To determine the value of dissecting the recurrent laryngeal nerve during thyroid surgery with respect to preventing recurrent laryngeal ...

In 2006 the island of Java, Indonesia was struck by a devastating earthquake followed by the onset of a mud eruption to the east, flooding villages over several square kilometers and that continues to erupt today. Until now, researchers believed the earthquake was too far from the mud volcano to trigger the eruption. Geophysicists at the University of Bonn, Germany and ETH Zurich, Switzerland use computer-based simulations to show that such triggering is possible over long distances. The results have been published in "Nature Geoscience." On May 27, 2006 the ground of ...

Synthetic materials made from organic polymers usually burn very well due to their high carbon content; when turned into foams, they ignite even more easily -- and, depending on their chemical compositions, they produce toxic gases such as hydrogen cyanide or carbon monoxide. For this reason, polyurethane foams and other similar products have to be treated with flame retardants. These foam materials are widely used in upholstered furniture and mattresses, as insulation and packaging materials and as expanding spray foams. Conventional halogenated flame retardants such ...

Neural stem cells proliferate in the subventricular zone and hippocampal dentate gyrus of adult mammals. However, the number of endogenous neural stem cells is insufficient to prevent cerebral ischemia/reperfusion injuries such as vascular dementia, so it is important to stimulate endogenous neural stem cell proliferation and differentiation. The ginkgo biloba extract EGb761 effectively and safely treats memory loss and cognitive impairments in patients with senile dementia. Prof. Yuliang Wang and team from Weifang Medical University observed the effects of EGb761 on proliferation ...

The first large non-commercial clinical study to investigate whether the main active constituent of cannabis (tetrahydrocannabinol or THC) is effective in slowing the course of progressive multiple sclerosis (MS), shows that there is no evidence to suggest this; although benefits were noted for those at the lower end of the disability scale. The study is published in The Lancet Neurology. The CUPID (Cannabinoid Use in Progressive Inflammatory brain Disease) study was carried out by researchers from Plymouth University Peninsula Schools of Medicine and Dentistry. The ...

In degenerative brain diseases and after stroke, nerve cells die while their support cells activate the brain's immune system to cause further damage. Now Jonathan Gilthorpe, Adrian Pini and Andrew Lumsden at the MRC Centre for Developmental Neurobiology at King's College London, have found that a single protein, histone H1, causes these distinct outcomes. The research passed peer review within a week of being published in F1000Research, where Jan-Marino Ramirez, of the University of Washington, called the work "a very important contribution to our understanding of neurodegenerative ...

PITTSBURGH—It would be impossible to compute all of the ways a piece of cloth might shift, fold and drape over a moving human figure. But after six months of computation, researchers at Carnegie Mellon University and the University of California, Berkeley, are pretty sure they've simulated almost every important configuration of that cloth. "I believe our approach generates the most beautiful and realistic cloth of any real-time technique," said Adrien Treuille, associate professor of computer science and robotics at Carnegie Mellon. To create this cloth database, ...

CAMBRIDGE, MA -- Although human cells have an estimated 20,000 genes, only a fraction of those are turned on at any given time, depending on the cell's needs — which can change by the minute or hour. To find out what those genes are doing, researchers need tools that can manipulate their status on similarly short timescales. That is now possible, thanks to a new technology developed at MIT and the Broad Institute that can rapidly start or halt the expression of any gene of interest simply by shining light on the cells. The work is based on a technique known as optogenetics, ...

Scientists led by the University of Leicester have set a new record for cosmic X-ray sources ever sighted – creating an unprecedented cosmic X-ray catalogue that will provide a valuable resource allowing astronomers to explore the extreme Universe. The XMM-Newton Survey Science Centre, led by a team from the University of Leicester's Department of Physics and Astronomy, used the University's 'ALICE' supercomputer to help them produce a new X-ray catalogue, dubbed "3XMM". This new catalogue contains over half a million X-ray source detections, representing a 50% increase ...