People with high blood pressure enrolled in a clinical pharmacist-led web-based monitoring program were more likely to lower their pressure to recommended level than people who did not use the program. The study was published in the American Heart Association journal Circulation: Cardiovascular Quality and Outcomes. The study, led by David J. Magid, M.D., M.P.H., at Kaiser Permanente Colorado in Denver, followed people who use the American Heart Association's Heart360 program. Heart360 is a free, online tool for tracking heart health where users can upload blood pressure ...

The mating success of male butterflies is often lower if they are inbred. But how do female butterflies know which males to avoid? New research reveals that inbred male butterflies produce significantly less sex pheromones, making them less attractive to females. The research was published today in the journal Proceedings of the Royal Society B. If animals (and humans) breed with a relative their offspring will be inbred and more likely to have genetic disorders. Because of these disorders inbred males are often weaker and, for instance, less able to defend the nest or ...

PROVIDENCE, R.I. [Brown University] — Scientists are using ever more complex models running on ever more powerful computers to simulate the earth's climate. But new research suggests that basic physics could offer a simpler and more meaningful way to model key elements of climate. The research, published in the journal Physical Review Letters, shows that a technique called direct statistical simulation does a good job of modeling fluid jets, fast-moving flows that form naturally in oceans and in the atmosphere. Brad Marston, professor of physics at Brown University and ...

ANN ARBOR—Researchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific proteins in the brain. The aggregation of these proteins, called metal-associated amyloids, is associated with Alzheimer's disease and other neurodegenerative conditions. A paper published recently in the Proceedings of the National Academy of Sciences explained how U-M Life Sciences Institute faculty member Mi Hee Lim and an interdisciplinary team of researchers used green tea extract to control the generation of metal-associated ...

A screening tool from the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) eases and greatly quickens one of the thorniest tasks in the biofuels industry: determining cell wall chemistry to find plants with ideal genes. NREL's new High-Throughput Analytical Pyrolysis tool (HTAP) can thoroughly analyze hundreds of biomass samples a day and give an early look at the genotypes that are most worth pursuing. Analysis of a sample that previously took two weeks can now be done in two minutes. That is potentially game changing for tree nurseries and the ...

Experiencing ostracism — being deliberately ignored or excluded — hurts, but ostracizing someone else could hurt just as much, according to new research published in Psychological Science, a journal of the Association for Psychological Science. Humans are social animals and they typically avoid causing harm to others when they can. But past experiments — and real-life events — suggest that people are willing to inflict harm in order to comply with authorities. Graduate student Nicole Legate, along with her advisor, Richard Ryan of the University of Rochester, and colleagues, ...

Patients who experience chronic pain may experience improvement in symptoms if their primary care providers are specifically trained in multiple aspects of pain, including emotional consequences. A collaborative team headed by Thomas C. Chelimsky, M.D., professor and chairman of the department of neurology at the Medical College of Wisconsin, conducted a pilot study assessing the Primary Practice Physician Program for Chronic Pain (4PCP) and its impact on both patients and providers. The findings are published in the Clinical Journal of Pain, http://journals.lww.com/clinicalpain/toc/publishahead. Chronic ...

GAINESVILLE, Fla. — University of Florida paleontologists have discovered remarkably well-preserved fossils of two crocodilians and a mammal previously unknown to science during recent Panama Canal excavations that began in 2009. The two new ancient extinct alligator-like animals and an extinct hippo-like species inhabited Central America during the Miocene about 20 million years ago. The research expands the range of ancient animals in the subtropics — some of the most diverse areas today about which little is known historically because lush vegetation prevents paleontological ...

New research from Rice University, Baylor College of Medicine (BCM) and the Puget Sound Blood Center (PSBC) has revealed how stresses of flow in the small blood vessels of the heart and brain could cause a common protein to change shape and form dangerous blood clots. The scientists were surprised to find that the proteins could remain in the dangerous, clot-initiating shape for up to five hours before returning to their normal, healthy shape. The study -- the first of its kind -- focused on a protein called von Willebrand factor, or VWF, a key player in clot formation. ...

(Boston) – Researchers at Boston University School of Medicine (BUSM) have, for the first time, identified a specific group of cells in the brainstem whose activation during rapid eye movement (REM) sleep is critical for the regulation of emotional memory processing. The findings, published in the Journal of Neuroscience, could help lead to the development of effective behavioral and pharmacological therapies to treat anxiety disorders, such as post-traumatic stress disorder, phobias and panic attacks. There are two main stages of sleep – REM and non-REM – and both are ...

Ann Arbor, Mich. — Each year, more than 130,000 children younger than 13 are treated in U.S. emergency departments after motor-vehicle crash-related injuries. Each of these visits offer a chance to pass along tips for proper use of child passenger restraints, but a new study from the University of Michigan indicates emergency departments may not be taking advantage of those opportunities. In the study published today in Pediatric Emergency Care, more than one-third of ER physicians say they are uncertain whether their departments provide information about child passenger ...

WASHINGTON, D.C. — Women's issues play a major role in the health of the nation and should be a key consideration for policymakers as they design and set up the new insurance exchanges, according to a report co-authored by policy experts at the George Washington University School of Public Health and Health Services (SPHHS). The report offers a checklist for the state-based health insurance exchanges, one that will help ensure that women, children and family members can get the services they need to prevent costly and debilitating medical problems. "Women often use a ...

PHILADELPHIA - Omega-3 fatty acids found in oily fish may have diverse health-promoting effects, potentially protecting the immune, nervous, and cardiovascular systems. But how the health effects of one such fatty acid -- docosahexaenoic acid (DHA) -- works remains unclear, in part because its molecular signaling pathways are only now being understood. Toshinori Hoshi, PhD, professor of Physiology, at the Perelman School of Medicine, University of Pennsylvania, and colleagues showed, in two papers out this week in the Proceedings of the National Academy of Sciences, ...

