CHAPEL HILL, N.C. – Despite a substantial increase in the number of people suffering the debilitating and often deadly effects of heart failure, treatments for the condition have not advanced significantly for at least 10 years. An analysis by researchers at the University of North Carolina School of Medicine shows new breakthroughs could be closer than we thought. The analysis points to striking similarities between heart cells in patients with heart failure and brain cells in patients with Alzheimer's disease, raising the possibility that some treatment approaches being ...

A systematic review published today in The Cochrane Library finds that in well-nourished adults current evidence does not support selenium for preventing heart disease. The review suggests that taking selenium supplements does not reduce a person's risk of developing heart disease, although most evidence is currently limited to healthy American adults. Diet is a key factor influencing heart disease risk. Selenium is one dietary element that could potentially play a role in preventing heart disease by protecting against oxidative stress and inflammation. It is a common ...

Magnetic fields produced by the naturally occurring electrical currents in the brain could potentially be used as an objective test for schizophrenia and help to better understand the disease, according to new research published today. A team of researchers from Plymouth and Spain have used the non-invasive magnetoencephalogram (MEG) technique to find two spectral features that are significantly different in schizophrenia patients compared to healthy control subjects. Furthermore, they found that there were four spectral features in the brain signals of schizophrenia ...

Dementia patients may benefit from a promising new treatment called Cerebrolysin, according to the results of a systematic review published in The Cochrane Library. The authors brought together the most up-to-date evidence on Cerebrolysin as a treatment for vascular dementia. Vascular dementia is a common form of dementia caused by damage to the network of blood vessels supplying the brain. Some of the symptoms are similar to those associated with Alzheimer's disease and stroke but in particular those with vascular dementia often experience difficulty thinking quickly, ...

People with hepatitis C and chronic liver disease who relapsed or failed to respond to initial treatment are unlikely to improve on interferon retreatment. In fact, they may face an increased risk of dying sooner, and are likely to experience a variety of adverse effects, according to an updated systematic review published in The Cochrane Library. Hepatitis C affects around 170 million people worldwide. In some cases, infection leads to chronic liver disease, liver failure or liver cancer, eventually resulting in death. Treatment is based on antiviral drugs. Interferon ...

A diagnostic test for tuberculosis (TB) can accurately and quickly detect both TB and drug-resistant strains, according to a new study. The authors of a new systematic review assessing the diagnostic accuracy of the Xpert® MTB/RIF test published in The Cochrane Library say their study can provide timely advice for clinicians and policymakers in countries where TB is a major public health problem. Millions of people develop TB every year. Around 13% of cases occur in people living with HIV and more than a quarter of these people die as a result. Drug resistance is a major ...

Global warming from greenhouse gases affects rainfall patterns in the world differently than that from solar heating, according to a study by an international team of scientists in the January 31 issue of Nature. Using computer model simulations, the scientists, led by Jian Liu (Chinese Academy of Sciences) and Bin Wang (International Pacific Research Center, University of Hawaii at Manoa), showed that global rainfall has increased less over the present-day warming period than during the Medieval Warm Period, even though temperatures are higher today than they were then. ...

STANFORD, Calif. - Tuberculosis is a devastating disease that kills nearly 2 million people worldwide each year. Although antibiotics exist that can ameliorate the symptoms, the courses of therapy last for months and don't completely eradicate the disease, which frequently recurs years or decades after the initial treatment. Now, in a classic case of bench-to-bedside research, scientists at the Stanford University School of Medicine have discovered a possible reason for the disease's resistance: The ability of the tuberculosis bacteria to infiltrate and settle down in ...

The Idu-Mishmi community and Arunachal Pradesh appeared on the world map today for its greatest contribution in studying dormant Mycobacterium in TB that has affected nearly 4 billion people in the world and causing 1.9 million deaths yearly. In India, one person is dying of TB every 3 minutes. The study details and the contribution of Idu-Mishmis of Arunachal Pradesh and RIWATCH (Research Institute of World's Ancient Traditions Cultures and Heritage) in accomplishing the study has been duly acknowledged in a research paper published in a reputed journal 'Science Translational ...

