This may be because family doctors tend to attribute women's - rather than men's - initial symptoms to harmless causes, such as bacterial infections, and some women therefore have to visit their GP several times before they get referred to a specialist, say the researchers. Currently, survival rates for kidney and bladder cancer in England show that fewer women than men live for five years after diagnosis. The researchers looked at the numbers of patients diagnosed with kidney and bladder cancers in England between 2009 and 2010. They used data from the National Audit ...

The findings are based on changes in the social class of two groups of individuals born in 1958 (17,419 people) and in 1970 (16,771 people). The researchers asked each of the children's mums, when their child was five or seven years old, whether they had breastfed him/her. They then compared people's social class as children - based on the social class of their father when they were 10 or 11 - with their social class as adults, measured when they were 33 or 34. Social class was categorised on a four-point scale ranging from unskilled/semi-skilled manual to professional/managerial. ...

BOSTON -- A new study by an international team led by Dana-Farber Cancer Institute scientists provides the first statistically-based guidelines for determining whether a stem cell transplant is appropriate for older patients with myelodysplastic syndromes (MDS) – the most common blood disorders in people over 60 years of age, and frequently a precursor for leukemia. Using mathematical models to analyze hundreds of MDS cases from around the world, the researchers found reduced intensity transplants of donor stem cells are advisable for patients aged 60-70 who have higher-risk ...

PROVIDENCE, R.I. [Brown University] —When working a cold case, smart investigators try something new. By taking a novel approach to nuclear magnetic resonance spectroscopy – a blending of four techniques – scientists have been able to resolve a key interaction between two proteins that could never be observed before. They report on their findings the week of June 24, 2013 in Proceedings of the National Academy of Sciences (PNAS). The interaction the team became the first to describe is nearly universal across all of life. A protein machines called a chaperone takes hold ...

DURHAM, NC -- Homeowners living within one kilometer of shale gas wells appear to be at higher risk of having their drinking water contaminated by stray gases, according to a new Duke University-led study. Duke scientists analyzed 141 drinking water samples from private water wells across northeastern Pennsylvania's gas-rich Marcellus shale basin. Their study documented not only higher methane concentrations in drinking water within a kilometer of shale gas drilling -- which past studies have shown -- but higher ethane and propane concentrations as well. Methane ...

VIDEO: Researchers from Brown University modeled the stickiness of cells associated with sickle cell anemia. The models suggest that squishy SS2 cells are more likely to get stuck to vessel walls... Click here for more information. PROVIDENCE, R.I. [Brown University] — Using powerful computer models, researchers from Brown University have shown for the first time how different types of red blood cells interact to cause sickle cell crisis, a dangerous blockage of blood flow in capillaries ...

Postmenopausal hormone therapy with conjugated equine estrogens (CEEs) was not associated with overall sustained benefit or risk to cognitive function when given to women ages 50 to 55 years, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication. The Women's Health Initiative Memory Study (WHIMS) demonstrated that postmenopausal hormone therapy with CEEs, when prescribed to women 65 years and older, caused deficits in global and domain-specific cognitive functioning. The Women's Health Initiative Memory Study of Younger Women ...

Hospital performance on publicly reported conditions (acute myocardial infarction [heart attack], congestive heart failure, and pneumonia), may potentially be used as a signal of overall hospital mortality rates, according to a study by Marta L. McCrum, M.D., of Harvard School of Public Health, Boston, and colleagues. (Online First) Using national Medicare data from 2,322 acute care hospitals, the authors examined whether mortality -rates for publicly reported medical conditions are correlated with hospitals' overall performance. The sample included 6,670,859 hospitalizations ...

Conversations between parents and adolescents that focus on weight and size are associated with an increased risk for unhealthy adolescent weight-control behaviors, according to a study published Online First by JAMA Pediatrics, a JAMA Network publication. The study by University of Minnesota, Minneapolis, researchers also found that overweight or obese adolescents whose mothers engaged in conversations that were focused only on healthful eating behaviors were less likely to diet and use unhealthy weight-control behaviors (UWCBs). "Because adolescence is a time when ...

The excess risk of death from ischemic (due to reduced blood flow), but not hemorrhagic (due to bleeding), stroke in US black children has decreased over the past decade, according to a study by Laura L. Lehman, M.D., of Boston Children's Hospital, and colleagues. (Online First) The study analyzed death certificate data from the National Center for Health Statistics for all children who died from 1988 through 2007 in the United States. Among 1.6 billion person-years of US children (1988-2007), there were 4,425 deaths attributed to stroke, yielding an average of 221 deaths ...

A unique health economics assessment of copper's role in preventing healthcare-associated infections (HCAIs) is being presented this week at the WHO's International Conference on Prevention and Infection Control (ICPIC) in Geneva, demonstrating rapid payback on the capital investment. Health economics evaluations are typically applied to medication or surgery costs, but this study from York Health Economics Consortium (YHEC) – part of the University of York in the UK – investigated the economic benefits of applying an engineering and design approach to infection control, ...

Planktonic bacteria inhabiting the world's oceans have streamlined their genetic makeup to become lean, mean survival machines, according to new research by an international team of researchers, including microbiologists at the University of British Columbia. The findings, published this week in the Proceedings of the National Academy of Sciences, is the first direct evidence of widespread genome reduction--organisms evolving to cast off superfluous genes and traits in favor of simpler, specialized genetic make-ups optimized for rapid growth. "Microbes are the dominant ...

