Save the Date for the 15th World Mitochondria Society Annua Meeting on October 29-31, 2024, at DoubleTree by Hilton Berlin Ku’damm, Berlin, Germany. The WMS is pleased to announce the participation of two distinguished keynote speakers for the Targeting Mitochondria 2024 conference in Berlin this October.   Keynote Speaker of Day 1: Prof. Eric Schon Professor Eric Schon from Columbia University, USA will deliver a presentation titled "Mitochondria in Alzheimer disease: it's not what you think". Prof. Schon challenges the conventional understanding ...

ABSTRACT CT013 SAN DIEGO ― Combining the KRAS G12C inhibitor adagrasib with the anti-EGFR antibody cetuximab demonstrated promising anti-tumor effects in patients with KRAS G12C-mutated metastatic colorectal cancer (CRC), according to pooled results from the Phase I/II KRYSTAL-1 trial reported by researchers from The University of Texas MD Anderson Cancer Center. The findings were presented today in a plenary session at the American Association for Cancer Research (AACR) Annual Meeting 2024 by Scott Kopetz, M.D., Ph.D., professor of Gastrointestinal ...

ABSTRACT CT014 SAN DIEGO – The first-in-class PARP1-selective inhibitor saruparib demonstrated encouraging early efficacy and a favorable safety profile in patients with homologous recombination repair (HRR)-deficient breast cancers, according to results from the Phase I/II PETRA trial led by researchers at The University of Texas MD Anderson Cancer Center. Results from the first-in-human trial were presented today at the American Association for Cancer Research (AACR) Annual Meeting 2024 by Timothy Yap, M.B.B.S., Ph.D., professor ...

LOS ANGELES — Researchers with City of Hope®, one of the largest cancer research and treatment organizations in the United States, will present more than 70 abstracts and sessions on innovative clinical trial results, breakthrough diagnostic techniques and advances in treatment options as well as share their expertise on molecular profiling and the microbiome at the AACR Annual Meeting, which started April 5 and ends April 10 in San Diego.  In addition to City of Hope’s robust data being presented throughout the meeting, John D. Carpten, Ph.D., the Irell & Manella Cancer Center Director’s ...

SAN DIEGO – A combination of the KRASG12C inhibitor adagrasib (Krazati) and the anti-epidermal growth factor receptor (EGFR) antibody cetuximab (Erbitux) showed clinical activity and promising survival outcomes in a cohort of patients with metastatic, heavily pretreated, KRASG12C-mutated colorectal cancer, according to results from the phase I/II KRYSTAL-1 trial presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10. The study was simultaneously published in Cancer Discovery. KRASG12C mutations occur in around 4% of colorectal cancers and are associated with a poor prognosis. Drugs targeting KRASG12C, such as adagrasib, have emerged ...

SAN DIEGO – Saruparib, a selective inhibitor of poly-ADP ribose polymerase 1 (PARP1), demonstrated a promising objective response rate and progression-free survival in patients with certain homologous recombination repair (HRR)-deficient breast cancers, according to results from the phase I/II PETRA trial presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10. Although blocking the enzyme PARP1 may be sufficient to prevent DNA repair in HRR-deficient tumors, all PARP inhibitors currently approved by the ...

SAN DIEGO – An investigational exosome-based liquid biopsy accurately detected 97% of stage 1-2 pancreatic cancers when combined with the biomarker CA 19-9, according to research presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10. “Pancreatic cancer is one of the most fatal malignancies, in large part because the majority of patients are diagnosed only after the cancer has already metastasized,” said Ajay Goel, PhD, senior author of the study and the chair of the Department of Molecular ...

1. Research groups from NIMS, Seagate Technology, and Tohoku University have made a breakthrough in the field of hard disk drives (HDD) by demonstrating the feasibility of multi-level recording using a three-dimensional magnetic recording medium to store digital information. The research groups have shown that this technology can be used to increase the storage capacity of HDDs, which could lead to more efficient and cost-effective data storage solutions in the future. 2. Data centers are increasingly storing vast amounts of data on hard disk drives (HDDs) that use perpendicular ...

