HGPS is a rare genetic disease that affects one in every 4-8 million births. The disease is caused by a spontaneous mutation in one of the two copies (alleles) of the gene LMNA, which codes for lamin A, a protein important for the integrity and function of the envelope surrounding the cell nucleus. The mutation causes incorrect processing of the messenger RNA for lamin proteins, resulting in the synthesis of an anomalous protein, called progerin. The new study, published in the leading cardiovascular research journal Circulation, identifies a possible treatment to block ...

This news release is available in German. Efficient, robust and economic catalyst materials hold the key to achieving a breakthrough in fuel cell technology. Scientists from Jülich and Berlin have developed a material for converting hydrogen and oxygen to water using a tenth of the typical amount of platinum that was previously required. With the aid of state-of-the-art electron microscopy, the researchers discovered that the function of the nanometre-scale catalyst particles is decisively determined by their geometric shape and atomic structure. This discovery opens ...

The plant genus Lepidiums is a small group of representatives of the economically important cabbage family Brassicaceae. Most commonly known as peppercress or peppergrass Lepidiums includes around 180 species worldwide. In a new extensive study, published in the open access journal PhytoKeys, scientists explore the diversity within the New Zealand Lepidiums oleraceum and allied species. Lepidiums oleraceum, is known in New Zealand, as "Cook's Scurvy Grass" because Captain James Cook, and other early explorers of that island nation, ate the plant as a scurvy preventive. ...

How does a social animal – mouse or human – gain dominance over his or her fellow creatures? A unique experiment conducted by Dr. Tali Kimchi and her team in the Weizmann Institute's Neurobiology Department provides some unusual insight into the social behavior that enables a social hierarchy, complete with a head honcho, to form. Kimchi and her research team, Aharon Weissbrod, Genady Wasserman and Alex Shapiro, together with Dr. Ofer Feinerman of the Institute's Physics of Complex Systems Department, developed a system that enabled them to observe a large group of animals ...

SAN FRANCISCO—- A mother's exposure to triclocarban, a common antibacterial chemical, while nursing her babies shortens the life of her female offspring, a new study in rats finds. The results were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco. Commonly used in antibacterial soap and other personal care products, triclocarban has the potential for a large portion of the public to be exposed to it, said the study's lead author, Rebekah Kennedy, a graduate student in the Department of Public Health at the University of Tennessee, Knoxville. "Our ...

SAN FRANCISCO-— New research suggests that fetal exposure to the common environmental chemical bisphenol A, or BPA, causes increased inflammation in fat tissues after birth, which can lead to obesity and metabolic syndrome. Results of the animal study were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco. Found in plastic water bottles, older baby bottles and many other consumer products, BPA is a known hormone disrupter with estrogen-like properties. Prior research has linked BPA in both animals and humans to obesity and the metabolic ...

New research shows that every third person who is diagnosed for the first time with a mood disorder has been admitted to hospital with an infection prior to the diagnosis. The study is the largest of its kind to date to show a clear correlation between infection levels and the risk of developing mood disorders. Anyone can suffer from an infection, for example in their stomach, urinary tract or skin. It would now appear that their distress does not necessarily end once the infection has been treated. A new PhD project shows that many people subsequently suffer from a mood ...

When it comes to honey bees, more mates is better. A new study from North Carolina State University, the University of Maryland and the U.S. Department of Agriculture (USDA) shows that genetic diversity is key to survival in honey bee colonies – meaning a colony is less likely to survive if its queen has had a limited number of mates. "We wanted to determine whether a colony's genetic diversity has an impact on its survival, and what that impact may be," says Dr. David Tarpy, an associate professor of entomology at North Carolina State University and lead author of a ...

The study, published in the journal Environmental Science and Technology by researchers at IIASA and Center for International Climate and Environmental Research (CICERO) calculates the climate impact for passenger trips of 500-1000 km—typical distances for business or holiday trips. It shows that while air travel continues to have the biggest climate impact per distance travelled, the choices that people make about how they drive or take public transport make a big difference in how much they contribute to climate change. "Traveling alone in a large car can be as bad ...

Aggression in school-age children may have its origins in children 3 years old and younger who witnessed violence between their mothers and partners, according to a new Case Western Reserve University study. "People may think children that young are passive and unaware, but they pay attention to what's happening around them," said Megan Holmes, assistant professor of social work at the Jack, Joseph and Morton Mandel School of Applied Social Sciences at Case Western Reserve in Cleveland. Between three and 10 million children witness some form of domestic violence each ...

Joseph Pidala, M.D., M.S., assistant member of the Blood and Bone Marrow Transplant and Immunology programs at Moffitt Cancer Center, and colleagues from the Chronic Graft-Versus-Host Disease Consortium have determined that certain gastrointestinal and liver-related types of chronic graft-versus-host disease (GVHD) are associated with worsened quality of life and death. Their study appeared in the May issue of Biology of Blood and Marrow Transplantation, the official journal of the American Society for Blood and Marrow Transplantation. GVHD is a complication that can ...

DURHAM, N.C. -- Next time you're doing a slow burn in security screening at the airport, calm yourself with the assurance that a more deliberate baggage scanner may do a better job. In a laboratory test of visual searching ability, scientists found trained Transportation Security Administration (TSA) screening officers were a lot slower than undergraduate students and other civilians. But the amateurs were sloppier. The test is part of ongoing research by Duke University psychologist Stephen Mitroff to understand how the brain manages visual searching, which is important ...

This news release is available in Spanish. The proposed system (Augmented Lecture Feedback System – ALFs) seeks to improve communication between students and professors during large lecture classes like those frequently given at universities. The way they work is quite intuitive: the professor wears a pair of augmented reality glasses that enable him/her to see symbols above each student; the symbols indicate the person's state while this activity is taking place. "These symbols are activated by the students via their cell phones and are used to tell the professor ...