WASHINGTON — Emergency department information systems (EDIS), a significant focus of both federal legislation and U.S. health care reform, may ultimately improve the quality of medical care delivered in hospitals, but as currently configured present numerous threats to health care quality and patient safety. Two physician work groups in the American College of Emergency Physicians assessed the potential harm lurking in EDIS and make recommendations on how to improve patient safety as these systems are implemented across the country. Their findings were published online ...

CAMBRIDGE, Mass. — MIT biologists have discovered a mechanism that allows cells to read their own DNA in the correct direction and prevents them from copying most of the so-called "junk DNA" that makes up long stretches of our genome. Only about 15 percent of the human genome consists of protein-coding genes, but in recent years scientists have found that a surprising amount of the junk, or intergenic DNA, does get copied into RNA — the molecule that carries DNA's messages to the rest of the cell. Scientists have been trying to figure out just what this RNA might be ...

The 'computer nerd' is a well-known stereotype in our modern society. While this stereotype is inaccurate, it still has a chilling effect on women pursuing a qualification in computer science, according to a new paper by Sapna Cheryan from the University of Washington in the US, and colleagues. However, when this image is downplayed in the print media, women express more interest in further education in computer science. The work is published online in Springer's journal, Sex Roles. Despite years of effort, it has proven difficult to recruit women into many fields that ...

Investigators in The Cancer Genome Atlas (TCGA) Research Network have uncovered a connection between how tumor cells use energy from metabolic processes and the aggressiveness of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC). Their findings demonstrate that normal metabolism is altered in ccRCC tumor cells, and involves a shift from using one metabolic pathway to another. This change – termed a metabolic shift – correlates with tumor stage and severity in some cases. The scientists also found mutations in a pathway that may cause increased ...

AUDIO: Rats like those used in University of Illinois speech and hearing sciences professor Aaron Johnson's study make ultrasonic vocalizations (USVs) that are above the range of human hearing, but special... Click here for more information. CHAMPAIGN, Ill. — A new study shows that the vocal training of older rats reduces some of the voice problems related to their aging, such as the loss of vocal intensity that accompanies changes in the muscles of the larynx. This is an ...

The oxygen content of the ocean may be subject to frequent ups and downs in a very literal sense — that is, in the form of the numerous sea creatures that dine near the surface at night then submerge into the safety of deeper, darker waters at daybreak. Research begun at Princeton University and recently reported on in the journal Nature Geoscience found that animals ranging from plankton to small fish consume vast amounts of what little oxygen is available in the ocean's aptly named "oxygen minimum zone" daily. The sheer number of organisms that seek refuge in water ...

CAMBRIDGE, Mass. — Nanoparticles that deliver short strands of RNA offer a way to treat cancer and other diseases by shutting off malfunctioning genes. Although this approach has shown some promise, scientists are still not sure exactly what happens to the nanoparticles once they get inside their target cells. A new study from MIT sheds light on the nanoparticles' fate and suggests new ways to maximize delivery of the RNA strands they are carrying, known as short interfering RNA (siRNA). "We've been able to develop nanoparticles that can deliver payloads into cells, ...

SAN ANTONIO (June 24, 2013) — Patients with type 2 diabetes fare significantly better if they are started on three medications at the time of diagnosis than if they are prescribed a single drug and have other therapies added later, a San Antonio researcher said June 22 at the 73rd Scientific Sessions of the American Diabetes Association in Chicago. The findings, from a study funded by the association, could revise the way physicians manage the endocrine disease. Comparison UT Medicine San Antonio physician Ralph DeFronzo, M.D., chief of the Diabetes Division in the ...

Philadelphia, Pa. (June 24, 2013) - Sophisticated new optical quality metrics can identify older adults likely to have more rapid age-related declines in vision, suggests a study, "Factors Accounting for the 4-Year Change in Acuity in Patients Between 50 and 80 Years", in the July issue of Optometry and Vision Science, official journal of the American Academy of Optometry. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. The study by Darren E. Koenig, OD, PhD, and colleagues of University of Houston College of Optometry defines ...

Chicago, June 24, 2013—The Associated Press-NORC Center for Public Affairs Research has released results of a major survey exploring resilience of people and neighborhoods directly affected by Superstorm Sandy. The study reveals the importance of social factors such as neighborhood bonds and social supports in coping with the storm and its aftermath. Striking landfall in the United States on October 29, 2012, Superstorm Sandy affected large areas of coastal New York and New Jersey, devastated communities, killed more than 130 people, and caused tens of billions of ...

Evolution, it seems, sometimes jumps instead of crawls. A research team led by a University of Chicago scientist has discovered two key mutations that sparked a hormonal revolution 500 million years ago. In a feat of "molecular time travel," the researchers resurrected and analyzed the functions of the ancestors of genes that play key roles in modern human reproduction, development, immunity and cancer. By re-creating the same DNA changes that occurred during those genes' ancient history, the team showed that two mutations set the stage for hormones like estrogen, ...

EAST BOOTHBAY, MAINE -- A research team led by Bigelow Laboratory for Ocean Sciences has discovered that marine microbes are adapted to very narrow and specialized niches in their environment. This may explain why so few of these microbes—usually less than 1%—can be grown for study in the laboratory. By utilizing new genetic tools, the researchers' new ability to read and interpret genetic information from the remaining 99% will be pivotal in detecting and mitigating the impact of human activities in the ocean. Funded by the National Science Foundation, the study was published ...

COLUMBUS, Ohio – Some open-minded people can be swayed to support government intervention on climate change – but only if they are presented with both the benefits and the costs, a new study suggests. Researchers found that those who were open-minded didn't change their view if they heard arguments for only one side of the issue. People who are relatively more closed-minded did not change their mind regardless of the messages they received, or what their original views were. There was also no evidence of open-minded people becoming less supportive of government intervention, ...