While 3D printing has exploded in popularity, many of the plastic materials these printers use to create objects cannot be easily recycled. While new sustainable materials are emerging for use in 3D printing, they remain difficult to adopt because 3D printer settings need to be adjusted for each material, a process generally done by hand. To print a new material from scratch, one must typically set up to 100 parameters in software that controls how the printer will extrude the material as it fabricates an object. Commonly ...

The biological brain, especially the human brain, is a desirable computing system that consumes little energy and runs at high efficiency. To build a computing system just as good, many neuromorphic scientists focus on designing hardware components intended to mimic the elusive learning mechanism of the brain. Recently, a research team has approached the goal from a different angle, focusing on measuring information transfer instead. Their method went through biological and simulation experiments and then proved effective in an electronic neuromorphic system. It was published ...

Philadelphia, April 8, 2024 – Researchers from Children’s Hospital of Philadelphia (CHOP) found that teens and young adults with mood disorders, such as depression and bipolar disorder, were 30% less likely to obtain their driver’s license than peers without such disorders. Additionally, those youths with mood disorders experienced a slightly elevated risk of crashing. These findings suggest that these teens and young adults could benefit from guidance on obtaining licensure and accessing training to avoid crashes when they are newly licensed. The findings were published online today ...

NEW YORK, NY (April 8, 2024)--A new type of investigational therapeutic in development for pancreatic cancer has shown unprecedented tumor-fighting abilities in preclinical models of the disease, suggesting it has the potential to offer novel treatment options for nearly all pancreatic tumors, a comprehensive study has found.  The inhibitors in this new class of oral medications, being developed by Revolution Medicines Inc., target the oncogenic or active cancer-causing form of RAS proteins (such as KRAS, NRAS, and HRAS). These RAS “oncoproteins” drive up to a third of all human cancers. The research ...

The introduction of a policy protecting parental leave benefits in Sweden in 1980 had unintended consequences on child health. The policy led to an increase in premature birth rates. This is shown by a study from researchers at Stockholm University, published in JAMA Pediatrics. The Swedish so-called speed premium policy was introduced in 1980 in order to protect couples’ level of income-based parental leave benefits when they had children in quick succession. The new study from Stockholm University evaluates the health consequences of the policy. The researchers conclude that by ...

IMMUNE KEY TO CHRONIC VIRAL INFECTIONS DISCOVERED Australian researchers have discovered a previously unknown rogue immune cell that can cause poor antibody responses in chronic viral infections. The finding, published today (9 April) in the journal, Immunity, may lead to earlier intervention and possibly prevention of some types of viral infections such as HIV or hepatitis. One of the remaining mysteries of the human immune system is why a certain cell, called a B cell, which retains a memory for past infections – ensuring we fight off diseases we have experienced before – often only has a weak capacity to protect us from persistent infections. Researchers ...

Per-and poly-fluoroalkyl substances – commonly known as PFAS – are a group of over 14,000 human-made chemicals that have been popular since the 1950s for their diverse skills in resisting heat, water, grease and stains.   They’ve been commonly found in household products like non-stick frypans, clothing, cosmetics, insecticides, and food packaging, as well as specialty industry products, like firefighting foam.  But despite their broad skillset, the chemicals have a dark side: they’re known as ‘forever chemicals’ as once they’re in the environment – ...

About 4.5 billion years ago, a small planet smashed into the young Earth, flinging molten rock into space. Slowly, the debris coalesced, cooled and solidified, forming our moon. This scenario of how the Earth's moon came to be is the one largely agreed upon by most scientists. But the details of how exactly that happened are "more of a choose-your-own adventure novel," according to researchers in the University of Arizona Lunar and Planetary Laboratory who published a paper in Nature Geoscience. The findings offer important insights into the evolution ...

Using artificial intelligence, satellite observations, and climate model projections, a team of researchers from Switzerland and Belgium calculate that for every tenth of a degree of increase in global air temperature, an average of nearly 9,000 meteorites disappear from the surface of the ice sheet. This loss has major implications, as meteorites are unique samples of extraterrestrial bodies that provide insights into the origin of life on Earth and the formation of the Moon. Disappearing at an alarming rate By 2050, about a quarter of the estimated of 300,000 - 800,000 meteorites in Antarctica will be lost ...

