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A primer on DUI maiming charges in Virginia

2013-02-16
Virginia is known for having some of the toughest DUI/DWI laws in the country, and that hard-nosed stance extends to those who are involved in injury-causing accidents while they are driving under the influence. The law refers to the offense colloquially as "DUI maiming," and while it doesn't get much public attention, it is still one of the most serious alcohol-related offenses, and a conviction will come with harsh, long-term consequences. The Womick case A recent high-profile case involving a DUI maiming has thrust the issue back into the spotlight. The ...

How to Protect Your Company's Trade Secrets

2013-02-16
In today's information age, knowledge is power. More and more companies nowadays are in the business of profiting by using and selling information, rather than by manufacturing goods. As a result, a company's "trade secrets" or confidential information are its stock-in-trade. Lose them, and profits nosedive. Our society recognizes the importance of keeping the confidentiality of certain information and as a result, 40 states and the District of Columbia have adopted the Uniform Trade Secrets Act ("UTSA"), with some modification in each state. Among ...

Let the Winner Games Begin!

2013-02-16
Winner.com is proud to announce the launching of Winner Games. Comprised of a collection of instant win and casual games, Winner features new hits such as Avengers Scratch, Rubik's Riches and Captain America Scratch. Visitors to Winner Games will find categories such as Sports & Virtual with casual horseracing and football games. Avengers Scratch is a new game that takes players through scenes from the hit Avengers movie. Players match The Incredible Hulk, Thor and Iron Man and collect Marvel-ous payouts. The Avengers Scratch jackpot is won by matching the S.H.I.E.L.D. ...

Biodiversity protects against disease, scientists find

Biodiversity protects against disease, scientists find
2013-02-15
The richer the assortment of amphibian species in a pond, the more protection that community of frogs, toads and salamanders has against a parasitic infection that can cause severe deformities, including the growth of extra legs. The findings, published in a paper in this week's issue of the journal Nature, support the idea that greater biodiversity in large-scale ecosystems, such as forests or grasslands, may also provide greater protection against diseases, including those that affect humans. A larger number of mammal species in an area may curb cases of Lyme disease, ...

Decoys could blunt spread of ash-killing beetles

Decoys could blunt spread of ash-killing beetles
2013-02-15
UNIVERSITY PARK, Pa. -- As the emerald ash borer ravages North American ash trees, threatening the trees' very survival, a team of entomologists and engineers may have found a way to prevent the spread of the pests. Emerald ash borers (EABs), a type of beetle native to Asia, first appeared in the U.S. about 20 years ago. They are now moving east from Michigan, killing ash trees on the Eastern Seaboard as far south as North Carolina. "Within 25 years, practically no ash trees may remain on either side of the St. Lawrence Seaway," said Akhlesh Lakhtakia, Charles Godfrey ...

Poor stress responses may lead to obesity in children

2013-02-15
UNIVERSITY PARK, Pa. -- Children who overreact to stressors may be at risk of becoming overweight or obese, according to researchers at Penn State and Johns Hopkins University. "Our results suggest that some children who are at risk of becoming obese can be identified by their biological response to a stressor," said Lori Francis, associate professor of biobehavioral health. "Ultimately, the goal is to help children manage stress in ways that promote health and reduce the risks associated with an over- or under-reactive stress response." Francis and her colleagues ...

A smoking gun in lung cancer epigenetics

2013-02-15
Recent studies have identified correlations between cigarette smoke-induced microRNA (miRNA) expression and different aspects of lung cancer; however, it is unclear how miRNA expression directly contributes to carcinogenesis. MiRNAs regulate the expression of target genes and can have a significant impact on when and how well different gene products are expressed. In this issue of the Journal of Clinical Investigation, David Schrump and colleagues at the National Cancer Institute in Bethesda, MD, measured miRNA expression in normal human lung cells exposed to cigarette ...

Increased heart attack-related mortality in diabetics linked to protein oxidation

2013-02-15
Diabetic patients are more than twice as likely to die from a heart attack as non-diabetic patients, but the mechanisms that underlie increased heart attack-related mortality in diabetic patients are unknown. High levels of the oxidized form of the protein CamKII (ox-CaMKII) have been linked to increased risk of sudden death after heart attack. Additionally, hearts from diabetic patients have significantly greater ox-CAMKII compared to hearts from non-diabetic patients. In this issue of the Journal of Clinical Investigation, Min Luo and colleagues at the University of Iowa ...