BETHESDA, MD – March 5, 2013 -- A team of European scientists from the University Medical Center Hamburg-Eppendorf (UKE) and the Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) at the University of Cologne in Germany has taken an important step closer to understanding the root cause of age-related dementia. In research involving both worms and mice, they have found that age-related dementia is likely the result of a declining ability of neurons to dispose of unwanted aggregated proteins. As protein disposal becomes significantly ...

In Africa and Thailand, communities that worked together on HIV-prevention efforts saw not only a rise in HIV screening but a drop in new infections, according to a new study presented this week at the Conference on Retroviruses and Opportunistic Infections in Atlanta. The U.S. National Institute of Mental Health's Project Accept — a trial conducted by the HIV Prevention Trials Network to test a combination of social, behavioral and structural HIV-prevention interventions — demonstrated that a series of community efforts was able to boost the number of people tested ...

Chevy Chase, MD—In a Position Statement unveiled today, The Endocrine Society advocates that all methods for measuring estrogens, which play a crucial role in human biology, be made traceable to a common standard. In addition to the well-known role of estrogens in sexual development, these hormones, particularly estradiol, have a significant impact on the health of the skin, blood vessels, bones, muscle, kidney, liver, digestive system, brain, lung and pancreas. Studies have linked changes in estradiol levels to coronary artery disease, stroke and breast cancer. "Estradiol ...

AMHERST, Mass. – Biochemists at the University of Massachusetts Amherst including assistant professor Peter Chien recently gained new insight into how protein synthesis and degradation help to regulate the delicate ballet of cell division. In particular, they reveal how two proteins shelter each other in "mutually assured cleanup" to insure that division goes smoothly and safely. Cells must routinely dispose of leftover proteins with the aid of proteases that cut up and recycle used proteins. The problem for biochemists is that the same protein molecule can be toxic garbage ...

A new report published today concludes that nearly half of Africa's wild lion populations may decline to near extinction over the next 20-40 years without urgent conservation measures. The plight of many lion populations is so bleak, the report concludes that fencing them in - and fencing humans out - may be their only hope for survival. Led by the University of Minnesota's Professor Craig Packer and co-authored by a large team of lion biologists, including Panthera's President, Dr. Luke Hunter, and Lion Program Director, Dr. Guy Balme, the report, entitled Conserving ...

In order to build and maintain cells, DNA is copied into ribonucleic acid (RNA) molecules, also called transcripts. Transcripts are often like a recipe for making proteins, and a collection of all the transcripts in a cell is called a transcriptome. Pankaj Jaiswal, Assistant Professor of Botany and Plant Pathology at Oregon State University, Samuel Fox, a Postdoctoral Associate in Jaiswal's laboratory, and colleagues assembled transcriptomes of a noxious weed, Brachypodium sylvaticum, or slender false brome. The transcriptome provides an extensive genetic tool for studying ...

Antarctica's topography began changing from flat to fjord-filled starting about 34 million years ago, according to a new report from a University of Arizona-led team of geoscientists. Knowing when Antarctica's topography started shifting from a flat landscape to one with glaciers, fjords and mountains is important for modeling how the Antarctic ice sheet affects global climate and sea-level rise. Although radar surveys have revealed a rugged alpine landscape under Antarctica's two-mile-thick ice sheet, the surveys tell nothing about when the continent's deep valleys ...

Washington, D.C.—New theoretical modeling by Carnegie's Alan Boss provides clues to how the gas giant planets in our solar system—Jupiter and Saturn—might have formed and evolved. His work was published recently by the Astrophysical Journal. New stars are surrounded by rotating gas disks during the early stages of their lives. Gas giant planets are thought to form in the presence of these disks. Observations of young stars that still have these gas disks demonstrate that sun-like stars undergo periodic outbursts, lasting about 100 years, which transfer mass from the ...

Men with low-risk prostate cancer who previously had to choose between aggressive treatment, with the potential for significant side effects, and active surveillance, with the risk of disease progression, may have a new option. Focal laser ablation uses precisely targeted heat, delivered through a small insertion and guided into the prostate by magnetic resonance imaging, to burn away cancerous cells in the prostate. A small, phase 1 trial, to published early online in the journal Radiology, found that this approach, designed to treat just the diseased portion of the ...

Isolation of DNA from some organisms is a routine procedure. For example, you can buy a kit at your local pharmacy or grocery store that allows you to swab the inside of your cheek and send the sample for DNA sequencing. However, for other organisms, DNA extraction is much more problematic. Researchers at Desert Botanical Garden in Phoenix, Arizona, have developed a novel procedure that greatly simplifies genomic DNA isolation from cactus tissue. For members of the family Cactaceae, isolation of genetic material can be difficult due to the presence of polysaccharide-based ...

(Philadelphia, PA) – Some 5.8 million Americans suffer from heart failure, a currently incurable disease. But scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine have discovered a key biochemical step underlying the condition that could aid the development of new drugs to treat and possibly prevent it. "Drugs we currently use for heart failure are not very effective," explained lead investigator Walter J. Koch, PhD, Professor and Chairman of the Department of Pharmacology at TUSM, and Director of the Center for Translational Medicine ...

PHILADELPHIA — A series of microRNA expression signatures that may help to define progression of the precancerous condition Barrett's esophagus into esophageal adenocarcinoma was reported recently in Cancer Prevention Research, a journal of the American Association for Cancer Research. "Once a rare cancer representing only 5 percent of all esophageal cancers in the United States, esophageal adenocarcinoma is the cancer with the fastest-rising incidence — six-fold increase in the past three decades — and currently comprises more than 80 percent of all new esophageal cancer ...