(Philadelphia, PA) – A major factor in the advance of heart disease is the death of heart tissue, a process that a team of scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine think could be prevented with new medicines. Now, the researchers are one step closer to achieving that goal, thanks to their discovery of a key molecule in an unexpected place in heart cells – mitochondria, tiny energy factories that house the controls capable of setting off cells' self-destruct sequence. The study is the first to identify the molecule, ...

A new technique based on atomic force microscopy was developed at the Institute of Food Research to help 'read' information encoded in the gut lining. The lining of our gut is an important barrier between the outside world and our bodies. Laid out, the gut lining would cover the area of a football pitch. It must let nutrients from our foods through, but prevent invasion by disease-causing bacteria, at the same time hosting the trillions of beneficial bacteria needed for proper digestion and immune function. At the forefront of the defensive system is a layer of mucus ...

JACKSONVILLE, Fla. — Researchers at Mayo Clinic in Florida participated in a nationwide study that found minor differences between genes that contribute to late-onset Alzheimer's disease in African-Americans and in Caucasians. The study, published April 10 in The Journal of the American Medical Association, was the first to look at the genetics of a large number of African-Americans diagnosed with this common form of Alzheimer's disease (1,968 patients) compared to 3,928 normal elderly African-American control participants. The Alzheimer's Disease Genetics Consortium ...

Newcastle University scientists have revealed the mechanism that causes a slime to form, making bacteria hard to shift and resistant to antibiotics. When under threat, some bacteria can shield themselves in a slimy protective layer, known as a biofilm. It is made up of communities of bacteria held together to protect themselves from attack. Biofilms cause dental plaque and sinusitis; in healthcare, biofilms can lead to life threatening and difficult to treat infections, particularly on medical implants such as catheters, heart valves, artificial hips and even breast ...

EVANSTON, Ill. --- Why do some memories last a lifetime while others disappear quickly? A new study suggests that memories rehearsed, during either sleep or waking, can have an impact on memory consolidation and on what is remembered later. The new Northwestern University study shows that when the information that makes up a memory has a high value (associated with, for example, making more money), the memory is more likely to be rehearsed and consolidated during sleep and, thus, be remembered later. Also, through the use of a direct manipulation of sleep, the research ...

On April 11, 2013, the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard NASA's Aqua satellite passed over Mexico and Central America, and acquired this true-color image of dozens of fires burning across the region. Fires dot the landscapes of Mexico, Guatemala, El Salvador, and Honduras in this image. Each red mark that appears is an area where the thermal detectors on the MODIS instrument recognized temperatures higher than the background which means that most likely those dots are fires. As these dots appear in satellite images during April, the dry season ...

Michael Woods m_woods@acs.org 504-670-4707 (New Orleans Press Center, April 5-10) 202-872-6293 American Chemical Society Enzymes from horse feces could hold secrets to streamlining biofuel production NEW ORLEANS, April 11, 2013 — Stepping into unexplored territory in efforts to use corn stalks, grass and other non-food plants to make biofuels, scientists today described the discovery of a potential treasure-trove of candidate enzymes in fungi thriving in the feces and intestinal tracts of horses. They reported on these enzymes — the key to economical production ...

Michael Woods m_woods@acs.org 504-670-4707 (New Orleans Press Center, April 5-10) 202-872-6293 American Chemical Society 'Seeing' the flavor of foods NEW ORLEANS, April 11, 2013 — The eyes sometimes have it, beating out the tongue, nose and brain in the emotional and biochemical balloting that determines the taste and allure of food, a scientist said here today. Speaking at the 245th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society, he described how people sometimes "see" flavors in foods and beverages ...

A new study by scientists at King's College London and the University of Arizona (UA) published in Science reveals the deep similarities in how the brain regulates behaviour in arthropods (such as flies and crabs) and vertebrates (such as fish, mice and humans). The findings shed new light on the evolution of the brain and behaviour and may aid understanding of disease mechanisms underlying mental health problems. Based on their own findings and available literature, Dr Frank Hirth (King's) and Dr Nicholas Strausfeld (UA) compared the development and function of the central ...

