A team of University of California, San Diego researchers has designed new compounds that mimic those naturally used by the body to regulate blood pressure. The most promising of them may literally be the key to controlling hypertension, switching off the signaling pathways that lead to the deadly condition. Published online this month in Bioorganic & Medicinal Chemistry, the scientists studied the properties of the peptide called catestatin that binds nicotinic acetylcholine receptors found in the nervous system, and developed a pharmacophore model of its active centers. ...

BOWLING GREEN, O.—Want to go to graduate school? Your weight could determine whether or not you receive an offer of admission. The study by Bowling Green State University Ph.D. candidates Jacob Burmeister and Allison Kiefner; Dr. Dara Musher-Eizenman, a professor of developmental psychology; and Dr. Robert Carels, an associate professor of clinical psychology, appeared in the May edition of the journal Obesity. "Weight Bias in Graduate School Admissions" found that applicants with a high body mass index (BMI) were less likely to be offered admission after an in-person ...

LA JOLLA - Dennis O'Leary of the Salk Institute was the first scientist to show that the basic functional architecture of the cortex, the largest part of the human brain, was genetically determined during development. But as it so often does in science, answering one question opened up many others. O'Leary wondered what if the layout of the cortex wasn't fixed? What would happen if it were changed? In the August issue of Nature Neuroscience, O'Leary, holder of the Vincent J. Coates Chair of Molecular Neurobiology at Salk, and Andreas Zembrzycki, a postdoctoral researcher ...

TORONTO, ON – Improving vaccination rates against the human papillomavirus (HPV) in boys is key to protecting both men and women, says new research from University of Toronto Professor Peter A. Newman from the Factor-Inwentash Faculty of Social Work. HPV has been linked to anal, penile and certain types of throat cancers in men. Since the virus is also responsible for various cancers in women, vaccinating boys aged 11 to 21 will play a crucial role in reducing cancer rates across the sexes. "HPV is the single most common sexually transmitted infection," says Newman, ...

A research team led by scientists from the Ernest Gallo Clinic and Research Center at the University of California, San Francisco has identified circuitry in the brain that drives compulsive drinking in rats, and likely plays a similar role in humans. The scientists found they could reduce compulsive drinking in rats by inhibiting key neural pathways that run between the prefrontal cortex, which is involved with higher functions such as critical thinking and risk assessment, and the nucleus accumbens, a critical area for reward and motivation. The authors noted ...

Climate data can help predict some crop failures several months before harvest, according to a new study from an international team, including a research scientist at NASA's Goddard Space Flight Center in Greenbelt, Md. Scientists found that in about one-third of global cropland, temperature and soil moisture have strong relationships to the yield of wheat and rice at harvest. For those two key crops, a computer model could predict crop failures three months in advance for about 20 percent of global cropland, according to the study, published July 21 in Nature Climate ...

In a twist on "survival of the fittest," researchers have discovered that evolution is driven not by a single beneficial mutation but rather by a group of mutations, including ones called "genetic hitchhikers" that are simply along for the ride. These hitchhikers are mutations that do not appear to have a role in contributing to an organism's fitness and therefore its evolution, yet may play an important role down the road. Researchers from Princeton University found in a study of 1,000 generations of adaptation in 40 yeast populations that about five to seven specific ...

Complications of diabetes, hypertension, asthma, and other preventable conditions are more likely to land former prisoners in the hospital, Yale School of Medicine researchers report in the July 22 online issue of JAMA Internal Medicine. According to the study, about one in 70 former inmates are hospitalized for an acute condition within seven days of release, and one in 12 by 90 days, a rate much higher than the general population. "The period immediately after release has a high risk of an event requiring hospitalization, indicating a potential target for improving ...

