Rice University researchers have found an unexpected link between a protein that triggers the formation of blood clots and other proteins that are essential for the body's immune system. The find could lead to new treatments for thousands of patients who suffer from inflammatory diseases and disorders that cause abnormal blood clotting. The research is available online in the journal PLOS ONE. "This link opens the door for studying severe, debilitating inflammatory disorders where the disease mechanism is still poorly understood, including lupus, rheumatoid arthritis, ...

Reston, Va. (April 1, 2013) – In vivo ventilation/perfusion (V/Q) imaging can detect early changes to the lung caused by cigarette smoke exposure and provides a noninvasive method for studying lung dysfunction in preclinical models, according to research published in the April issue of The Journal of Nuclear Medicine. These measures have the potential to be applied clinically to study and diagnose the early stages of chronic obstructive pulmonary disease (COPD). COPD is a slow-progressing, debilitating lung disease which is commonly caused by cigarette smoking. Defining ...

CHICAGO --- For-profit hospitals are out-performing other hospitals when treating stroke, heart attack and pneumonia patients in emergency departments and, thus, will be more likely to receive bonuses under Medicare's new payment rules, according to a new Northwestern Medicine® study. Though nonprofit and public hospitals are lagging behind in performance, many are making noticeable improvements and also many will be eligible for bonuses, too. The findings give an early look at how hospitals are measuring up under the new, mandatory Hospital Inpatient Value-Based Purchasing ...

Scientists have mostly focused on the benefits of meditation for the brain and the body, but a recent study by Northeastern University's David DeSteno, published in Psychological Science, takes a look at what impacts meditation has on interpersonal harmony and compassion. Several religious traditions have suggested that mediation does just that, but there has been no scientific proof—until now. In this study, a team of researchers from Northeastern University and Harvard University examined the effects meditation would have on compassion and virtuous behavior, and ...

Amsterdam, NL, April 1, 2013 – In a mouse model of early Parkinson's disease (PD), animals displayed movement deficits, loss of tyrosine-hydroxylase (TH)-positive fibers in the striatum, and astro-gliosis and micro-gliosis in the substantia nigra (SN), without the loss of nigral dopaminergic neurons. These findings, which may cast light on the molecular processes involved in the initial stages of PD, are available in the current issue of Restorative Neurology and Neuroscience. "The most intriguing finding of our study was the lack of a significant decrease of TH levels ...

Ann Arbor, Mich. — Medications used to treat gastroesophageal reflux disease, or GERD, are some of the most widely used medications in children less than one year old. But in a new study, researchers from the University of Michigan and the University of Missouri concluded that physicians often label common symptoms in infants, such as crying and spitting up, as disease. Frequent use of the GERD label can lead to overuse of medication, according to study published today online ahead of print in the journal Pediatrics. The study found that doctors' use of the label GERD ...

ANN ARBOR—Surface appearances can be so misleading: In most forests, the amount of carbon held in soils is substantially greater than the amount contained in the trees themselves. If you're a land manager trying to assess the potential of forests to offset carbon emissions and climate change by soaking up atmospheric carbon and storing it, what's going on beneath the surface is critical. But while scientists can precisely measure and predict the amount of above-ground carbon accumulating in a forest, the details of soil-carbon accounting have been a bit fuzzy. Two ...

CAMBRIDGE, MA -- Clumps of proteins that accumulate in brain cells are a hallmark of neurological diseases such as dementia, Parkinson's disease and Alzheimer's disease. Over the past several years, there has been much controversy over the structure of one of those proteins, known as alpha synuclein. MIT computational scientists have now modeled the structure of that protein, most commonly associated with Parkinson's, and found that it can take on either of two proposed states — floppy or rigid. The findings suggest that forcing the protein to switch to the rigid structure, ...

Research by a University of Tennessee, Knoxville professor has found that about a thousand bird species became extinct following human colonization. Research by Alison Boyer, a research assistant professor in ecology and evolutionary biology, and an international team studied the extinction rates of nonperching land birds in the Pacific Islands from 700 to 3,500 years ago. Some of the birds studied included birds of prey and ducks. The team uncovered the magnitude of the extinctions and insight into how and why human impacts varied across the region. The findings are ...

African American men on average wait a week longer than their Caucasian counterparts between the initial diagnosis of prostate cancer and treatment, according to University of North Carolina researchers. The study was published online March 28 in Cancer, the journal of the American Cancer Society, by a team led by Ronald Chen, MD, MPH, assistant professor with the UNC Lineberger Comprehensive Cancer Center. The study is the first published population-based examination of racial disparities in prostate cancer treatment delay. Using data from Medicare patients, Dr. Chen ...

PHILADELPHIA - Neurosurgeons can visualize important pathways in the brain using an imaging technique called diffusion tensor imaging (DTI), to better adapt brain tumor surgeries and preserve language, visual and motor function while removing cancerous tissue. In the latest issue of Neurosurgical Focus, researchers from the Perelman School of Medicine at the University of Pennsylvania review research showing that this ability to visualize relevant white matter tracts during glioma resection surgeries can improve accuracy and, in some groups, significantly extend survival ...

The word "organic" can mean many things to consumers. Even so, the power of an organic label can be very strong: studies have shown that this simple label can lead us to think that a food is healthier, through what is known as the 'health halo effect'. But can this bias go further? A study by Cornell University's Food and Brand Lab researchers Lee, Shimizu, Kniffin and Wansink set out to answer this question. Their study shows that an organic label can influence much more than health views: perceptions of taste, calories and value can be significantly altered when a food ...