AUDIO: Prof. Lee Berger from the Evolutionary Sciences Institute at the University of the Witwatersrand speaks about the six papers published in Science describing how Au. sediba walked, chewed and moved.... Click here for more information. Johannesburg – A team of South African and international scientists from the Evolutionary Studies Institute (ESI) at the University of the Witwatersrand (Wits) and 15 other global institutions, are publishing six papers and an introduction ...

COLUMBUS, Ohio – A dental study of fossilized remains found in South Africa in 2008 provides new support that this species is one of the closest relatives to early humans. The teeth of this species – called Australopithecus sediba – indicate that it is also a close relative to the previously identified Australopithecus africanus. Both of these species are clearly more closely related to humans than other australopiths from east Africa, according to the new research. The study, published in the journal Science, revealed that both africanus and sediba shared about the ...

April 11, 2013, Fort Lauderdale, Fla. -- Surgical patients who demonstrated heightened pain sensitivity, or hyperalgesia, induced by high doses of a synthetic opioid had their symptoms alleviated by co-treatment with dexmedetomidine, according to new research. Study investigators, who presented their results today at the 29th Annual Meeting of the American Academy of Pain Medicine, concluded that dexmedetomidine may be a new and effective treatment option for opioid-induced hyperalgesia (OIH). OIH refers to increased pain sensitivity due to high-dose or prolonged opioid ...

Berlin, Germany: People with sleep apnoea are more likely to fail a driving simulator test and report nodding whilst driving, according to new research. The study will be presented today (12 April 2013) at the Sleep and Breathing Conference in Berlin, organised by the European Respiratory Society and the European Sleep Research Society. Sleep apnoea has previously been linked with an increased chance of being involved road traffic accidents. A research team from the University Hospital in Leeds, UK, carried out two separate studies looking at the effect sleep apnoea ...

Highlights There is substantial regional variation in the magnitude of racial differences in end-of-life care among US adults with kidney failure. Black-white differences in dialysis discontinuation and hospice referral are most pronounced in regions with the highest levels of end-of-life spending. More than 590,000 Americans in 2010 were treated for kidney failure. Washington, DC (April 11, 2013) — At the end of life, black patients with kidney failure receiving chronic dialysis are less likely to be referred to hospice and to discontinue dialysis compared with ...

Highlights People with apple-shaped bodies tend to have lower kidney function, lower kidney blood flow, and higher blood pressure within the kidneys than people with pear-shaped bodies. The findings may help explain why people with apple-shaped bodies are more likely than those with pear-shaped bodies to develop kidney disease. Washington, DC (April 11, 2013) — High blood pressure in the kidneys of people with apple-shaped bodies may be responsible for their increased risk of developing kidney disease later in life, according to a study appearing in an upcoming issue ...

LA JOLLA, CA – April 11, 2013 – Scientists at The Scripps Research Institute (TSRI) have made a counterintuitive finding that may lead to new ways to clear persistent infection that is the hallmark of such diseases as AIDS, hepatitis B and hepatitis C. The study, reported in the April 12, 2013 issue of the journal Science, focused on the activity of the body's type 1 interferon (IFN-I) proteins. Since its discovery over 50 years ago, IFN-I has been believed to be an especially powerful antiviral agent that marshals the immune system's response against the body's foreign ...

CHAMPAIGN, Ill. — A new class of tiny, injectable LEDs is illuminating the deep mysteries of the brain. Researchers at the University of Illinois at Urbana-Champaign and Washington University in St. Louis developed ultrathin, flexible optoelectronic devices – including LEDs the size of individual neurons – that are lighting the way for neuroscientists in the field of optogenetics and beyond. Led by John A. Rogers, the Swanlund professor of materials science and engineering at the U. of I., and Michael R. Bruchas, a professor of anesthesiology at Washington University, ...