JCI early table of contents for Feb. 15, 2013

2013-02-15
A smoking gun in lung cancer epigenetics Recent studies have identified correlations between cigarette smoke-induced microRNA (miRNA) expression and different aspects of lung cancer; however, it is unclear how miRNA expression directly contributes to carcinogenesis. MiRNAs regulate the expression of target genes and can have a significant impact on when and how well different gene products are expressed. In this issue of the Journal of Clinical Investigation, David Schrump and colleagues at the National Cancer Institute in Bethesda, MD, measured miRNA expression in normal ...

Most comprehensive report in 50 years on education of key scientists

2013-02-15
In the most comprehensive report in a half century, experts today described fundamental changes needed in the education of the scientists whose work impacts medicine, drug discovery and virtually every other discipline. The result of a year-long project of a presidential commission of the American Chemical Society (ACS), the world's largest scientific society, the report was the topic of a symposium here at the 2013 annual meeting of the American Association for the Advancement of Science (AAAS). Although it concluded that the state of graduate education in the chemical ...

'The Scars of Human Evolution' briefing explores physical fallout from 2-footed walking

2013-02-15
From sore feet to backaches, blame it on human evolution. "Because we are the only mammals to walk on two feet," says Bruce Latimer, an anthropologist from the Case Western Reserve University School of Dental Medicine. Latimer will present "A Backache of Longstanding: An Evolutionary Perspective on the Human Vertebral Column" at the 2013 American Association for the Advancement of Science's annual meeting in Boston, Feb. 14-18. His talk will be featured in the session, "The Scars of Human Evolution." Latimer and other panelists will explain how adapting to upright ...

The science of uncertainty in genomic medicine

2013-02-15
BOSTON - The notion of "personalizing" health care through the use of an individual's genetic code has attracted considerable enthusiasm and investment. Impressive examples, confirmed through formal studies of clinical validity and utility, suggest that we have only scratched the surface of applications to treat disease more precisely, identify risk factors for complex disease, and guide preventative measures. As the cost of sequencing entire genomes falls, the opportunities for people around the world to take possession of their entire genetic code will proliferate. ...

Artificial platelets could treat injured soldiers on the battlefield

Artificial platelets could treat injured soldiers on the battlefield
2013-02-15
When it comes to healing the terrible wounds of war, success may hinge on the first blood clot – the one that begins forming on the battlefield right after an injury. Researchers exploring the complex stream of cellular signals produced by the body in response to a traumatic injury believe the initial response – formation of a blood clot – may control subsequent healing. Using that information, they're developing new biomaterials, including artificial blood platelets laced with regulatory chemicals that could be included in an injector device the size of an iPhone. Soldiers ...

NIH study shows big improvement in diabetes control over past decades

2013-02-15
More people are meeting recommended goals in the three key markers of diabetes control, according to a study conducted and funded by the National Institutes of Health and the Centers for Disease Control and Prevention. The report, published online February 15 in Diabetes Care, shows that, from 1988 to 2010, the number of people with diabetes able to meet or exceed all three of the measures that demonstrate good diabetes management rose from about 2 percent to about 19 percent. Each measure also showed substantial improvement, with over half of people meeting each individual ...

Climate change's costly wild weather consequences

Climate changes costly wild weather consequences
2013-02-15
CHAMPAIGN, Ill. — Throughout 2012, the United States was battered by severe weather events such as hurricanes and droughts that affected both pocketbooks and livelihoods. Research suggests that in the coming years, U.S. five-day forecasts will show greater numbers of extreme weather events, a trend linked to human-driven climate change. Donald Wuebbles, a professor of atmospheric sciences at the University of Illinois at Urbana-Champaign, will discuss extreme weather in a presentation Feb. 15 at the annual meeting of the American Association for the Advancement of Science ...

Scientists find promising new approach to preventing progression of breast cancer

Scientists find promising new approach to preventing progression of breast cancer
2013-02-15
LA JOLLA, CA – February 15, 2013 – Doctors currently struggle to determine whether a breast tumor is likely to shift into an aggressive, life-threatening mode—an issue with profound implications for treatment. Now a group from The Scripps Research Institute (TSRI) has identified a mechanism through which mitochondria, the powerhouses of a cell, control tumor aggressiveness. Based on their findings, the team developed a simple treatment that inhibits cancer progression and prolongs life when tested in mice. The research team, which describes its results February 15, 2013, ...

Study finds that 'Big Pharma' fails at self-policing ED drug advertising

2013-02-15
CHARLOTTE, N.C. –Feb. 14, 2013– The pharmaceutical industry's efforts to self-regulate its direct-to-consumer (DTC) advertising are "an industry-sponsored ruse," intended to deflect criticism and collectively block new Federal regulation, a study released today in the Journal of Health Politics, Policy and Law found. The paper, "The Politics and Strategy of Industry Self-Regulation: The Pharmaceutical Industry's Principles for Ethical Direct-to-Consumer Advertising as a Deceptive Blocking Strategy," was written by Denis Arnold, Associate Professor of Management and Surtman ...

