Afatinib (trade name: GIOTRIF) has been approved in Germany since September 2013 for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating EGF receptor mutations who have not been treated with an EGF receptor tyrosine-kinase inhibitor (EGFR TKI). In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether this new drug offers an added benefit over the appropriate comparator ...

Scientists at the University of Bristol have discovered that a mechanism for preventing mutation within important genes involves long distance scanning of DNA by a molecular motor protein. The results, published in the Proceedings of the National Academy of Sciences (PNAS), show that the method for detecting DNA damage within active genes is more sophisticated than previously thought. The research team hope that the mechanistic insights provided by this study will help to explain the complicated genome-wide patterns of mutation that underlie the evolution of new species, ...

It has become increasingly clear in recent years that asthma comes in several variations, with different causes, different pathologies and different responses to therapy. These subtypes of asthma can be identified by knowing which genes are expressed at higher and lower levels in patients' airways. That information can, in turn, help guide personalized treatment to more effectively manage asthma and inspire research to better understand, manage, and possibly prevent asthma. The difficulty is that tissue samples necessary for this kind of genetic profiling are currently ...

Messier 7, also known as NGC 6475, is a brilliant cluster of about 100 stars located some 800 light-years from Earth. In this new picture from the Wide Field Imager on the MPG/ESO 2.2-metre telescope it stands out against a very rich background of hundreds of thousands of fainter stars, in the direction of the centre of the Milky Way. At about 200 million years old, Messier 7 is a typical middle-aged open cluster, spanning a region of space about 25 light-years across. As they age, the brightest stars in the picture — a population of up to a tenth of the total stars in ...

Duckweed is a tiny floating plant that's been known to drive people daffy. It's one of the smallest and fastest-growing flowering plants that often becomes a hard-to-control weed in ponds and small lakes. But it's also been exploited to clean contaminated water and as a source to produce pharmaceuticals. Now, the genome of Greater Duckweed (Spirodela polyrhiza) has given this miniscule plant's potential as a biofuel source a big boost. In a paper published February 19, 2014 in the journal Nature Communications, researchers from Rutgers University, the Department of Energy ...

Providing secure wireless connections and improving the efficiency of communication devices could be another application for graphene, as demonstrated by scientists at Queen Mary University of London and the Cambridge Graphene Centre. Often touted as a wonder material, graphene is a one-atom thick layer of carbon with remarkable, record breaking properties. Until now its ability to absorb electromagnetic radiation – energy from across the radio frequency spectrum – was not known. Publishing in the journal Scientific Reports, the scientists demonstrated that the transparent ...

Chexx Inc. provides convenient international payout services by check, electronic payments and prepaid credit cards. With over 19 years of experience in outbound payments for international beneficiaries, Chexx Inc. offers the ability to send fast payment to beneficiaries in locations around the globe. Chexx will be co-located at the PacNet Services booth, ID6, located in the International Direct Marketing Expo section of TFM&A. The IDMX is the show dedicated to all aspects of direct marketing and provides a highly sought-after dedicated marketplace for response-based ...

According to the Canadian Cancer Society, there are an average of 187,000 new cases of cancer around the country each year, and 75,000 deaths per year. Cancer is the leading cause of death in Canada, accounting for 30 percent of all deaths. Every donation to the organization is considered a gift of life, as it helps with their ongoing life-saving work. Digital Lion has made its first charitable donation of the year to the Canadian Cancer Society, in an effort to help support their ongoing vital work. "Just about everyone has been impacted by cancer in some way, ...

B2B Soft, a business-to-business software company specializing in retail management for the wireless/cellular retail industry, is pleased to announce a new partnership with Phobio, a mobile trade-in provider to the wireless industry. Phobio's Salepoint trade-in service is now integrated with B2B Soft's Wireless Standard Retail Management Platform. Wireless dealers can now instantly access and offer their customers Phobio's full range of device trade-in services including Backspace Data Wiping for immediate in-store credit. B2B Soft's Wireless Standard Retail Management ...

Within a few weeks of first publishing the event, we've received abstract submissions both from every states and territories in Australia and from overseas. Registration numbers are also filling fast; hence, we encourage anyone who wishes to attend the conference to register as soon as possible. More than 80 % of the submitted papers are from community based organizations, wishing to share successes in programs implemented within their communities. One of the featured speakers is MS. CHERI YAVU-KAMA-HARATHUNIAN. Cheri is a traditional Australian Aboriginal woman of the ...

Gina F. Rubel, President and CEO of the marketing and public relations agency Furia Rubel Communications, recently presented "Building Brand Through Social Media" to the Bucks County Estate Planning Council. Rubel addressed ways professional service providers such as attorneys, accountants, financial planners and bankers can reap the most benefit from their use of social media platforms. "The use of various social media platforms has spread far beyond the early adopters to professionals and decision makers across the globe," Rubel said. "Social ...

Music's importance lies in the feelings it evokes in listeners, such is Vision's aim with the hit bound reggae single "We Jammin". Produced by Jon "fx" Crawford and Dubloise for Keynote Records, the feel good vibe of "We Jammin" brings nostalgic memories. "We Jammin is a song that reflects the most memorable and happy times of my life in Jamaica. Jammin means to kick back and relax, instead of saying Chillin or vibing, in Jamaica we just say Jam short for Jammin. The song tells you a lot about who I am and where I'm from. Living in ...

Tracking What Matters Most The SilverCloud Tag Personal Live GPS Tracker is a portable, pocket-sized, live GPS tracker that can be used for a variety of personal tracking applications. It's ultra-compact size allows it to be placed virtually anywhere - inside a purse, backpack, briefcase or car. The powerful internal GPS module provides accurate live location updates, which can be viewed from a computer, laptop or mobile device. The SilverCloud Tag utilizes the user-friendly SilverCloud Online mapping software. With the web-based SilverCloud Online, users will have ...

