The Genomic Instability Group led by researcher Óscar Fernández-Capetillo at the Spanish National Cancer Research Centre (CNIO), has for the first time obtained a panoramic photo of the proteins that take part in human DNA division, a process known as replication. The research article, published today in the journal Cell Reports, is the result of a collaborative study in which other CNIO groups have also participated, including the Proteomics Unit led by Javier Muñoz and the DNA Replication Group led by Juan Méndez. DNA replication is the chemical process that sustains ...

Detroit – Researchers at Wayne State University, in collaboration with Illinois Institute of Technology, recently published a study advising clinical gerontologists in the field to be aware of older adults' needs for assessment of financial exploitation or its potential when working with highly vulnerable individuals. Financial exploitation of the elderly is on the rise according to the National Association of Area Agencies on Aging, and the numbers are expected to continue to grow as Baby Boomers age. This exploitation, which includes telemarketing scams, fake home ...

(Boston) – A study conducted by researchers at Boston University School of Medicine (BUSM) provides new evidence that longwave ultraviolet light (UVA) induces a protein that could result in premature skin aging. The findings demonstrate that aspects of photoaging, the process of skin aging by chronic exposure to ultraviolet radiation, could be linked to genetic factors that accelerate the aging process when induced by the environment. The study, published in the Journal of Investigative Dermatology, was led by BUSM co-authors Thomas M. Ruenger MD, PhD, professor and ...

(Boston) - Physicians from the Departments of Pediatrics and Family Medicine at Boston Medical Center (BMC) and Boston University School of Medicine (BUSM) are proposing that current pediatric guidelines and practices could be implemented within a Patient Centered Medical Home model to address social determinants of health. The article, published in the Journal of the American Medical Association (JAMA), also suggests that these guidelines could reduce socioeconomic disparities in health care for all patients. Arvin Garg, MD, MPH, assistant professor of pediatrics at ...

April 25, 2013, New York, NY and Oxford, UK – Cancer cells are a problem for the body because they multiply recklessly, refuse to die and blithely metastasize to set up shop in places where they don't belong. One protein that keeps healthy cells from behaving this way is a tumor suppressor named p53. This protein stops potentially precancerous cells from dividing and induces suicide in those that are damaged beyond repair. Not surprisingly, p53's critical function is disrupted in most cancers. In the April 25 issue of Cancer Cell, a research team, led by Xin Lu, PhD, ...

School violence is a very important social issue world-wide. It poses a significant threat to the health, achievement, and well-being of students. Although the most highly published incidents involve serious physical violence, less serious forms of physical aggression and psychological violence (including harassment, bullying, and relational aggression) present far more prevalent and persistent problems. During the last twenty years there has been extensive research on identifying risk factors of school violence. Especially the concept of school climate has received ...

ROCHESTER, Minn. -- Using a one-of-a-kind computer-aided program, Mayo Clinic has developed and implemented a Mayo-wide electronic warning system to identify patients at risk of QT-related deaths from an abnormality in the heart's electrical system. The system informs all physicians, regardless of their specialty or QT awareness, if their patient's ECG activated the QT alarm. In addition, the researchers discovered that the death rate of patients whose 12-lead electrocardiogram (ECG) activated the QT alert was nearly four times greater than all other patients who had an ...

RIVERSIDE, Calif. —RNA molecules, made from DNA, are best known for their role in protein production. MicroRNAs (miRNAs), however, are short (~22) nucleotide RNA sequences found in plants and animals that do not encode proteins but act in gene regulation and, in the process, impact almost all biological processes — from development to physiology to stress response. Present in almost in every cell, microRNAs are known to target tens to hundreds of genes each and to be able to repress, or "silence," their expression. What is less well understood is how exactly miRNAs repress ...

This spring, a team of researchers has released results from an eight-year study that shows improved survival rates for women diagnosed with ovarian cancer who undergo cancer tumor testing to determine the best treatment. Part of the team was Richard G. Moore, MD, director of the Center for Biomarkers and Emerging Technologies and a gynecologic oncologist with the Program in Women's Oncology at Women & Infants Hospital of Rhode Island. "Essentially, we have demonstrated that by using a tissue sample from the patient's tumor and a chemoresponse assay, we are able to ...

An international team of researchers, including Scripps Institution of Oceanography, UC San Diego, geochemist James Day, has found new evidence that material contained in oceanic lava flows originated in Earth's ancient Archean crust. These findings support the theory that much of the Earth's original crust has been recycled by the process of subduction, helping to explain how the Earth has formed and changed over time. The Archean geologic eon, Earth's second oldest, dating from 3.8 to 2.5 billion years ago, is the source of the oldest exposed rock formations on the ...

A dramatic leap forward in the ability of scientists to study the structural states of macromolecules such as proteins and nanoparticles in solution has been achieved by a pair of researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab). The researchers have developed a new set of metrics for analyzing data acquired via small angle scattering (SAS) experiments with X-rays (SAXS) or neutrons (SANS). Among other advantages, this will reduce the time required to collect data by up to 20 times. "SAS is the only technique ...

A study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, reports that donor mortality is about 1 in 500 donors with living donor liver transplantation (LDLT). Research of transplant centers around the world found that those with more experience conducting live donor procedures had lower rates of aborted surgery and life-threatening "near-miss" events. For patients with end-stage liver disease, liver transplantation is their only option to prolong life. However, ...