Washington, DC—A team of researchers has for the first time mapped the above ground carbon density of an entire country in high fidelity. They integrated field data with satellite imagery and high-resolution airborne Light Detection and Ranging (LiDAR) data to map the vegetation and to quantify carbon stocks throughout the Republic of Panama. The results are the first maps that report carbon stocks locally in areas as small as a hectare (2.5 acres) and yet cover millions of hectares in a short time. The system has the lowest demonstrated uncertainty of any carbon-counting ...

PHILADELPHIA - Overturning a commonly-held belief that cities are inherently more dangerous than suburban and rural communities, researchers from the Perelman School of Medicine at the University of Pennsylvania and the Children's Hospital of Philadelphia (CHOP) have found that risk of death from injuries is lowest on average in urban counties compared to suburban and rural counties across the U.S. The new study, which appears online ahead of print in the Annals of Emergency Medicine, found that for the entire population, as well as for most age subgroups, the top three ...

WASHINGTON — Large cities in the U.S. are significantly safer than their rural counterparts, with the risk of injury death more than 20 percent higher in the country. A study to be published online tomorrow in Annals of Emergency Medicine upends a common perception that urban areas are more dangerous than small towns ("Safety in Numbers: Are Major Cities the Safest Places in the U.S.?"). "Cars, guns and drugs are the unholy trinity causing the majority of injury deaths in the U.S.," said lead study author Sage Myers, MD, MSCE, of the University of Pennsylvania in Philadelphia, ...

PerFluoroAlkyl Substances (PFASs) and precursor compounds have been used in a wide variety of commercial and industrial products over the past six decades. Applications include water and oil repellent coatings, e.g. for textiles, paper products, carpets and food packaging, pharmaceuticals and surfactants in cleaning products and fire-fighting foams. PFASs are highly resistant to chemical, thermal and biological degradation. PFASs and their precursor compounds have shown a dramatic increase and dispersal around the world over the past four decades. An increasing amount ...

Expert ballet dancers seem to glide effortlessly across the stage, but learning the steps is both physically and mentally demanding. New research suggests that dance marking — loosely practicing a routine by "going through the motions" — may improve the quality of dance performance by reducing the mental strain needed to perfect the movements. The new findings, published in Psychological Science, a journal of the Association for Psychological Science, suggest that marking may alleviate the conflict between the cognitive and physical aspects of dance practice, allowing ...

Detrusor overactivity is common after stroke, and is characterized by frequent micturition and urinary incontinence. However, the optimal treatment for post-stroke detrusor overactivity remains unclear. According to a study reported in the Neural Regeneration Research (Vol. 8, No. 18, 2013), patients with post-stroke detrusor overactivity from the Department of Neurology, Fourth Hospital of Harbin Medical University, China, received electroacupuncture at points Baliao [including bilateral Shangliao (BL31), bilateral Ciliao (BL32), bilateral Zhongliao (BL33), and bilateral ...

Chinese herbal medicine, which has been used for thousands of years in China, has long been considered an effective treatment for vascular dementia. There are already meta-analyses of the effects of herbal extracts (ginkgo biloba and huperzine A) on vascular dementia. However, there has been no systematic review of the efficacy and safety of Chinese herbal medicines for vascular dementia, despite its wide use in clinical practice. A recent study published in the Neural Regeneration Research (Vol. 8, No. 18, 2013) evaluated the efficacy and safety of Chinese herbal medicines ...

A recent study published in the Neural Regeneration Research (Vol. 8, No. 17, 2013) injected recombinant lentivirus carrying enhanced green fluorescent protein and the target gene Atoh1 into the cochlea of normal rats using a postauricular approach via the round window membrane. After 30 days, recombinant lentivirus was shown to have no impact on the hair cell numbers and auditory functions, infect hair and supporting cells, and promote supporting cells to transdifferentiate into hair cells. Researchers believed that it may be a new approach for gene therapy in the treatment ...

Considerable improvement in device performance of polymer-based optoelectronic devices is reported today by researchers from Ulsan National Institute of Science and Technology (UNIST), South Korea. The new plasmonic material, can be applied to both polymer light-emitting diodes (PLEDs) and polymer solar cells (PSCs), with world-record high performance, through a simple and cheap process. The contrary demands of these devices mean that there are few metal nanoparticles that can enhance performance in PLEDs and PSCs at the same time. Most semiconducting optoelectronic ...