PITTSBURGH, Jan. 30, 2012 –A novel head-to-head study looking at differences in how the antiretroviral (ARV) drug tenofovir gets absorbed in the body as either an oral tablet or a vaginal gel found tenofovir gel can achieve substantially higher concentrations of active drug in vaginal tissue than the oral tablet, suggesting that tenofovir gel should be highly effective in protecting women against HIV transmitted through vaginal sex. Yet, as unequivocal as the study's results may be, they have not been borne out in HIV prevention trials to date, leading the researchers to ...

Severely malnourished children are far more likely to recover and survive when given antibiotics along with a therapeutic peanut-based food than children who are simply treated with the therapeutic food alone, researchers at Washington University School of Medicine in St. Louis have found. "The findings are remarkable," says Indi Trehan, MD, lead author of the research, published Jan. 31 in The New England Journal of Medicine. "Based on previous research, we didn't think there would be much benefit from antibiotics. We did not at all expect to see a drop in the death ...

A first ever study of the range and habits of white-backed vultures across southern Africa shows that they often shun national parks, preferring to forage further afield on private farmland. This behaviour and their tendency to scavenge in groups, means that vultures risk encountering dead cattle that have been administered veterinary drugs that are poisonous to them, or even poisoned carcasses intended to control other carnivores such as jackals. The research, using Global Positioning System (GPS) satellite transmitters to track the movements of adolescent vultures, ...

Children whose mothers take the antiepileptic drug sodium valproate while pregnant are at significantly increased risk of autism and other neurodevelopmental disorders, suggests a small study published online in the Journal of Neurology Neurosurgery and Psychiatry. The authors base their findings on children born to 528 pregnant women between 2000 and 2004 in the North West of England. Just fewer than half the mums (243) had epilepsy, all but 34 of whom took antiepileptic drugs during their pregnancy. Fifty nine mums took carbamazepine; 59 took valproate; 36 took lamotrigine; ...

Comforting a friend or relative in distress may be a more hard-wired behavior than previously thought, according to a new study of bonobos, which are great apes known for their empathy and close relation to humans and chimpanzees. This finding provides key evolutionary insight into how critical social skills may develop in humans. The results are published in the online journal PLOS ONE. Researchers from the Yerkes National Primate Research Center, Emory University, observed juvenile bonobos at the Lola ya Bonobo sanctuary in the Democratic Republic of Congo engaging ...

The largest study of epilepsy in sub-Saharan Africa to date reveals that programmes to control parasitic diseases and access to better antenatal care could substantially reduce the prevalence of the disease in this region. Epilepsy is one of the most common neurological conditions worldwide and it is well known that it is significantly more prevalent in poorer countries and rural areas. The study of over half a million people in five countries of sub-Saharan Africa is the first to reveal the true extent of the problem and the impact of different risk factors. The ...

[The fox and the grapes: an Anglo-Irish perspective on conscientious objection to the supply of emergency hormonal contraception without prescription Online First doi 10.1136/medethics-2012-100975] Conscience clauses, which allow pharmacists to opt out of providing the "morning after pill" without a prescription, risk unwanted pregnancies and undermine the principle of universal healthcare in the NHS, say pharmacists in the Journal of Medical Ethics. These clauses should either be banned or enhanced so that pharmacists and patients know exactly where they stand, rather ...

PULLMAN, Wash.—Washington State University researchers have linked orchards and vineyards with a greater prevalence of West Nile virus in mosquitoes and the insects' ability to spread the virus to birds, horses and people. The finding, reported in the latest issue of the journal PLOS ONE, is the most finely scaled look at the interplay between land use and with the virus's activity in key hosts. By giving a more detailed description of how the disease moves across the landscape, it opens the door to management efforts that might bring the disease under control, says David ...

