While considerable recent progress has been made against childhood diarrheal diseases, the number of children dying from diarrhoea remains unacceptably high. This week, PLOS Medicine publishes a report based upon the work of over 150 international experts who convened to review and discuss research priorities to address this global problem. Zulfiqar Bhutta from the Aga Khan University in Pakistan and colleagues report that the most important priority is for more research on implementation of known interventions. Research questions involving improving implementation, especially ...

Non-communicable diseases (NCD) and mental disorders each constitute a huge portion of the worldwide health care burden, and often occur together, so they should be addressed together. These are the conclusions of the third article in a series published in PLOS Medicine that provides a global perspective on integrating mental health. Victoria Ngo from the RAND Corporation in California and international colleagues say that collaborative care models, where NCD care and mental health care are integrated and provided in the primary care setting, are effective for patients, ...

MAYWOOD – The initial success rates of the most durable surgery for a common condition in women declines over the long-term, according to data published today in the Journal of the American Medical Association. The procedure, abdominal sacrocolpopexy, is used to manage pelvic organ prolapse, a widespread but little-known condition that occurs when the vaginal wall protrudes outside of the vaginal opening. More than 225,000 surgeries are performed annually in the United States for pelvic organ prolapse. The cost for these procedures is more than $1 billion per year, ...

Even though patients receiving an implantable cardioverter-defibrillator (ICD) for primary prevention often receive a dual-chamber ICD, an analysis that included more than 32,000 patients receiving an ICD without indications for pacing finds that the use of a dual-chamber device compared with a single-chamber device was associated with a higher risk of device-related complications and similar 1-year mortality and hospitalization outcomes, according to a study in the May 15 issue of JAMA. "The central decision regarding ICD therapy is whether to use a single- or dual-chamber ...

Results after seven years of follow-up suggest that women considering abdominal sacrocolpopexy (surgery for pelvic organ prolapse [POP]) should be counseled that this procedure effectively provides relief from POP symptoms; however, the anatomic support deteriorates over time; and that adding an anti-incontinence procedure decreases, but does not eliminate the risk of stress urinary incontinence, and mesh erosion can be a problem, according to a study in the May 15 issue of JAMA. "Pelvic organ prolapse occurs when the uterus or vaginal walls bulge into or beyond the ...

Tobacco use remains the leading preventable cause of death and disease in the United States. Declines in smoking among youths were observed from the late 1990s. "However, limited information exists on trends in smokeless tobacco use among U.S. youths," writes Israel T. Agaku, D.M.D., M.P.H., of the Harvard School of Public Health, Boston, and colleagues. As reported in a Research Letter in the May 15 issue of JAMA, the authors analyzed recent trends in prevalence of smokeless tobacco use among youths using the 2000-2011 National Youth Tobacco Survey, a biennial national ...

Berkeley — New technology developed at the University of California, Berkeley, is using wireless signals to provide real-time, non-invasive diagnoses of brain swelling or bleeding. The device analyzes data from low energy, electromagnetic waves, similar to the kind used to transmit radio and mobile signals. The technology, described in the May 14 issue of the journal PLOS ONE, could potentially become a cost-effective tool for medical diagnostics and to triage injuries in areas where access to medical care, especially medical imaging, is limited. The researchers tested ...

All mammals sleep, as do birds and some insects. However, how this basic function is regulated by the brain remains unclear. According to a new study by researchers from the RIKEN Brain Science Institute, a brain region called the lateral habenula plays a central role in the regulation of REM sleep. In an article published today in the Journal of Neuroscience, the team shows that the lateral habenula maintains and regulates REM sleep in rats through regulation of the serotonin system. This study is the first to show a role of the lateral habenula in linking serotonin metabolism ...

Women with a lean body shape have a greater risk of developing endometriosis than women who are morbidly obese, according to the largest prospective study to investigate the link. The study, which is published online today (Wednesday) in Europe's leading reproductive medicine journal Human Reproduction [1], found that the risk of endometriosis was 39% lower in morbidly obese women – those with a body mass index (BMI) greater than 40 kg/m2 – compared with women with a current BMI in the low normal range (18.5-22.4 kg/m2). When the researchers looked back at the women's ...

Women's immune systems age more slowly than men's, suggests research in BioMed Central's open access journal Immunity & Ageing. The slower decline in a woman's immune system may contribute to women living longer than men. Researchers looked at the blood of healthy volunteers in Japan, ranging in age between 20 and 90 years old; in both sexes the total number of white blood cells per person decreased with age. The number of neutrophils decreased for both sexes and lymphocytes decreased in men and increased in women. Younger men generally have higher levels of lymphocytes ...

Scientists from Royal Holloway University have found that when white Caucasians are under the illusion that they have a dark skin, their racial bias changes in a positive way. In the study that was funded by the European Research Council and published today in Cognition, the team used the tried and tested Rubber Hand Illusion, where participants are asked to look at a fake hand being touched, while at the same time, the experimenter touches the participants' own hand which is hidden out of view. The combination of seeing the touch on the rubber hand and feeing touch ...

The authors say that, while helmets reduce head injuries and their use should be encouraged, in the context of existing safety campaigns, the impact of legislation seems to be minimal. Cyclists are vulnerable road users and head injuries among cyclists account for 75% of cycling related deaths. But debate exists about whether or not helmet legislation is an effective strategy to reduce serious head injuries among cyclists of all ages. So a team of researchers based in Canada examined changes in the rate of cycling related head injuries associated with helmet legislation ...