AUSTIN, Texas — Thanks to a rare bacteria that grows only on rocks in the Swiss Alps, researchers at The University of Texas at Austin and the Pasteur Institute in France have been the first to identify how alcohol might affect key brain proteins. It's a major step on the road to eventually developing drugs that could disrupt the interaction between alcohol and the brain. "Now that we've identified this key brain protein and understand its structure, it's possible to imagine developing a drug that could block the binding site," said Adron Harris, professor of biology ...

MINNEAPOLIS – The teenage years may be a key period of vulnerability related to living in the "stroke belt" when it comes to future stroke risk, according to a new study published in the April 24, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology. More people have strokes and die of strokes in the southeastern area known as the stroke belt than in the rest of the United States. So far, research has shown that only part of the difference can be explained by traditional risk factors such as diabetes and high blood pressure. Previous ...

An invisible barrier separates land animals in Australia from those in south-east Asia may also restrict the spillover of animal-borne diseases like avian flu, but researchers have found that fruit bats on either side of this line can carry Nipah virus, a pathogen that causes severe human disease. The findings are published April 24 in the open access journal PLOS ONE by Andrew Breed from the University of Queensland, Australia and colleagues from other institutions. Previous studies have suggested that this biogeographic boundary, named Wallace's line, may have played ...

Deep male voices and high-pitched female voices are perceived as more attractive because listeners gauge the speaker's body size from the frequency of their voice, according to research published April 24 in the open access journal PLOS ONE by Yi Xu from University College London (UK) and colleagues. Studies of animals and birds reveal that listeners can perceive a caller's body size and intension based on the frequency, voice quality and formant spacing of a call. For example, low frequency growls are more likely to indicate larger body size, dominance or a potential ...

Clenching your right hand may help form a stronger memory of an event or action, and clenching your left may help you recollect the memory later, according to research published April 24 in the open access journal PLOS ONE by Ruth Propper and colleagues from Montclair State University. Participants in the research study were split into groups and asked to first memorize, and later recall words from a list of 72 words. There were 4 groups who clenched their hands; One group clenched their right fist for about 90 seconds immediately prior to memorizing the list and then ...

Washington, DC — Stimulating a region of the brain known to be involved in reward decreases binge eating behavior in mice, according to a study published in the April 24 issue of The Journal of Neuroscience. The findings add to a growing body of evidence supporting the role of the brain’s reward system in driving the consumption of palatable food. It could one day pave the way for more effective and lasting treatments for obesity. The numbers of people worldwide living with obesity continues to climb. Recent studies suggest that the consumption of high calorie ...

Lexington, MA, April 24, 2013 (Embargoed until 2:00 PM US Eastern Time) – T2 Biosystems, a company developing direct detection products enabling superior diagnostics, today announced the publication of research supporting the Company's flagship diagnostic test, T2Candida®, in Science Translational Medicine. The research highlights T2Candida as a breakthrough approach to rapid and sensitive identification of species-specific Candida, a sepsis-causing fungus, directly from whole blood in approximately three hours, or up to 25 times faster than the current gold standard of ...

An Autistica consultation published this month found that 24% of children with autism were non-verbal or minimally verbal, and it is known that these problems can persist into adulthood. Professionals have long attempted to support the development of language in these children but with mixed outcomes. An estimated 600,000 people in the UK and 70 million worldwide have autism, a neuro-developmental condition which is life-long. Today, scientists at the University of Birmingham publish a paper in Frontiers in Neuroscience showing that while not all of the current interventions ...

The rediscovery of a mystery animal in a museum's underground storeroom proves that a non-native 'big cat' prowled the British countryside at the turn of the last century. The animal's skeleton and mounted skin was analysed by a multi-disciplinary team of Durham University scientists and fellow researchers at Bristol, Southampton and Aberystwyth universities and found to be a Canadian lynx – a carnivorous predator more than twice the size of a domestic cat. The research, published today in the academic journal Historical Biology, establishes the animal as the earliest ...

MIAMI –– When the eye cancer retinoblastoma is diagnosed in racial and ethnic minority children whose families don't have private health insurance, it often takes a more invasive, potentially life-threatening course than in other children, probably because of delays in diagnosis, Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) researchers will report at the 26th annual meeting of the American Society of Pediatric Hematology Oncology being held in Miami, April 24-27. By analyzing data and tumor samples from 203 children across the United States who had been treated ...

MIAMI--The stem cell transplant regimen that was commonly used in the United States to treat advanced neuroblastoma in children appears to be more toxic than the equally effective regimen employed in Europe and Egypt, according to a new study being presented at the 26th annual meeting of the American Society of Pediatric Hematology Oncology in Miami April 24-27. The U.S. regimen was associated with more acute toxicity to the kidneys and liver. This and other research informed the recent decision of the Children's Oncology Group (COG) to switch to the busulfan-based regimen ...

Chevy Chase, MD—More than a quarter of a century after the Chernobyl nuclear disaster, many children and teenagers who developed thyroid cancer due to radiation are in complete or near remission, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Following the April 26, 1986 explosion and fire at the Chernobyl nuclear plant in the former Soviet Union, the number of children and teenagers diagnosed with differentiated thyroid cancer spiked in Ukraine, Belarus and western areas of Russia. ...

Biologists at UC San Diego have identified eight genes never before suspected to play a role in wound healing that are called into action near the areas where wounds occur. Their discovery, detailed this week in the open-access journal PLOS ONE, was made in the laboratory fruit fly Drosophila. But the biologists say many of the same genes that regulate biological processes in the hard exoskeleton, or cuticle, of Drosophila also control processes in human skin. That makes them attractive candidates for new kinds of wound-healing drugs or other compounds that could be used ...