(Seattle, January 30, 2013) Researchers from Benaroya Research Institute at Virginia Mason (BRI) have found that proteins in the IL-6 signaling pathway may be leveraged as novel biomarkers of multiple sclerosis (MS) to gauge disease activity and as a target for new therapies. The research, which investigated how several components involved in immune response differ between MS patient and control samples, was conducted by a team of researchers at BRI led by Dr. Jane Buckner in collaboration with Dr. Mariko Kita at Virginia Mason Medical Center and was published today in ...

Scientists from the University of Cambridge have created, for the first time, a new type of microchip which allows information to travel in three dimensions. Currently, microchips can only pass digital information in a very limited way - from either left to right or front to back. The research was published today, 31 January, in Nature. Dr Reinoud Lavrijsen, an author on the paper from the University of Cambridge, said: "Today's chips are like bungalows – everything happens on the same floor. We've created the stairways allowing information to pass between floors." Researchers ...

A natural disaster can bring out the best in older children, prompting 9-year-olds to be more willing to share, while 6-year-olds become more selfish. Researchers at the University of Toronto, the University of Chicago, and Liaoning Normal University made this finding in a rare natural experiment in China around the time of a horrific earthquake. A crucial difference between the two age groups emerged one month after the disaster. The 6-year-olds' willingness to share in a test measuring altruism dropped by a third, while among 9-year-olds, willingness to give to others ...

In this month's edition of Physics World, science writer Richard Corfield casts doubt on the alleged "brainwashing" of the late British astronomer Sir Bernard Lovell by the Soviets at the height of the Cold War and explains how his trips beyond the Iron Curtain laid the foundations for the easing of geopolitical tensions between the UK and the USSR. Speaking to Lovell's son Bryan, Corfield reveals a more mundane explanation for why Lovell, who founded the Jodrell Bank telescope in the UK, fell ill on his return from the USSR in 1963. "For me the more likely explanation ...

A study of young twins in Malawi, in sub-Saharan Africa, finds that bacteria living in the intestine are an underlying cause of a form of severe acute childhood malnutrition. The research, led by Washington University School of Medicine in St. Louis and reported Feb. 1 in the journal Science, shows how dysfunctional communities of gut microbes conspire with a poor diet to trigger malnutrition. The discovery is bolstered by additional studies in mice, showing that gut microbes transplanted from malnourished children cause dramatic weight loss and alter metabolism when ...

Winemakers have long known that blending different grape varietals can favorably balance the flavor characteristics of the wine they produce. In the future, makers of advanced biofuels might use a similar strategy, blending different feedstock varieties to balance the energy characteristics of the transportation fuel they produce. A collaborative study by researchers with the U.S. Department of Energy (DOE)'s Joint BioEnergy Institute (JBEI), a bioenergy research center led by Berkeley Lab, and the Idaho National Laboratory (INL) has shown that an ionic liquid proven ...

Jan. 30 2013 - Scientists have long known that cattle produce carbon dioxide and methane throughout their lives, but a new study pinpoints the cow-calf stage as a major contributor of greenhouse gases during beef production. In a new paper for the Journal of Animal Science, scientists estimate greenhouse gas emissions from beef cattle during different stages of life. They show that, depending on which production system farmers used, beef production has a carbon footprint ranging from 10.7 to 22.6 kg of carbon dioxide equivalent per kg of hot carcass weight. According ...

PROVIDENCE, R.I. [Brown University] — Ecology is rife with predation, competition, and other dramatic "negative interactions," but those alone do not determine the course life on Earth. Organisms sometimes benefit each other, too, and according to the Stress Gradient Hypothesis, their "positive interactions" become measurably more influential when ecosystems become threatened by conditions such as drought. Ecologists have argued about the hypothesis ever since Brown University ecologist Mark Bertness co-proposed it in 1994; Bertness says a large new global meta-analysis ...