The journal says it is committed to "stepping up its commitment to patient partnership" and wants to "develop a strategy for patient partnership that will be reflected across the entire journal." In an editorial, BMJ editors along with Professor Victor Montori and Dave Paul at the Mayo Clinic in the US, argue that the preservation of institutional bureaucracies, as well as professional and commercial vested interests, "have consistently trumped the interests of patients." They say clinicians and patients need to work in partnership "if we are to improve healthcare and ...

Having a hysterectomy with or without ovary removal in mid-life does not increase a woman's risk of cardiovascular disease compared to women who reach natural menopause, contrary to many previously reported studies, according to research published online today in the Journal of the American College of Cardiology. "Middle-aged women who are considering hysterectomy should be encouraged because our results suggest that increased levels of cardiovascular risk factors are not any more likely after hysterectomy relative to after natural menopause," said Karen A. Matthews, ...

A combination of two FDA-approved osteoporosis drugs with different mechanisms of action was found to increase bone density better than treatment with either drug alone in a small clinical trial. As reported in paper receiving Online First publication in The Lancet, Massachusetts General Hospital (MGH) investigators found that treatment combining denosumab (Prolia) and teriparatide (Forteo) was superior to single-agent treatment in a 12-month trial in women with postmenopausal osteoporosis. The authors note that additional study is required before their findings should ...

Community groups in rural Vietnam comprised of local health workers, politicians and laywomen (Maternal and Newborn Health Groups) set up to tackle challenges to maternal and neonatal health may reduce the neonatal death rate after three years and increase antenatal care attendance, according to a study by researchers from Sweden and Vietnam published in this week's PLOS Medicine. These findings are important as they show that is it feasible to implement community-based activity into the public sector system at low cost. The researchers (also the authors of this paper) ...

An international team of scientists have revealed a new species of ichthyosaur (a dolphin-like marine reptile from the age of dinosaurs) from Iraq, which revolutionises our understanding of the evolution and extinction of these ancient marine reptiles. The results, produced by a collaboration of researchers from universities and museums in Belgium and the UK and published today (May 15) in Biology Letters, contradict previous theories that suggest the ichthyosaurs of the Cretaceous period (the span of time between 145 and 66 million years ago) were the last survivors ...

AURORA, Colo. (May 14, 2013) – A device commonly used to treat dangerous heart rhythms may cause more issues for patients than a simpler version of the same device. The implantable cardioverter-defibrillator (ICD) prevents sudden cardiac death by detecting irregularities and delivering an electrical jolt to restart the heart. An analysis led by researchers at University of Colorado School of Medicine and published in the May 15 issue of The Journal of the American Medical Association focused on people getting ICDs who do not have a clear reason for pacemaker support. ...

ANN ARBOR, Mich. – African-Americans know the signs of stroke, but concerns about medical cost, ambulance response time and unfamiliarity with the need for prompt hospital care impacted whether they called 9-1-1 immediately. A study that included 77 African-Americans in Flint, Mich., revealed barriers among adults and youth in getting help for stroke which is significantly higher among African-Americans and leads to more deaths and disability. Adults mentioned the cost of paying for an ambulance, while young people worried about staying calm if they witnessed someone ...

A novel drug may help increase the effectiveness of radiation therapy for the most deadly form of brain cancer, report scientists at Virginia Commonwealth University Massey Cancer Center. In mouse models of human glioblastoma multiforme (GBM), the new drug helped significantly extend survival when used in combination with radiation therapy. Recently published in the journal Clinical Cancer Research, the study provides the first preclinical evidence demonstrating that an ATM kinase inhibitor radiosensitizes gliomas. Gliomas are brain tumors that originate from glial cells, ...

Boston, MA – In new research published online May 13, 2013 in Advanced Materials, researchers from Brigham and Women's Hospital (BWH) are the first to report that synthetic silicate nanoplatelets (also known as layered clay) can induce stem cells to become bone cells without the need of additional bone-inducing factors. Synthetic silicates are made up of simple or complex salts of silicic acids, and have been used extensively for various commercial and industrial applications, such as food additives, glass and ceramic filler materials, and anti-caking agents. Silicate ...

PHILADELPHIA — Labs around the world, and a core group at Penn, have been studying recently described populations of immune cells called innate lymphoid cells (ILCs). Some researchers liken them to foot soldiers that protect boundary tissues such as the skin, the lining of the lung, and the lining of the gut from microbial onslaught. They also have shown they play a role in inflammatory disease, when the body's immune system is too active. In animal studies, group-2 innate lymphoid cells (ILC2s) confer immunity during a parasitic infection in mice and are also involved ...

The song, "Get Happy," famously performed by Judy Garland, has encouraged people to improve their mood for decades. Recent research at the University of Missouri discovered that an individual can indeed successfully try to be happier, especially when cheery music aids the process. This research points to ways that people can actively improve their moods and corroborates earlier MU research. "Our work provides support for what many people already do – listen to music to improve their moods," said lead author Yuna Ferguson, who performed the study while she was an MU doctoral ...

Sporting events can bring a community together, such as when the Louisville Cardinals won the NCAA championship and University of Louisville campus was filled with camaraderie. They also can fuel bitter rivalries, such as the long-standing animosity between the St. Louis Cardinals and the Chicago Cubs. A University of Missouri study has found that testosterone levels during group competition are modulated depending on the relationships among the competitors and may be related to the formation of alliances in warfare. "One interesting thing about humans is that we are ...

New Rochelle, NY, May 14, 2013—Animals, insects, and plants use a variety of sensing mechanisms to detect invading pathogens such as viruses. One complex and effective antiviral defense system they share is based on recognition of double-stranded RNA (dsRNA), often produced when a virus invades a host cell. New information leading to a clearer understanding of the mechanisms underlying viral dsRNA sensing is presented in a comprehensive Review article published in Journal of Interferon & Cytokine Research, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. ...