By the time they reached toddlerhood, very preterm infants originally treated with higher oxygen levels continued to show benefits when compared to a group treated with lower oxygen levels, according to a follow-up study by a research network of the National Institutes of Health that confirms earlier network findings. Moreover, infants treated with a respiratory therapy commonly prescribed for adults with obstructive sleep apnea fared as well as those who received the traditional therapy for infant respiratory difficulties, the new study found. In the original 2010 ...

Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. Cell loss due to aging or corneal endothelial disorders, such as Fuchs dystrophy, can lead to cornea edema and blindness, resulting in the need for cornea transplants. Studying human corneal endothelium has been difficult for cell biologists because limited cellular model systems exist and have significant drawbacks. The major drawback is that HCEnC cells do not divide and there is a limited source of these cells ...

As anyone familiar with the X-Men knows, mutants can be either very good or very bad — or somewhere in between. The same appears true within cancer cells, which may harbor hundreds of mutations that set them apart from other cells in the body; the scientific challenge has been to figure out which mutations are culprits and which are innocent bystanders. Now, researchers at Johns Hopkins Medicine have devised a novel approach to sorting them out: they generated random mutations in a gene associated with lymphoma, tested the proteins produced by the genes to see how they ...

ROCHESTER, Minn. -- For nearly a decade, breast cancer researchers studying the hormone therapy tamoxifen have been divided as to whether genetic differences in a liver enzyme affect the drug's effectiveness and the likelihood breast cancer will recur. A new study by researchers from the Mayo Clinic Cancer Center and the Austrian Breast and Colorectal Cancer Study Group provides evidence that genetic differences in the enzyme CYP2D6 play a key role in how well tamoxifen works. "Our findings confirm that, in early breast cancer treated with tamoxifen, genetic alterations ...

PHILADELPHIA – Nearly half of the 700,000 cancer patients who undergo surgical removal of a primary tumor each year suffer a recurrence of their disease at some point, and many of those patients will eventually die from their disease. The traditional view of recurrent tumors is that they are resistant to therapy because they've acquired additional genetic mutations that make them more aggressive and impervious to drugs. Now, however, researchers at the Perelman School of Medicine at the University of Pennsylvania show in an animal model that the enhanced aggressiveness ...

Taking into consideration its size, an ancient relative of piranhas weighing about 20 pounds delivered a bite with a force more fierce than prehistoric whale-eating sharks, the four-ton ocean-dwelling Dunkleosteus terrelli and – even – Tyrannosaurus rex. Besides the force of the bite, Megapiranha paranensis appears to have had teeth capable of shearing through soft tissue the way today's piranhas do, while also being able to pierce thick shells and crack armoring and bones, according to Stephanie Crofts, a University of Washington doctoral student in biology. "If our ...

Many of the most common inpatient surgeries in the United States are performed electively. These surgeries are expected to significantly increase with the enactment of the Affordable Care Act. In a new perspectives article, published in the Dec. 27 edition of The New England Journal of Medicine, a team of Weill Cornell Medical College researchers are recommending the nation's health care leaders and medical community join forces to establish evidence-based appropriateness criteria to determine which patients are most in need of elective procedures, such as joint replacement ...

CHAPEL HILL - Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell. The study, published December 27, 2012 by the journal Molecular Cell, implicates ...

Congenital hyperinsulinism is a genetic condition where a baby's pancreas secretes too much insulin. It affects approximately one in 50,000 live births and in severe cases requires the surgical removal of all or part of the pancreas. Researchers at the University of Exeter Medical School are the first in the world to utilise new genetic sequencing technology to sequence the entirety of a gene in order to identify mutations that cause hyperinsulinism. Previously, existing technology limited such sequencing to only part of the coding regions of the gene which meant that ...

Researchers at McGill University have discovered that a key regulator of energy metabolism in cancer cells known as the AMP-activated protein kinase (AMPK) may play a crucial role in restricting cancer cell growth. AMPK acts as a "fuel gauge" in cells; AMPK is turned on when it senses changes in energy levels, and helps to change metabolism when energy levels are low, such as during exercise or when fasting. The researchers found that AMPK also regulates cancer cell metabolism and can restrict cancer cell growth. The discovery was made by Russell (Rusty) Jones, an assistant ...

KANSAS CITY, MO—Unlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility "pluripotency," meaning that as an organism develops, stem cells must be ready at a moment's notice to activate highly diverse gene expression programs used to turn them into blood, brain, or kidney cells. Scientists from the lab of Stowers Investigator Ali Shilatifard, Ph.D., report in the December 27, 2012 online issue of Cell that one way cells stay so plastic is by stationing a protein called Ell3 ...

In the period just before they went extinct, the American lions and saber-toothed cats that roamed North America in the late Pleistocene were living well off the fat of the land. That is the conclusion of the latest study of the microscopic wear patterns on the teeth of these great cats recovered from the La Brea tar pits in southern California. Contrary to previous studies, the analysis did not find any indications that the giant carnivores were having increased trouble finding prey in the period before they went extinct 12,000 years ago. The results, published on ...

PHILADELPHIA - When trying to determine the root cause of a person's dementia, using an MRI can effectively and non-invasively screen patients for Alzheimer's disease or Frontotemporal Lobar Degeneration (FTLD), according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. Using an MRI-based algorithm effectively differentiated cases 75 percent of the time, according to the study, published in the December 26th, 2012, issue of Neurology®, the medical journal of the American Academy of Neurology. The non-invasive approach ...

