University of Granada researchers have designed a guideline for physicians and patients on the Androgen Insensitivity Syndrome (AIS), a rare disease that makes the subject develop reverse sex, which occurs when a subject looks like a woman but has male genes. AIS has low prevalence (it only affects one in 2000 people), and it is characterized by the inability of tissues to respond to the action of male hormones. This prevents individuals with XY sex hormones (i.e. 46,XY) to develop male genitalia. This disorder is caused by a mutation in the gene that codifies the receptor ...

CHICAGO (Feb. 6, 2013)—Impacting approximately one-third of the U.S. population, obesity is a significant health concern for Americans. It's a risk factor for developing type 2 diabetes, heart disease, and certain forms of cancer, and now, according to an article published in the January/February 2013 issue of General Dentistry, the peer-reviewed clinical journal of the Academy of General Dentistry (AGD), it also may be a risk factor for gum disease. "We know that being overweight can affect many aspects of a person's health," says Charlene Krejci, DDS, MSD, lead author ...

European Science Foundation's ESSC comments the decisions taken (or not) at ESA's council meeting at ministerial level. Strasbourg – 6, February, 2013 - The European Space Sciences Committee (ESSC) today released its position on the perspectives for the European Space Agency's (ESA) scientific programmes. The position statement provides recommendations on the outcomes of the ESA council meeting at ministerial level, which took place on 26-27 November 2012 in Naples. The statement comments on the impact for science-relevant ESA's programmes resulting from the decisions ...

Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie reprogramming are still not understood. Scientists from the EMBL Hamburg and from the Max Planck Institute for Molecular Biomedicine in Münster, Germany now shed new light on this process. In a study published today in Nature Cell Biology, the scientists describe important details ...

The location of an underwater volcanic vent, marked by a low-lying plume of shimmering water, has been revealed by scientists at the National Oceanography Centre, Southampton. Writing in the journal PLOS ONE the researchers describe how the vent, discovered in a remote region of the Southern Ocean, differs from what we have come to recognise as "classic" hydrothermal vents. Using SHRIMP, the National Oceanography Centre's high resolution deep-towed camera platform, scientists imaged the seafloor at Hook Ridge, more than 1,000 metres deep. The study, funded by the ...

DURHAM, N.H. – Abusive bosses who target employees with ridicule, public criticism, and the silent treatment not only have a detrimental effect on the employees they bully, but they negatively impact the work environment for the co-workers of those employees who suffer from "second-hand" or vicarious abusive supervision, according to new research from the University of New Hampshire. In the first ever study to investigate vicarious supervisory abuse, Paul Harvey, associate professor of organizational behavior at UNH, and his research colleagues Kenneth Harris and Raina ...

Since its inception in 2009, the "Contributions to the systematics of New World macro- moths" series in ZooKeys has been playing an important role in publishing taxonomic changes and new discoveries concerning moth diversity in North America. With a total of 49 publications by 38 authors, this well-established series is among the topic leaders, alongside publications such as Canadian Staphylinidae. Geographic coverage in Zookeys has previously focused primarily on the North American fauna (Canada, United States and Mexico). This issue marks a rapid acceleration in contributions ...

Roughly a quarter of recreational skiers who tear their anterior cruciate ligament (ACL) while hitting the slopes can be successfully treated without surgery, according to a new study. The study, conducted by researchers at Hospital for Special Surgery in New York City, appears online ahead of print in the journal Knee Surgery Sports Traumatology Arthroscopy. "Some patients who tear their ACL while skiing can get away without surgery. Their ligament heals by itself, they will have stable knees, and they will be able to do whatever they want, including skiing," said Robert ...

Engineered to produce the bacterial toxin, Bt, "Bt corn" resists attack by corn rootworm, a pest that feeds on roots and can cause annual losses of up to $1 billion. But besides merely protecting against these losses, the Bt trait has also boosted corn yields, in some cases beyond normal expectations. So what makes it so successful? Fred Below and Jason Haegele of the University of Illinois at Urbana-Champaign set out to answer that question by determining how Bt corn uses nitrogen in the soil. Nitrogen is an important nutrient for corn, and with better root systems, ...

Chemists at the University of Burgos (Spain) have manufactured a sheet that changes colour in the presence of water contaminated with mercury. The results can be seen with the naked eye but when photographing the membrane with a mobile phone the concentration of this extremely toxic metal can be quantified. Mercury contamination is a problem that is particularly affecting developing countries. It poses a risk to public health since it accumulates in the brain and the kidneys causing long term neurological illnesses. It is emitted from industrial and mining waste, especially ...

The preservation of immovable historic relics displayed in large open spaces like China's world-renowned Museum of Qin Terracotta Warriors and Horses requires air curtains and other modifications to recreate the primitive environment from which archaeologists excavated the relics. That's the conclusion of a study of environmental control measures for archaeology museums in the People's Republic of China. Their study appears in ACS' journal Environmental Science & Technology. ZhaoLin Gu and colleagues point out that environmental factors have deteriorated many of the ...

NEW YORK February 6, 2012 From banks to telecom providers, various industries are moving to pricing plans that offer a certain amount of "free" service. Bank customers are allowed a certain number of free ATM withdrawals each month, and cell phone users receive free minutes. These three-part plans — which also include a regular (usually monthly) access fee as well as a usage fee if the customer exceeds the free allotment — are replacing older two-part plans that charged an access fee and a usage price for every unit of consumption. Recent studies show that consumers ...