Gloria Larkin, national federal contracting expert and TargetGov President, is a key-note speaker at the GRO-Biz Conference & Idea Expo in Cheyenne, Wyoming at the Little America Hotel on February 19, 2014. Gloria Larkin, is an eight-time award winner, national marketing and business development expert, and President of TargetGov. Larkin has been interviewed on MSNBC, quoted in, the Wall Street Journal, USAToday, Forbes, INC Magazine, and TheStreet.com. She is the author of two books and an expert author with hundreds of articles regarding federal business development ...

As rapidly expanding industries like manufacturing and solar energy create major demand for skilled workers, community colleges and for-profit institutions across the country are looking to provide curricula that get their students job-ready. Adding vocational training to the course syllabus is a challenging process for any learning center whose educational offerings have historically been more academic. This is why CleanEdison is ramping up its School as a Service (SAAS) model as a turnkey solution that allows schools to streamline the integration of skills-based coursework ...

Author Robert Friedrich is proud to announce the release of his new, fast-paced Sci-Fi/Thriller "SEED OF EVIL", where the elements of occult meet with an advanced military, wrapped in a colossal battle between good and evil. About the book From a distant galaxy far beyond our time, the most ancient of all evil awoke before descending upon our unsuspecting galaxy. The planet it reached never faced such a threat, but didn't submit to it, either. In a final attempt to survive, a prison between dimensions was built, the last hope to hold the dark power for an ...

1200 The Ocean LLC, an affiliate of West Seneca, N.Y.-based Marrano/Marc Equity Corporation, announces that Caprice Weber, president of Baker Real Estate Florida, will be the exclusive sales agent and marketing manager for 1200 The Ocean. The gated, beachfront condominium on prestigious "Hillsboro Mile" is located between Boca Raton and Ft. Lauderdale in Hillsboro Beach and will showcase a limited-edition collection of only 18 condominium residences with up to nearly 3,000 sq. ft. from the $800's to $1.95 million. Highlights include private or semi-private elevator ...

Gardere Wynne Sewell LLP is pleased to announce that Trial Attorney Scott D. Ellis has been elected to membership in the prestigious Fellows of the Texas Bar Foundation. Selection as a Fellow of the Texas Bar Foundation is based on exceptional professional achievements and dedication to the justice system throughout the state of Texas. Mr. Ellis, a 2006 graduate of the University of Houston Law Center, is an associate in the Firm's Houston office, where he represents both plaintiffs and defendants in complex commercial, oil and gas, construction, real estate, products ...

Alicia Isaacs Howes, founder of http://www.yoursoulstory.com and Soul Connection Expert, loves to help those who are struggling with new or recurring patterns in their health, finances or relationships and are committed to changing them. Through Akashic Records-based sessions, Alicia helps individuals pinpoint and heal pain points in their lives that are preventing them from aligning to vitality, inspiration, happiness and well-being. Alicia is now offering a brand-new programme to help people neutralize the most persistent patterns, illusions and beliefs that hold ...

'Angel's Delights Company' has designed and developed the App exclusively as a fun, exciting and addictive game, which appeals to both children and adults alike. The confectionary based game concept is a simple one, the basics of which is users tapping the screen to 'munch' the sweet treats in order to score points. 'Munch' features a number of exciting game features for players to contend with, such as creeping hands which race to grab the point scoring treats and gumball bonuses which allow players to build up their scores quickly. The company is preparing to launch ...

Kayla Gillan, Leader of PwC's Investor Resource Institute, attended the DirectWomen Board Institute from January 22-24 in New York City. DirectWomen, an organization formed to position women lawyers to serve on boards of public companies, selects a group of qualified women lawyers from a competitive pool of applicants across the country to participate in the three-day program. At the DirectWomen Board Institute Gillan attended informational sessions on key issues facing current and future corporate directors and had the opportunity to interact with Institute alumnae ...

Officials of Glacier Bottling Company, L.L.C., makers of IndigoH2O Premium Bottled Alkaline Mineral Water today announced they would accept the controversial digital currency for purchase of their bottled water on the website indigoh2o.com with transactions processed by CoinBase, the payment platform. "Today we proudly announce that IndigoH2O is officially the first bottled water to accept Bitcoin as a payment option." said Yuri Cataldo, president and CEO of Glacier Bottling Company. "It is an ideal currency for online shopping as it doesn't have the same ...

Empirical Bioscience LLC has elected Richard Leach, Ph.D., Vice President of Business Development at Complete Genomics Inc. and an expert in human genome sequencing, to its board of directors, effective immediately. With more than 18 years of experience in genome sequencing and its application in fields such as personalized medicine, Leach will give Empirical Bioscience an unparalleled perspective on how to grow its existing and prospective markets for reagents used in polymerase chain reactions (PCR) of human, animal and plant DNA, company officials said. "We ...

Accessory Power, a Global Electronics and Accessories Manufacturer in Los Angeles with offices in Europe and Asia, proudly brings a close to the GOgroove Film Festival. The overwhelming success of the Film Festival and tremendous outpour of entries caught Accessory Power by surprise; so much so, that the company extended the deadline three different times. Entries were submitted from across the United States with many notable videos from Florida, including the Grand Prize Winner and two honorable mentions. Second in submissions was Accessory Power's home state California, ...

Benchmark Systems, a leading Internet based provider of fully integrated medical practice management solutions, announced today that it has partnered with PatientPay to offer electronic statements and online bill pay through their patient portal. The electronic statement feature eliminates the costly and complicated paper-based billing method used by the overwhelming majority of healthcare providers. It will eliminate the rising expense of postage and the time it takes to collect patient balances. Since PatientPay reduces the time to payment in half, practices utilizing ...