SAN FRANCISCO—A joint guideline released today from the Endocrine Society and the European Society of Endocrinology (ESE) recommends women with diabetes receive proper preconception care and access to emerging diabetes technology and therapeutics to manage their blood sugar before, during and after pregnancy. Adverse pregnancy outcomes such as miscarriages or birth defects are common in individuals with pre-existing diabetes and are often related to modifiable factors such as maternal high blood sugar and body mass index (BMI). Screening women of reproductive age who have diabetes for intent to conceive at ...

SAN FRANCISCO—People who are older than 80 should be considered for osteoporosis treatment after a fracture to avoid further risk, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. “The burden of osteoporosis is rising as the global population ages rapidly,” said Gianina Flocco, M.D., a resident at the Cleveland Clinic in Cleveland, Ohio. “Our study supports the initiation of osteoporosis treatment after a fracture ...

SAN FRANCISCO—Women and older adults taking the anti-obesity drug semaglutide may be at higher risk for muscle loss, but higher protein intake may help prevent muscle loss in these patients, according to a small study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. Losing muscle (or lean mass) is a common side effect of weight loss in adults with obesity and may negatively affect metabolism and bone health. This is because muscle helps control blood sugar after meals and plays an important role in keeping bones strong, according to study lead researcher Melanie Haines, M.D., of Massachusetts ...

SAN FRANCISCO—People with an underactive thyroid may have an increased risk of developing small intestinal bacterial overgrowth (SIBO), a risk that may be reduced with thyroid hormone treatment, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. “We now know that people with hypothyroidism, especially those with autoimmune thyroiditis, are more likely to develop SIBO, but this risk appear to be mitigated in those taking thyroid medications,” said Ruchi Mathur, M.D., Director of the Diabetes Outpatient ...

SAN FRANCISCO—Using tirzepatide and menopause hormone therapy at the same time leads to increased weight loss in postmenopausal women with overweight or obesity compared to use of tirzepatide treatment alone, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. “These data are the first to show the combined use of tirzepatide and menopause hormone therapy significantly increases treatment effectiveness in postmenopausal women,” said Regina Castaneda, ...

SAN FRANCISCO—Metabolic health factors, including small increases in blood sugar, are the main drivers of change in the reproductive systems and sexual functioning of aging men, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. “Although age and testosterone levels have long been considered an impetus for men’s declining sexual health, our research indicates that these changes more closely correlate with modest increases in blood sugar and other metabolic changes,” said Michael Zitzmann, ...

SAN FRANCISCO—Strong emotional links between children with chronic conditions and their family caregivers suggest that improving parent well-being may directly benefit a child’s overall health and coping mechanisms, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. The study observed children with growth hormone deficiency and their caregivers to better understand the impact that physical or emotional distress can have. Findings suggest that when parents or caregivers of children with growth hormone deficiency report symptoms of stress, anxiety and depression, so does the child they ...

SAN FRANCISCO—Oxytocin, often called “the love hormone,” may play a protective role in mood disturbances triggered by sleep loss and hormonal shifts during key reproductive transitions like postpartum and menopause, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. Researchers at Brigham and Women’s Hospital and Harvard Medical School studied the combined impact of sleep interruption and estrogen suppression on mood and oxytocin levels in healthy premenopausal women. Their findings suggest that oxytocin may help reduce the negative mood effects brought on by fragmented sleep, which ...

SAN FRANCISCO—The anti-obesity medication tirzepatide, marketed as Mounjaro for diabetes and Zepbound for obesity, reduced obesity-associated breast cancer growth in a mouse model, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. "Obesity is a significant risk factor for breast cancer, and while it is very preliminary data, our studies in mice suggest that these new anti-obesity drugs may be a way to reduce obesity-associated breast cancer risk or improve outcomes,” said study author Amanda Kucinskas, ...

https://doi.org/10.1016/j.apsb.2025.05.003 This new article publication from Acta Pharmaceutica Sinica B, discusses how a CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury.   Acute liver injury (ALI) serves as a critical precursor and major etiological factor in the progression and ultimate manifestation of various hepatic disorders. The prevention and treatment of ALI is still a serious global challenge. Given the limited therapeutic options for ALI, exploring novel targeted therapeutic agents becomes imperative. The potential therapeutic ...

https://doi.org/10.1016/j.apsb.2025.05.018 This new article publication from Acta Pharmaceutica Sinica B, discusses how melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.   A major obstacle in type 2 diabetes mellitus (T2DM) is sleep fragmentation (SF), which negatively affects testicular function. However, the underlying mechanisms remain to be elucidated. This study demonstrated that SF induces testicular damage through a mechanism involving lipid metabolism, ...

https://doi.org/10.1016/j.apsb.2025.05.013 This new article publication from Acta Pharmaceutica Sinica B, discusses how single-cell RNA sequencing reveals that Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells.   Colorectal tumorigenesis generally progresses from adenoma to adenocarcinoma, accompanied by dynamic changes in the tumor microenvironment (TME). A randomized controlled trial has confirmed the efficacy and safety of Shen-Bai-Jie-Du decoction (SBJDD) in preventing colorectal ...

https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/15/issue/7 Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences. APSB is a monthly journal, in English, which publishes ...