The semi-aquatic earthworms in the genus Glyphidrilus are somewhat unfamiliar species that live between the terrestrial and freshwater ecosystems of rivers, streams, canals, ponds, swamps and paddy systems. Remarkably, each species is endemic to a single water basin, carrying its own signature of evolution from their common origin. A study describing ten newly discovered species of the genus has been published in the open access journal ZooKeys. In Thailand, the species demonstrate astonishing biodiversity due to the monsoon climate contributing to drastic river system ...

February 6, 2013 (Ottawa, ON) - Cities are major players in the climate change game. More than half of the world's population lives in urban areas and over 70% of global GHG (greenhouse gas) emissions can be attributed to cities. A case study of Toronto demonstrates alternative strategies for how the city can implement a low carbon urban infrastructure plan by 2031. Two scenarios are described: one based on Toronto's current policies was found to reduce GHG emissions by 31%; and another suggests aggressive alternatives that could reduce GHG emissions by 71%. Strategies ...

Laboratory experiments conducted by scientists at Virginia Commonwealth University Massey Cancer Center suggest that a novel combination of the drugs ibrutinib and bortezomib could potentially be an effective new therapy for several forms of blood cancer, including diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). The study, published in the British Journal of Hematology, showed that the experimental drug combination killed cancer cells through a form of cell suicide known as apoptosis, but was relatively non-toxic to normal, healthy cells. Ibrutinib ...

ROCHESTER, Minn. — Acute kidney injury strikes large numbers of hospitalized patients, including those with no prior kidney-related illness, and is one of the most costly and deadly conditions affecting critically ill patients. Findings published today in Critical Care from a Mayo Clinic-led, multicenter study identify two biomarkers of acute kidney injury that can be easily measured in urine and detect affected patients roughly 12 to 36 hours earlier than current tests. "Failure to recognize and manage acute kidney injury in the early stages can lead to devastating ...

No clear evidence exists to support the idea that celiac disease is increasing in prevalence because farmers are growing strains of wheat that contain more gluten. That's the conclusion of an article in the ACS' Journal of Agricultural and Food Chemistry. Donald D. Kasarda cites evidence that the incidence of celiac disease increased during the second half of the 20th century. Some estimates indicate that the disease is 4 times more common today. Also known as gluten intolerance, celiac disease occurs when gluten, a protein in wheat, barley and rye, damages the lining ...

High levels of drinking have repeatedly been shown to predict divorce. The most cited explanation for this is that excessive alcohol use disrupts daily tasks and functioning, and increases spousal conflicts. A study of the effects of drinking among husbands versus wives, and of similar versus dissimilar drinking in couples, has found that both level of drinking and compatibility in drinking can have an influence on divorce. Results will be published in the May 2013 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View. "On ...

Individuals who drink excessively or are alcohol dependent (AD) have reduced central serotonergic neurotransmission, which can have an impact on planning, judgment, self-control, and emotional regulation. Childhood maltreatment has also been found to have a negative impact on central serotonergic neurotransmission. A new evaluation of the impact of childhood maltreatment on central serotonergic dysfunction in AD individuals has found that self-reported childhood emotional abuse is associated with a 90-percent reduction in central serotonergic neurotransmission in male ...

An individual's breath alcohol concentration (BrAC) following alcohol intake is influenced by several factors, including food. While it is known that food delays the stomach emptying, thus reducing BrAC, only recently has the role of nonalcoholic drink mixers used with alcohol been explored as a factor influencing BrAC. A new comparison of BrACs of alcohol consumed with an artificial sweetener versus alcohol consumed with a sugared beverage has found that mixing alcohol with a diet soft drink can result in a higher BrAC. Results will be published in the April 2013 ...

In 2009, according to the Centers for Disease Control and Prevention, suicide ranked as the 10th leading overall cause of death in the United States. Prior research has also shown that alcohol use disorders confer increased risk for suicide, and are second only to mood disorders as common among individuals who have committed suicide. A study of the prevalence and sociodemographic correlates of suicide involving acute alcohol intoxication among U.S. ethnic minorities has found that American Indians are at much greater risk than other groups. Results will be published ...

PHILADELPHIA — Researchers have identified two molecules that could potentially serve as biomarkers in predicting brain metastases in patients with breast cancer, according to data published in Cancer Research, a publication of the American Association for Cancer Research. Currently, most deaths from breast cancer are a result of metastatic disease. New research shows that cancer stem-like cells — commonly defined as cells within a tumor with the capacity to initiate a new tumor, proliferate rapidly, differentiate and cause chemotherapy resistance — may play a role in ...

PROVIDENCE, R.I. [Brown University] — A study published Feb. 6 in the Journal of the American Medical Association finds that while more seniors are dying with hospice care than a decade ago, they are increasingly doing so for very few days right after being in intensive care. The story told by the data, said the study's lead author, is that for many seniors palliative care happens only as an afterthought. "For many patients, hospice is an 'add-on' to a very aggressive pattern of care during the last days of life," said Dr. Joan Teno, professor of health services policy ...

In a study that included data on more than 800,000 Medicare beneficiaries who died between 2000 – 2009, a lower proportion died in an acute care hospital in recent years, although both intensive care unit (ICU) use and the rate of health care transitions increased during the last month of life, according to a study appearing in the February 6 issue of JAMA. "Site of death has been proposed as a quality measure for end-of-life care because, despite general population surveys indicating the majority of respondents and those with serious illness want to die at home, in ...

Among patients with peripheral artery disease and intermittent claudication (pain in the calf that comes and goes, typically felt while walking), 24 weeks of treatment with the angiotensin-converting enzyme (ACE) inhibitor ramipril was associated with improvement in pain-free and maximum walking times and the physical health aspect of quality of life, according to a study appearing in the February 6 issue of JAMA. "Approximately 27 million individuals in Europe and North America have peripheral artery disease (PAD). Intermittent claudication occurs in approximately one-third ...