URBANA - Inclusion of corn germ in swine diets can reduce diet costs, depending on the local cost of corn germ and other ingredients. Recent research conducted at the University of Illinois indicates that corn germ can be included at up to 30 percent in diets fed to growing pigs. "In previous research, we had seen that pigs do very well on diets containing 10 percent corn germ, so we wanted to investigate if higher inclusion rates can be used," said Hans Stein, professor of animal sciences at Illinois. The corn germ used in this study came from the ethanol, or dry grind, ...

CAMBRIDGE, MA -- Imagine if you could drink a glass of water just by inserting a solid wire into it and sucking on it as though it were a soda straw. It turns out that if you were tiny enough, that method would work just fine — and wouldn't even require the suction to start. New research carried out at MIT and elsewhere has demonstrated for the first time that when inserted into a pool of liquid, nanowires — wires that are only hundreds of nanometers (billionths of a meter) across — naturally draw the liquid upward in a thin film that coats the surface of the wire. The ...

ANN ARBOR, Mich. — Men with an inherited genetic condition called Lynch syndrome face a higher lifetime risk of developing prostate cancer and appear to develop the disease at an earlier age, according to a new study led by researchers at the University of Michigan Comprehensive Cancer Center. Lynch syndrome is an inherited condition linked to a higher risk of several types of cancer. People with Lynch syndrome have up to 80 percent lifetime risk of colorectal cancer and are also more likely to develop endometrial, gastric, ovarian, urinary tract, pancreatic and brain ...

Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. New research from C. David Allis' laboratory at Rockefeller University may bring scientists closer to designing cancer therapeutics that can target tumors with pinpoint accuracy. Their findings, published last week in Science Express, follow a recent series of discoveries by several international genome sequencing consortiums that directly links a mutated histone protein to a rare brain ...

Rochester, MN, April 1, 2013 – A retrospective study of patients who had in-hospital electroencephalography (EEG) has established that EEG is a valuable tool that could be deployed more widely to identify treatable causes of impaired consciousness in the hospital setting. The study is published in the April issue of the Mayo Clinic Proceedings. Altered mental status (AMS) and paroxysmal spells of uncertain origin are common among hospitalized patients. Impaired consciousness can sometimes be linked to metabolic or cardiac causes, but some of these spells may represent ...

ROCHESTER, Minn. -- Researchers at Mayo Clinic Cancer Center have developed new guidelines to treat recently diagnosed multiple myeloma patients who are not participating in clinical trials. The guidelines give physicians practical, easy to follow recommendations for providing initial therapy, stem cell transplant and maintenance therapy. The guidelines are published in the current issue of the journal Mayo Clinic Proceedings and represent a consensus opinion of hematologists at Mayo Clinic Cancer Center sites in Minnesota, Florida and Arizona. "Multiple myeloma is an ...

LOS ALAMOS, N. M., March 29, 2013—A new study by Los Alamos National Laboratory and University of Pennsylvania scientists defines previously unknown properties of transmitted HIV-1, the virus that causes AIDS. The viruses that successfully pass from a chronically infected person to a new individual are both remarkably resistant to a powerful initial human immune-response mechanism, and they are blanketed in a greater amount of envelope protein that helps them access and enter host cells. These findings will help inform vaccine design and interpretation of vaccine trials, ...

CHAPEL HILL, N.C. – A study led by researchers at the University of North Carolina indicates that a newly approved blood thinner that blocks a key component of the human blood clotting system may increase the risk and severity of certain viral infections, including flu and myocarditis, a viral infection of the heart and a significant cause of sudden death in children and young adults. For the past 50 years, people with the heartbeat irregularity, atrial fibrillation, and others at increased risk for forming potentially life-threatening blood clots have been given the ...

Jena (Germany) The Earth is dynamic. What we perceive as solid ground beneath our feet, is in reality constantly changing. In the space of a year Africa and America are drifting apart at the back of the Middle Atlantic for some centimeters while the floor of the Pacific Ocean is subducted underneath the South American Continent. "In 100 million years' time Africa will be pulled apart and North Australia will be at the equator," says Prof. Dr. Falko Langenhorst from the Friedrich Schiller University Jena (Germany). Plate tectonics is leading to a permanent renewal of the ...

Johns Hopkins scientists say they have evidence from animal studies that a type of central nervous system cell other than motor neurons plays a fundamental role in the development of amyotrophic lateral sclerosis (ALS), a fatal degenerative disease. The discovery holds promise, they say, for identifying new targets for interrupting the disease's progress. In a study described online in Nature Neuroscience, the researchers found that, in mice bred with a gene mutation that causes human ALS, dramatic changes occurred in oligodendrocytes — cells that create insulation for ...

New research predicts that rising temperatures will lead to a massive "greening," or increase in plant cover, in the Arctic. In a paper published on March 31 in Nature Climate Change, scientists reveal new models projecting that wooded areas in the Arctic could increase by as much as 50 percent over the next few decades. The researchers also show that this dramatic greening will accelerate climate warming at a rate greater than previously expected. "Such widespread redistribution of Arctic vegetation would have impacts that reverberate through the global ecosystem," said ...

Scientists at the University of Pittsburgh School of Medicine have discovered a new biological pathway of innate immunity that ramps up inflammation and then identified agents that can block it, leading to increased survival and improved lung function in animal models of pneumonia. They reported their findings today in Nature Immunology. Pneumonia and other infections sometimes provoke an inflammatory response from the body that is more detrimental than the disease-causing bacteria, said senior author Rama Mallampalli, M.D, professor and vice chair for research, Department ...

It is known that family-based treatment that combines nutrition and exercise education, along with behavior modification, is a good approach to help children lose weight. But clinic-based weight-control programs for childhood obesity are not accessible to many families, due to issues such as cost or time commitment. Initial studies at the University of California, San Diego School of Medicine indicate that a self-help treatment program for overweight children and their parents, guided by clinical experts, may be an effective solution. The study, led by Kerri Boutelle, ...