Understanding how gastric bypass surgery changes the properties of nerve cells that help regulate the digestive system could lead to new treatments that produce the same results without surgery, according to Penn State College of Medicine scientists, who have shown how surgery restores some properties of nerve cells that tell people their stomachs are full. The results may also better predict which patients will keep the weight off after surgery. Roux-en-Y gastric bypass surgery is the most effective way to get severe obesity under control. Doctors make the stomach ...

As Anthony Weiner enters the New York mayoral race two years after scandal forced him from office, a new study in Social Science Quarterly explores the lingering effect of scandals and asks how long a politician need wait before hitting the come-back trail. Using research into 'brand crisis' this study is the first systematic test of the idea that scandals can linger in voters' minds and damage a politician's reelection campaign. The authors find evidence that this lingering effect ensures politicians do not return to their pre-scandal predicted margins of victory until ...

The value of a fuel's long-term usefulness and viability is judged through its energy return on investment; the comparison between the eventual fuel and the energy invested to create it. The energy return on investment (EROI) study published in the Journal of Industrial Ecology finds that shale gas has a return value which is close to coal. In the United States, gas is mined from horizontal, hydraulically fractured wells in the Marcellus Shale of Pennsylvania. The study compares the total input energy with the energy expected to be made available to end users. The ...

Fracking, the controversial method of mining shale gas, is widespread across Pennsylvania, covering up to 280,000 km² of the Appalachian Basin. New research in the Annals of the New York Academy of Sciences explores the threat posed to biodiversity including pollution from toxic chemicals, the building of well pads and pipelines, and changes to wetlands. "Shale gas has engendered a great deal of controversy, largely because of its impact on human health, but effects on biological diversity and resources have scarcely been addressed in the public debate," said study author ...

CAMBRIDGE, MA -- Researchers working to design new materials that are durable, lightweight and environmentally sustainable are increasingly looking to natural composites, such as bone, for inspiration: Bone is strong and tough because its two constituent materials, soft collagen protein and stiff hydroxyapatite mineral, are arranged in complex hierarchical patterns that change at every scale of the composite, from the micro up to the macro. While researchers have come up with hierarchical structures in the design of new materials, going from a computer model to the production ...

SAN FRANCISCO—- Exposing developing tissue to low levels of the plastic bisphenol A, commonly known as BPA, is linked to a greater incidence of prostate cancer in tissue grown from human prostate stem cells, a new study finds. The results were presented Monday, June 17, at The Endocrine Society's 95th Annual Meeting in San Francisco. BPA is a synthetic estrogen that is used to add flexibility to many common products, including food cans and containers, compact discs, eyeglasses, and even baby bottles. It is universally prevalent, and tests indicate that almost everyone ...

SAN FRANCISCO-- A new study links fetal exposure to a common chemical pollutant, bisphenol A (BPA), to defects of a testicular hormone in newborn boys with undescended testicles. The results, which were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco, suggest yet another potential harmful effect of BPA, which is widely used in many plastics, liners of food cans and dental sealants. "Alone, our study cannot be considered as definitive evidence for an environmental cause of undescended testis," said lead author Patrick Fenichel, MD, PhD, ...

SAN FRANCISCO-- Vitamin D supplementation may help delay early onset of puberty in girls, a new clinical study finds. The results were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco. Among girls, puberty generally begins between the ages of 10 and 14. Boys undergo these changes later, usually between 12 to 16 years of age. Precocious puberty is diagnosed in girls when sexual development begins before the age of 8; in boys, it is diagnosed when these changes occur before age 9. Recently, medical research has linked vitamin D deficiency ...

SAN FRANCISCO-- Women with polycystic ovary syndrome, or PCOS, lost significantly more weight when they took two drugs that are traditionally used to treat diabetes, rather than either drug alone, a study from Slovenia demonstrates. The results will be presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco. PCOS is the leading cause of infertility among women. In the United States, the disorder affects approximately 5 million women, according to the U.S. Department of Health and Human Services Office of Women's Health. This translates to 1 in ...

This news release is available in French. A new study shows that memory pathology in older mice with Alzheimer's disease can be reversed with treatment. The study by researchers from the Montreal Neurological Institute and Hospital - The Neuro, at McGill University and at Université de Montréal found that blocking the activity of a specific receptor in the brain of mice with advanced Alzheimer's disease (AD) recovers memory and cerebrovascular function. The results, published in the Journal of Neuroinflammation in May, also suggest an underlying mechanism of AD as a ...

ANN ARBOR, Mich. – Cases of pertussis, also known as whooping cough, are on the rise in the U.S., recently reaching their highest level in 50 years. The disease can be serious or even fatal to newborns who have not yet received vaccinations. Effective vaccines against pertussis have been available for many decades, but that vaccine protection can wear off over time. A new University of Michigan poll shows that 61 percent of adults say they don't know when they were last vaccinated against pertussis, which could mean they might be unwittingly exposing vulnerable babies ...

Mannitol, a sugar alcohol produced by fungi, bacteria, and algae, is a common component of sugar-free gum and candy. The sweetener is also used in the medical field — it's approved by the FDA as a diuretic to flush out excess fluids and used during surgery as a substance that opens the blood/brain barrier to ease the passage of other drugs. Now Profs. Ehud Gazit and Daniel Segal of Tel Aviv University's Department of Molecular Microbiology and Biotechnology and the Sagol School of Neuroscience, along with their colleague Dr. Ronit Shaltiel-Karyo and PhD candidate Moran ...