Climate change could drive the Iberian lynx ‒ the world's most threatened cat – to extinction within 50 years, despite substantial ongoing conservation efforts, a new international study has found. Published today in Nature Climate Change, the research team says the impact of climate change must be incorporated in strategies to reintroduce the Iberian lynx to new habitats if the species is to be saved. "We show that climate change could lead to a rapid and severe decrease in lynx abundance in coming decades, and probably lead to its extinction in the wild within ...

Concussions, the most common traumatic brain injury, can have serious long-term health effects; therefore, diagnosis and management of these injuries are important. A primer published in CMAJ (Canadian Medical Association Journal) provides physicians with current approaches to diagnosing and managing concussions in patients. "The importance of accurate and timely recognition and management stems from the consequences of misdiagnosis or faulty management that can lead to major disability or death, in both the short and long term," writes Dr. Charles Tator, Division of ...

ANN ARBOR, Mich. – An animal model of the human norovirus created at the University of Michigan Health System lays the groundwork for understanding the biology of the pesky virus and developing antiviral drug treatment. Well-known as the virus that impacts cruise ship vacations, norovirus leads to misery on land too. The virus spreads quickly from person to person in any closed-in space, such as schools, nursing homes, or day-care centers. "The first virus in this group was discovered in 1972 following a disease outbreak at a school in Norwalk, Ohio in 1968. Since then ...

Researchers from Aalto University and Paris Tech have placed water droplets containing magnetic nanoparticles on strong water repellent surfaces and have made them align in various static and dynamic structures using periodically oscillating magnetic fields. This is the first time researchers have demonstrated reversible switching between static and dynamic self-assembly. 'We are conducting this line of research because it opens up a way to create new responsive and intelligent systems and materials,' said Dr. Robin Ras of Aalto University, Finland. Self-assembly is ...

A new finding provides fresh hope for the millions of women worldwide with oestrogen receptor positive breast cancer. Australian scientists have shown that a specific change, which occurs when tumours become resistant to anti-oestrogen therapy, might make the cancers susceptible to treatment with chemotherapy drugs. Seventy percent of breast cancer patients have oestrogen receptor positive cancer, and most patients respond well to anti-oestrogen therapies, for a few years at least. Within 15 years, however, 50% will relapse and eventually die from the disease. Dr Andrew ...

July 22, 2013, Shenzhen, China - The largest genomic institute of the world, BGI Shenzhen, China (hereinafter BGI), together with Reproductive & Genetic Hospital CITIC-XIANGYA (hereinafter CITIC-XIANGYA) announced today that they have successfully applied Next Generation Sequencing (NGS) to detect in vitro fertilized (IVF) embryos with genetic abnormalities. The successful application of preimplantation sequencing (the most advanced form of preimplantation genetic screening, PGS) opens a new chapter in the field of human assisted reproduction, providing new hopes for IVF ...

This news release is available in German. The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), the central, self-governing research funding organisation in Germany, presented a position paper on the future of the German research system at its annual press conference in Berlin on 4 July 2013. Drawn up by the DFG's Executive Committee and Executive Board, the paper was the subject of intense discussion among representatives from all areas of science and the humanities and the federal and state government funding bodies at the DFG's Annual Meeting, which ...

Thiols are sulfur-containing molecules found in most proteins of the human body. Characterized by their 'garlicky' smell, they also give coffee, sweat and the spray of skunks their unique odor. Because they are so widespread in biology, medicine and materials science, thiols are ideal targets for connecting molecules like drugs or polymers together, except that they must first be fitted with a chemical group that acts like an adaptor to other molecules. One of the most potentially useful of these 'adaptors' are the alkynes, which can be extremely powerful in bioconjugation. ...