In a first for the field, researchers from The Grainger College of Engineering at the University of Illinois Urbana-Champaign have reported a photopumped lasing from a buried dielectric photonic-crystal surface-emitting laser emitting at room temperature and an eye-safe wavelength. Their findings, published in IEEE Photonics Journal, improve upon current laser design and open new avenues for defense applications. For decades, the lab of Kent Choquette, professor of electrical and computer engineering, have explored VCSELs, a type of surface-emitting laser used in common technology like smartphones, laser printers, barcode scanners, and even vehicles. But ...

A new study led by investigators from Mass General Brigham trialed stereotactic (targeted) brain-directed radiation in 100 patients with small cell lung cancer and brain metastases, finding they experienced positive outcomes that support use of targeted radiation in the future for such patients. Results are published in the Journal of Clinical Oncology. “Despite being the historical standard, whole brain radiation might not be necessary for all patients,” said first author Ayal Aizer, MD, MHS, director of Central Nervous System Radiation Oncology at Brigham and Women’s Hospital, a founding member of the ...

  https://doi.org/10.1016/j.apsb.2025.04.020 This new article publication from Acta Pharmaceutica Sinica B, discusses a high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers.   An ideal dermal filler should integrate filling, repair, and anti-aging effects, with immediate tissue augmentation, slow degradation, and progressive stimulation of collagen regeneration. However, commonly used hyaluronic ...

A traditionally overlooked type of RNA plays an important role in promoting resilience to depression—but only in females. According to a new study led by the Icahn School of Medicine at Mount Sinai, researchers have now discovered a novel role this molecule plays in how the female brain makes decisions. The authors revealed brain-region-specific and sex-dependent effects of this biomarker, translated from humans to animals, on how individuals make only certain types of choices. This study uncovered ...

Analyzed 174 donated brains, including from former high school, college football players Larger studies needed to understand how p-tau relates to aging and the extent to which repetitive impact from contact sport predisposes to p-tau accumulation Whether such changes cause or are associated with clinical problems during life remains unclear CHICAGO --- In recent years, some scientists and advocates have warned that playing contact sports like football and hockey may increase the risk of brain diseases like Alzheimer’s disease or chronic traumatic encephalopathy (CTE) due to a buildup of a specific protein in the brain. But a new ...

An international research team led by Freiburg biologists Dr. Wenjing Qi and Prof. Ralf Baumeister has discovered how the LINE1 retrotransposon exploits a cell protein to become active itself, as occurs in tumours. At the same time, the researchers have also deciphered the cell's appropriate countermeasure to prevent conditions such as tumour formation or chronic inflammation. The results have been published in the journal Nature Communications. Cellular sleepers "Sleepers" are the name the Secret Service gives agents who live inconspicuously in ...

LA JOLLA, CA—A new microchip invented by Scripps Research scientists can reveal how a person’s antibodies interact with viruses—using just a drop of blood. The technology offers researchers faster, clearer insights that could help accelerate vaccine development and antibody discovery. “This lets us take a quick snapshot of antibodies as they are evolving after a vaccine or pathogen exposure,” says Andrew Ward, professor in the Department of Integrative Structural and Computational Biology at Scripps Research and senior author of the new paper published ...

Why do some communities unite in times of crisis, while others fall apart? The study of Kaunas University of Technology researchers revealed a surprising link – cultural heritage is not just a historical asset, but also a powerful tool that helps people build a sense of belonging and act collectively when challenges arise. Along with trust and emotional attachment to place, it becomes a foundation for communities to care for their environment, maintain relationships, and respond to crises together. “A resilient community is a group of people who can unite, ...

For decades, the story of Alzheimer’s research has been dominated by a battle between A-beta and tau amyloids, both of which can kill neurons and impact the brain’s ability to function. A new study suggests, however, that these sticky brain plaques may not be operating alone.   Johns Hopkins University researchers have identified more than 200 types of misfolded proteins in rats that could be associated with age-related cognitive decline.  The findings could lead the way to finding new therapeutic targets and treatments in humans that could provide relief for the millions of people over 65 who suffer from Alzheimer’s, ...

Study finds autistic people describe nonverbal communication as "decoding a complex, unwritten language in real time" Autistic adults take acting classes and study gestures to emulate neurotypical body language Research shows communication breakdowns aren't one-sided - non-autistic adults also struggle to understand autistic communication  Peer-reviewed, data analysis, people Imagine having a conversation where every gesture and glance feels like a test. You're juggling eye contact, facial expressions, and tone of voice, all while trying to keep up with the words. You might miss ...

Despite a warming climate, bone-chilling winter cold can grip parts of the U.S.—and this study explains why. Researchers found that two specific patterns in the polar vortex, a swirling mass of cold air high in the stratosphere, steer extreme cold to different regions of the country. One pattern drives Arctic air into the Northwest U.S., the other into the Central and Eastern areas. Since 2015, the Northwest has experienced more of these cold outbreaks, thanks to a shift in stratospheric behavior tied to broader climate cycles. In short: what happens high above the Arctic can shape the winter on your doorstep. As winters in the United States continue ...

Scientists have discovered how a key protein helps maintain strong connections between brain cells that are crucial for learning and memory. Results of the study, published in the journal Science Advances, could point the way to new treatments for traumatic brain injuries and diseases, such as Parkinson’s and Alzheimer’s, the scientists said. Their research, led by a Rutgers University-New Brunswick professor, uncovered a previously unknown role for cypin, a brain protein. Members of the research team found that cypin promotes the presence ...