Anyone whose hand or foot has "fallen asleep" has an idea of the numbness and tingling often experienced by people with peripheral nerve damage. The condition also can cause a range of other symptoms, including unrelenting pain, stinging, burning, itching and sensitivity to touch. Although peripheral neuropathies afflict some 20 million Americans, their underlying causes are not completely understood. Much research has focused on the breakdown of cellular energy factories in nerve cells as a contributing factor. Now, new research at Washington University School of Medicine ...

RIVERSIDE, Calif. (http://www.ucr.edu) — A University of California, Riverside Bourns College of Engineering professor and a team of researchers published a paper today that shows how they solved an almost century-old problem that could further help downscale the size of electronic devices. The work, led by Alexander A. Balandin, a professor of electrical engineering at UC Riverside, focused on the low-frequency electronic 1/f noise, also known as pink noise and flicker noise. It is a signal or process with a power spectral density inversely proportional to the frequency. ...

Viruses often spread through the brain in patchwork patterns, infecting some cells but missing others. New research at Washington University School of Medicine in St. Louis helps explain why. The scientists showed that natural immune defenses that resist viral infection are turned on in some brain cells but switched off in others. "The cells that a pathogen infects can be a major determinant of the seriousness of brain infections," says senior author Michael Diamond, MD, PhD, professor of medicine. "To understand the basis of disease, it is important to understand which ...

The earthquake zones off of certain coasts—like those of Japan and Java—make them especially vulnerable to tsunamis, according to a new study. They can produce a focusing point that creates massive and devastating tsunamis that break the rules for how scientists used to think tsunamis work. Until now, it was largely believed that the maximum tsunami height onshore could not exceed the depth of the seafloor. But new research shows that when focusing occurs, that scaling relationship breaks down and flooding can be up to 50 percent deeper with waves that do not lose height ...

A research team at the University of Guelph has developed a new line of transgenic "Enviropigs." The new line of pigs is called the Cassie line, and it is known for passing genes on more reliably. The results of this project were published ahead of print in the Journal of Animal Science. Enviropigs have genetically modified salivary glands, which help them digest phosphorus in feedstuffs and reduce phosphorus pollution in the environment. After developing the initial line of Enviropigs, researchers found that the line had certain genes that could be unstable during reproduction ...

Wednesday, March 6, 2013, Cleveland: Concussions are the leading cause of brain damage in sports, particularly in football. However, researchers at Cleveland Clinic and the University of Rochester have found that football players may suffer long-term brain changes even in the absence of concussion. In a study of 67 college football players, researchers found that the more hits to the head a player absorbed, the higher the levels of a particular brain protein that's known to leak into the bloodstream after a head injury. Even though none of the football players in the ...

Scientists at A*STAR's Genome Institute of Singapore (GIS) have developed a novel technique to precisely monitor and study the evolution of micro-organisms such as viruses and bacteria. This is an extremely important capability as it allows scientists to investigate if new drugs designed to kill them are working, and catch the development of resistance early on. Micro-organisms and cancer cells evolve more quickly than normal human cells as their rapid life-cycles enable faster selection of advantageous mutations. Previously, scientists have had to wait for the selection ...

Flu viruses are a major cause of death and sickness around the world, and antiviral drugs currently do not protect the most seriously ill patients. A study published March 7th by Cell Press in the journal Cell reveals that a compound derived from fats found in fish oils prevents death in influenza-virus-infected mice, even at advanced stages of disease. The study offers a promising strategy for the treatment of patients with severe influenza virus infections. "Given the potential for future lethal pandemics, effective drugs are needed for the treatment of severe influenza, ...

When animals like dogs or rats sniff one another, there might be more going on than you'd think. Research reported in Current Biology, a Cell Press publication, on March 7th finds in rats that those sniffing behaviors communicate information about an individual's social status. In those encounters, more dominant rats act as primary sniffers, while subordinate sniffees actually slow their breath. "We know that rats and other animals can communicate through vocalizations, physical contact, odors, and also visual displays," says Daniel Wesson of Case Western Reserve University. ...

A new study explains how young brains are protected when nutrition is poor. The findings, published on March 7th in Cell Reports, a Cell Press publication, reveal a coping strategy for producing a fully functional, if smaller, brain. The discovery, which was made in larval flies, shows the brain as an incredibly adaptable organ and may have implications for understanding the developing human brain as well, the researchers say. The key is a carefully timed developmental system that ultimately ensures neural diversity at the expense of neural numbers. "In essence, this ...

VIDEO: What happens when human brain cells that surround and support neurons are implanted into the brains of newborn mice? Researchers reporting in the March 7th issue of the Cell Press... Click here for more information. What happens when human brain cells that surround and support neurons are implanted into the brains of newborn mice? Researchers reporting in the March 7th issue of the Cell Press journal Cell Stem Cell recently found that such mice had enhanced learning and ...

An Australian researcher has found the third and final missing piece in the genetic puzzle of an unusual form of hemophilia, more than 20 year after he discovered the first two pieces. Professor Merlin Crossley, of the University of New South Wales, and his international team studied the blood-clotting disorder, hemophilia B Leyden, which is unusual because symptoms improve after puberty. The results, published in The American Journal of Human Genetics, explain how more than half of the cases of this rare, hereditary bleeding disorder occur, and could help improve understanding ...

What do cancer cells, weeds, and pathogens have in common? They all evolve resistance to the treatments that are supposed to eliminate them. However, researchers developing the next generation of antibiotics, herbicides, and anti-cancer therapeutics rarely come together to explore the common evolutionary principles at work across their different biological systems. The new American Academy of Microbiology report "Moving Targets: Fighting Resistance in Infections, Pests, and Cancer" concludes that scientists working on different kinds of treatments have much to learn from ...