Through a large-scale analysis, researchers at the Netherlands Institute for Neuroscience have uncovered the ways in which consensual touch can benefit a person’s physical and mental wellbeing. You might recognize the comforting feeling when someone offers you a hug at the end of a stressful day or strokes your shoulder when you’re feeling down. But the question remains: can touch really help you feel better, and does it matter who it’s from or how they touch you? To explore these questions, researchers from the Social Brain Lab at the Netherlands Institute for Neuroscience and the University Hospital ...

(BOSTON) — The Wyss Institute for Biologically Inspired Engineering at Harvard University and Northpond Ventures announced today that the VC firm’s affiliate Northpond Labs has signed an agreement to support the development of the AminoX project toward commercialization. This is the fourth Wyss project selected by Northpond Labs for additional funding.   Established in 2020 with the involvement of Harvard’s Office of Technology Development, the five-year strategic research alliance created The Laboratory for Bioengineering Research and Innovation at the Wyss Institute through a $12 million commitment from Northpond Labs to support impactful research ...

A new automated workflow developed by scientists at Lawrence Berkeley National Laboratory (Berkeley Lab) has the potential to allow researchers to analyze the products of their reaction experiments in real time, a key capability needed for future automated chemical processes. The developed workflow – which applies statistical analysis to process data from nuclear magnetic resonance (NMR) spectroscopy – could help speed the discovery of new pharmaceutical drugs, and accelerate the development of new chemical reactions. The Berkeley Lab scientists who developed the groundbreaking technique ...

For millions of years, underground fungi have lived in symbiosis with plant roots. Plants provide photosynthesized carbon, while fungi deliver water and nutrients. In order to do so, these organisms share space at cellular scale: fungi stretch a network of tendrils called arbuscules into a plant’s root cells, and both organisms rearrange their cells around this structure to facilitate sharing.  Recently, researchers have been able to study both sides of this interaction up close, using RNA sequencing to understand gene expression: one of the first cross-kingdom spatially-resolved transcriptomics studies to date. This paper ...

Donations for a political candidate can be motivated by support for that candidate or by opposition to the candidate’s opponent. New research published in Social Science Quarterly found that female Democrats and non-white male Democrats in the United States have a fundraising advantage when running against a white male Republican. Female Republicans or non-white male Republicans do not have this advantage when running against white male Democrats. To assess the impact that race, gender, and party ...

Berlin, Germany – 8 April 2024:  The first randomised trial to investigate preventive ablation of a potential arrhythmogenic substrate associated with coronary chronic total occlusion (CTO) in patients at high risk of ventricular arrhythmias (VAs)  reduces the risk of appropriate implantable cardioverter-defibrillator (ICD) therapy and unplanned hospitalisation in patients with no previously recorded VAs. The late-breaking science is presented at EHRA 2024, a scientific congress of the European ...

PLYMOUTH MEETING, PA [April 8, 2024] — The National Comprehensive Cancer Network® (NCCN®)—a nonprofit devoted to patient care, research, and education—is announcing the election of Matt Kalaycio, MD, FACP, as Chair of the Board of Directors, with Christopher H. Lieu, MD, elected as Vice-Chair, succeeding Dr. Kalaycio in the position he has held since 2022. “The exemplary leadership from our board of directors is invaluable as NCCN defines and advances high-quality, high-value, patient-centered cancer care around the world,” said NCCN Chief Executive Officer Crystal S. Denlinger, ...

A new study presented at the European Psychiatric Association Congress 2024 reveals a significant rise in mental health issues among children and adolescents displaced by the war in Ukraine. The research, conducted by the Institute of Forensic Psychiatry of MoH of Ukraine, highlights the devastating impact of prolonged exposure to violence and displacement on the mental well-being of young people. As per UNICEF’s recent report on “The State of the World’s Children 2021”, the current COVID-pandemic ...