A national drug shortage has been linked to a higher rate of relapse among children, teenagers and young adults with Hodgkin lymphoma enrolled in a national clinical trial, according to research led by St. Jude Children's Research Hospital. Estimated two-year cancer-free survival for patients enrolled in the study fell from 88 to 75 percent after the drug cyclophosphamide was substituted for mechlorethamine for treatment of patients with intermediate- or high-risk Hodgkin lymphoma. The study was launched before the drug shortages began. The change occurred after a mechlorethamine ...

STANFORD, Calif. — A national drug shortage has been linked to a higher rate of relapse among children, teenagers and young adults with Hodgkin lymphoma enrolled in a national clinical trial, according to research led by St. Jude Children's Research Hospital. Estimated two-year cancer-free survival for patients enrolled in the study fell from 88 to 75 percent after the drug cyclophosphamide was substituted for mechlorethamine for treatment of patients with intermediate- or high-risk Hodgkin lymphoma. The study was launched before the drug shortages began. The change occurred ...

Children who make an effort to perform acts of kindness are happier and experience greater acceptance from their peers, suggests new research from the University of British Columbia and the University of California, Riverside. Kimberly Schonert-Reichl, a professor in UBC's Faculty of Education, and co-author Kristin Layous, of the University of California, Riverside, say that increasing peer acceptance is key to preventing bullying. In the study, published today by PLOS ONE, researchers examined how to boost happiness in students aged 9 to 11 years. Four hundred students ...

Nine to twelve-year-olds who perform kind acts are not only happier, but also find greater acceptance in their peer groups, according to research published December 26, 2012 in the open access journal PLOS ONE by Kristin Layous and colleagues from the University of California, Riverside. The authors randomly assigned over 400 students aged 9-12 to two groups: one group performed 'acts of kindness' and the other kept track of pleasant places they visited each week. Examples of kind acts included descriptions like "gave someone some of my lunch" or "gave my mom a hug when ...

When prey is scarce, large carnivores may gnaw prey to the bone, wearing their teeth down in the process. A new analysis of the teeth of saber-toothed cats and American lions reveals that they did not resort to this behavior just before extinction, suggesting that lack of prey was probably not the main reason these large cats became extinct. The results, published December 26 in the open access journal PLOS ONE by Larisa DeSantis of Vanderbilt University and colleagues, compares tooth wear patterns from the fossil cats that roamed California 12,000 to 30,000 years ago. ...

In the virtual world of Second Life, female avatars expose substantially more skin than males, independent of their virtual body proportions, according to research published December 26 in the open access journal PLOS ONE by Matthieu Guitton and colleagues from Laval University, Canada. The human tendency to cover up stems from climatic, environmental, physical and cultural constraints, so measuring people's propensity to reveal skin can be difficult in the real world. To study human behavior free of at least some of these constraints, the researchers analyzed how male ...

Choosing the perfect wine may soon involve more than just knowing the perfect vintage and chateau. Differences in the microbes present on grapes even in different parts of the same vineyard may contribute to flavor fluctuations in samples of grapes from different tanks, according to research published December 26 in the open access journal PLOS ONE by Mathabatha Setati and colleagues from Stellenbosch University, South Africa. "In the wine industry, the fungal communities on grapes are especially important. The microbial species present on the berry may contribute to ...

Men and women with mental health disorders, across all diagnoses, are more likely to have experienced domestic violence than the general population, according to new research from King's College London's Institute of Psychiatry, in collaboration with the University of Bristol. Previous studies into the link between domestic violence and mental health problems have mainly focused on depression, but this is the first study to look at a wide range of mental health problems in both male and female victims. In this study, funded by the National Institute for Health Research ...

The rate of people who seek preventive cancer screenings has fallen over the last ten years in the United States with wide variations between white-collar and blue-collar workers, according to a University of Miami Miller School of Medicine study published on December 27 in the open-access journal Frontiers in Cancer Epidemiology. While earlier diagnoses and improved treatments have increased the number of survivors, cancer remains one of the most prominent chronic diseases and, last year alone, claimed the lives of more than 570,000 people in the U.S. "There is a ...

A bird listening to birdsong may experience some of the same emotions as a human listening to music, suggests a new study on white-throated sparrows, published in Frontiers of Evolutionary Neuroscience. "We found that the same neural reward system is activated in female birds in the breeding state that are listening to male birdsong, and in people listening to music that they like," says Sarah Earp, who led the research as an undergraduate at Emory University. For male birds listening to another male's song, it was a different story: They had an amygdala response ...

The TrueConf video conferencing solution for OS X is designed for OS X 10.7 and its newer versions. It provides video conferencing calls for the corporate video network- based TrueConf Server, as well as the cloud video conferencing service TrueConf Online. Currently, TrueConf solutions for OS X are available for download on the TrueConf website: http://trueconf.com/download/trueconf-client.dmg TrueConf experts implemented a number of tasks in developing this new application, providing integration into hand-held systems (iPhone, iPad, etc), and have introduced a new ...

Vacation exchange provider Dial An Exchange (DAE) announces last minute travel destinations for vacationers looking for different ways to ring in 2013. It could be a party in the French Quarter of New Orleans, hitting the slopes in Idaho or strolling along the shore in Florida. These and other terrific options are available through DAE's easy to use online booking service where members can exchange their timeshare week and know immediately whether their exchange has been approved. DAE offers free membership and no-cost requests for resort availability - with payment ...