USC scientists have discovered how two different structural apparatuses collaborate to protect repetitive DNA when it is at its most vulnerable – while it is being unzipped for replication. The centromere—the center of the "X" shape of a chromosome—contains repeated DNA sequences that are epigenetically coded to attract so-called heterochromatin proteins. This protects the structure to ensure that the chromosomes separate properly. If the heterochromatin is lost (due to mutations in the cell), the repetitive DNA becomes vulnerable to rearrangements and recombination. ...

According to his theory, bacteria that are non-resistant to antibiotics acquire said resistance accidentally because they take up the DNA of others that are resistant, due to the stress to which they are subjected. A University of Granada researcher has formulated a new hypothesis concerning an enigma that the scientific community has still not been able to solve and which could revolutionise the pharmaceutical industry: Why are bacteria becoming increasingly more resistant to antibiotics? His work has revealed that the use of antibiotics can even cause non-resistant bacteria ...

Delhi, March 7, 2013 - In the first gender benchmarking study of its kind, researchers have found that numbers of women in the science, technology and innovation fields are alarmingly low in the world's leading economies, and are actually on the decline in many, including the United States. India's low overall ranking in the study shows slow progress despite women friendly policies which have been in place for a number of years. The full gender benchmarking study maps the opportunities and obstacles faced by women in science in Brazil, South Africa, India, the Republic ...

Cape Town, March 7, 2013 – In the first gender benchmarking study of its kind, researchers have found that numbers of women in the science, technology and innovation fields (STI) are alarmingly low in the world's leading economies, and are actually on the decline in many, including the United States. For South Africa, results show that women have more opportunities available to them than ever before, however, their participation in the science, technology and innovation workforce remains low. The full gender benchmarking study maps the opportunities and obstacles faced ...

Using the technique that created Dolly the sheep, researchers from the RIKEN Center for Developmental Biology in Kobe, Japan have identified a way to produce healthy mouse clones that live a normal lifespan and can be sequentially cloned indefinitely. Their study is published today in the journal Cell Stem Cell. In an experiment that started in 2005, the team led by Dr. Teruhiko Wakayama has used a technique called somatic cell nuclear transfer (SNCT) to produce 581 clones of one original 'donor' mouse, through 25 consecutive rounds of cloning. SNCT is a widely ...

SAN FRANCISCO (March 7, 2013) —A nationwide study of women in Denmark who are of child-bearing age finds that those who are obese appear to have a much greater risk of heart attack or stroke, according to research being presented at the American College of Cardiology's 62nd Annual Scientific Session. In fact, women with a high body mass index (BMI)—a measure of the body's fat content—that is indicative of obesity were twice as likely as those of normal weight to suffer a potentially life-threatening heart attack or stroke within just four to five years following childbirth. ...

The search for a less-expensive, sustainable source of biomass, or plant material, for producing gasoline, diesel and jet fuel has led scientists to duckweed, that fast-growing floating plant that turns ponds and lakes green. That's the topic of a report in ACS' journal Industrial & Engineering Chemistry Research. Christodoulos A. Floudas, Xin Xiao and colleagues explain that duckweed, an aquatic plant that floats on or near the surface of still or slow-moving freshwater, is ideal as a raw material for biofuel production. It grows fast, thrives in wastewater that has ...

In a step toward understanding and exploiting an exotic form of matter that has been sparking excitement for potential applications in a new genre of supercomputers, scientists are reporting the first identification of a naturally occurring "topological insulator" (TI). Their report on discovery of the material, retrieved from an abandoned gold mine in the Czech Republic, appears in the ACS journal Nano Letters. Pascal Gehring and colleagues point out that synthetic TIs, discovered only a decade ago, are regarded as a new horizon in materials science. Unlike conventional ...

WASHINGTON and NEW YORK—A report released today by the George Washington University School of Public Health and Health Services (SPHHS) and the RCHN Community Health Foundation offers the first-ever in-depth examination of health centers' role in access to family planning. The report finds that virtually all health centers furnish family planning services to some extent but for both financial and non-financial reasons, only 1 in 5 is able to offer access to the full range of contraceptive services. The report offers a series of recommendations to strengthen performance, ...

WASHINGTON – Older adults who haven't been in school for a while are as capable of learning from tests as younger adults and college students, according to new research published by the American Psychological Association. No matter their age or if they work or go to college full time, people appear to learn more when tested on material, rather than simply rereading or restudying information, according to research published online in the APA journal Psychology and Aging. "The use of testing as a way to learn new information has been thoroughly examined in young students. ...

São Paolo, March 7, 2013 – In the first gender benchmarking study of its kind, researchers have found that numbers of women in the science, technology and innovation fields are alarmingly low in the world's leading economies, and are actually on the decline in many, including the United States. Results from Brazil show that despite women having a strong representation in parts of the science, technology and innovation sector, and a slight increase in engineering, physics and computer science, overall numbers are on the decline. Brazil ranks the highest in this study ...

Climate change could lead to dozens of species of lizards becoming extinct within the next 50 years, according to new research published today. Globally it has been observed that lizards with viviparous reproduction (retention of embryos within the mother's body) are being threatened by changing weather patterns. A new study suggests that the evolution of this mode of reproduction, which is thought to be a key successful adaptation, could, in fact, be the species' downfall under global warming. Researchers from the University of Exeter and the University of Lincoln ...