April 11, 2013, Fort Lauderdale, Fla. -- Researchers from Virginia Commonwealth University (VCU) sought to shed light on the biopsychosocial and spiritual effects of taking prescribed opioids to treat noncancer pain. Such questions have received little examination and impact the challenging decision of when and how to use opioids, the study authors wrote in a scientific poster presented today at the 29th Annual Meeting of the American Academy of Pain Medicine. They found that taking opioids had many and diverse consequences for patients in terms of biological, psychological, ...

April 11, 2013, Fort Lauderdale, Fla. -- Veterans who sustained major limb injuries during combat reported little improvement in symptoms of depression, anxiety, post-traumatic stress disorder (PTSD) and other mental-health problems up to 2 years post injury, according to research presented today. In contrast, pain showed the most improvement 3-6 months after acute hospitalization, and then leveled off after 1 year. The investigative team, led by Rollin M. Gallagher, MD, MPH, reported results during a poster session at the 29th Annual Meeting of the American Academy of ...

April 11, 2013, Fort Lauderdale, Fla. -- A new study suggests that the type of bio-cellular grafts increasingly used by surgeons to repair damaged tissue may be useful for treating low-back pain (LBP). However, not all sufferers responded equally to the novel therapy. Results reported today at the 29th Annual Meeting of the American Academy of Pain Medicine ranged from complete pain relief to no improvement. The procedure involved injecting a concentrated form of bone-marrow cellular aspirate into lumbar discs in patients with clinical and objective evidence of disc ...

April 11, 2013, Fort Lauderdale, Fla. -- Half of patients on high-dose, long-term opioid therapy had hormonal disturbances or signs of inflammation, while 100 percent reported improved pain control and mental outlook, new research shows. The results, reported today at the 29th Annual Meeting of the American Academy of Pain Medicine, present rare data on the effects of opioids beyond 10 years. Most clinical trials that examine opioid use are of short duration, and little is known about long-term outcomes, particularly in patients who suffer from noncancer pain. The 40 ...

April 11, 2013, Fort Lauderdale, Fla. -- Changing the parameters used to deliver radiofrequency (RF) treatment greatly affects the size of the resulting heat lesion, researchers reported today in a study expected to deliver greater precision and more treatment options in interventional pain management. Results were presented at the 29th Annual Meeting of the American Academy of Pain Medicine. "This is the most comprehensive study of radiofrequency heat lesion size for pain management to date," said the study's lead author, Eric Cosman Jr., PhD, scientific director of ...

April 11, 2013, Fort Lauderdale, Fla. -- Two innovative techniques in the placement of an implanted spinal cord stimulator (SCS) are expected to reduce common complications at the implant site, according to new research revealed today. Results from a case series highlighted an advanced lead anchoring technique and the emerging technology of using large single-port introducers, which enable placement of multiple neurostimulation leads through a single needle-entry point. Neurostimulation leads are used in SCS therapy for the management of chronic pain. The researchers ...

April 11, 2013, Fort Lauderdale, Fla. -- Researchers are suggesting new ways to use existing Internet tools to recruit more study participants for clinical pain trials and to increase the likelihood they will remain throughout the study period. An innovative website allowed recruiters to reach out broadly to target and recruit potential subjects and to avoid many of the common difficulties of pain research, according to results presented today at the 29th Annual Meeting of the American Academy of Pain Medicine. Research is important to establish which therapies are safe ...

April 11, 2013, Fort Lauderdale, Fla. -- First-of-its-kind research presented today showed microwave ablation (MWA) therapy cut pain in half for patients with painful bone and soft-tissue tumors and took less time to complete than radiofrequency ablation. Pain relief lasted over 4 months on average and up to 15 months in some patients, according to results reported at the 29th Annual Meeting of the American Academy of Pain Medicine. Approximately 10,600 new cases of soft-tissue sarcoma and 2,570 new cases of bone sarcoma were diagnosed in the United States in 2009, according ...