Avoiding virus dangers in 'domesticating' wild plants for biofuel use

2013-02-15
In our ongoing quest for alternative energy sources, researchers are looking more to plants that grow in the wild for use in biofuels, plants such as switchgrass. However, attempts to "domesticate" wild-growing plants have a downside, as it could make the plants more susceptible to any number of plant viruses. In a presentation at this year's meeting of the American Association for the Advancement of Science, Michigan State University plant biologist Carolyn Malmstrom said that when we start combining the qualities of different types of plants into one, there can be ...

Breast cancer risk prediction model for African American women underestimates risk

2013-02-15
(Boston) – A breast cancer risk prediction model developed for African Americans tends to underestimate risk in certain subgroups, according to a new study from the Slone Epidemiology Center (SEC) at Boston University. The model predicted estrogen receptor (ER)-negative breast cancer, which is a more aggressive form of breast cancer that disproportionately affects African American women, more poorly than ER-positive breast cancer. The study, published online today in the Journal of the National Cancer Institute, was led by Deborah Boggs, ScD, postdoctoral associate at ...

Neuronal activity induces tau release from healthy neurons

2013-02-15
HEIDELBERG, 15 February 2013 – Researchers from King's College London have discovered that neuronal activity can stimulate tau release from healthy neurons in the absence of cell death. The results published by Diane Hanger and her colleagues in EMBO reports show that treatment of neurons with known biological signaling molecules increases the release of tau into the culture medi-um. The release of tau from cortical neurons is therefore a physiological process that can be regulated by neuronal activity. Tau proteins stabilize microtubules, the long threads of polymers ...

University of Waterloo researchers propose breakthrough architecture for quantum computers

2013-02-15
WATERLOO, Ont. (Thursday, Feb. 14, 2013) A team of researchers at the University of Waterloo's Institute for Quantum Computing has proposed a new computational model that may become the architecture for a scalable quantum computer. In a paper to be published in the journal Science this week, the research team of IQC Associate Professor Andrew Childs, post-doctoral fellow David Gosset and PhD student Zak Webb proposes using multi-particle quantum walks for universal computation. In a multi-particle quantum walk, particles live on the vertices of a graph and can move between ...

UTSW researchers identify new enzyme that acts as innate immunity sensor

UTSW researchers identify new enzyme that acts as innate immunity sensor
2013-02-15
DALLAS – Feb. 15, 2013 – Two studies by researchers at UT Southwestern Medical Center could lead to new treatments for lupus and other autoimmune diseases and strengthen current therapies for viral, bacterial, and parasitic infections. The studies identify a new enzyme that acts as a sensor of innate immunity – the body's first line of defense against invaders – and describe a novel cell signaling pathway. This pathway detects foreign DNA or even host DNA when it appears in a part of the cell where DNA should not be. In addition, the investigations show that the process ...

Researchers uncover new findings on genetic risks of Behçet's disease

Researchers uncover new findings on genetic risks of Behçets disease
2013-02-15
ANN ARBOR, Mich. — Researchers don't know the exact cause of Behçet's disease, a chronic condition that leads to oral and genital sores and serious complications such as blindness, but new research brings better understanding to what makes some people more susceptible to being affected. In one of the most extensive genetic analyses of Behçet's disease, a University of Michigan-led, international team of researchers has identified novel gene variants in the inflammatory disorder and uncovered data that could apply to studies of other diseases. The results appear in the ...

Spectacular forcepfly species discovered for the first time in South America

Spectacular forcepfly species discovered for the first time in South America
2013-02-15
Forcepflies are usually known as earwigflies, because the males have a large genital forceps that resembles the cerci of earwigs. A new species of forcepfly Meropeidae (Mecoptera) from Brazil was described, representing only the 3rd extant species described in this family and the 1st record of the family from the Neotropical region. The distribution and biogeography of the family are discussed and it is even proposed that Meropeidae originated before continental drift and then divided into two branches, northern and southern, with the breakup of the old supercontinent Pangea. ...

This is why it takes so long to get over tendon injuries

This is why it takes so long to get over tendon injuries
2013-02-15
The Achilles heel of the body – getting over damage to tendons can be a long and painful process. By combining the nuclear tests of the 1950s with tissue samples and modern technology, a research collaboration between the Aarhus University and University of Copenhagen now reveals why the healing process is so slow. Many people are affected by injuries caused by straining the Achilles tendon and other tendons in the body. Danish athletes alone account for up to 200,000 injuries per year. This often leads to frustration over the poor treatment options available, and it can ...
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